Jak3 (Janus kinase 3) - Rat Genome Database

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Gene: Jak3 (Janus kinase 3) Rattus norvegicus
Analyze
Symbol: Jak3
Name: Janus kinase 3
RGD ID: 2940
Description: Predicted to enable growth hormone receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and protein phosphatase binding activity. Involved in several processes, including positive regulation of activated T cell proliferation; positive regulation of calcium ion transport; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in cytoplasm; endomembrane system; and membrane. Predicted to be active in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Used to study graft-versus-host disease. Biomarker of tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe combined immunodeficiency. Orthologous to human JAK3 (Janus kinase 3); PARTICIPATES IN altered Jak-Stat signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: JAK-3; Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; RATJAK3; tyrosine-protein kinase JAK3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,418,807 - 18,432,515 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1618,420,415 - 18,433,222 (+)EnsemblGRCr8
mRatBN7.21618,386,330 - 18,398,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,386,405 - 18,398,536 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,437,879 - 18,449,181 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,570,477 - 19,581,792 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,490,818 - 18,502,120 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1618,567,302 - 18,578,615 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1618,440,250 - 18,451,565 (+)NCBILyon_Normotensive
Lyon_Hypertensive1618,434,201 - 18,445,516 (+)NCBILyon_Hypertensive
F344_StmMcwi1618,579,213 - 18,590,520 (+)NCBIF344_StmMcwi
Rnor_6.01620,107,471 - 20,120,678 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,109,200 - 20,120,668 (+)Ensemblrn6Rnor6.0
Rnor_5.01619,968,486 - 19,981,132 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41618,878,139 - 18,889,441 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,589,820 - 18,601,138 (+)NCBICelera
RGSC_v3.11618,878,136 - 18,889,439 (+)NCBI
RH 3.4 Map16181.8RGD
Cytogenetic Map16p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
afimoxifene  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
baricitinib  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
ceritinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyanidin cation  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
genistein  (ISO)
hypochlorous acid  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylphenidate  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
paracetamol  (EXP,ISO)
PD 168393  (ISO)
Pervanadate  (ISO)
PF-956980  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
prostaglandin E2  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (EXP)
tetraphene  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
trametinib  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
B cell differentiation  (ISO,ISS)
cell differentiation  (IBA)
cell surface receptor signaling pathway via JAK-STAT  (IBA)
cellular response to cytokine stimulus  (ISO)
cytokine-mediated signaling pathway  (IBA,IDA,IEA,ISO)
enzyme-linked receptor protein signaling pathway  (ISO,ISS)
growth hormone receptor signaling pathway via JAK-STAT  (IBA)
immune system process  (IEA)
innate immune response  (IEA)
interleukin-15-mediated signaling pathway  (ISO)
interleukin-2-mediated signaling pathway  (ISO)
interleukin-4-mediated signaling pathway  (ISO)
interleukin-7-mediated signaling pathway  (ISO)
interleukin-9-mediated signaling pathway  (ISO)
intracellular signal transduction  (IBA,IEA,ISO,ISS)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of dendritic cell cytokine production  (ISO,ISS)
negative regulation of glycoprotein biosynthetic process  (ISO,ISS)
negative regulation of interleukin-10 production  (ISO,ISS)
negative regulation of interleukin-12 production  (ISO,ISS)
negative regulation of T cell activation  (ISO,ISS)
negative regulation of T-helper 1 cell differentiation  (ISO,ISS)
negative regulation of T-helper 17 cell lineage commitment  (ISO)
negative regulation of thymocyte apoptotic process  (ISO,ISS)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of activated T cell proliferation  (IMP)
positive regulation of calcium ion transport  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of dendritic cell apoptotic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,IMP)
positive regulation of T cell proliferation  (IDA)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of apoptotic process  (IBA)
regulation of leukocyte cell-cell adhesion  (IEA)
regulation of T cell activation  (IEA)
regulation of T cell apoptotic process  (ISO,ISS)
response to interleukin-4  (ISO)
T cell homeostasis  (ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Combined immunodeficiency evolving into predominant CD4+ lymphopenia caused by somatic chimerism in JAK3. Ban SA, etal., J Clin Immunol. 2014 Nov;34(8):941-53. doi: 10.1007/s10875-014-0088-2. Epub 2014 Sep 10.
2. Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts. Behbod F, etal., J Immunol. 2001 Mar 15;166(6):3724-32.
3. Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia. Bergmann AK, etal., Genes Chromosomes Cancer. 2014 Apr;53(4):309-16. doi: 10.1002/gcc.22141. Epub 2014 Jan 21.
4. Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. Bingisser RM, etal., J Immunol. 1998 Jun 15;160(12):5729-34.
5. Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. Bixler GV, etal., BMC Med Genomics. 2011 May 15;4:40. doi: 10.1186/1755-8794-4-40.
6. An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. Bongfen SE, etal., PLoS One. 2012;7(2):e31012. doi: 10.1371/journal.pone.0031012. Epub 2012 Feb 21.
7. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Bunting KD, etal., Nat Med. 1998 Jan;4(1):58-64.
8. JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model. Degryse S, etal., Blood. 2014 Nov 13;124(20):3092-100. doi: 10.1182/blood-2014-04-566687. Epub 2014 Sep 5.
9. FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma. Elliott NE, etal., Blood. 2011 Oct 6;118(14):3911-21. doi: 10.1182/blood-2010-12-319467. Epub 2011 Aug 5.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4-nitroquinoline 1-oxide. Ge S, etal., Mol Med Rep. 2016 Mar;13(3):2561-9. doi: 10.3892/mmr.2016.4883. Epub 2016 Feb 8.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats. Kim BH, etal., Br J Pharmacol. 2011 Sep;164(1):106-18. doi: 10.1111/j.1476-5381.2011.01353.x.
14. Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase. Kirken RA, etal., J Biol Chem. 1994 Jul 22;269(29):19136-41.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Macchi P, etal., Nature. 1995 Sep 7;377(6544):65-8.
17. VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease. Mahajan S, etal., J Pharmacol Exp Ther. 2015 May;353(2):405-14. doi: 10.1124/jpet.114.221176. Epub 2015 Mar 11.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Milici AJ, etal., Arthritis Res Ther. 2008;10(1):R14. doi: 10.1186/ar2365. Epub 2008 Jan 30.
20. Localization of molecules involved in cytokine receptor signaling in the rat trigeminal ganglion. Mizuno M, etal., Brain Res Mol Brain Res. 1997 Feb;44(1):163-6.
21. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons. Orellana DI, etal., Neurotox Res. 2005 Nov;8(3-4):295-304.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. JAKs, STATs and Src kinases in hematopoiesis. Rane SG and Reddy EP, Oncogene 2002 May 13;21(21):3334-58.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies. Ross JA, etal., Leukemia. 2014 Apr;28(4):941-4. doi: 10.1038/leu.2013.309. Epub 2013 Oct 23.
32. Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy. Saini MK, etal., Eur J Cancer Prev. 2013 May;22(3):215-28. doi: 10.1097/CEJ.0b013e3283584932.
33. Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Sakaguchi H, etal., Nat Genet. 2013 Aug;45(8):937-41. doi: 10.1038/ng.2698. Epub 2013 Jul 7.
34. Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Stepkowski SM, etal., Blood. 2002 Jan 15;99(2):680-9.
35. Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases. Takahashi T and Shirasawa T, FEBS Lett 1994 Apr 4;342(2):124-8.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model. Uckun FM, etal., Blood. 2002 Jun 1;99(11):4192-9.
38. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Walters DK, etal., Cancer Cell. 2006 Jul;10(1):65-75.
39. Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A(2)-IIA in microvascular endothelial cells of the injured brain. Wang G, etal., J Neuroinflammation. 2012 Jul 12;9:170. doi: 10.1186/1742-2094-9-170.
40. [Changes of interleukin-6 and Janus kinases in rats with hypoxic pulmonary hypertension]. Wang GS, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2003 Nov;26(11):664-7.
41. Hemagglutinin from the H5N1 virus activates Janus kinase 3 to dysregulate innate immunity. Xu W, etal., PLoS One. 2012;7(2):e31721. doi: 10.1371/journal.pone.0031721. Epub 2012 Feb 16.
42. Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats. Yin L, etal., J Neuroimmunol. 2014 Sep 15;274(1-2):28-37. doi: 10.1016/j.jneuroim.2014.06.022. Epub 2014 Jun 28.
Additional References at PubMed
PMID:7538655   PMID:7594533   PMID:8022486   PMID:9498750   PMID:9973401   PMID:10485657   PMID:10872802   PMID:11909529   PMID:16020505   PMID:19220965   PMID:19233270   PMID:19414010  
PMID:19531027   PMID:21414324   PMID:22971540   PMID:24280217   PMID:26446793   PMID:28473442   PMID:30664158   PMID:33416962   PMID:33910370  


Genomics

Comparative Map Data
Jak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,418,807 - 18,432,515 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1618,420,415 - 18,433,222 (+)EnsemblGRCr8
mRatBN7.21618,386,330 - 18,398,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,386,405 - 18,398,536 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,437,879 - 18,449,181 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,570,477 - 19,581,792 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,490,818 - 18,502,120 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1618,567,302 - 18,578,615 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1618,440,250 - 18,451,565 (+)NCBILyon_Normotensive
Lyon_Hypertensive1618,434,201 - 18,445,516 (+)NCBILyon_Hypertensive
F344_StmMcwi1618,579,213 - 18,590,520 (+)NCBIF344_StmMcwi
Rnor_6.01620,107,471 - 20,120,678 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,109,200 - 20,120,668 (+)Ensemblrn6Rnor6.0
Rnor_5.01619,968,486 - 19,981,132 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41618,878,139 - 18,889,441 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,589,820 - 18,601,138 (+)NCBICelera
RGSC_v3.11618,878,136 - 18,889,439 (+)NCBI
RH 3.4 Map16181.8RGD
Cytogenetic Map16p14NCBI
JAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,824,782 - 17,847,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,824,780 - 17,848,071 (-)Ensemblhg38GRCh38
GRCh371917,935,591 - 17,958,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,797,961 - 17,819,800 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341917,797,960 - 17,819,800NCBI
Celera1917,837,310 - 17,860,555 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,500,992 - 17,524,212 (-)NCBIHuRef
CHM1_11917,935,132 - 17,958,532 (-)NCBICHM1_1
T2T-CHM13v2.01917,958,895 - 17,982,060 (-)NCBIT2T-CHM13v2.0
Jak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,129,027 - 72,143,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,128,940 - 72,143,219 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38871,676,383 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,676,296 - 71,690,575 (+)Ensemblmm10GRCm38
MGSCv37874,200,473 - 74,214,473 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36874,605,563 - 74,619,563 (+)NCBIMGSCv36mm8
Celera874,191,138 - 74,205,120 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Jak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,401,642 - 3,411,643 (+)Ensembl
ChiLan1.0NW_0049555243,399,895 - 3,412,018 (+)NCBIChiLan1.0ChiLan1.0
JAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,681,699 - 22,713,145 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,686,968 - 21,719,944 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,299,129 - 17,330,700 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,283,157 - 18,304,641 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,283,560 - 18,300,964 (-)EnsemblpanPan2panpan1.1
JAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,051,135 - 45,068,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,050,526 - 45,072,805 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2044,963,131 - 44,980,402 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02045,535,925 - 45,553,392 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,535,982 - 45,557,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,772,769 - 44,789,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,183,055 - 45,200,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,459,016 - 45,476,242 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Jak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,661,414 - 203,676,227 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,212,593 - 3,224,048 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,212,593 - 3,224,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,905,919 - 59,926,495 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1259,905,901 - 59,926,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,475,346 - 59,495,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,301,760 - 16,323,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,300,525 - 16,322,859 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660743,064,511 - 3,086,605 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,371,595 - 1,383,879 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249081,371,595 - 1,383,879 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Jak3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11313,277,803 - 13,290,206 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Jak3
53 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:43
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000025312
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D16Rat82  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81618,426,311 - 18,426,495 (+)Marker Load Pipeline
mRatBN7.21618,392,338 - 18,392,522 (+)MAPPERmRatBN7.2
Rnor_6.01620,114,475 - 20,114,658NCBIRnor6.0
Rnor_5.01619,974,929 - 19,975,112UniSTSRnor5.0
RGSC_v3.41618,883,254 - 18,883,437RGDRGSC3.4
RGSC_v3.41618,883,254 - 18,883,437UniSTSRGSC3.4
Celera1618,594,935 - 18,595,118UniSTS
RGSC_v3.11618,883,252 - 18,883,435RGD
RH 3.4 Map16186.4UniSTS
RH 3.4 Map16186.4RGD
RH 2.0 Map16165.9RGD
SHRSP x BN Map165.71RGD
Cytogenetic Map16p14UniSTS
RH142198  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81618,432,109 - 18,432,278 (+)Marker Load Pipeline
RH 3.4 Map16181.8UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025312   ⟹   ENSRNOP00000025312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,420,415 - 18,433,222 (+)Ensembl
mRatBN7.2 Ensembl1618,386,405 - 18,398,536 (+)Ensembl
Rnor_6.0 Ensembl1620,110,148 - 20,120,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079784   ⟹   ENSRNOP00000071081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1620,109,200 - 20,120,446 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080146   ⟹   ENSRNOP00000073659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1620,110,148 - 20,120,662 (+)Ensembl
RefSeq Acc Id: NM_012855   ⟹   NP_036987
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,421,197 - 18,432,515 (+)NCBI
mRatBN7.21618,387,224 - 18,398,542 (+)NCBI
Dahl_SR_JrHsd1618,567,302 - 18,578,615 (+)NCBI
Lyon_Normotensive1618,440,250 - 18,451,565 (+)NCBI
Lyon_Hypertensive1618,434,201 - 18,445,516 (+)NCBI
F344_StmMcwi1618,579,213 - 18,590,520 (+)NCBI
Rnor_6.01620,109,360 - 20,120,678 (+)NCBI
Rnor_5.01619,968,486 - 19,981,132 (+)NCBI
RGSC_v3.41618,878,139 - 18,889,441 (+)RGD
Celera1618,589,820 - 18,601,138 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771064   ⟹   XP_008769286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,515 (+)NCBI
mRatBN7.21618,386,330 - 18,398,542 (+)NCBI
Rnor_6.01620,107,472 - 20,120,678 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599993   ⟹   XP_017455482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,515 (+)NCBI
mRatBN7.21618,386,330 - 18,398,542 (+)NCBI
Rnor_6.01620,107,471 - 20,120,678 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094203   ⟹   XP_038950131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,421,297 - 18,432,515 (+)NCBI
mRatBN7.21618,387,315 - 18,398,542 (+)NCBI
RefSeq Acc Id: XM_063275068   ⟹   XP_063131138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,515 (+)NCBI
RefSeq Acc Id: XM_063275069   ⟹   XP_063131139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,515 (+)NCBI
RefSeq Acc Id: XR_005494533
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,418,807 - 18,432,116 (+)NCBI
mRatBN7.21618,386,330 - 18,398,542 (+)NCBI
RefSeq Acc Id: NP_036987   ⟸   NM_012855
- UniProtKB: Q63272 (UniProtKB/Swiss-Prot),   F1LR79 (UniProtKB/TrEMBL),   A0A8L2UK66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769286   ⟸   XM_008771064
- Peptide Label: isoform X1
- UniProtKB: Q63272 (UniProtKB/Swiss-Prot),   F1LR79 (UniProtKB/TrEMBL),   A0A8L2UK66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455482   ⟸   XM_017599993
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UK66 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073659   ⟸   ENSRNOT00000080146
Ensembl Acc Id: ENSRNOP00000071081   ⟸   ENSRNOT00000079784
Ensembl Acc Id: ENSRNOP00000025312   ⟸   ENSRNOT00000025312
RefSeq Acc Id: XP_038950131   ⟸   XM_039094203
- Peptide Label: isoform X1
- UniProtKB: Q63272 (UniProtKB/Swiss-Prot),   F1LR79 (UniProtKB/Swiss-Prot),   A0A8L2UK66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131138   ⟸   XM_063275068
- Peptide Label: isoform X1
- UniProtKB: Q63272 (UniProtKB/Swiss-Prot),   F1LR79 (UniProtKB/Swiss-Prot),   A0A8L2UK66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131139   ⟸   XM_063275069
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UK66 (UniProtKB/TrEMBL)
Protein Domains
FERM   Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63272-F1-model_v2 AlphaFold Q63272 1-1100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2940 AgrOrtholog
BioCyc Gene G2FUF-11829 BioCyc
Ensembl Genes ENSRNOG00000018669 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025312 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Band_41_domain UniProtKB/Swiss-Prot
  FERM_domain UniProtKB/Swiss-Prot
  FERM_F1 UniProtKB/Swiss-Prot
  FERM_F2 UniProtKB/Swiss-Prot
  JAK UniProtKB/Swiss-Prot
  Jak1_PHL_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/Swiss-Prot
  Tyr_kinase_non-rcpt_Jak3 UniProtKB/Swiss-Prot
KEGG Report rno:25326 UniProtKB/Swiss-Prot
NCBI Gene 25326 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE HOPSCOTCH UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE JAK3 UniProtKB/Swiss-Prot
Pfam FERM_F1 UniProtKB/Swiss-Prot
  FERM_F2 UniProtKB/Swiss-Prot
  Jak1_Phl UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2_1 UniProtKB/Swiss-Prot
PhenoGen Jak3 PhenoGen
PIRSF TyrPK_Jak UniProtKB/Swiss-Prot
PRINTS JANUSKINASE UniProtKB/Swiss-Prot
  JANUSKINASE3 UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE FERM_3 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018669 RatGTEx
SMART B41 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC231103
UniProt A0A8L2UK66 ENTREZGENE, UniProtKB/TrEMBL
  F1LR79 ENTREZGENE
  JAK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LR79 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Jak3  Janus kinase 3, protein-tyrosine kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen, lung, kidney and intestine 729028
gene_protein 1,100 amino acids 729028