Pafah1b3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3) - Rat Genome Database

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Gene: Pafah1b3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3) Rattus norvegicus
Analyze
Symbol: Pafah1b3
Name: platelet-activating factor acetylhydrolase 1b, catalytic subunit 3
RGD ID: 620333
Description: Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity. Contributes to platelet-activating factor acetyltransferase activity. Predicted to be involved in lipid catabolic process. Predicted to act upstream of or within spermatogenesis. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex. Orthologous to human PAFAH1B3 (platelet activating factor acetylhydrolase 1b catalytic subunit 3); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; ether lipid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC156583; PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH alpha 1; PAF-AH subunit gamma; PAFAH subunit gamma; platelet-activating factor acetylhydrolase alpha 1 subunit; platelet-activating factor acetylhydrolase IB subunit alpha1; platelet-activating factor acetylhydrolase IB subunit gamma; platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit; platelet-activating factor acetylhydrolase, isoform 1b, subunit 3; platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,009,085 - 90,011,611 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl190,009,085 - 90,011,611 (-)EnsemblGRCr8
mRatBN7.2180,881,263 - 80,883,789 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,881,309 - 80,883,893 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,273,482 - 86,276,008 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,824,609 - 94,827,135 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,029,259 - 88,031,785 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,163,733 - 82,166,259 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,163,595 - 82,166,363 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,427,895 - 83,430,421 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,570,160 - 80,572,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,324,171 - 75,326,697 (-)NCBICelera
RGSC_v3.1180,648,270 - 80,650,797 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenpyroximate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
genistein  (ISO)
hydralazine  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. Manya H, etal., J Biol Chem. 1998 Jul 17;273(29):18567-72.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase. Watanabe M, etal., Biochim Biophys Acta 1998 Jan 2;1401(1):73-9.
10. The Pafah1b complex interacts with the reelin receptor VLDLR. Zhang G, etal., PLoS One. 2007 Feb 28;2(2):e252.
Additional References at PubMed
PMID:10940388   PMID:12477932   PMID:12551946   PMID:16189514   PMID:19946888   PMID:20074623   PMID:21516116   PMID:23376485   PMID:25416956  


Genomics

Comparative Map Data
Pafah1b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,009,085 - 90,011,611 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl190,009,085 - 90,011,611 (-)EnsemblGRCr8
mRatBN7.2180,881,263 - 80,883,789 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,881,309 - 80,883,893 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,273,482 - 86,276,008 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,824,609 - 94,827,135 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,029,259 - 88,031,785 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,163,733 - 82,166,259 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,163,595 - 82,166,363 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,427,895 - 83,430,421 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,570,160 - 80,572,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,324,171 - 75,326,697 (-)NCBICelera
RGSC_v3.1180,648,270 - 80,650,797 (-)NCBI
Cytogenetic Map1q21NCBI
PAFAH1B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,297,033 - 42,302,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,297,023 - 42,303,546 (-)Ensemblhg38GRCh38
GRCh371942,801,185 - 42,806,952 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,493,025 - 47,498,563 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341947,493,024 - 47,498,563NCBI
Celera1939,601,981 - 39,607,748 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,231,325 - 39,237,093 (-)NCBIHuRef
CHM1_11942,802,836 - 42,808,603 (-)NCBICHM1_1
T2T-CHM13v2.01945,116,406 - 45,122,173 (-)NCBIT2T-CHM13v2.0
Pafah1b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,994,473 - 24,997,377 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,994,474 - 24,997,411 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38725,295,048 - 25,297,986 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,295,049 - 25,297,986 (-)Ensemblmm10GRCm38
MGSCv37726,080,068 - 26,082,974 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36725,003,809 - 25,006,715 (-)NCBIMGSCv36mm8
Celera719,910,093 - 19,912,999 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.73NCBI
Pafah1b3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555609,925 - 612,701 (+)Ensembl
ChiLan1.0NW_004955555609,925 - 612,701 (+)NCBIChiLan1.0ChiLan1.0
PAFAH1B3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,401,972 - 48,407,301 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11950,270,609 - 50,275,893 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,184,734 - 39,190,522 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,455,270 - 133,455,822 (-)NCBIPanPan1.1PanPan1.1panPan2
PAFAH1B3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,078,131 - 112,080,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,063,074 - 112,080,873 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1111,504,270 - 111,507,037 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01112,690,772 - 112,693,507 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,676,028 - 112,693,506 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,244,948 - 112,247,717 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,880,891 - 111,883,654 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,807,432 - 112,810,199 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pafah1b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,849,621 - 15,868,155 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706212,096 - 215,497 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936706212,635 - 215,498 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAFAH1B3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,619,241 - 49,638,171 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,635,625 - 49,638,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,556,126 - 45,558,674 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAFAH1B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,501,726 - 36,508,027 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,501,314 - 36,507,846 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607314,747,530 - 14,753,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pafah1b3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907454,407 - 459,441 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624907454,434 - 457,551 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pafah1b3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12169,417,425 - 169,420,011 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pafah1b3
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:49
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000027774
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
D1Rat96  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,883,820 - 80,883,973 (+)MAPPERmRatBN7.2
Rnor_6.0182,166,291 - 82,166,443NCBIRnor6.0
Rnor_5.0183,430,453 - 83,430,605UniSTSRnor5.0
RGSC_v3.4180,572,711 - 80,572,987RGDRGSC3.4
RGSC_v3.4180,572,718 - 80,572,870UniSTSRGSC3.4
Celera175,326,729 - 75,326,881UniSTS
RGSC_v3.1180,650,829 - 80,650,981RGD
RH 3.4 Map1824.5RGD
RH 3.4 Map1824.5UniSTS
RH 2.0 Map1506.5RGD
FHH x ACI Map142.2599RGD
Cytogenetic Map1q21UniSTS
RH133477  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,881,298 - 80,881,503 (+)MAPPERmRatBN7.2
Rnor_6.0182,163,769 - 82,163,973NCBIRnor6.0
Rnor_5.0183,427,931 - 83,428,135UniSTSRnor5.0
RGSC_v3.4180,570,196 - 80,570,400UniSTSRGSC3.4
Celera175,324,207 - 75,324,411UniSTS
Cytogenetic Map1q21UniSTS
Pafah1b3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,881,320 - 80,881,504 (+)MAPPERmRatBN7.2
Rnor_6.0182,163,791 - 82,163,974NCBIRnor6.0
Rnor_5.0183,427,953 - 83,428,136UniSTSRnor5.0
RGSC_v3.4180,570,218 - 80,570,401UniSTSRGSC3.4
Celera175,324,229 - 75,324,412UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027774   ⟹   ENSRNOP00000027774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl190,009,085 - 90,011,611 (-)Ensembl
mRatBN7.2 Ensembl180,881,309 - 80,883,893 (-)Ensembl
Rnor_6.0 Ensembl182,163,595 - 82,166,363 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115494   ⟹   ENSRNOP00000086997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl190,009,865 - 90,011,611 (-)Ensembl
mRatBN7.2 Ensembl180,882,043 - 80,883,893 (-)Ensembl
RefSeq Acc Id: NM_053654   ⟹   NP_446106
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,009,085 - 90,011,611 (-)NCBI
mRatBN7.2180,881,263 - 80,883,789 (-)NCBI
Rnor_6.0182,163,733 - 82,166,259 (-)NCBI
Rnor_5.0183,427,895 - 83,430,421 (-)NCBI
RGSC_v3.4180,570,160 - 80,572,686 (-)RGD
Celera175,324,171 - 75,326,697 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228365   ⟹   XP_006228427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,009,085 - 90,011,486 (-)NCBI
mRatBN7.2180,881,263 - 80,883,664 (-)NCBI
Rnor_6.0182,163,733 - 82,166,138 (-)NCBI
Rnor_5.0183,427,895 - 83,430,421 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588652   ⟹   XP_017444141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,009,085 - 90,011,258 (-)NCBI
mRatBN7.2180,881,263 - 80,883,467 (-)NCBI
Rnor_6.0182,163,733 - 82,165,946 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063262359   ⟹   XP_063118429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,009,085 - 90,011,486 (-)NCBI
RefSeq Acc Id: NP_446106   ⟸   NM_053654
- UniProtKB: O35263 (UniProtKB/Swiss-Prot),   A6J951 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228427   ⟸   XM_006228365
- Peptide Label: isoform X1
- UniProtKB: O35263 (UniProtKB/Swiss-Prot),   A6J951 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444141   ⟸   XM_017588652
- Peptide Label: isoform X1
- UniProtKB: O35263 (UniProtKB/Swiss-Prot),   A6J951 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027774   ⟸   ENSRNOT00000027774
Ensembl Acc Id: ENSRNOP00000086997   ⟸   ENSRNOT00000115494
RefSeq Acc Id: XP_063118429   ⟸   XM_063262359
- Peptide Label: isoform X1
- UniProtKB: O35263 (UniProtKB/Swiss-Prot),   A6J951 (UniProtKB/TrEMBL)
Protein Domains
SGNH hydrolase-type esterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35263-F1-model_v2 AlphaFold O35263 1-232 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689813
Promoter ID:EPDNEW_R338
Type:initiation region
Name:Pafah1b3_1
Description:platelet-activating factor acetylhydrolase 1b, catalytic subunit3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,166,340 - 82,166,400EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620333 AgrOrtholog
BioCyc Gene G2FUF-60393 BioCyc
Ensembl Genes ENSRNOG00000020481 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027774 ENTREZGENE
  ENSRNOT00000027774.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1110 UniProtKB/Swiss-Prot
InterPro SGNH_hydro UniProtKB/Swiss-Prot
  SGNH_hydro_sf UniProtKB/Swiss-Prot
KEGG Report rno:114113 UniProtKB/Swiss-Prot
NCBI Gene 114113 ENTREZGENE
PANTHER PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE UniProtKB/Swiss-Prot
  PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT ALPHA1 UniProtKB/Swiss-Prot
Pfam Lipase_GDSL_2 UniProtKB/Swiss-Prot
PhenoGen Pafah1b3 PhenoGen
RatGTEx ENSRNOG00000020481 RatGTEx
Superfamily-SCOP SGNH hydrolase UniProtKB/Swiss-Prot
UniProt A0A8I6A6G3_RAT UniProtKB/TrEMBL
  A0JN11_RAT UniProtKB/TrEMBL
  A6J951 ENTREZGENE, UniProtKB/TrEMBL
  A6J952_RAT UniProtKB/TrEMBL
  O35263 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Pafah1b3  platelet-activating factor acetylhydrolase 1b, catalytic subunit 3  Pafah1b3  platelet-activating factor acetylhydrolase, isoform 1b, subunit 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-04-21 Pafah1b3  platelet-activating factor acetylhydrolase, isoform 1b, subunit 3  Pafah1b3  platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Pafah1b3  platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit   Pafah1b3  platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pafah1b3  platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pafah1b3  platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL