Syk (spleen associated tyrosine kinase) - Rat Genome Database

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Gene: Syk (spleen associated tyrosine kinase) Rattus norvegicus
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Symbol: Syk
Name: spleen associated tyrosine kinase
RGD ID: 3796
Description: Enables protein domain specific binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of mast cell degranulation and regulation of immune response. Predicted to be located in early phagosome and nucleus. Predicted to be part of B cell receptor complex and T cell receptor complex. Predicted to be active in plasma membrane. Used to study anti-basement membrane glomerulonephritis. Human ortholog(s) of this gene implicated in immunodeficiency 82. Orthologous to human SYK (spleen associated tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p72syk; spleen tyrosine kinase; tyrosine-protein kinase SYK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Iddm20
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81712,756,493 - 12,830,927 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1712,756,493 - 12,813,278 (-)EnsemblGRCr8
mRatBN7.21712,604,615 - 12,678,437 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1712,604,619 - 12,661,410 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1712,538,728 - 12,595,465 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01714,142,936 - 14,199,625 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01712,459,903 - 12,516,603 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01712,614,311 - 12,669,568 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1712,614,311 - 12,669,573 (-)Ensemblrn6Rnor6.0
Rnor_5.01714,703,903 - 14,759,160 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41718,440,672 - 18,498,001 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1712,367,624 - 12,424,213 (-)NCBICelera
RGSC_v3.11718,440,671 - 18,498,006 (-)NCBI
RH 3.4 Map17126.2RGD
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-amanitin  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antigen  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucan  (ISO)
beta-lapachone  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
camptothecin  (ISO)
cangrelor  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dieldrin  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
Harpagoside  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
leukotriene C4  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
nitroglycerin  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
thioacetamide  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IBA,IEA,ISS)
amyloid-beta clearance  (IEA,ISO)
angiogenesis  (IEA)
apoptotic signaling pathway  (IEA,ISO)
B cell receptor signaling pathway  (IBA,IEA,ISO,ISS)
beta selection  (ISO)
blood vessel morphogenesis  (IEA,ISO,ISS)
cell activation  (IEA,ISO)
cell surface pattern recognition receptor signaling pathway  (IEA,ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to lectin  (IEA,ISO)
cellular response to lipid  (IEA,ISO)
cellular response to low-density lipoprotein particle stimulus  (IEA,ISO,ISS)
cellular response to molecule of fungal origin  (IEA,ISO,ISS)
collagen-activated tyrosine kinase receptor signaling pathway  (ISO)
defense response to bacterium  (IEA,ISO,ISS)
enzyme-linked receptor protein signaling pathway  (ISO)
immune system process  (IEA)
innate immune response  (IEA,ISO,ISS)
integrin-mediated signaling pathway  (IEA,ISO,ISS)
interleukin-3-mediated signaling pathway  (IEA,ISO,ISS)
intracellular signal transduction  (IEA,ISO)
leukocyte activation involved in immune response  (IEA,ISO,ISS)
leukocyte cell-cell adhesion  (IEA,ISO,ISS)
leukotriene biosynthetic process  (ISO)
lymph vessel development  (IEA,ISO,ISS)
macrophage activation involved in immune response  (IBA,IEA,ISO,ISS)
neutrophil activation involved in immune response  (IBA,IEA,ISO,ISS)
neutrophil chemotaxis  (IEA,ISO,ISS)
peptidyl-serine phosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO,ISS)
positive regulation of alpha-beta T cell differentiation  (ISO)
positive regulation of alpha-beta T cell proliferation  (ISO)
positive regulation of B cell differentiation  (IEA,ISO)
positive regulation of bone resorption  (IEA,ISO,ISS)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of cell adhesion mediated by integrin  (IBA,IEA,ISO,ISS)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of cytokine production  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-3 production  (ISO)
positive regulation of interleukin-4 production  (IEA,ISO,ISS)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mast cell degranulation  (IEA,IMP,ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of receptor internalization  (IEA,ISO)
positive regulation of superoxide anion generation  (IEA,ISO)
positive regulation of TORC1 signaling  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type I interferon production  (IEA,ISO)
protein autophosphorylation  (IDA,ISO)
protein import into nucleus  (ISO)
protein phosphorylation  (ISO)
receptor internalization  (IEA,ISO,ISS)
regulation of arachidonate secretion  (IEA,ISO,ISS)
regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
regulation of immune response  (IDA,IEA)
regulation of neutrophil degranulation  (IEA,ISO,ISS)
regulation of phagocytosis  (IEA,ISO,ISS)
regulation of platelet activation  (IEA,ISO,ISS)
regulation of platelet aggregation  (IEA,ISO,ISS)
regulation of superoxide anion generation  (IEA,ISO,ISS)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
serotonin secretion  (ISO)
serotonin secretion by platelet  (IEA,ISO,ISS)
stimulatory C-type lectin receptor signaling pathway  (IEA,ISO)

Cellular Component
B cell receptor complex  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,TAS)
early phagosome  (IEA,ISO,ISS)
nucleus  (IEA,ISO)
plasma membrane  (IBA,IEA)
protein-containing complex  (IEA,ISO)
T cell receptor complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. Amir-Moazami O, etal., J Biol Chem. 2008 Sep 12;283(37):25514-23. Epub 2008 Jun 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. SYK kinase mediates brown fat differentiation and activation. Knoll M, etal., Nat Commun. 2017 Dec 13;8(1):2115. doi: 10.1038/s41467-017-02162-3.
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells. Lee JH, etal., Blood. 2006 Aug 1;108(3):956-64.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. Ota Y, etal., J Exp Med. 1996 Nov 1;184(5):1713-23.
10. Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells. Paolini R, etal., J Biol Chem 2002 Oct 4;277(40):36940-7.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Molecular cloning of rodent p72Syk. Evidence of alternative mRNA splicing. Rowley RB, etal., J Biol Chem 1995 May 26;270(21):12659-64.
17. Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Ryan J, etal., Lab Invest. 2011 Dec;91(12):1727-38. doi: 10.1038/labinvest.2011.137. Epub 2011 Sep 5.
18. Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibody. Zhang J, etal., J Biol Chem. 2000 Nov 10;275(45):35442-7.
19. Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells. Zhang J, etal., Mol Cell Biol 2002 Dec;22(23):8144-54.
Additional References at PubMed
PMID:7477352   PMID:7477353   PMID:7499277   PMID:7693687   PMID:7744830   PMID:8163536   PMID:8176201   PMID:8626447   PMID:8629002   PMID:8657103   PMID:8790395   PMID:8798454  
PMID:9000133   PMID:9099676   PMID:9171347   PMID:9275205   PMID:10648173   PMID:10872802   PMID:10940905   PMID:11672534   PMID:11744621   PMID:11940607   PMID:12051764   PMID:12077122  
PMID:12522250   PMID:12885943   PMID:15123770   PMID:15173175   PMID:15489638   PMID:15845454   PMID:16456001   PMID:17086186   PMID:17353363   PMID:17365510   PMID:17621553   PMID:17681949  
PMID:17993265   PMID:18021750   PMID:18369315   PMID:18806259   PMID:18818202   PMID:19038866   PMID:19098920   PMID:19151749   PMID:19358895   PMID:19409513   PMID:19584058   PMID:19770268  
PMID:19797524   PMID:20624904   PMID:21055270   PMID:21083985   PMID:21189061   PMID:21354221   PMID:21642504   PMID:22041900   PMID:22078883   PMID:22267217   PMID:22451653   PMID:22496641  
PMID:23071339   PMID:23395392   PMID:23962979   PMID:24700868   PMID:25246527   PMID:25251945   PMID:25529862   PMID:25644261   PMID:26138128   PMID:27609517   PMID:28393919   PMID:29845271  
PMID:29901140   PMID:30942391  


Genomics

Comparative Map Data
Syk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81712,756,493 - 12,830,927 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1712,756,493 - 12,813,278 (-)EnsemblGRCr8
mRatBN7.21712,604,615 - 12,678,437 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1712,604,619 - 12,661,410 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1712,538,728 - 12,595,465 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01714,142,936 - 14,199,625 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01712,459,903 - 12,516,603 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01712,614,311 - 12,669,568 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1712,614,311 - 12,669,573 (-)Ensemblrn6Rnor6.0
Rnor_5.01714,703,903 - 14,759,160 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41718,440,672 - 18,498,001 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1712,367,624 - 12,424,213 (-)NCBICelera
RGSC_v3.11718,440,671 - 18,498,006 (-)NCBI
RH 3.4 Map17126.2RGD
Cytogenetic Map17p14NCBI
SYK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38990,801,600 - 90,898,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl990,801,579 - 90,898,549 (+)Ensemblhg38GRCh38
GRCh37993,563,882 - 93,660,831 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36992,603,891 - 92,698,305 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34990,643,624 - 90,738,036NCBI
Celera963,998,674 - 64,095,487 (+)NCBICelera
Cytogenetic Map9q22.2NCBI
HuRef963,244,666 - 63,341,118 (+)NCBIHuRef
CHM1_1993,710,484 - 93,807,287 (+)NCBICHM1_1
T2T-CHM13v2.09102,966,952 - 103,064,392 (+)NCBIT2T-CHM13v2.0
Syk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391352,736,670 - 52,802,828 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1352,737,209 - 52,802,828 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381352,582,610 - 52,648,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1352,583,173 - 52,648,792 (+)Ensemblmm10GRCm38
MGSCv371352,692,251 - 52,744,161 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361352,609,314 - 52,661,224 (+)NCBIMGSCv36mm8
Celera1353,673,505 - 53,725,528 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1327.41NCBI
Syk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555151,328,630 - 1,380,581 (-)Ensembl
ChiLan1.0NW_0049555151,328,793 - 1,400,206 (-)NCBIChiLan1.0ChiLan1.0
SYK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21148,594,158 - 48,691,283 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1948,596,546 - 48,693,675 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0961,859,767 - 61,956,619 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1989,959,599 - 90,056,101 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl989,959,599 - 90,056,101 (+)EnsemblpanPan2panpan1.1
SYK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1195,903,501 - 95,955,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl195,903,566 - 95,955,583 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha196,356,719 - 96,440,184 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0196,507,029 - 96,590,534 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl196,506,228 - 96,590,524 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1196,134,620 - 96,217,990 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0195,855,025 - 95,938,496 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0196,615,264 - 96,698,710 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Syk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494412,408,886 - 12,455,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367801,553,605 - 1,598,158 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367801,553,605 - 1,601,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,056,670 - 2,161,171 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1142,103,706 - 2,160,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2142,866,432 - 2,869,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112101,254,085 - 101,374,724 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12101,260,061 - 101,349,856 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603889,575,971 - 89,671,205 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248681,653,997 - 1,701,391 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248681,654,079 - 1,738,648 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Syk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11470,903,375 - 70,973,626 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Syk
766 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:448
Count of miRNA genes:185
Interacting mature miRNAs:216
Transcripts:ENSRNOT00000016942, ENSRNOT00000041726
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
Mx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,609,871 - 12,610,041 (+)MAPPERmRatBN7.2
Rnor_6.01712,619,565 - 12,619,734NCBIRnor6.0
Rnor_5.01714,709,157 - 14,709,326UniSTSRnor5.0
RGSC_v3.41718,445,925 - 18,446,094UniSTSRGSC3.4
Celera1712,372,877 - 12,373,046UniSTS
Cytogenetic Map17p14UniSTS
RH94716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,649,496 - 12,649,634 (+)MAPPERmRatBN7.2
Rnor_6.01712,657,678 - 12,657,815NCBIRnor6.0
Rnor_5.01714,747,270 - 14,747,407UniSTSRnor5.0
RGSC_v3.41718,485,426 - 18,485,563UniSTSRGSC3.4
Celera1712,412,355 - 12,412,492UniSTS
RH 3.4 Map17126.2UniSTS
Cytogenetic Map17p14UniSTS
RH137235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21712,604,688 - 12,604,888 (+)MAPPERmRatBN7.2
Rnor_6.01712,614,381 - 12,614,580NCBIRnor6.0
Rnor_5.01714,703,973 - 14,704,172UniSTSRnor5.0
RGSC_v3.41718,440,742 - 18,440,941UniSTSRGSC3.4
Celera1712,367,694 - 12,367,893UniSTS
RH 3.4 Map17128.4UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 141 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000016942   ⟹   ENSRNOP00000016942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1712,756,493 - 12,813,273 (-)Ensembl
mRatBN7.2 Ensembl1712,604,619 - 12,661,410 (-)Ensembl
Rnor_6.0 Ensembl1712,614,311 - 12,669,573 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000041726   ⟹   ENSRNOP00000039482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1712,758,471 - 12,813,278 (-)Ensembl
mRatBN7.2 Ensembl1712,604,619 - 12,661,410 (-)Ensembl
Rnor_6.0 Ensembl1712,614,311 - 12,669,573 (-)Ensembl
RefSeq Acc Id: NM_012758   ⟹   NP_036890
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,756,493 - 12,813,273 (-)NCBI
mRatBN7.21712,604,619 - 12,661,405 (-)NCBI
Rnor_6.01712,614,311 - 12,669,568 (-)NCBI
Rnor_5.01714,703,903 - 14,759,160 (-)NCBI
RGSC_v3.41718,440,672 - 18,498,001 (-)RGD
Celera1712,367,624 - 12,424,213 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095375   ⟹   XP_038951303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,756,493 - 12,830,927 (-)NCBI
mRatBN7.21712,604,615 - 12,678,437 (-)NCBI
RefSeq Acc Id: XM_039095376   ⟹   XP_038951304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,756,493 - 12,813,335 (-)NCBI
mRatBN7.21712,604,615 - 12,661,467 (-)NCBI
RefSeq Acc Id: XM_039095377   ⟹   XP_038951305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81712,756,493 - 12,830,302 (-)NCBI
mRatBN7.21712,604,615 - 12,678,437 (-)NCBI
RefSeq Acc Id: NP_036890   ⟸   NM_012758
- UniProtKB: Q64725 (UniProtKB/Swiss-Prot),   G3V7N4 (UniProtKB/TrEMBL),   A6J6S3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016942   ⟸   ENSRNOT00000016942
Ensembl Acc Id: ENSRNOP00000039482   ⟸   ENSRNOT00000041726
RefSeq Acc Id: XP_038951305   ⟸   XM_039095377
- Peptide Label: isoform X1
- UniProtKB: Q64725 (UniProtKB/Swiss-Prot),   G3V7N4 (UniProtKB/TrEMBL),   A6J6S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951303   ⟸   XM_039095375
- Peptide Label: isoform X1
- UniProtKB: Q64725 (UniProtKB/Swiss-Prot),   G3V7N4 (UniProtKB/TrEMBL),   A6J6S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951304   ⟸   XM_039095376
- Peptide Label: isoform X1
- UniProtKB: Q64725 (UniProtKB/Swiss-Prot),   G3V7N4 (UniProtKB/TrEMBL),   A6J6S3 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64725-F1-model_v2 AlphaFold Q64725 1-629 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700336
Promoter ID:EPDNEW_R10859
Type:multiple initiation site
Name:Syk_1
Description:spleen associated tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01712,669,618 - 12,669,678EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3796 AgrOrtholog
BioCyc Gene G2FUF-10101 BioCyc
Ensembl Genes ENSRNOG00000012160 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016942 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Syk Kinase, Chain A, domain 2 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Kinase_SYK/ZAP-70_inter-SH2_sf UniProtKB/Swiss-Prot
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SYK/ZAP-70_N_SH2 UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_non-rcpt_SYK/ZAP70 UniProtKB/Swiss-Prot
KEGG Report rno:25155 UniProtKB/Swiss-Prot
NCBI Gene 25155 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PharmGKB SYK RGD
PhenoGen Syk PhenoGen
PIRSF TyrPK_SYK UniProtKB/Swiss-Prot
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012160 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A6J6S2_RAT UniProtKB/TrEMBL
  A6J6S3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZH44_RAT UniProtKB/TrEMBL
  G3V7N4 ENTREZGENE, UniProtKB/TrEMBL
  KSYK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Syk  spleen associated tyrosine kinase  Syk  spleen tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Syk  Spleen tyrosine kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to Fc epsilon RI in mast cells to activate mast cell effector functions 730070
gene_process controls tyrosine phosphorylation of Syk-associated Cbl following Fc epsilon RI receptor engagement 730201
gene_process plays a role in its own ubiquitination 730070
gene_process plays a role in its own ubiquitination 730201
gene_regulation Tyr342 but not Tyr346 is critical for regulating protein function 730070
gene_transcript alternative splicing produces two different transcripts and proteins in RBL-2H3 cells, both of which are functional tyrosine kinases 730000