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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2837
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd17b7
Name: hydroxysteroid (17-beta) dehydrogenase 7
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd17b7decreases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HSD17B7 mRNAPMID:20959002
Hsd17b7increases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B7 mRNAPMID:23196670
Hsd17b7decreases methylationISOHSD17B7 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased methylation of HSD17B7 promoterPMID:27663891
Hsd17b7increases expressionISOHSD17B7 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B7 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B7 proteinPMID:27663891
Hsd17b7multiple interactionsISOHSD17B7 (Homo sapiens)6480464CTD3',4'-dimethoxyflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B7 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B7 protein]PMID:27663891
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