GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3006
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lhb
Name: luteinizing hormone beta
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
CasRN: 50-28-2
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDbisphenol A inhibits the reaction [Estradiol results in increased secretion of LHB protein]

PMID:20951796
multiple interactionsEXP 6480464CTDbisphenol A promotes the reaction [Estradiol results in increased secretion of LHB protein]

p-271 peptide inhibits the reaction [Estradiol results in increased secretion of LHB protein]

p-271 peptide inhibits the reaction [bisphenol A promotes the reaction [Estradiol results in increased secretion of LHB protein]]

PMID:21303948
increases secretionEXP 6480464CTDEstradiol results in increased secretion of LHB protein

PMID:21303948
PMID:20951796
PMID:18162529
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of LHB mRNA

PMID:16522720
PMID:16614383
PMID:21187122
multiple interactionsEXP 6480464CTDEstradiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LHB mRNA]

PMID:21187122
decreases secretionISORGD:690976480464CTDEstradiol results in decreased secretion of LHB protein

PMID:3299987
multiple interactionsISORGD:690976480464CTD[FSHB protein co-treated with LHB protein co-treated with CGB protein] results in increased abundance of Estradiol

PMID:8263139
multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in decreased secretion of LHB protein

PMID:19215433
multiple interactionsEXP 6480464CTD[Estradiol co-treated with Testosterone] results in decreased secretion of LHB protein

[[Estradiol co-treated with Testosterone] results in decreased secretion of LHB protein] which results in decreased abundance of Testosterone

PMID:2113863
multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of LHB protein

nociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]

PMID:17640482
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of LHB mRNA

PMID:16522720
PMID:16614383
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of LHB protein

PMID:20144698
PMID:16522720
decreases secretionEXP 6480464CTDEstradiol results in decreased secretion of LHB protein

PMID:16614383
PMID:909588
increases secretionEXP 6480464CTDEstradiol results in increased secretion of LHB protein

PMID:18162529
multiple interactionsEXP 6480464CTD[Testosterone co-treated with Estradiol] results in decreased secretion of LHB protein

PMID:909588
decreases secretionEXP 6480464CTDEstradiol results in decreased secretion of LHB protein

PMID:909588
PMID:16614383
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of LHB protein

PMID:16522720
PMID:20144698
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of LHB mRNA

PMID:16614383
PMID:16522720
increases secretionEXP 6480464CTDEstradiol results in increased secretion of LHB protein

PMID:18162529
PMID:20951796
PMID:21303948
increases secretionEXP 6480464CTDEstradiol results in increased secretion of LHB protein

PMID:20951796
PMID:21303948
PMID:18162529
multiple interactionsEXP 6480464CTDEstradiol affects the reaction [LHB protein results in increased susceptibility to GNRH1 protein]

PMID:17596564
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