Gss (glutathione synthetase) - Rat Genome Database

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Gene: Gss (glutathione synthetase) Rattus norvegicus
Analyze
Symbol: Gss
Name: glutathione synthetase
RGD ID: 2752
Description: Enables several functions, including anion binding activity; glutathione synthase activity; and identical protein binding activity. Involved in several processes, including glutathione biosynthetic process; response to amino acid; and response to tumor necrosis factor. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; congenital nonspherocytic hemolytic anemia 6; glutathione synthetase deficiency; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione synthase; Glutathione synthetase gene; GSH synthetase; GSH-S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,508,005 - 164,538,343 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,508,005 - 164,538,306 (-)EnsemblGRCr8
mRatBN7.23144,047,849 - 144,078,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,047,850 - 144,078,198 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3147,914,375 - 147,944,469 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,531,652 - 156,561,750 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,271,186 - 154,301,288 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,076,254 - 151,106,557 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,076,254 - 151,106,557 (-)Ensemblrn6Rnor6.0
Rnor_5.03157,443,738 - 157,474,042 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43146,057,517 - 146,087,820 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,772,407 - 142,802,700 (-)NCBICelera
RGSC_v3.13145,963,138 - 145,993,442 (-)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
Anetholtrithion  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
celecoxib  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethyl malate  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
diquat  (ISO)
enilconazole  (ISO)
erdosteine  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galactose  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (ISO)
Glutathione ethyl ester  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipoic acid  (EXP)
lithocholic acid  (ISO)
LY294002  (ISO)
lycopene  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
misonidazole  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrogen dioxide  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oligopeptide  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Glutathione synthesis in normal liver and in Yoshida AH-130 hepatoma. Biocca ME, etal., Toxicol Pathol. 1986;14(4):415-6.
2. Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. Dahl N, etal., Hum Mol Genet 1997 Jul;6(7):1147-52.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Effects of chondroitin sulfate on alteration of actin cytoskeleton in rats with acute necrotizing pancreatitis. He ZY and Guo RX, Hepatobiliary Pancreat Dis Int. 2007 Oct;6(5):537-43.
6. Amino acid sequence of rat kidney glutathione synthetase. Huang CS, etal., Proc Natl Acad Sci U S A 1995 Feb 14;92(4):1232-6.
7. High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Jobgen W, etal., Amino Acids. 2009 May;37(1):187-98. Epub 2009 Feb 12.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats. Lee JS, etal., Toxicol Sci. 2008 Nov;106(1):263-83. Epub 2008 Jul 24.
10. Gender differences in glutathione metabolism in Alzheimer's disease. Liu H, etal., J Neurosci Res. 2005 Mar 15;79(6):861-7.
11. Novel kinetics of mammalian glutathione synthetase: characterization of gamma-glutamyl substrate cooperative binding. Luo JL, etal., Biochem Biophys Res Commun. 2000 Aug 28;275(2):577-81.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Mutations in the glutathione synthetase gene cause 5-oxoprolinuria. Shi ZZ, etal., Nat Genet. 1996 Nov;14(3):361-5.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. A spectrophotometric assay of gamma-glutamylcysteine synthetase and glutathione synthetase in crude extracts from tissues and cultured mammalian cells. Volohonsky G, etal., Chem Biol Interact. 2002 Apr 20;140(1):49-65.
23. Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. Yang H, etal., Biochem J. 2005 Oct 15;391(Pt 2):399-408.
24. Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone. Yang H, etal., J Biol Chem 2002 Sep 20;277(38):35232-9.
Additional References at PubMed
PMID:8660701   PMID:10369661   PMID:15489334   PMID:19056867   PMID:21988832   PMID:23376485   PMID:23533145   PMID:25416956   PMID:26871637  


Genomics

Comparative Map Data
Gss
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,508,005 - 164,538,343 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,508,005 - 164,538,306 (-)EnsemblGRCr8
mRatBN7.23144,047,849 - 144,078,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,047,850 - 144,078,198 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3147,914,375 - 147,944,469 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,531,652 - 156,561,750 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,271,186 - 154,301,288 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,076,254 - 151,106,557 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,076,254 - 151,106,557 (-)Ensemblrn6Rnor6.0
Rnor_5.03157,443,738 - 157,474,042 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43146,057,517 - 146,087,820 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,772,407 - 142,802,700 (-)NCBICelera
RGSC_v3.13145,963,138 - 145,993,442 (-)NCBI
Cytogenetic Map3q42NCBI
GSS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,928,432 - 34,956,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,928,432 - 34,956,027 (-)Ensemblhg38GRCh38
GRCh372033,516,235 - 33,543,830 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,979,897 - 33,007,262 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342032,979,897 - 33,007,262NCBI
Celera2030,265,329 - 30,292,695 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,294,556 - 30,321,979 (-)NCBIHuRef
CHM1_12033,417,456 - 33,444,826 (-)NCBICHM1_1
T2T-CHM13v2.02036,649,086 - 36,676,682 (-)NCBIT2T-CHM13v2.0
Gss
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,405,101 - 155,434,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,405,101 - 155,434,730 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382155,563,181 - 155,592,810 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,563,181 - 155,592,810 (-)Ensemblmm10GRCm38
MGSCv372155,388,919 - 155,418,442 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362155,254,624 - 155,284,147 (-)NCBIMGSCv36mm8
Celera2161,495,432 - 161,524,969 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Gss
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,427,581 - 26,463,781 (+)Ensembl
ChiLan1.0NW_00495542226,427,581 - 26,483,380 (+)NCBIChiLan1.0ChiLan1.0
GSS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,661,205 - 40,688,813 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,654,308 - 40,682,219 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,256,734 - 31,284,356 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,381,745 - 32,409,327 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,381,745 - 32,409,297 (-)EnsemblpanPan2panpan1.1
GSS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,973,807 - 24,000,281 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,901,045 - 23,997,286 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2423,619,971 - 23,646,466 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02424,665,657 - 24,692,375 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,665,043 - 24,692,288 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,952,937 - 23,979,420 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,048,251 - 24,074,736 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,487,171 - 24,513,688 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gss
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,955,595 - 172,983,992 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,765,610 - 5,793,567 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,765,637 - 5,793,951 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,312,720 - 38,342,298 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11738,316,199 - 38,342,253 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,511,098 - 43,539,281 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1239,230,629 - 39,258,511 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,230,487 - 39,254,648 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605087,554,278 - 87,582,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gss
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248424,446,721 - 4,478,450 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248424,445,015 - 4,470,124 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gss
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15134,895,200 - 134,925,205 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gss
299 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:69
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000025657
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
D3Got112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,050,848 - 144,051,023 (+)MAPPERmRatBN7.2
Rnor_6.03151,079,253 - 151,079,427NCBIRnor6.0
Rnor_5.03157,446,738 - 157,446,912UniSTSRnor5.0
RGSC_v3.43146,060,515 - 146,060,690RGDRGSC3.4
RGSC_v3.43146,060,516 - 146,060,690UniSTSRGSC3.4
Celera3142,775,406 - 142,775,580UniSTS
RGSC_v3.13145,966,138 - 145,966,312RGD
RH 3.4 Map31298.6RGD
RH 3.4 Map31298.6UniSTS
Cytogenetic Map3q42UniSTS
RH127607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,048,021 - 144,048,222 (+)MAPPERmRatBN7.2
Rnor_6.03151,076,426 - 151,076,626NCBIRnor6.0
Rnor_5.03157,443,911 - 157,444,111UniSTSRnor5.0
RGSC_v3.43146,057,689 - 146,057,889UniSTSRGSC3.4
Celera3142,772,579 - 142,772,779UniSTS
RH 3.4 Map31305.9UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025657   ⟹   ENSRNOP00000025657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,508,005 - 164,538,306 (-)Ensembl
mRatBN7.2 Ensembl3144,047,852 - 144,078,198 (-)Ensembl
Rnor_6.0 Ensembl3151,076,254 - 151,106,557 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115033   ⟹   ENSRNOP00000094043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,508,005 - 164,537,938 (-)Ensembl
mRatBN7.2 Ensembl3144,047,850 - 144,078,028 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170884   ⟹   ENSRNOP00000107930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,508,005 - 164,533,211 (-)Ensembl
RefSeq Acc Id: NM_012962   ⟹   NP_037094
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,508,005 - 164,538,306 (-)NCBI
mRatBN7.23144,047,850 - 144,078,154 (-)NCBI
Rnor_6.03151,076,254 - 151,106,557 (-)NCBI
Rnor_5.03157,443,738 - 157,474,042 (-)NCBI
RGSC_v3.43146,057,517 - 146,087,820 (-)RGD
Celera3142,772,407 - 142,802,700 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104373   ⟹   XP_038960301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,508,007 - 164,538,343 (-)NCBI
mRatBN7.23144,047,849 - 144,078,197 (-)NCBI
RefSeq Acc Id: NP_037094   ⟸   NM_012962
- UniProtKB: P46413 (UniProtKB/Swiss-Prot),   A6KI44 (UniProtKB/TrEMBL),   A0A8I6AYD3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025657   ⟸   ENSRNOT00000025657
RefSeq Acc Id: XP_038960301   ⟸   XM_039104373
- Peptide Label: isoform X1
- UniProtKB: A6KI45 (UniProtKB/TrEMBL),   A0A8I6AYD3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094043   ⟸   ENSRNOT00000115033
Ensembl Acc Id: ENSRNOP00000107930   ⟸   ENSRNOT00000170884
Protein Domains
Glutathione synthase substrate-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46413-F1-model_v2 AlphaFold P46413 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692585
Promoter ID:EPDNEW_R3110
Type:initiation region
Name:Gss_1
Description:glutathione synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03151,106,540 - 151,106,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2752 AgrOrtholog
BioCyc Gene G2FUF-47127 BioCyc
BioCyc Pathway GLUTATHIONESYN-PWY [glutathione biosynthesis] BioCyc
  PWY-8043 [ophthalmate biosynthesis] BioCyc
BioCyc Pathway Image GLUTATHIONESYN-PWY BioCyc
  PWY-8043 BioCyc
Ensembl Genes ENSRNOG00000018964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025657 ENTREZGENE
  ENSRNOT00000025657.3 UniProtKB/Swiss-Prot
  ENSRNOT00000170884 ENTREZGENE
Gene3D-CATH 3.30.1490.50 UniProtKB/Swiss-Prot
  3.30.1490.80 UniProtKB/Swiss-Prot
  3.40.50.1760 UniProtKB/Swiss-Prot
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot
  Glutathione Synthetase, Chain A, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110971 IMAGE-MGC_LOAD
InterPro Glutathione_synthase UniProtKB/Swiss-Prot
  Glutathione_synthase_a-hlx UniProtKB/Swiss-Prot
  Glutathione_synthase_C_euk UniProtKB/Swiss-Prot
  Glutathione_synthase_N_euk UniProtKB/Swiss-Prot
  GSH-S_sub-bd_sf UniProtKB/Swiss-Prot
  GSH_synth_subst-bd UniProtKB/Swiss-Prot
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25458 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93095 IMAGE-MGC_LOAD
NCBI Gene 25458 ENTREZGENE
PANTHER GLUTATHIONE SYNTHETASE UniProtKB/Swiss-Prot
  PTHR11130 UniProtKB/Swiss-Prot
Pfam GSH_synth_ATP UniProtKB/Swiss-Prot
  GSH_synthase UniProtKB/Swiss-Prot
PharmGKB GSS RGD
PhenoGen Gss PhenoGen
PIRSF GSHase UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018964 RatGTEx
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  SSF52440 UniProtKB/Swiss-Prot
TIGR TC230939
UniProt A0A8I6AYD3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LUM5_RAT UniProtKB/TrEMBL
  A6KI43_RAT UniProtKB/TrEMBL
  A6KI44 ENTREZGENE, UniProtKB/TrEMBL
  A6KI45 ENTREZGENE, UniProtKB/TrEMBL
  GSHB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gss  glutathione synthetase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA and enzyme are detected in kidney 69853