Man2b1 (mannosidase alpha class 2B member 1) - Rat Genome Database

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Gene: Man2b1 (mannosidase alpha class 2B member 1) Heterocephalus glaber
Analyze
Symbol: Man2b1
Name: mannosidase alpha class 2B member 1
RGD ID: 18904881
Description: ENCODES a protein that exhibits alpha-mannosidase activity (ortholog); D-mannose binding (ortholog); INVOLVED IN learning or memory (ortholog); mannose metabolic process (ortholog); oligosaccharide catabolic process (ortholog); ASSOCIATED WITH alpha-mannosidosis (ortholog); Charcot-Marie-Tooth disease dominant intermediate B (ortholog); Craniosynostosis Syndrome, Autosomal Recessive (ortholog); FOUND IN extracellular space (ortholog); intracellular membrane-bounded organelle (ortholog); lysosomal lumen (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lysosomal alpha-mannosidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901285,978 - 307,249 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901285,981 - 307,177 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Man2b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901285,978 - 307,249 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901285,981 - 307,177 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MAN2B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,646,512 - 12,666,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,646,511 - 12,666,742 (-)EnsemblGRCh38hg38GRCh38
GRCh371912,757,326 - 12,777,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,618,322 - 12,638,828 (-)NCBINCBI36Build 36hg18NCBI36
Build 341912,618,321 - 12,638,828NCBI
Celera1912,647,038 - 12,667,305 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,330,278 - 12,350,679 (-)NCBIHuRef
CHM1_11912,757,826 - 12,778,096 (-)NCBICHM1_1
T2T-CHM13v2.01912,771,019 - 12,791,240 (-)NCBIT2T-CHM13v2.0
Man2b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,809,941 - 85,824,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,809,899 - 85,824,911 (+)EnsemblGRCm39 Ensembl
GRCm38885,082,730 - 85,098,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,083,270 - 85,098,282 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,607,168 - 87,622,638 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,973,435 - 87,987,622 (+)NCBIMGSCv36mm8
Celera889,377,736 - 89,392,568 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.55NCBI
Man2b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81939,959,964 - 39,979,299 (-)NCBIGRCr8
mRatBN7.21923,055,092 - 23,074,398 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,055,097 - 23,074,389 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1929,877,660 - 29,896,989 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,532,022 - 30,551,353 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,754,699 - 32,774,034 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,196,797 - 26,216,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,196,837 - 26,216,267 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,172,434 - 37,191,891 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,711,378 - 24,730,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,716,204 - 24,735,485 (-)NCBI
Celera1922,613,060 - 22,632,343 (-)NCBICelera
Cytogenetic Map19q11NCBI
Man2b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,743,812 - 31,770,284 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,743,813 - 31,770,560 (-)NCBIChiLan1.0ChiLan1.0
MAN2B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,575,076 - 17,595,722 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,575,673 - 16,596,297 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,208,319 - 12,228,934 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11912,954,103 - 12,974,056 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1912,954,103 - 12,974,056 (-)Ensemblpanpan1.1panPan2
MAN2B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,446,162 - 49,461,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,319,770 - 49,335,161 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,964,867 - 49,980,270 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,964,838 - 49,985,978 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,175,662 - 49,191,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,602,404 - 49,618,026 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,844,716 - 49,860,091 (+)NCBIUU_Cfam_GSD_1.0
Man2b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,561,069 - 208,578,396 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,774,773 - 1,793,670 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,776,212 - 1,793,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAN2B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,329,045 - 66,348,056 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,329,051 - 66,347,051 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,706,800 - 66,724,791 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAN2B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,334,639 - 11,355,391 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,334,752 - 11,355,334 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,442,103 - 8,462,838 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000011965   ⟹   ENSHGLP00000011836
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624901285,978 - 307,249 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000011966   ⟹   ENSHGLP00000011837
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624901285,978 - 307,249 (-)Ensembl
RefSeq Acc Id: XM_004872367   ⟹   XP_004872424
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901285,981 - 307,177 (-)NCBI
RefSeq Acc Id: XM_004872368   ⟹   XP_004872425
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901285,981 - 307,177 (-)NCBI
RefSeq Acc Id: XM_013068409   ⟹   XP_012923863
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901285,981 - 307,177 (-)NCBI
RefSeq Acc Id: XM_013068410   ⟹   XP_012923864
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901285,981 - 307,177 (-)NCBI
RefSeq Acc Id: XM_013068411   ⟹   XP_012923865
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901285,981 - 307,177 (-)NCBI
RefSeq Acc Id: XM_021250374   ⟹   XP_021106033
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901285,981 - 307,177 (-)NCBI
RefSeq Acc Id: XM_021250375   ⟹   XP_021106034
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901285,981 - 307,141 (-)NCBI
RefSeq Acc Id: XM_021250376   ⟹   XP_021106035
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901285,981 - 305,992 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_012923865   ⟸   XM_013068411
- Peptide Label: isoform X7
- UniProtKB: G5BYY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923864   ⟸   XM_013068410
- Peptide Label: isoform X5
- UniProtKB: G5BYY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004872425   ⟸   XM_004872368
- Peptide Label: isoform X2
- UniProtKB: G5BYY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106033   ⟸   XM_021250374
- Peptide Label: isoform X4
- UniProtKB: G5BYY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923863   ⟸   XM_013068409
- Peptide Label: isoform X3
- UniProtKB: G5BYY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004872424   ⟸   XM_004872367
- Peptide Label: isoform X1
- UniProtKB: G5BYY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106034   ⟸   XM_021250375
- Peptide Label: isoform X6
- UniProtKB: G5BYY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106035   ⟸   XM_021250376
- Peptide Label: isoform X8
RefSeq Acc Id: ENSHGLP00000011837   ⟸   ENSHGLT00000011966
RefSeq Acc Id: ENSHGLP00000011836   ⟸   ENSHGLT00000011965


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008472 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000011966 ENTREZGENE
Gene3D-CATH 2.60.40.1360 UniProtKB/TrEMBL
  Glycoside hydrolase 38, N terminal domain UniProtKB/TrEMBL
  Glycoside hydrolase family 38, central domain UniProtKB/TrEMBL
  Golgi alpha-mannosidase II UniProtKB/TrEMBL
InterPro Gal_mutarotase_sf_dom UniProtKB/TrEMBL
  Glyco_hydro/deAcase_b/a-brl UniProtKB/TrEMBL
  Glyco_hydro_38_C UniProtKB/TrEMBL
  Glyco_hydro_38_cen UniProtKB/TrEMBL
  Glyco_hydro_38_cen_sf UniProtKB/TrEMBL
  Glyco_hydro_38_N UniProtKB/TrEMBL
  Glyco_hydro_38_N_sf UniProtKB/TrEMBL
  Glyco_hydro_57/38_cen_sf UniProtKB/TrEMBL
  Glyco_hydro_b UniProtKB/TrEMBL
  Man2a1-like_dom UniProtKB/TrEMBL
NCBI Gene Man2b1 ENTREZGENE
PANTHER ALPHA-MANNOSIDASE UniProtKB/TrEMBL
  ALPHA-MANNOSIDASE 2-RELATED UniProtKB/TrEMBL
Pfam Alpha-mann_mid UniProtKB/TrEMBL
  Glyco_hydro_38C UniProtKB/TrEMBL
  Glyco_hydro_38N UniProtKB/TrEMBL
  Laman-like_dom UniProtKB/TrEMBL
SMART Alpha-mann_mid UniProtKB/TrEMBL
Superfamily-SCOP Families 57/38 glycoside transferase middle domain UniProtKB/TrEMBL
  Galactose mutarotase-like UniProtKB/TrEMBL
  Glycoside hydrolase/deacetylase UniProtKB/TrEMBL
UniProt G5BYY1 ENTREZGENE, UniProtKB/TrEMBL