Lhb (luteinizing hormone subunit beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lhb (luteinizing hormone subunit beta) Rattus norvegicus
Analyze
Symbol: Lhb
Name: luteinizing hormone subunit beta
RGD ID: 3006
Description: Predicted to enable hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within luteinizing hormone signaling pathway involved in ovarian follicle development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Orthologous to several human genes including LHB (luteinizing hormone subunit beta); PARTICIPATES IN luteinizing hormone signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LH-B; LSH-B; LSH-beta; luteinizing hormone (lutropin) subunit beta; luteinizing hormone beta; luteinizing hormone beta polypeptide; luteinizing hormone beta subunit; lutropin beta chain; lutropin subunit beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,037,457 - 105,038,446 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,037,457 - 105,038,445 (+)EnsemblGRCr8
mRatBN7.2195,898,269 - 95,901,973 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,898,267 - 95,901,963 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl195,900,984 - 95,901,972 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,286,408 - 101,287,397 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,759,086 - 109,760,075 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,049,485 - 103,050,474 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,409,992 - 101,413,725 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,410,019 - 101,413,724 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,489,421 - 102,493,135 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,892,999 - 95,893,988 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,156,575 - 90,157,564 (+)NCBICelera
RGSC_v3.1195,971,118 - 95,972,098 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-Dibromo-3-chloropropane  (EXP)
1,3-dinitrobenzene  (EXP)
1-methylnicotinamide  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dihydroxybenzoic acid  (EXP)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nonylphenol  (EXP)
4-tert-Octylphenol  (EXP)
5-formyltetrahydrofolic acid  (EXP)
5-hydroxymethylfurfural  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (EXP)
acetaldehyde  (ISO)
acetamiprid  (EXP)
acetate ester  (EXP)
acrylamide  (EXP)
alcohol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
alpha-amanitin  (EXP)
alprazolam  (ISO)
aminoglutethimide  (ISO)
amitraz  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
anastrozole  (EXP)
androst-4-ene-3,17-dione  (ISO)
androstane-3,17-diol  (EXP)
apocynin  (EXP)
arecoline  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (EXP,ISO)
baclofen  (EXP)
benoxaprofen  (EXP)
benzo[a]pyrene  (EXP,ISO)
betamethasone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bromocriptine  (ISO)
bromodichloromethane  (EXP)
busulfan  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
canagliflozin  (EXP)
carbendazim  (EXP)
carvacrol  (EXP)
celecoxib  (EXP)
cetrorelix  (EXP,ISO)
chlormequat chloride  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
chrysin  (EXP)
cilostazol  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clomiphene  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
crizotinib  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproterone acetate  (EXP,ISO)
D-aspartic acid  (EXP)
danazol  (EXP)
DDT  (ISO)
desogestrel  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (EXP,ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (EXP)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (EXP,ISO)
dioxygen  (EXP)
dipentyl phthalate  (EXP)
disodium selenite  (EXP)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (EXP,ISO)
enilconazole  (EXP)
equol  (EXP)
erythrosin B  (EXP)
Estradiol 17beta-cyclopentylpropionate  (EXP)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenitrothion  (EXP)
fenvalerate  (EXP)
fisetin  (EXP)
flufenamic acid  (EXP)
flurbiprofen  (EXP)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
fructose  (EXP)
furan  (EXP)
fursultiamine  (EXP)
galaxolide  (EXP)
gallic acid  (EXP,ISO)
Gallopamil  (EXP)
ganirelix  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (EXP,ISO)
glycidol  (EXP)
glyphosate  (EXP,ISO)
guanosine 5'-[beta,gamma-imido]triphosphate  (EXP)
herbicide  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
iodoacetic acid  (ISO)
iprodione  (EXP)
isoflavones  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (EXP,ISO)
lamotrigine  (EXP)
lansoprazole  (EXP)
lead diacetate  (EXP)
lead oxide  (EXP)
lead(0)  (ISO)
letrozole  (EXP,ISO)
leuprolide  (ISO)
levonorgestrel  (ISO)
Licochalcone B  (ISO)
linagliptin  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
manganese(II) chloride  (EXP)
masoprocol  (EXP)
melatonin  (EXP)
menadione  (EXP)
mercury dichloride  (EXP)
mestranol  (ISO)
metformin  (EXP)
Methanandamide  (EXP)
Methandrostenolone  (EXP)
methimazole  (EXP)
methiocarb  (EXP)
methomyl  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP,ISO)
methylmercury chloride  (EXP)
metoclopramide  (ISO)
mifepristone  (EXP)
mirtazapine  (ISO)
molinate  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
morphine  (EXP)
muscimol  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
naloxone  (EXP,ISO)
naltrexone  (ISO)
Nandrolone decanoate  (EXP)
naringin  (EXP)
nickel atom  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nimodipine  (ISO)
nitrofurazone  (EXP)
nobiletin  (EXP)
Nonylphenol  (EXP)
Norbinaltorphimine  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
pentobarbital  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
perphenazine  (EXP)
Pf-06840003  (ISO)
Phenoxybenzamine  (EXP)
phenylhydrazine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pimozide  (EXP)
pinostrobin  (EXP)
potassium dichromate  (EXP)
prazosin  (EXP)
pregnenolone  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
promegestone  (ISO)
propyzamide  (EXP)
pyrethrins  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
raloxifene  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rofecoxib  (EXP)
saccharin  (EXP)
selenium atom  (EXP)
sertraline  (EXP)
sildenafil citrate  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
sodium fluoride  (EXP)
sodium perchlorate  (EXP)
sophoraflavanone B  (EXP)
sphingosine  (EXP)
spironolactone  (EXP)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulpiride  (EXP)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tartrazine  (EXP)
taurine  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
Testosterone propionate  (EXP,ISO)
Tetrachlorobisphenol A  (EXP)
thimerosal  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
triclosan  (EXP)
triphenylstannane  (EXP)
triptonide  (ISO)
triptorelin  (EXP)
tyrphostin AG 1478  (EXP,ISO)
uranium atom  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vinclozolin  (EXP)
vitamin E  (EXP)
vitexin  (ISO)
wogonin  (EXP)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin. Chin WW, etal., Proc Natl Acad Sci U S A 1983 Aug;80(15):4649-53.
2. Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays. Dalkin AC, etal., Endocrinology 2001 Jan;142(1):139-46.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence. Jameson L, etal., J Biol Chem 1984 Dec 25;259(24):15474-80.
6. The regulation and organization of thyroid stimulating hormone genes. Kourides IA, etal., Recent Prog Horm Res 1984;40:79-120.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene. Valdes-Socin H, etal., N Engl J Med. 2004 Dec 16;351(25):2619-25.
18. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Wei L, etal., Biochem Cell Biol. 2010 Aug;88(4):723-30. doi: 10.1139/O10-022.
19. Isolation and characterization of testis-specific cDNAs for luteinizing hormone beta-subunit in the rat. Zhang FP, etal., Biochem Biophys Res Commun 1995 May 25;210(3):858-65.
Additional References at PubMed
PMID:8889548   PMID:9582327   PMID:12409218   PMID:12940464   PMID:14512439   PMID:16087728   PMID:17932215   PMID:18248883   PMID:18292086   PMID:18363807   PMID:19095772   PMID:19200975  
PMID:19253008   PMID:19474061   PMID:19710510   PMID:20430510   PMID:20797425   PMID:21187122   PMID:21228211   PMID:23376485   PMID:23518923   PMID:23678542   PMID:23734233   PMID:24739304  
PMID:25258388  


Genomics

Comparative Map Data
Lhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,037,457 - 105,038,446 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,037,457 - 105,038,445 (+)EnsemblGRCr8
mRatBN7.2195,898,269 - 95,901,973 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,898,267 - 95,901,963 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl195,900,984 - 95,901,972 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,286,408 - 101,287,397 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,759,086 - 109,760,075 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,049,485 - 103,050,474 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,409,992 - 101,413,725 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,410,019 - 101,413,724 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,489,421 - 102,493,135 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,892,999 - 95,893,988 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,156,575 - 90,157,564 (+)NCBICelera
RGSC_v3.1195,971,118 - 95,972,098 (+)NCBI
Cytogenetic Map1q22NCBI
LHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,015,980 - 49,019,498 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,015,980 - 49,017,091 (-)Ensemblhg38GRCh38
GRCh371949,519,237 - 49,520,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,211,049 - 54,212,159 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341954,211,048 - 54,212,159NCBI
Celera1946,386,444 - 46,387,554 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,895,957 - 45,897,067 (-)NCBIHuRef
CHM1_11949,521,461 - 49,522,571 (-)NCBICHM1_1
T2T-CHM13v2.01952,010,754 - 52,014,273 (-)NCBIT2T-CHM13v2.0
Lhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,070,370 - 45,071,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,070,244 - 45,071,321 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,417,608 - 45,421,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,418,353 - 45,421,854 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl745,420,820 - 45,421,897 (+)Ensemblmm10GRCm38
MGSCv37752,676,316 - 52,677,224 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,288,988 - 45,289,896 (+)NCBIMGSCv36mm8
Celera740,876,980 - 40,877,888 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
Lhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,656,291 - 1,657,151 (+)Ensembl
ChiLan1.0NW_0049555591,656,106 - 1,657,192 (+)NCBIChiLan1.0ChiLan1.0
LOC100992969
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,150,366 - 55,159,280 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,069,851 - 57,078,655 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,053,779 - 46,055,250 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,738,139 - 54,739,424 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,738,139 - 54,739,424 (+)EnsemblpanPan2panpan1.1
LHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,382,855 - 107,384,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01107,907,413 - 107,908,590 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11107,575,256 - 107,576,428 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,221,425 - 107,222,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,057,035 - 108,058,209 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,263,576 - 54,271,086 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,263,574 - 54,269,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,063,469 - 50,065,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q21NCBI
LHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,247,254 - 42,248,822 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,134,416 - 22,135,718 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Lhb
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:63
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000067468
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 85 84 53 87 53 6 336 186 9 135 73 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000042039   ⟹   ENSRNOP00000051337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,034,723 - 105,037,526 (+)Ensembl
mRatBN7.2 Ensembl195,898,267 - 95,901,963 (+)Ensembl
Rnor_6.0 Ensembl1101,410,019 - 101,413,715 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067468   ⟹   ENSRNOP00000060360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,037,457 - 105,038,445 (+)Ensembl
mRatBN7.2 Ensembl195,900,984 - 95,901,972 (+)Ensembl
Rnor_6.0 Ensembl1101,412,736 - 101,413,724 (+)Ensembl
RefSeq Acc Id: NM_001033975   ⟹   NP_001029147
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,037,664 - 105,038,446 (+)NCBI
mRatBN7.2195,901,191 - 95,901,973 (+)NCBI
Rnor_6.01101,412,943 - 101,413,725 (+)NCBI
Rnor_5.01102,489,421 - 102,493,135 (+)NCBI
RGSC_v3.4195,892,999 - 95,893,988 (+)RGD
Celera190,156,782 - 90,157,564 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012858   ⟹   NP_036990
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,037,457 - 105,038,446 (+)NCBI
mRatBN7.2195,900,984 - 95,901,973 (+)NCBI
Rnor_6.01101,412,736 - 101,413,725 (+)NCBI
Rnor_5.01102,489,421 - 102,493,135 (+)NCBI
RGSC_v3.4195,892,999 - 95,893,988 (+)RGD
Celera190,156,575 - 90,157,564 (+)RGD
Sequence:
RefSeq Acc Id: NP_036990   ⟸   NM_012858
- Peptide Label: isoform 1 precursor
- UniProtKB: P01230 (UniProtKB/Swiss-Prot),   A0A0A0MY50 (UniProtKB/TrEMBL),   Q62778 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029147   ⟸   NM_001033975
- Peptide Label: isoform 2 precursor
- UniProtKB: Q62778 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060360   ⟸   ENSRNOT00000067468
Ensembl Acc Id: ENSRNOP00000051337   ⟸   ENSRNOT00000042039
Protein Domains
Glycoprotein hormone subunit beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01230-F1-model_v2 AlphaFold P01230 1-141 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690038
Promoter ID:EPDNEW_R562
Type:single initiation site
Name:Lhb_1
Description:luteinizing hormone beta polypeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,410,008 - 101,410,068EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3006 AgrOrtholog
BioCyc Gene G2FUF-59686 BioCyc
Ensembl Genes ENSRNOG00000047040 Ensembl
  ENSRNOG00000063034 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067468 ENTREZGENE
  ENSRNOT00000067468.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Glyco_hormone_CN UniProtKB/Swiss-Prot
  Gonadotropin_bsu UniProtKB/Swiss-Prot
  Gonadotropin_bsu_CS UniProtKB/Swiss-Prot
KEGG Report rno:25329 UniProtKB/Swiss-Prot
NCBI Gene 25329 ENTREZGENE
PANTHER LUTROPIN SUBUNIT BETA UniProtKB/Swiss-Prot
  PTHR11515 UniProtKB/Swiss-Prot
Pfam Cys_knot UniProtKB/Swiss-Prot
PhenoGen Lhb PhenoGen
PROSITE GLYCO_HORMONE_BETA_1 UniProtKB/Swiss-Prot
  GLYCO_HORMONE_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047040 RatGTEx
  ENSRNOG00000063034 RatGTEx
SMART GHB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
TIGR TC206487
UniProt A0A0A0MY50 ENTREZGENE, UniProtKB/TrEMBL
  LSHB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62778 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Lhb  luteinizing hormone subunit beta  Lhb  luteinizing hormone beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-01-31 Lhb  luteinizing hormone beta polypeptide  Lhb  luteinizing hormone beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Lhb  luteinizing hormone beta    luteinizing hormone subunit beta  Name updated 629478 APPROVED
2002-06-10 Lhb  luteinizing hormone subunit beta      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression synthesized by gonadotropes of the anterior pituitary 61523
gene_expression synthesized by gonadotropes of the anterior pituitary 61787
gene_transcript contains 3 exons 61787
gene_transcript exist testis-specific mRNA variants of the gene 729008