RGD Reference Report - Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats. - Rat Genome Database

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Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats.

Authors: Yin, L  Chen, Y  Qu, Z  Zhang, L  Wang, Q  Zhang, Q  Li, L 
Citation: Yin L, etal., J Neuroimmunol. 2014 Sep 15;274(1-2):28-37. doi: 10.1016/j.jneuroim.2014.06.022. Epub 2014 Jun 28.
RGD ID: 11533939
Pubmed: PMID:25012120   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2014.06.022   (Journal Full-text)

In the present study, we investigated the therapeutic benefit of cornel iridoid glycoside (CIG), the main component extracted from Cornus officinalis, in experimental autoimmune encephalomyelitis (EAE) rats. CIG was intragastrically administered daily after EAE initiation for 20days and reduced disease severity, incidence, disease onset and ongoing paralysis. Histopathological staining showed that CIG could reduce T cell entry to the central nervous system and microglia activation, increased brain-derived neurotrophic factor (BDNF) expression and mature oligodendrocytes, and decreased oligodendrocyte progenitor cells (OPCs). Also, CIG treatment inhibited brain JAK/STAT1/3 and reduced proinflammatory cytokines. CIG might be a novel potential therapeutic agent for multiple sclerosis (MS).

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Encephalomyelitis treatmentISOJak3 (Rattus norvegicus)11533939; 11533939 RGD 
Experimental Autoimmune Encephalomyelitis treatmentIDA 11533939 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Jak3  (Janus kinase 3)

Genes (Mus musculus)
Jak3  (Janus kinase 3)

Genes (Homo sapiens)
JAK3  (Janus kinase 3)


Additional Information