Man2b1 (mannosidase, alpha, class 2B, member 1)

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Gene: Man2b1 (mannosidase, alpha, class 2B, member 1) Rattus norvegicus

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Symbol:

Man2b1

Name:

mannosidase, alpha, class 2B, member 1

RGD ID:

3039

Description:

Enables D-mannose binding activity and alpha-mannosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to act upstream of or within learning or memory and mannose metabolic process. Predicted to be located in extracellular space. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

lysosomal alpha-mannosidase; Manb; mannosidase 2, alpha B1; Mannosidase alpha B lysosomal; Mannosidase, alpha B, lysosomal; MGC72561; similar to mannosidase 2, alpha B1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MAN2B1 (mannosidase alpha class 2B member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Man2b1 (mannosidase 2, alpha B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Man2b1 (mannosidase alpha class 2B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MAN2B1 (mannosidase alpha class 2B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MAN2B1 (mannosidase alpha class 2B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Man2b1 (mannosidase alpha class 2B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MAN2B1 (mannosidase alpha class 2B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MAN2B1 (mannosidase alpha class 2B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Man2b1 (mannosidase alpha class 2B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Man2b1 (mannosidase alpha class 2B member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MAN2B1 (mannosidase alpha class 2B member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Man2b1 (mannosidase 2, alpha B1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	man2b1 (mannosidase, alpha, class 2B, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	aman-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	LManI	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	LManII	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	LManIII	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	LManIII	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	LManIV	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	LManV	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	LManVI	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	man2b1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	man2b1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	39,959,964 - 39,979,299 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	39,959,965 - 39,979,246 (-)	Ensembl				GRCr8
mRatBN7.2	19	23,055,092 - 23,074,398 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	23,055,097 - 23,074,389 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	29,877,660 - 29,896,989 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	30,532,022 - 30,551,353 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	32,754,699 - 32,774,034 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	26,196,797 - 26,216,981 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	26,196,837 - 26,216,267 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	37,172,434 - 37,191,891 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	24,711,378 - 24,730,659 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	22,613,060 - 22,632,343 (-)	NCBI		Celera
RGSC_v3.1	19	24,716,204 - 24,735,485 (-)	NCBI
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alpha-mannosidosis (ISO,ISS)

Craniosynostosis Syndrome, Autosomal Recessive (ISO)

Desbuquois dysplasia (ISO)

genetic disease (ISO)

IgA glomerulonephritis (ISO)

intellectual disability (ISO)

methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency (ISO)

myoepithelioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

actinomycin D (ISO)

amiodarone (EXP)

antirheumatic drug (ISO)

bafilomycin A1 (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

cisplatin (ISO)

clofibrate (EXP,ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

diethylstilbestrol (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (ISO)

etoposide (ISO)

fenamidone (ISO)

fenthion (ISO)

fumonisin B1 (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

ketamine (EXP)

L-ethionine (EXP)

lidocaine (EXP)

methidathion (ISO)

N-nitrosodiethylamine (EXP)

nimesulide (EXP)

Nutlin-3 (ISO)

omeprazole (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (EXP)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

swainsonine (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

topotecan (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (IEA)

glycoprotein catabolic process (ISO)

learning or memory (ISO)

mannose metabolic process (IEA,ISO)

Cellular Component

extracellular space (ISO)

lysosomal lumen (IEA,ISO)

lysosome (IBA,IEA)

Molecular Function

alpha-mannosidase activity (IBA,IDA,IEA,IMP,ISO)

carbohydrate binding (IEA)

catalytic activity (IEA)

D-mannose binding (IDA)

hydrolase activity (IEA)

hydrolase activity, acting on glycosyl bonds (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Cloning, expression, purification, and characterization of the murine lysosomal acid alpha-mannosidase.	Merkle RK, etal., Biochim Biophys Acta 1997 Aug 29;1336(2):132-46.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration.	Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70.
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis.	Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8910458	PMID:9355733	PMID:10400983	PMID:16014715	PMID:23376485	PMID:23533145	PMID:25645918	PMID:25797317

Genomics

Comparative Map Data

Man2b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	39,959,964 - 39,979,299 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	39,959,965 - 39,979,246 (-)	Ensembl				GRCr8
mRatBN7.2	19	23,055,092 - 23,074,398 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	23,055,097 - 23,074,389 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	29,877,660 - 29,896,989 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	30,532,022 - 30,551,353 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	32,754,699 - 32,774,034 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	26,196,797 - 26,216,981 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	26,196,837 - 26,216,267 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	37,172,434 - 37,191,891 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	24,711,378 - 24,730,659 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	22,613,060 - 22,632,343 (-)	NCBI		Celera
RGSC_v3.1	19	24,716,204 - 24,735,485 (-)	NCBI
Cytogenetic Map	19	q11	NCBI

MAN2B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	12,646,512 - 12,666,742 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	12,643,831 - 12,666,762 (-)	Ensembl			hg38	GRCh38
GRCh37	19	12,757,326 - 12,777,556 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	12,618,322 - 12,638,828 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	12,618,321 - 12,638,828	NCBI
Celera	19	12,647,038 - 12,667,305 (-)	NCBI		Celera
Cytogenetic Map	19	p13.13	NCBI
HuRef	19	12,330,278 - 12,350,679 (-)	NCBI		HuRef
CHM1_1	19	12,757,826 - 12,778,096 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	12,771,019 - 12,791,240 (-)	NCBI		T2T-CHM13v2.0

Man2b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	85,809,941 - 85,824,215 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	85,809,899 - 85,824,911 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	85,082,730 - 85,098,739 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	85,083,270 - 85,098,282 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	87,607,168 - 87,622,638 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	87,973,435 - 87,987,622 (+)	NCBI		MGSCv36	mm8
Celera	8	89,377,736 - 89,392,568 (+)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.55	NCBI

Man2b1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	31,743,812 - 31,770,284 (-)	Ensembl
ChiLan1.0	NW_004955415	31,743,813 - 31,770,560 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAN2B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	17,575,076 - 17,595,722 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	16,575,673 - 16,596,297 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	12,208,319 - 12,228,934 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	12,954,103 - 12,974,056 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	12,954,103 - 12,974,056 (-)	Ensembl			panPan2	panpan1.1

MAN2B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	49,446,162 - 49,461,812 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	49,319,770 - 49,335,161 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	49,964,867 - 49,980,270 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	49,964,838 - 49,985,978 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	49,175,662 - 49,191,234 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	49,602,404 - 49,618,026 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	49,844,716 - 49,860,091 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Man2b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	208,561,069 - 208,578,396 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	1,774,773 - 1,793,670 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	1,776,212 - 1,793,651 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAN2B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	66,329,045 - 66,348,056 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	66,329,051 - 66,347,051 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	66,706,800 - 66,724,791 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAN2B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	11,334,639 - 11,355,391 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	11,334,752 - 11,355,334 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	8,442,103 - 8,462,838 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Man2b1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624901	285,978 - 307,249 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624901	285,981 - 307,177 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Man2b1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	15,189,264 - 15,208,905 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Man2b1
391 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	98
Count of miRNA genes:	88
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000037699
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	5748064	50748064	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	31287532	51431640	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	30099383	47207961	Rat

Markers in Region

D19Rat13

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	23,069,265 - 23,069,484 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	26,201,726 - 26,201,944	NCBI	Rnor6.0
Rnor_5.0	19	37,177,349 - 37,177,567	UniSTS	Rnor5.0
RGSC_v3.4	19	24,725,428 - 24,725,843	RGD	RGSC3.4
RGSC_v3.4	19	24,725,553 - 24,725,771	UniSTS	RGSC3.4
Celera	19	22,627,236 - 22,627,454	UniSTS
RGSC_v3.1	19	24,730,254 - 24,730,669	RGD
FHH x ACI Map	19	21.7099	RGD
FHH x ACI Map	19	21.7099	UniSTS
Cytogenetic Map	19	q11	UniSTS

AU047579

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	23,059,835 - 23,060,066 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	26,211,292 - 26,211,524	NCBI	Rnor6.0
Rnor_5.0	19	37,186,915 - 37,187,147	UniSTS	Rnor5.0
RGSC_v3.4	19	24,716,121 - 24,716,353	UniSTS	RGSC3.4
Celera	19	22,617,804 - 22,618,036	UniSTS
Cytogenetic Map	19	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	92	59	6	356	192	11	139	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC061819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037699 ⟹ ENSRNOP00000030766

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	39,959,965 - 39,979,246 (-)	Ensembl
mRatBN7.2 Ensembl	19	23,055,097 - 23,074,389 (-)	Ensembl
Rnor_6.0 Ensembl	19	26,196,837 - 26,216,267 (+)	Ensembl

RefSeq Acc Id:

NM_199404 ⟹ NP_955436

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	39,959,964 - 39,979,246 (-)	NCBI
mRatBN7.2	19	23,055,092 - 23,074,372 (-)	NCBI
Rnor_6.0	19	26,196,837 - 26,216,268 (+)	NCBI
Rnor_5.0	19	37,172,434 - 37,191,891 (+)	NCBI
RGSC_v3.4	19	24,711,378 - 24,730,659 (-)	RGD
Celera	19	22,613,060 - 22,632,343 (-)	RGD

Sequence:

show sequence

CTGCGGAAGCAGCGTCGCCGGAACCATGGGCACCGGATCGCTTGCCCCTGGTGTCCGTGCTGGT
GGCGGGAACACTGGGTGGCTCTGGATGAGCTCCTGCAACTTAGGTTTGCCAGTCCTGTCTATTT
CTTTTCTTATTTGGTTGTTACTGGCTGCGCCTGGCGCTCAGGCCGCGGGTTACAAGACATGTCC
CACCACGAAGCCAGGCATGCTCAACGTGCACCTGCTGCCTCACACACACGATGATGTGGGCTGG
CTGAAGACAGTAGACCAATACTACTACGGCATCATGAGTGACGTCCAGCATGCATCTGTTCAGT
ACATCCTAGACTCAGTGATTTACTCTCTACTGAACGATCCCACCCGTCGCTTCATATACGTGGA
AATGGCTTTCTTCTCCCGTTGGTGGAAGCAGCAGACCAATGTAACACAGGACGCTGTACGGAAC
CTGGTGCGCCAGGGGCGCCTGGAGTTTGTCAATGGTGGCTGGGTAATGAATGATGAGGCAGCCA
CTCACTATGGTGCTATTGTGGACCAGATGACACTTGGGCTACGCTTCCTGCAGGACACATTTGG
TAGTGATGGACTTCCCCGTGTGGCCTGGCACATTGACCCTTTTGGCCATTCTCGAGAACAGGCC
TCCCTGTTTGCCCAGATGGGTTTTGATGGCTTCTTCCTCGGGCGCATTGACTACCAAGATAAAT
TTAACCGGAAGAGAAAGCTGAAGATGGAGGAACTCTGGAGGGCTAGCGCCAGCTTGAAGCCCCC
TGCTGCTGACCTCTTTACTGGTGTGCTCCCCAATAATTACAACCCTCCAAAAGACCTGTGCTGG
GATGTGCTGTGTACAGACCCTCCCGTGGTGGACGATCCCACAAGCCCTGAGTTTAATGCCAATA
AGTTGGTTGATTACTTCCTGAACCTCGCCTCTTCCCAGAAAAAGTATTACCGAACCAACCACAC
CGTGATGACCATGGGCTCAGACTTCCAGTATGAGAATGCCAACATGTGGTTCAAAAACATGGAC
AAGCTTATCCGCCTGGTCAACGAGCAGCAGGCAAACGGGAGCAAGGTCCACGTGCTCTACTCCA
CCCCTTCGTGTTACCTCTGGGAGCTGAACAAGGCCAATCTCACTTGGACAGTGAAGGAGGACGA
CTTCTTTCCTTATGCTGATGGCCCCCACATGTTCTGGACTGGCTATTTCTCCAGTAGGCCAGCC
CTCAAGCGCTATGAGCGCCTCAGCTACAACTTCCTGCAGGTGTGCAACCAGCTGGAAGCACTGG
TGGGTCCCGAGGCCAAAGTGGGACCCTACGGCTCAGGAGACAGTGCACCCCTCAATGAGGCAAT
GGCGGTGCTGCAGCACCACGATGCTGTCACTGGTACTGCAAGGCAGAATGTTGTCAATGACTAT
GCGAAGCAGCTGGCGGCAGGCTGGGGACCCTGTGAGGTTCTCGTGAGCAACGCTCTGGCGCGAC
TCAGCCTTTACAAACAGAACTTCTCATTCTGTCGGGAGATCAACATCAGTATCTGCCCAGCCAG
CCAGACGTCAGAGCACTTCCGGGTAATTATTTACAACCCCGTGGGGCGGAAGGTGGATCTGATG
GTTCGGCTGCCGGTCAGTGAAGGCATCTTCCTTGTGAAGGACCCTAACGATAGGAGAATTTCCA
GTAATGTGGTGATGGTTCCCAGTGCTTACAGTAAGACGTATCAATGGGAGCTGCTGTTCCCAGC
CTCAGTGCCTGCCCTGGGCTTCAGCATCTACTCTGTGAACAAAATGAGTGGCCATAACCATCAG
GCCCACAACCTAACGGCCAGGCCCAAGAAATCCAAGTCCCGTGTCTTAGTCATTGAAAATAAGT
ACATACGGGCCACATTTGACTCTGACACAGGGTTATTGAGGAAGATTGAAAACCTGGAACAGAA
CATTTCGCTCCCTGTGAGACAAGGCTTCTTTTGGTACAATGCCAGCGCTGGTGATGAGGAGAGT
CCTCAGGCCTCTGGTGCCTACATCTTCAGACCCAGTCATCGTAAACCACTGCCTGTGAGCCACT
GGGCTCAGGTCACTTTGGTGAAGACAAACTTGGTGCAGGAGGTACACCAGAATTTTTCAGCCTG
GTGTTCCCAAGTGATTCGCCTGTATGAAGGACAGCGTCATTTGGAGCTGGAGTGGACGGTGGGA
CCAATCCCAGTGAAAGATGACTGGGGAAAGGAAGTCATCAGCCGCTTTAACACCCCGATGAGAA
CCAGGGGGCAGTTCTTCACGGACAGCAACGGCCGGGAAATCCTGAAGAGGAGGGACGATTTCCG
ACCCACCTGGACATTAAATCAGACTGAACCAGTGGCTGGAAATTACTACCCTGTCAACACTCGC
ATTTACATCACGGACGGGCATATGCAGCTGACCGTGCTGACCGACCGTTCCCAGGGGGGCAGCA
GTCTGCTGGATGGCTCATTGGAGCTCATGGTTCACCGACGGCTGTTGGTAGATGATGAACGTGG
GGTGGCGGAACCCTTGCTGGAGACAGATACGGGGGATAAGGTTCGAGGGCGCCACCTTGTGATT
TTGAGTTCTGTCAGTGATGCGGCTGCAAGACACCGACTGCTGGCGGAGCAGGAAGTCCTGGCCC
CTCAGGTGGTGCTGGCCCACGGGGGTAGCAGTCCCTATCACTCGCAGGCACCAAAAATGCAGTT
CTCCGCACTTCGCCGGGAGCTACCTCCGCAGGTGCATCTGCTCACCCTGGCTCGCTGGGGTCCA
AAGATGCTGCTGCTGCGCTTGGAGCACCAGTTCGCTGTGAAGGAAGATTCAAATCGCAACCTGA
GCTCTCCGGTGACCTTGAACTTGCAGAACCTGTTCAAGACCTTCACTATCAACTACCTGCAGGA
GACCACACTGGCAGCCAACCAGCCCCTATCCAGGGTTTCCAGGCTCAAGTGGATGACAGATACT
GGTCCCATCTCCTACCCTGCTCCTTCCCGGTTGGACCCTACCTCAATCACACTGCAGCCTATGC
AAATCCGTACCTTCCTGGCCTCGGTTCAATGGCAGAGACTCATCTAGGCCTGCCAGGAGGAGGG
GCAGGCCTCCCCTTCTCTTGCTGGAACCACTCACAAAAATCATTAAAAGACTTCTATTGAGACT
CAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006255273 ⟹ XP_006255335

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	39,959,968 - 39,979,299 (-)	NCBI
mRatBN7.2	19	23,055,096 - 23,074,392 (-)	NCBI
Rnor_6.0	19	26,196,798 - 26,216,264 (+)	NCBI
Rnor_5.0	19	37,172,434 - 37,191,891 (+)	NCBI

Sequence:

show sequence

GGCGGAGCATTCGCAAGGATTTAGCTAAACCAGAGAAAGCTGCGGAAGCAGCGTCGCCGGAACC
ATGGGCACCGGATCGCTTGCCCCTGGTGTCCGTGCTGGTGGCGGGAACACTGGGTGGCTCTGGA
TGAGCTCCTGCAACTTAGGTTTGCCAGTCCTGTCTATTTCTTTTCTTATTTGGTTGTTACTGGC
TGCGCCTGGCGCTCAGGCCGCGGGTTACAAGACATGTCCCACCACGAAGCCAGGCATGCTCAAC
GTGCACCTGCTGCCTCACACACACGATGATGTGGGCTGGCTGAAGACGGTAGACCAATACTACT
ACGGCATGGACCCTCACTTGCTGACCTTCATGCCCATAGTCATGAGTGACGTCCAGCATGCATC
TGTTCAGTACATCCTAGACTCAGTGATTTACTCTCTACTGAACGATCCCACCCGTCGCTTCATA
TACGTGGAAATGGCTTTCTTCTCCCGTTGGTGGAAGCAGCAGACCAATGTAACACAGGACGCTG
TACGGAACCTGGTGCGCCAGGGGCGCCTGGAGTTTGTCAATGGTGGCTGGGTAATGAATGATGA
GGCAGCCACTCACTATGGTGCTATTGTGGACCAGATGACACTTGGGCTACGCTTCCTGCAGGAC
ACATTTGGTAGTGATGGACTTCCCCGTGTGGCCTGGCACATTGACCCTTTTGGCCATTCTCGAG
AACAGGCCTCCCTGTTTGCCCAGATGGGTTTTGATGGCTTCTTCCTCGGGCGCATTGACTACCA
AGATAAATTTAACCGGAAGAGAAAGCTGAAGATGGAGGAACTCTGGAGGGCTAGCGCCAGCTTG
AAGCCCCCTGCTGCTGACCTCTTTACTGGTGTGCTCCCCAATAATTACAACCCTCCAAAAGACC
TGTGCTGGGATGTGCTGTGTACAGACCCTCCCGTGGTGGACGATCCCACAAGCCCTGAGTTTAA
TGCCAATAAGTTGGTTGATTACTTCCTGAACCTCGCCTCTTCCCAGAAAAAGTATTACCGAACC
AACCACACCGTGATGACCATGGGCTCAGACTTCCAGTATGAGAATGCCAACATGTGGTTCAAAA
ACATGGACAAGCTTATCCGCCTGGTCAACGAGCAGCAGCAGGCAAACGGGAGCAAGGTCCACGT
GCTCTACTCCACCCCTTCGTGTTACCTCTGGGAGCTGAACAAGGCCAATCTCACTTGGACAGTG
AAGGAGGACGACTTCTTTCCTTATGCTGATGGCCCCCACATGTTCTGGACTGGCTATTTCTCCA
GTAGGCCAGCCCTCAAGCGCTATGAGCGCCTCAGCTACAACTTCCTGCAGGTGTGCAACCAGCT
GGAAGCACTGGTGGGTCCCGAGGCCAAAGTGGGACCCTACGGCTCAGGAGACAGTGCACCCCTC
AATGAGGCAATGGCGGTGCTGCAGCACCACGATGCTGTCACTGGTACTGCAAGACAGAATGTTG
TCAATGACTATGCGAAGCAGCTGGCGGCAGGCTGGGGACCCTGTGAGGTTCTCGTGAGCAACGC
TCTGGCGCGACTCAGCCTTTACAAACAGAACTTCTCATTCTGTCGGGAGATCAACATCAGTATC
TGCCCAGCCAGCCAGACGTCAGAGCACTTCCGGGTAATTATTTACAACCCCGTGGGGCGGAAGG
TGGATCTGATGGTTCGGCTGCCGGTCAGTGAAGGCATCTTCCTTGTGAAGGACCCTAACGATAG
GAGAATTTCCAGTAATGTGGTGATGGTTCCCAGTGCTTACAGTAAGACGTATCAATGGGAGCTG
CTGTTCCCAGCCTCAGTGCCTGCCCTGGGCTTCAGCATCTACTCTGTGAACAAAATGAGTGGCC
ATAACCATCAGGCCCACAACCTAACGGCCAGGCCCAAGAAATCCAAGTCCCGTGTCTTAGTCAT
TGAAAATAAGTACATACGGGCCACATTTGACTCTGACACAGGGTTATTGAGGAAGATTGAAAAC
CTGGAACAGAACATTTCGCTCCCTGTGAGACAAGGCTTCTTTTGGTACAATGCCAGCGCTGGTG
ATGAGGAGAGTCCTCAGGCCTCTGGTGCCTACATCTTCAGACCCAGTCATCGTAAACCACTGCC
TGTGAGCCACTGGGCTCAGGTCACTTTGGTGAAGACAAACTTGGTGCAGGAGGTACACCAGAAT
TTTTCAGCCTGGTGTTCCCAAGTGATTCGCCTGTATGAAGGACAGCGTCATTTGGAGCTGGAGT
GGACGGTGGGACCAATCCCAGTGAAAGATGACTGGGGAAAGGAAGTCATCAGCCGCTTTAACAC
CCCGATGAGAACCAGGGGGCAGTTCTTCACGGACAGCAACGGCCGGGAAATCCTGAAGAGGAGG
GACGATTTCCGACCCACCTGGACATTAAATCAGACTGAACCAGTGGCTGGAAATTACTACCCTG
TCAACACTCGCATTTACATCACGGACGGGCATATGCAGCTGACCGTGCTGACCGACCGTTCCCA
GGGGGGCAGCAGTCTGCTGGATGGCTCATTGGAGCTCATGGTTCACCGACGGCTGTTGGTAGAT
GATGAACGTGGGGTGGCGGAACCCTTGCTGGAGACAGATACGGGGGATAAGGTTCGAGGGCGCC
ACCTTGTGATTTTGAGTTCTGTCAGTGATGCGGCTGCAAGACACCGACTGCTGGCGGAGCAGGA
AGTCCTGGCCCCTCAGGTGGTGCTGGCCCACGGGGGTAGCAGTCCCTATCACTCGCAGGCACCA
AAAATGCAGTTCTCCGCACTTCGCCGGGAGCTACCTCCGCAGGTGCATCTGCTCACCCTGGCTC
GCTGGGGTCCAAAGATGCTGCTGCTGCGCTTGGAGCACCAGTTCGCTGTGAAGGAAGATTCAAA
TCGCAACCTGAGCTCTCCGGTGACCTTGAACTTGCAGAACCTGTTCAAGACCTTCACTATCAAC
TACCTGCAGGAGACCACACTGGCAGCCAACCAGCCCCTATCCAGGGTTTCCAGGCTCAAGTGGA
TGACAGATACTGGTCCCATCTCCTACCCTGCTCCTTCCCGGTTGGACCCTACCTCAATCACACT
GCAGCCTATGCAAATCCGTACCTTCCTGGCCTCGGTTCAATGGCAGAGACTCATCTAGGCCTGC
CAGGAGGAGGGGCAGGCCTCCCCTTCTCTTGCTGGAACCACTCACAAAAATCATTAAAAGACTT
CTATTGAGA

hide sequence

RefSeq Acc Id:

XM_039097817 ⟹ XP_038953745

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	39,959,968 - 39,979,299 (-)	NCBI
mRatBN7.2	19	23,055,096 - 23,074,391 (-)	NCBI

RefSeq Acc Id:

XM_039097818 ⟹ XP_038953746

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	39,959,968 - 39,979,299 (-)	NCBI
mRatBN7.2	19	23,055,096 - 23,074,398 (-)	NCBI

RefSeq Acc Id:

XM_063278113 ⟹ XP_063134183

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	39,962,444 - 39,979,299 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_955436	(Get FASTA)	NCBI Sequence Viewer
	XP_006255335	(Get FASTA)	NCBI Sequence Viewer
	XP_038953745	(Get FASTA)	NCBI Sequence Viewer
	XP_038953746	(Get FASTA)	NCBI Sequence Viewer
	XP_063134183	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61819	(Get FASTA)	NCBI Sequence Viewer
	EDL92152	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000030766
	ENSRNOP00000030766.4

RefSeq Acc Id:	NP_955436 ⟸ NM_199404
- Peptide Label:	precursor
- UniProtKB:	Q6P762 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGTGSLAPGVRAGGGNTGWLWMSSCNLGLPVLSISFLIWLLLAAPGAQAAGYKTCPTTKPGMLN VHLLPHTHDDVGWLKTVDQYYYGIMSDVQHASVQYILDSVIYSLLNDPTRRFIYVEMAFFSRWW KQQTNVTQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVA WHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKFNRKRKLKMEELWRASASLKPPAADLFTGV LPNNYNPPKDLCWDVLCTDPPVVDDPTSPEFNANKLVDYFLNLASSQKKYYRTNHTVMTMGSDF QYENANMWFKNMDKLIRLVNEQQANGSKVHVLYSTPSCYLWELNKANLTWTVKEDDFFPYADGP HMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEAKVGPYGSGDSAPLNEAMAVLQHHDA VTGTARQNVVNDYAKQLAAGWGPCEVLVSNALARLSLYKQNFSFCREINISICPASQTSEHFRV IIYNPVGRKVDLMVRLPVSEGIFLVKDPNDRRISSNVVMVPSAYSKTYQWELLFPASVPALGFS IYSVNKMSGHNHQAHNLTARPKKSKSRVLVIENKYIRATFDSDTGLLRKIENLEQNISLPVRQG FFWYNASAGDEESPQASGAYIFRPSHRKPLPVSHWAQVTLVKTNLVQEVHQNFSAWCSQVIRLY EGQRHLELEWTVGPIPVKDDWGKEVISRFNTPMRTRGQFFTDSNGREILKRRDDFRPTWTLNQT EPVAGNYYPVNTRIYITDGHMQLTVLTDRSQGGSSLLDGSLELMVHRRLLVDDERGVAEPLLET DTGDKVRGRHLVILSSVSDAAARHRLLAEQEVLAPQVVLAHGGSSPYHSQAPKMQFSALRRELP PQVHLLTLARWGPKMLLLRLEHQFAVKEDSNRNLSSPVTLNLQNLFKTFTINYLQETTLAANQP LSRVSRLKWMTDTGPISYPAPSRLDPTSITLQPMQIRTFLASVQWQRLI hide sequence

RefSeq Acc Id:

XP_006255335 ⟸ XM_006255273

- Peptide Label:

isoform X1

- Sequence:

show sequence

MGTGSLAPGVRAGGGNTGWLWMSSCNLGLPVLSISFLIWLLLAAPGAQAAGYKTCPTTKPGMLN
VHLLPHTHDDVGWLKTVDQYYYGMDPHLLTFMPIVMSDVQHASVQYILDSVIYSLLNDPTRRFI
YVEMAFFSRWWKQQTNVTQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQD
TFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKFNRKRKLKMEELWRASASL
KPPAADLFTGVLPNNYNPPKDLCWDVLCTDPPVVDDPTSPEFNANKLVDYFLNLASSQKKYYRT
NHTVMTMGSDFQYENANMWFKNMDKLIRLVNEQQQANGSKVHVLYSTPSCYLWELNKANLTWTV
KEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEAKVGPYGSGDSAPL
NEAMAVLQHHDAVTGTARQNVVNDYAKQLAAGWGPCEVLVSNALARLSLYKQNFSFCREINISI
CPASQTSEHFRVIIYNPVGRKVDLMVRLPVSEGIFLVKDPNDRRISSNVVMVPSAYSKTYQWEL
LFPASVPALGFSIYSVNKMSGHNHQAHNLTARPKKSKSRVLVIENKYIRATFDSDTGLLRKIEN
LEQNISLPVRQGFFWYNASAGDEESPQASGAYIFRPSHRKPLPVSHWAQVTLVKTNLVQEVHQN
FSAWCSQVIRLYEGQRHLELEWTVGPIPVKDDWGKEVISRFNTPMRTRGQFFTDSNGREILKRR
DDFRPTWTLNQTEPVAGNYYPVNTRIYITDGHMQLTVLTDRSQGGSSLLDGSLELMVHRRLLVD
DERGVAEPLLETDTGDKVRGRHLVILSSVSDAAARHRLLAEQEVLAPQVVLAHGGSSPYHSQAP
KMQFSALRRELPPQVHLLTLARWGPKMLLLRLEHQFAVKEDSNRNLSSPVTLNLQNLFKTFTIN
YLQETTLAANQPLSRVSRLKWMTDTGPISYPAPSRLDPTSITLQPMQIRTFLASVQWQRLI

hide sequence

Ensembl Acc Id:

ENSRNOP00000030766 ⟸ ENSRNOT00000037699

RefSeq Acc Id:	XP_038953746 ⟸ XM_039097818
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038953745 ⟸ XM_039097817
- Peptide Label:	isoform X2
- UniProtKB:	F7FG85 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063134183 ⟸ XM_063278113
- Peptide Label:	isoform X4

Protein Domains

Glycoside hydrolase family 38 central

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P762-F1-model_v2	AlphaFold	Q6P762	1-1009	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701043

Promoter ID:

EPDNEW_R11566

Type:

initiation region

Name:

Man2b1_1

Description:

mannosidase, alpha, class 2B, member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	26,196,844 - 26,196,904	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3039	AgrOrtholog
BioCyc Gene	G2FUF-6149	BioCyc
Ensembl Genes	ENSRNOG00000023910	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037699	ENTREZGENE
	ENSRNOT00000037699.5	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.50	UniProtKB/TrEMBL
	2.60.40.1180	UniProtKB/TrEMBL
	2.60.40.1360	UniProtKB/TrEMBL
	3.20.110.10	UniProtKB/TrEMBL
	Golgi alpha-mannosidase II, domain 4	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5599365	IMAGE-MGC_LOAD
InterPro	GH38_C	UniProtKB/TrEMBL
	Glyco_hydro-type_carb-bd	UniProtKB/TrEMBL
	Glyco_hydro/deAcase_b/a-brl	UniProtKB/TrEMBL
	Glyco_hydro_38/57_N	UniProtKB/TrEMBL
	Glyco_hydro_38_C	UniProtKB/TrEMBL
	Glyco_hydro_38_cen_dom	UniProtKB/TrEMBL
	Glyco_hydro_38_cen_sf	UniProtKB/TrEMBL
	Glyco_hydro_38_core	UniProtKB/TrEMBL
	Glyco_hydro_57/38_cen	UniProtKB/TrEMBL
	Glyco_hydro_b	UniProtKB/TrEMBL
	Glycosyl_Hydrlase_38	UniProtKB/TrEMBL
	Man2a1-like_dom	UniProtKB/TrEMBL
KEGG Report	rno:361378	UniProtKB/TrEMBL
MGC_CLONE	MGC:72561	IMAGE-MGC_LOAD
NCBI Gene	Man2b1	ENTREZGENE
PANTHER	ALPHA-MANNOSIDASE	UniProtKB/TrEMBL
	ALPHA-MANNOSIDASE 2-RELATED	UniProtKB/TrEMBL
Pfam	Alpha-mann_mid	UniProtKB/TrEMBL
	Glyco_hydro38C2	UniProtKB/TrEMBL
	Glyco_hydro_38	UniProtKB/TrEMBL
	Glyco_hydro_38C	UniProtKB/TrEMBL
	Laman-like_dom	UniProtKB/TrEMBL
PhenoGen	Man2b1	PhenoGen
RatGTEx	ENSRNOG00000023910	RatGTEx
SMART	Alpha-mann_mid	UniProtKB/TrEMBL
Superfamily-SCOP	Gal_mut_like	UniProtKB/TrEMBL
	Glyco_hydro/deAcase_b/a-brl	UniProtKB/TrEMBL
	SSF88688	UniProtKB/TrEMBL
UniProt	F7FG85	ENTREZGENE, UniProtKB/TrEMBL
	Q6P762	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-11-06	Man2b1	mannosidase, alpha, class 2B, member 1	Man2b1	mannosidase 2, alpha B1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-02-28	Man2b1	mannosidase 2, alpha B1	MGC72561	similar to mannosidase 2, alpha B1	Data merged from RGD:735135	737654	APPROVED
2002-11-06	Man2b1	mannosidase 2, alpha B1	Manb	Mannosidase, alpha B, lysosomal	Symbol and Name updated	625702	APPROVED
2002-06-10	Manb	Mannosidase, alpha B, lysosomal			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM