Anpep (alanyl aminopeptidase, membrane) - Rat Genome Database

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Gene: Anpep (alanyl aminopeptidase, membrane) Rattus norvegicus
Analyze
Symbol: Anpep
Name: alanyl aminopeptidase, membrane
RGD ID: 2991
Description: Enables aminopeptidase activity and peptide binding activity. Involved in metanephric proximal tubule development; peptide catabolic process; and protein processing. Located in brush border membrane. Orthologous to human ANPEP (alanyl aminopeptidase, membrane); PARTICIPATES IN angiotensin IV signaling pathway; renin-angiotensin cascade pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alanyl (membrane) aminopeptidase; alanyl aminopeptidase; aminopeptidase M; aminopeptidase N; AP-M; AP-N; Apm; APN; cluster of differentiation antigen 13 (CD13); kidney aminopeptidase M; kidney Zn peptidase; KZP; Lap1; leucine arylaminopeptidase 1; membrane alanine aminopeptidase; microsomal aminopeptidase; rAPN
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Mcs32
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,176,645 - 143,219,447 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,176,645 - 143,195,101 (-)EnsemblGRCr8
mRatBN7.21133,767,332 - 133,810,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,767,332 - 133,785,789 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1141,676,519 - 141,695,002 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,845,924 - 148,864,407 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,763,630 - 141,782,111 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,561,364 - 141,604,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,561,334 - 141,604,273 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,522,426 - 142,565,721 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41135,600,751 - 135,619,208 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1125,830,648 - 125,849,086 (-)NCBICelera
RGSC_v3.11135,679,156 - 135,697,614 (-)NCBI
RH 3.4 Map11063.2RGD
Cytogenetic Map1q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP)
ethylenediaminetetraacetic acid  (ISO)
eugenol  (EXP)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP,ISO)
glycitein  (ISO)
glycitin  (ISO)
GW 4064  (ISO)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
mifepristone  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PD 0325901  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirimiphos-methyl  (EXP)
pirinixic acid  (ISO)
porphyrins  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
streptozocin  (EXP)
succimer  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tobramycin  (EXP)
toluene  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
8. Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases. Malfroy B, etal., Biochem Biophys Res Commun 1989 May 30;161(1):236-41.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats. Padia SH, etal., Hypertension. 2010 Feb;55(2):474-80. Epub 2009 Dec 7.
13. Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea. Pilar Carrera M, etal., Anticancer Res. 2006 Mar-Apr;26(2A):1011-4.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
21. Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N. Watt VM and Yip CC, J Biol Chem 1989 Apr 5;264(10):5480-7.
22. Human aminopeptidase N is a receptor for human coronavirus 229E. Yeager CL, etal., Nature 1992 Jun 4;357(6377):420-2.
Additional References at PubMed
PMID:1673322   PMID:2564851   PMID:9305626   PMID:9765589   PMID:11672613   PMID:15308636   PMID:15326289   PMID:16502470   PMID:17169335   PMID:17242304   PMID:17519555   PMID:17897319  
PMID:17952634   PMID:18547641   PMID:19056867   PMID:19199708   PMID:19876009   PMID:20096929   PMID:20851150   PMID:21082674   PMID:21708977   PMID:21982785   PMID:22206666   PMID:22373413  
PMID:23376485   PMID:23533145   PMID:23894332   PMID:25461922   PMID:25645918   PMID:26449746   PMID:30531704   PMID:36765308  


Genomics

Comparative Map Data
Anpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,176,645 - 143,219,447 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,176,645 - 143,195,101 (-)EnsemblGRCr8
mRatBN7.21133,767,332 - 133,810,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,767,332 - 133,785,789 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1141,676,519 - 141,695,002 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,845,924 - 148,864,407 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,763,630 - 141,782,111 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,561,364 - 141,604,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,561,334 - 141,604,273 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,522,426 - 142,565,721 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41135,600,751 - 135,619,208 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1125,830,648 - 125,849,086 (-)NCBICelera
RGSC_v3.11135,679,156 - 135,697,614 (-)NCBI
RH 3.4 Map11063.2RGD
Cytogenetic Map1q31NCBI
ANPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,784,895 - 89,814,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,784,875 - 89,815,401 (-)Ensemblhg38GRCh38
GRCh371590,328,126 - 90,358,084 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,129,130 - 88,159,076 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341588,129,130 - 88,150,938NCBI
Celera1566,730,914 - 66,760,859 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,440,812 - 66,470,613 (-)NCBIHuRef
CHM1_11590,169,132 - 90,199,097 (-)NCBICHM1_1
T2T-CHM13v2.01587,540,783 - 87,570,713 (-)NCBIT2T-CHM13v2.0
Anpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,471,551 - 79,497,958 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,471,551 - 79,510,807 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38779,821,803 - 79,848,210 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,821,803 - 79,861,059 (-)Ensemblmm10GRCm38
MGSCv37786,966,689 - 86,987,238 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36779,695,316 - 79,715,797 (-)NCBIMGSCv36mm8
Celera777,221,100 - 77,243,027 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.19NCBI
Anpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,424,932 - 15,444,075 (+)Ensembl
ChiLan1.0NW_00495541615,415,981 - 15,442,032 (+)NCBIChiLan1.0ChiLan1.0
ANPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,335,577 - 79,365,554 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,037,936 - 83,059,833 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,479,349 - 68,509,238 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,681,826 - 87,703,713 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,681,826 - 87,703,713 (-)EnsemblpanPan2panpan1.1
ANPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,764,418 - 52,779,516 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,764,418 - 52,779,746 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha355,398,319 - 55,413,377 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,181,131 - 53,196,208 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,181,130 - 53,203,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,702,917 - 52,717,931 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,912,916 - 52,927,956 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,253,252 - 53,268,352 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Anpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,745,212 - 130,770,994 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,563,528 - 15,589,601 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,563,540 - 15,582,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,351,087 - 55,373,881 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1755,351,081 - 55,373,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,240,144 - 60,262,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7cen-q21NCBI
ANPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,324,094 - 8,354,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,323,797 - 8,346,581 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605938,429,007 - 38,487,801 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,838,693 - 16,856,059 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476816,840,743 - 16,856,158 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Anpep
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12120,403,839 - 120,422,586 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Anpep
341 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:54
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000020002
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
D1Rat350  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81143,196,215 - 143,196,370 (+)Marker Load Pipeline
mRatBN7.21133,786,907 - 133,787,062 (+)MAPPERmRatBN7.2
Rnor_6.01141,580,935 - 141,581,089NCBIRnor6.0
Rnor_5.01142,541,997 - 142,542,151UniSTSRnor5.0
RGSC_v3.41135,620,322 - 135,620,477RGDRGSC3.4
RGSC_v3.41135,620,323 - 135,620,477UniSTSRGSC3.4
Celera1125,850,075 - 125,850,229UniSTS
RGSC_v3.11135,698,729 - 135,698,883RGD
RH 3.4 Map11058.1UniSTS
RH 3.4 Map11058.1RGD
SHRSP x BN Map168.8399UniSTS
SHRSP x BN Map168.8399RGD
FHH x ACI Map167.73RGD
Cytogenetic Map1q31UniSTS
RH130139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21133,767,436 - 133,767,626 (+)MAPPERmRatBN7.2
Rnor_6.01141,561,469 - 141,561,658NCBIRnor6.0
Rnor_5.01142,522,531 - 142,522,720UniSTSRnor5.0
RGSC_v3.41135,600,856 - 135,601,045UniSTSRGSC3.4
Celera1125,830,753 - 125,830,942UniSTS
RH 3.4 Map11062.9UniSTS
Cytogenetic Map1q31UniSTS
RH94699  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21133,767,385 - 133,767,584 (+)MAPPERmRatBN7.2
Rnor_6.01141,561,418 - 141,561,616NCBIRnor6.0
Rnor_5.01142,522,480 - 142,522,678UniSTSRnor5.0
RGSC_v3.41135,600,805 - 135,601,003UniSTSRGSC3.4
Celera1125,830,702 - 125,830,900UniSTS
RH 3.4 Map11063.2UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 92 59 6 356 192 11 138 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000020002   ⟹   ENSRNOP00000020002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,176,645 - 143,195,101 (-)Ensembl
mRatBN7.2 Ensembl1133,767,332 - 133,785,789 (-)Ensembl
Rnor_6.0 Ensembl1141,561,457 - 141,579,871 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092125   ⟹   ENSRNOP00000069456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,176,645 - 143,195,101 (-)Ensembl
mRatBN7.2 Ensembl1133,767,332 - 133,785,789 (-)Ensembl
Rnor_6.0 Ensembl1141,561,334 - 141,604,273 (-)Ensembl
RefSeq Acc Id: NM_031012   ⟹   NP_112274
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,176,645 - 143,195,101 (-)NCBI
mRatBN7.21133,767,332 - 133,785,789 (-)NCBI
Rnor_6.01141,561,364 - 141,579,820 (-)NCBI
Rnor_5.01142,522,426 - 142,565,721 (-)NCBI
RGSC_v3.41135,600,751 - 135,619,208 (-)RGD
Celera1125,830,648 - 125,849,086 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229407   ⟹   XP_006229469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,176,646 - 143,200,776 (-)NCBI
mRatBN7.21133,767,333 - 133,791,462 (-)NCBI
Rnor_6.01141,561,365 - 141,585,498 (-)NCBI
Rnor_5.01142,522,426 - 142,565,721 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229408   ⟹   XP_006229470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,176,646 - 143,197,340 (-)NCBI
mRatBN7.21133,767,333 - 133,788,027 (-)NCBI
Rnor_6.01141,561,365 - 141,582,066 (-)NCBI
Rnor_5.01142,522,426 - 142,565,721 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229409   ⟹   XP_006229471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,176,646 - 143,219,447 (-)NCBI
mRatBN7.21133,767,333 - 133,810,137 (-)NCBI
Rnor_6.01141,561,365 - 141,604,249 (-)NCBI
Rnor_5.01142,522,426 - 142,565,721 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112274   ⟸   NM_031012
- Peptide Label: precursor
- UniProtKB: Q9JHP4 (UniProtKB/Swiss-Prot),   P15684 (UniProtKB/Swiss-Prot),   A0A0G2JVE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229471   ⟸   XM_006229409
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVE6 (UniProtKB/TrEMBL),   A6JC72 (UniProtKB/TrEMBL),   G3V7W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229469   ⟸   XM_006229407
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVE6 (UniProtKB/TrEMBL),   A6JC72 (UniProtKB/TrEMBL),   G3V7W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229470   ⟸   XM_006229408
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVE6 (UniProtKB/TrEMBL),   A6JC72 (UniProtKB/TrEMBL),   G3V7W7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069456   ⟸   ENSRNOT00000092125
Ensembl Acc Id: ENSRNOP00000020002   ⟸   ENSRNOT00000020002
Protein Domains
Aminopeptidase N-like N-terminal   ERAP1-like C-terminal   Peptidase M1 membrane alanine aminopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15684-F1-model_v2 AlphaFold P15684 1-965 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690135
Promoter ID:EPDNEW_R657
Type:multiple initiation site
Name:Anpep_1
Description:alanyl aminopeptidase, membrane
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01141,579,844 - 141,579,904EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2991 AgrOrtholog
BioCyc Gene G2FUF-58771 BioCyc
Ensembl Genes ENSRNOG00000014610 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020002 ENTREZGENE
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot
  1.25.50.20 UniProtKB/Swiss-Prot
  2.60.40.1730 UniProtKB/Swiss-Prot
  2.60.40.1910 UniProtKB/Swiss-Prot
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  ERAP1-like_C_dom UniProtKB/Swiss-Prot
  M1_APN-typ UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_aminopeptidases UniProtKB/Swiss-Prot
  Peptidase_M1_dom UniProtKB/Swiss-Prot
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot
KEGG Report rno:81641 UniProtKB/Swiss-Prot
NCBI Gene Anpep ENTREZGENE
PANTHER AMINOPEPTIDASE N UniProtKB/Swiss-Prot
  PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/Swiss-Prot
Pfam ERAP1_C UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_N UniProtKB/Swiss-Prot
PhenoGen Anpep PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014610 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF63737 UniProtKB/Swiss-Prot
UniProt A0A0G2JVE6 ENTREZGENE, UniProtKB/TrEMBL
  A6JC72 ENTREZGENE, UniProtKB/TrEMBL
  AMPN_RAT UniProtKB/Swiss-Prot
  G3V7W7 ENTREZGENE, UniProtKB/TrEMBL
  P15684 ENTREZGENE
  Q9JHP4 ENTREZGENE
UniProt Secondary Q9JHP4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Anpep  alanyl aminopeptidase, membrane  Anpep  alanyl (membrane) aminopeptidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Anpep  alanyl (membrane) aminopeptidase      Symbol and Name status set to approved 70586 APPROVED
2001-12-10 Anpep  alanyl (membrane) aminopeptidase      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in large amount in kidney, lung, liver, heart and aorta 69943
gene_expression expressed in large amount in kidney, lung, liver, heart and aorta 69944
gene_function broad specificity aminopeptidase; found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells 724707
gene_process plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases; may be involved in the metabolism of regulatory peptides of diverse cell types; may have a role in angiogenesis 724707
gene_process plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases 69943
gene_process plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases 69944
gene_product glycoprotein, member of the peptidase family m1 (zinc metalloprotease) 69943
gene_product glycoprotein, member of the peptidase family m1 (zinc metalloprotease) 69944
gene_protein 965 amino acids, 140 kDa 69943
gene_protein 965 amino acids, 140 kDa 69944