Gene: Pafah1b2 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 2)
Rattus norvegicus
Symbol:
Pafah1b2
Name:
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
Description:
ENCODES a protein that exhibits platelet-activating factor acetyltransferase activity; protein heterodimerization activity; protein homodimerization activity; INVOLVED IN brain development; positive regulation of macroautophagy (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; ether lipid metabolic pathway; ASSOCIATED WITH Lymphoma (ortholog); FOUND IN cytosol; cytoplasm (ortholog); nucleolus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; ammonium chloride
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
MGC93124; PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH alpha 2; PAF-AH subunit beta; PAFAH subunit beta; platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2); platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit; platelet-activating factor acetylhydrolase, isoform 1b, subunit 2; platelet-activating factor acetylhydrolase, isoform Ib, beta subunit; platelet-activating factor acetylhydrolase, isoform Ib, beta subunit ; platelet-activating factor acetylhydrolase, isoform Ib, subunit 2
Orthologs:
Homo sapiens : PAFAH1B2
(platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa))
HGNC
Pafah1b2
(platelet-activating factor acetylhydrolase, isoform 1b, subunit 2)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 8 q22 NCBI RGSC Genome Assembly v5.0 8 48,883,712 - 48,902,445 - NCBI RGSC Genome Assembly v3.4 8 48,938,556 - 48,957,109 - NCBI Rat Celera Assembly 8 45,843,851 - 45,862,380 - NCBI Genome Assembly 3.1 8 48,947,322 - 48,965,875 - NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol affects expression ISO RGD:733677 6480464 Ethinyl Estradiol affects the expression of PAFAH1B2 mRNA CTD PMID:17555576 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PAFAH1B2 protein CTD PMID:16548065 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733676 6480464 Tetrachlorodibenzodioxin affects the expression of PAFAH1B2 mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:733677 6480464 Tetrachlorodibenzodioxin results in decreased expression of PAFAH1B2 mRNA CTD PMID:19770486 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of PAFAH1B2 mRNA CTD PMID:21346803 aflatoxin B1 decreases expression ISO RGD:733677 6480464 Aflatoxin B1 results in decreased expression of PAFAH1B2 mRNA CTD PMID:19770486 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PAFAH1B2 mRNA CTD PMID:16483693 arsenite(3-) increases expression ISO RGD:733677 6480464 arsenite results in increased expression of PAFAH1B2 mRNA CTD PMID:18191166 benzo[a]pyrene multiple interactions ISO RGD:733677 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PAFAH1B2 mRNA CTD PMID:21715664 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of PAFAH1B2 mRNA CTD PMID:21297351 cisplatin increases phosphorylation ISO RGD:733677 6480464 Cisplatin results in increased phosphorylation of PAFAH1B2 protein CTD PMID:22006019 copper(2+) sulfate increases expression ISO RGD:733676 6480464 Copper Sulfate results in increased expression of PAFAH1B2 mRNA CTD PMID:19549813 cypermethrin decreases expression EXP 6480464 cypermethrin results in decreased expression of PAFAH1B2 protein CTD PMID:21561882 cypermethrin multiple interactions EXP 6480464 Minocycline inhibits the reaction [cypermethrin results in decreased expression of PAFAH1B2 protein] CTD PMID:21561882 hypochlorous acid increases expression ISO RGD:733677 6480464 Hypochlorous Acid results in increased expression of PAFAH1B2 mRNA CTD PMID:19376150 methylazoxymethanol increases expression ISO RGD:733677 6480464 methylazoxymethanol results in increased expression of PAFAH1B2 mRNA CTD PMID:17107856 minocycline multiple interactions EXP 6480464 Minocycline inhibits the reaction [cypermethrin results in decreased expression of PAFAH1B2 protein] CTD PMID:21561882 paracetamol affects expression ISO RGD:733677 6480464 Acetaminophen affects the expression of PAFAH1B2 mRNA CTD PMID:17562736 phenytoin decreases expression ISO RGD:733677 6480464 Phenytoin results in decreased expression of PAFAH1B2 mRNA CTD PMID:15136057 pirinixic acid increases expression ISO RGD:733677 6480464 pirinixic acid results in increased expression of PAFAH1B2 mRNA CTD PMID:17950772 pirinixic acid multiple interactions ISO RGD:733677 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of PAFAH1B2 mRNA] CTD PMID:17950772 tamoxifen affects expression ISO RGD:733677 6480464 Tamoxifen affects the expression of PAFAH1B2 mRNA CTD PMID:17555576 valproic acid decreases expression ISO RGD:733677 6480464 Valproic Acid results in decreased expression of PAFAH1B2 mRNA CTD PMID:21427059
Biological Process brain development IEP 4107046 RGD lipid catabolic process IEA UniProtKB-KW:KW-0442 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 positive regulation of macroautophagy ISO RGD:733676 1624291 PMID:22354037 RGD PMID:22354037 positive regulation of macroautophagy IEA Ensembl:ENSP00000435289 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 spermatogenesis ISO RGD:733677 1624291 MGI:MGI:2655809 RGD MGI:MGI:2655038 PMID:12551946 spermatogenesis IEA Ensembl:ENSMUSP00000127851 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component cytoplasm ISO RGD:733677 1624291 MGI:MGI:2655038|PMID:12551946 RGD MGI:MGI:2655038 PMID:12551946 cytoplasm ISO RGD:733676 1624291 GO_REF:0000052 RGD GO_REF:0000052 cytosol IDA 4107046 RGD nucleolus IEA Ensembl:ENSP00000435289 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 nucleolus ISO RGD:733676 1624291 GO_REF:0000052 RGD GO_REF:0000052 plasma membrane IEA Ensembl:ENSP00000435289 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 plasma membrane ISO RGD:733676 1624291 GO_REF:0000052 RGD GO_REF:0000052 Molecular Function 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA EC:3.1.1.47 1600115 GO_REF:0000003 UniProtKB GO_REF:0000003 platelet-activating factor acetyltransferase activity TAS 729515 RGD platelet-activating factor acetyltransferase activity IDA 4107046 RGD protein binding IPI UniProtKB:P43033 633389 PMID:10940388 IntAct protein heterodimerization activity IPI RGD:620333 4107046 RGD protein homodimerization activity IDA 4107046 RGD
71120 Niddm21 Non-insulin dependent diabetes mellitus QTL 21 3.73 Glucose level postprandial 8 3039822 61462321 Rat 2317032 Ginf2 Gastrointestinal inflammation QTL 2 3.21 .005 Gastrointestinal inflammation 8 5914098 50914098 Rat 2317036 Livw3 Liver weight QTL 3 2.43 .01 Liver weight 8 5914098 50914098 Rat 2317048 Ginf1 Gastrointestinal inflammation QTL 1 3.52 .005 Gastrointestinal inflammation gut score 8 5914098 50914098 Rat 2301416 Bp315 Blood pressure QTL 315 .008 Blood pressure mean arterial 8 7408118 52408118 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 Brain/spinal cord inflammation demyelination 8 8294860 115338082 Rat 1354595 Despr4 Despair related QTL 4 .0036 Activity level immobility level 8 9008612 54008612 Rat 1354627 Despr14 Despair related QTL 14 .0056 Activity level swimming level 8 9008612 54008612 Rat 1598824 Memor4 Memory QTL 4 2.5 Memory navigation-spatial 8 9581132 56397678 Rat 61353 Bp35 Blood pressure QTL 35 Blood pressure 8 9581132 103685771 Rat 2317030 Wbc5 White blood cell count QTL 5 3.21 .005 White blood cell count 8 10116155 55116155 Rat 2317051 Aia18 Adjuvant induced arthritis QTL 18 2.42 Joint/bone inflammation adjuvant induced 8 10116155 55116155 Rat 1558646 Swd5 Spike wave discharge measurement QTL 5 3.45 .00036 Spike wave discharge measurement frequency 8 16442230 61442230 Rat 631271 Cati1 Cataract Ihara QTL 1 .001 Cataract susceptibility 8 16468237 61468237 Rat 731182 Uae24 Urinary albumin excretion QTL 24 6.4 Renal function urine albumin level 8 19815642 98451660 Rat 631842 Inf1 Infertility severity QTL 1 4.1 .001 Seminal vesicle mass 8 26358063 71358063 Rat 1359021 Bp271 Blood pressure QTL 271 1.8 Blood pressure mean arterial 8 27021985 49403011 Rat 631648 Stl5 Serum triglyceride level QTL 5 4 .0003 Lipid level triglyceride 8 28414004 58991068 Rat 1358892 Kidm26 Kidney mass QTL 26 3.69 Kidney mass 8 28414004 103684785 Rat 1358896 Bp262 Blood pressure QTL 262 2.89 Blood pressure post sympathetic nervous system block 8 28414004 103684785 Rat 1358907 Cm40 Cardiac mass QTL 40 1.89 Cardiac mass 8 28414004 103684785 Rat 2303572 Insul13 Insulin level QTL 13 2 Insulin level 8 29077622 74077622 Rat 2303564 Gluco43 Glucose level QTL 43 3 Glucose level fasting 8 29077622 74077622 Rat 1300146 Rf17 Renal function QTL 17 2.9 Renal function salt-loaded renal blood flow 8 29559446 74559446 Rat 1331804 Cm30 Cardiac mass QTL 30 3.77443 Cardiac mass 8 29559446 103672447 Rat 2302278 Gluco36 Glucose level QTL 36 4.2 Glucose level 8 30878636 53049477 Rat 724514 Uae15 Urinary albumin excretion QTL 15 2.9 Renal function urine albumin level 8 30878636 74178909 Rat 1549908 Neudeg1 Neurodegradation QTL 1 5 0 Neurodegradation motoneuron cell number 8 31508524 98947320 Rat 1331744 Bp217 Blood pressure QTL 217 3.398 Blood pressure systolic 8 32203394 61853629 Rat 1359033 Bp273 Blood pressure QTL 273 Blood pressure response to intrathecal cytisine 8 32203394 64762616 Rat 2313046 Bss78 Bone structure and strength QTL 78 3.5 .0001 Bone strength 8 32203394 86628010 Rat 2313057 Bss76 Bone structure and strength QTL 76 3 .0001 Bone structure 8 32203394 86628010 Rat 2313067 Bss77 Bone structure and strength QTL 77 3.1 .0001 Bone structure 8 32203394 86628010 Rat 2313088 Bss75 Bone structure and strength QTL 75 3.1 .0001 Bone structure 8 32203394 86628010 Rat 724540 Uae8 Urinary albumin excretion QTL 8 5 Renal function urine abumin level 8 32203394 98986263 Rat 1578755 Pur5 Proteinuria QTL 5 3.3 .0001 Renal function urine protein level 8 32203394 98986263 Rat 1578765 Klgr1 Kidney lesion grade QTL 1 3.3 .0001 Renal histology kidney lesion grade 8 32203499 98986085 Rat 1578769 Uae31 Urinary albumin excretion QTL 31 3.3 .001 Renal function urine albumin level 8 32203499 98986085 Rat 2316950 Scl66 Serum cholesterol level QTL 66 4.1 Lipid level serum cholesterol 8 32203499 110106272 Rat 1298065 Scl16 Serum cholesterol level QTL 16 3.8 Lipid level cholesterol 8 33897608 78897608 Rat 1582222 Epfw2 Epididymal fat weight QTL 2 3.2 .0005 Epididymal fat weight 8 34808657 79808657 Rat 1331838 Niddm61 Non-insulin dependent diabetes mellitus QTL 61 3.53 .0004 Insulin level fasting 8 38003289 103665018 Rat 61358 Bp39 Blood pressure QTL 39 2 Blood pressure 8 38902937 83902937 Rat 737824 Hcar10 Hepatocarcinoma resistance QTL 10 2.9 Liver tumor resistance nodule number 8 43313902 87122960 Rat 1358906 Bp253 Blood pressure QTL 253 4 .0004 Blood pressure post sympathetic nervous system block 8 43313902 98451660 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 .0001 Bone mineral density distal femur volumetric BMD by pQCT 8 43561064 129041809 Rat 1331769 Rf39 Renal function QTL 39 3.871 Renal function urine volume 8 44484215 103672447 Rat 1298079 Activ2 Activity QTL 2 9.5 .000001 Activity level novel environment 8 44484215 129041809 Rat 631216 Stl9 Serum triglyceride level QTL 9 4.71 .0001 Lipid level triglyceride 8 44484347 74178405 Rat 5684993 Bmd84 Bone mineral density QTL 84 4.1 Bone mineral density bone mineral content 8 45291674 53049477 Rat 70161 Bp62 Blood pressure QTL 62 2.9 .001 Blood pressure salt-loaded systolic 8 45291674 94514282 Rat
Gene-Chemical Interaction Annotations
