Hsd17b7 (hydroxysteroid (17-beta) dehydrogenase 7) - Rat Genome Database

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Gene: Hsd17b7 (hydroxysteroid (17-beta) dehydrogenase 7) Rattus norvegicus
Analyze
Symbol: Hsd17b7
Name: hydroxysteroid (17-beta) dehydrogenase 7
RGD ID: 2837
Description: Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and prolactin receptor binding activity. Involved in several processes, including estrogen biosynthetic process; response to estradiol; and response to prolactin. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Biomarker of polycystic ovary syndrome. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; dihydrotestosterone oxidoreductase; estradiol 17-beta-dehydrogenase 7; hydroxysteroid 17-beta dehydrogenase 7; hydroxysteroid dehydrogenase 17 beta, type 7; PRAP; PRL receptor-associated protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,702,875 - 84,722,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1384,705,631 - 84,722,754 (-)EnsemblGRCr8
mRatBN7.21382,170,079 - 82,190,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,173,179 - 82,190,017 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1384,799,751 - 84,816,641 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01386,093,813 - 86,110,564 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,324,993 - 83,341,883 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,288,116 - 88,308,019 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,288,046 - 88,307,988 (-)Ensemblrn6Rnor6.0
Rnor_5.01392,914,581 - 92,934,289 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41385,776,077 - 85,792,977 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1381,835,166 - 81,852,028 (-)NCBICelera
RGSC_v3.11385,790,264 - 85,807,165 (-)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3',4'-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
apigenin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
auramine O  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
Bufotalin  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
Chorionic gonadotropin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
dimethyl sulfoxide  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
estrone  (ISO)
finasteride  (EXP)
fipronil  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
letrozole  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP)
luteolinidin  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phytosterols  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
propiconazole  (EXP)
resveratrol  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triclosan  (EXP)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. PRAP, a prolactin receptor associated protein: its gene expression and regulation in the corpus luteum. Duan WR, etal., Endocrinology. 1997 Aug;138(8):3216-21.
2. Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor. Duan WR, etal., J Biol Chem 1996 Jun 28;271(26):15602-7.
3. Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats. Einbond LS, etal., Fundam Clin Pharmacol. 2009 Jun;23(3):311-21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
8. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Liu Z, etal., Mol Endocrinol. 2009 May;23(5):649-61. Epub 2009 Feb 5.
9. Identification and characterization of an abundant phosphoprotein specific to the large luteal cell. McLean MP, etal., Endocrinology. 1990 Apr;126(4):1796-805.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Nokelainen P, etal., Mol Endocrinol. 1998 Jul;12(7):1048-59. doi: 10.1210/mend.12.7.0134.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids. Salilew-Wondim D, etal., J Ovarian Res. 2015 Apr 13;8(1):24. doi: 10.1186/s13048-015-0151-5.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12829805   PMID:15731358   PMID:21515572   PMID:26873413   PMID:31587341   PMID:34800366  


Genomics

Comparative Map Data
Hsd17b7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,702,875 - 84,722,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1384,705,631 - 84,722,754 (-)EnsemblGRCr8
mRatBN7.21382,170,079 - 82,190,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,173,179 - 82,190,017 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1384,799,751 - 84,816,641 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01386,093,813 - 86,110,564 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,324,993 - 83,341,883 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,288,116 - 88,308,019 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,288,046 - 88,307,988 (-)Ensemblrn6Rnor6.0
Rnor_5.01392,914,581 - 92,934,289 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41385,776,077 - 85,792,977 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1381,835,166 - 81,852,028 (-)NCBICelera
RGSC_v3.11385,790,264 - 85,807,165 (-)NCBI
Cytogenetic Map13q24NCBI
HSD17B7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,790,702 - 162,812,823 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,790,702 - 162,812,823 (+)Ensemblhg38GRCh38
GRCh371162,760,492 - 162,782,613 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,027,120 - 161,049,232 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341159,492,153 - 159,514,265NCBI
Celera1135,864,558 - 135,886,965 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1134,005,589 - 134,028,003 (+)NCBIHuRef
CHM1_11164,183,061 - 164,205,170 (+)NCBICHM1_1
T2T-CHM13v2.01162,134,938 - 162,157,387 (+)NCBIT2T-CHM13v2.0
Hsd17b7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,777,109 - 169,796,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,777,104 - 169,796,810 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,949,535 - 169,969,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,949,535 - 169,969,241 (-)Ensemblmm10GRCm38
MGSCv371171,879,668 - 171,899,336 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361171,786,212 - 171,805,880 (-)NCBIMGSCv36mm8
Celera1172,391,590 - 172,411,249 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map176.84NCBI
Hsd17b7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546213,557,292 - 13,574,593 (-)Ensembl
ChiLan1.0NW_00495546213,555,488 - 13,574,506 (-)NCBIChiLan1.0ChiLan1.0
LOC100985156
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2851,005,870 - 51,028,676 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11051,011,219 - 51,034,004 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01038,424,713 - 38,447,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11142,001,063 - 142,017,150 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1142,001,162 - 142,022,865 (+)EnsemblpanPan2panpan1.1
HSD17B7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13819,975,935 - 19,999,077 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3819,977,086 - 19,999,010 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3820,031,119 - 20,054,229 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03820,059,511 - 20,082,663 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3820,058,310 - 20,082,624 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,034,574 - 20,057,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03820,386,347 - 20,409,416 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03820,677,507 - 20,700,653 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hsd17b7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050588,635,691 - 8,660,282 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936831951,562 - 977,208 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936831951,603 - 976,159 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl487,720,118 - 87,742,992 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1487,720,747 - 87,743,037 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2495,571,675 - 95,593,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1201,271,259 - 1,289,232 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl201,273,052 - 1,288,930 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038290,535 - 308,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248261,260,223 - 1,283,741 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248261,260,133 - 1,287,565 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hsd17b7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11049,162,066 - 49,178,647 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hsd17b7
103 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:227
Count of miRNA genes:158
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000003812
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH130925  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81384,706,192 - 84,706,369 (+)Marker Load Pipeline
mRatBN7.21382,173,401 - 82,173,578 (+)MAPPERmRatBN7.2
Rnor_6.01388,291,439 - 88,291,615NCBIRnor6.0
Rnor_5.01392,917,904 - 92,918,080UniSTSRnor5.0
RGSC_v3.41385,776,265 - 85,776,441UniSTSRGSC3.4
Celera1381,835,357 - 81,835,533UniSTS
RH 3.4 Map13514.1UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 88 59 6 352 188 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI045145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY390340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM383605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM073997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN803430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ113345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003812   ⟹   ENSRNOP00000003812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1384,705,631 - 84,722,754 (-)Ensembl
mRatBN7.2 Ensembl1382,173,179 - 82,190,017 (-)Ensembl
Rnor_6.0 Ensembl1388,288,046 - 88,307,988 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111937   ⟹   ENSRNOP00000095732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1384,706,002 - 84,721,930 (-)Ensembl
mRatBN7.2 Ensembl1382,173,179 - 82,189,139 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159263   ⟹   ENSRNOP00000109240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1384,706,592 - 84,722,754 (-)Ensembl
RefSeq Acc Id: NM_017235   ⟹   NP_058931
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,706,002 - 84,722,754 (-)NCBI
mRatBN7.21382,173,211 - 82,189,963 (-)NCBI
Rnor_6.01388,291,248 - 88,307,988 (-)NCBI
Rnor_5.01392,914,581 - 92,934,289 (-)NCBI
RGSC_v3.41385,776,077 - 85,792,977 (-)RGD
Celera1381,835,166 - 81,852,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250215   ⟹   XP_006250277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,702,875 - 84,722,810 (-)NCBI
mRatBN7.21382,170,083 - 82,190,018 (-)NCBI
Rnor_6.01388,288,116 - 88,308,019 (-)NCBI
Rnor_5.01392,914,581 - 92,934,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250216   ⟹   XP_006250278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,702,875 - 84,722,810 (-)NCBI
mRatBN7.21382,170,079 - 82,190,018 (-)NCBI
Rnor_6.01388,288,116 - 88,308,019 (-)NCBI
Rnor_5.01392,914,581 - 92,934,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250217   ⟹   XP_006250279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,702,875 - 84,722,810 (-)NCBI
mRatBN7.21382,170,079 - 82,190,018 (-)NCBI
Rnor_6.01388,288,116 - 88,308,019 (-)NCBI
Rnor_5.01392,914,581 - 92,934,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598772   ⟹   XP_017454261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,702,875 - 84,722,810 (-)NCBI
mRatBN7.21382,170,083 - 82,190,018 (-)NCBI
Rnor_6.01388,288,116 - 88,308,019 (-)NCBI
Sequence:
RefSeq Acc Id: NP_058931   ⟸   NM_017235
- UniProtKB: Q62904 (UniProtKB/Swiss-Prot),   A6IDN2 (UniProtKB/TrEMBL),   A0A0H2UHB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250279   ⟸   XM_006250217
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006250278   ⟸   XM_006250216
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006250277   ⟸   XM_006250215
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454261   ⟸   XM_017598772
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UHB1 (UniProtKB/TrEMBL),   A6IDN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003812   ⟸   ENSRNOT00000003812
Ensembl Acc Id: ENSRNOP00000095732   ⟸   ENSRNOT00000111937
Ensembl Acc Id: ENSRNOP00000109240   ⟸   ENSRNOT00000159263

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62904-F1-model_v2 AlphaFold Q62904 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698981
Promoter ID:EPDNEW_R9506
Type:initiation region
Name:Hsd17b7_1
Description:hydroxysteroid (17-beta) dehydrogenase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01388,307,984 - 88,308,044EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2837 AgrOrtholog
BioCyc Gene G2FUF-17488 BioCyc
BioCyc Pathway PWY-6074 [zymosterol biosynthesis] BioCyc
BioCyc Pathway Image PWY-6074 BioCyc
Ensembl Genes ENSRNOG00000002826 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003812 ENTREZGENE
  ENSRNOT00000159263 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106149 IMAGE-MGC_LOAD
InterPro 3KSR/17beta-HSD UniProtKB/Swiss-Prot
  HSD17B7 UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:29540 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93527 IMAGE-MGC_LOAD
NCBI Gene 29540 ENTREZGENE
PANTHER 3-KETO-STEROID REDUCTASE UniProtKB/Swiss-Prot
  3-KETO-STEROID REDUCTASE/17-BETA-HYDROXYSTEROID DEHYDROGENASE 7 UniProtKB/Swiss-Prot
Pfam adh_short UniProtKB/Swiss-Prot
PhenoGen Hsd17b7 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002826 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
TIGR TC232143
UniProt A0A0H2UHB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AU17_RAT UniProtKB/TrEMBL
  A0ABK0LSW1_RAT UniProtKB/TrEMBL
  A6IDN2 ENTREZGENE, UniProtKB/TrEMBL
  A6IDN3_RAT UniProtKB/TrEMBL
  DHB7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hsd17b7  hydroxysteroid (17-beta) dehydrogenase 7    hydroxysteroid dehydrogenase 17 beta, type 7  Name updated 1299863 APPROVED
2002-06-10 Hsd17b7  hydroxysteroid dehydrogenase 17 beta, type 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in the effects of PRL on the corpus luteum during pregnancy 69856