Fhl1 (four and a half LIM domains 1) - Rat Genome Database

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Gene: Fhl1 (four and a half LIM domains 1) Rattus norvegicus
Analyze
Symbol: Fhl1
Name: four and a half LIM domains 1
RGD ID: 2615
Description: Predicted to enable potassium channel activator activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of mitotic cell cycle phase transition; positive regulation of potassium ion transmembrane transport; and regulation of atrial cardiac muscle cell membrane depolarization. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FHL-1; four and a half LIM domains 1 (skeletal muscle LIM-protein 1); four and a half LIM domains protein 1; skeletal muscle LIM-protein 1; SLIM1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X139,592,794 - 139,652,290 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX139,592,604 - 139,652,282 (+)EnsemblGRCr8
mRatBN7.2X134,555,399 - 134,614,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,555,479 - 134,614,928 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX136,752,757 - 136,811,835 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X140,307,326 - 140,366,426 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X137,876,719 - 137,935,825 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X159,112,516 - 159,172,528 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,112,880 - 159,172,524 (+)Ensemblrn6Rnor6.0
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X141,315,765 - 141,329,278 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX142,605,050 - 142,663,917 (+)NCBICelera
RGSC_v3.1X141,389,200 - 141,401,948 (+)NCBI
Cytogenetic MapXq36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
25-hydroxycholesterol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bleomycin A2  (EXP)
brefeldin A  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
cannabidiol  (ISO)
capecitabine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
lead nitrate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metaproterenol  (EXP)
methapyrilene  (EXP)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP)
milrinone  (EXP)
mitomycin C  (ISO)
mitoxantrone  (EXP)
Monobutylphthalate  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
orciprenaline  (EXP)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleus  (ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes. Lim DS, etal., J Am Coll Cardiol. 2001 Oct;38(4):1175-80.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:17161435   PMID:18281375   PMID:18756007   PMID:20149813   PMID:21126853   PMID:21423176   PMID:21702045   PMID:23628900   PMID:24265776   PMID:25931508   PMID:25975448  
PMID:26316108  


Genomics

Comparative Map Data
Fhl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X139,592,794 - 139,652,290 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX139,592,604 - 139,652,282 (+)EnsemblGRCr8
mRatBN7.2X134,555,399 - 134,614,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,555,479 - 134,614,928 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX136,752,757 - 136,811,835 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X140,307,326 - 140,366,426 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X137,876,719 - 137,935,825 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X159,112,516 - 159,172,528 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,112,880 - 159,172,524 (+)Ensemblrn6Rnor6.0
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X141,315,765 - 141,329,278 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX142,605,050 - 142,663,917 (+)NCBICelera
RGSC_v3.1X141,389,200 - 141,401,948 (+)NCBI
Cytogenetic MapXq36NCBI
FHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,146,702 - 136,211,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX136,146,702 - 136,211,359 (+)Ensemblhg38GRCh38
GRCh37X135,228,861 - 135,293,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,057,346 - 135,121,176 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X134,955,199 - 135,019,028NCBI
CeleraX135,591,521 - 135,656,168 (+)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX124,502,588 - 124,565,831 (+)NCBIHuRef
CHM1_1X135,139,444 - 135,204,087 (+)NCBICHM1_1
T2T-CHM13v2.0X134,455,091 - 134,519,750 (+)NCBIT2T-CHM13v2.0
Fhl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X55,776,569 - 55,838,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX55,777,147 - 55,838,706 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X56,731,209 - 56,793,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX56,731,787 - 56,793,346 (+)Ensemblmm10GRCm38
MGSCv37X53,984,964 - 54,046,523 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X53,078,598 - 53,140,127 (+)NCBIMGSCv36mm8
CeleraX43,224,152 - 43,274,965 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX30.06NCBI
Fhl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,888,779 - 8,901,970 (-)Ensembl
ChiLan1.0NW_0049554898,888,845 - 8,944,778 (-)NCBIChiLan1.0ChiLan1.0
FHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X135,559,521 - 135,624,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X135,563,121 - 135,627,771 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X125,270,340 - 125,334,961 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X135,538,152 - 135,602,375 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX135,559,321 - 135,602,375 (+)EnsemblpanPan2panpan1.1
FHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X106,542,450 - 106,604,494 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX106,590,988 - 106,604,029 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX92,361,797 - 92,424,954 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X108,518,918 - 108,582,088 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX108,518,948 - 108,582,088 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X105,662,634 - 105,725,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X107,839,961 - 107,904,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,494,648 - 107,557,811 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fhl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,530,356 - 104,588,870 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651311,025,715 - 11,064,312 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651311,025,753 - 11,064,312 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,356,011 - 111,367,903 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X111,309,989 - 111,367,900 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,231,947 - 127,289,864 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXq23-q24NCBI
FHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606328,253,608 - 28,258,035 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480810,924,248 - 10,965,164 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480810,924,606 - 10,984,422 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fhl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11163,344,019 - 163,348,818 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fhl1
301 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:946
Count of miRNA genes:295
Interacting mature miRNAs:391
Transcripts:ENSRNOT00000001169, ENSRNOT00000043820
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
AI556806  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X134,614,703 - 134,614,892 (+)MAPPERmRatBN7.2
Rnor_6.0X159,172,302 - 159,172,490NCBIRnor6.0
Rnor_5.0X153,802,934 - 153,803,122UniSTSRnor5.0
RGSC_v3.4X141,329,057 - 141,329,245UniSTSRGSC3.4
CeleraX142,663,691 - 142,663,879UniSTS
RH 3.4 MapX952.91UniSTS
Cytogenetic MapXq36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF134773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY115564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB702630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK477468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK840296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM042472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ119120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001169   ⟹   ENSRNOP00000001169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX139,638,369 - 139,652,282 (+)Ensembl
mRatBN7.2 EnsemblX134,601,136 - 134,614,920 (+)Ensembl
Rnor_6.0 EnsemblX159,158,194 - 159,172,518 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000043820   ⟹   ENSRNOP00000049677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX139,592,604 - 139,652,282 (+)Ensembl
mRatBN7.2 EnsemblX134,555,479 - 134,614,755 (+)Ensembl
Rnor_6.0 EnsemblX159,158,194 - 159,172,518 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083502   ⟹   ENSRNOP00000072490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX139,638,522 - 139,652,282 (+)Ensembl
mRatBN7.2 EnsemblX134,601,137 - 134,614,924 (+)Ensembl
Rnor_6.0 EnsemblX159,158,195 - 159,172,524 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084594   ⟹   ENSRNOP00000074052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX139,592,842 - 139,652,280 (+)Ensembl
mRatBN7.2 EnsemblX134,555,694 - 134,614,926 (+)Ensembl
Rnor_6.0 EnsemblX159,112,880 - 159,172,518 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087274   ⟹   ENSRNOP00000074817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX139,646,336 - 139,652,282 (+)Ensembl
mRatBN7.2 EnsemblX134,608,976 - 134,614,924 (+)Ensembl
Rnor_6.0 EnsemblX159,165,169 - 159,172,518 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110431   ⟹   ENSRNOP00000088085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX139,638,244 - 139,652,282 (+)Ensembl
mRatBN7.2 EnsemblX134,601,030 - 134,614,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141257   ⟹   ENSRNOP00000110147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX139,592,604 - 139,650,680 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170371   ⟹   ENSRNOP00000100750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX139,592,968 - 139,652,280 (+)Ensembl
RefSeq Acc Id: NM_001033926   ⟹   NP_001029098
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,638,496 - 139,652,290 (+)NCBI
mRatBN7.2X134,601,136 - 134,614,930 (+)NCBI
Rnor_6.0X159,158,194 - 159,172,528 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
RGSC_v3.4X141,315,765 - 141,329,278 (+)RGD
CeleraX142,650,349 - 142,663,917 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271199   ⟹   NP_001258128
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,593,180 - 139,652,290 (+)NCBI
mRatBN7.2X134,555,816 - 134,614,930 (+)NCBI
Rnor_6.0X159,112,880 - 159,172,528 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
CeleraX142,605,050 - 142,663,917 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271200   ⟹   NP_001258129
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,645,472 - 139,652,290 (+)NCBI
mRatBN7.2X134,608,112 - 134,614,930 (+)NCBI
Rnor_6.0X159,165,169 - 159,172,528 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
CeleraX142,657,325 - 142,663,917 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271201   ⟹   NP_001258130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,645,472 - 139,652,290 (+)NCBI
mRatBN7.2X134,608,112 - 134,614,930 (+)NCBI
Rnor_6.0X159,165,169 - 159,172,528 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
CeleraX142,657,325 - 142,663,917 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145669   ⟹   NP_663702
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,638,496 - 139,652,290 (+)NCBI
mRatBN7.2X134,601,136 - 134,614,930 (+)NCBI
Rnor_6.0X159,158,194 - 159,172,528 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
RGSC_v3.4X141,315,765 - 141,329,278 (+)RGD
CeleraX142,650,349 - 142,663,917 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257671   ⟹   XP_006257733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,638,375 - 139,652,288 (+)NCBI
mRatBN7.2X134,601,085 - 134,614,928 (+)NCBI
Rnor_6.0X159,157,945 - 159,172,526 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257672   ⟹   XP_006257734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,592,794 - 139,652,288 (+)NCBI
mRatBN7.2X134,555,399 - 134,614,928 (+)NCBI
Rnor_6.0X159,112,516 - 159,172,526 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257673   ⟹   XP_006257735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,593,069 - 139,652,288 (+)NCBI
mRatBN7.2X134,555,705 - 134,614,928 (+)NCBI
Rnor_6.0X159,112,792 - 159,172,526 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257674   ⟹   XP_006257736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,592,845 - 139,652,288 (+)NCBI
mRatBN7.2X134,555,500 - 134,614,928 (+)NCBI
Rnor_6.0X159,112,516 - 159,172,526 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257675   ⟹   XP_006257737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,645,380 - 139,652,288 (+)NCBI
mRatBN7.2X134,608,022 - 134,614,928 (+)NCBI
Rnor_6.0X159,165,080 - 159,172,526 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257676   ⟹   XP_006257738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X139,592,795 - 139,652,288 (+)NCBI
mRatBN7.2X134,555,436 - 134,614,928 (+)NCBI
Rnor_6.0X159,112,516 - 159,172,526 (+)NCBI
Rnor_5.0X153,743,208 - 153,803,160 (+)NCBI
Sequence:
RefSeq Acc Id: NP_663702   ⟸   NM_145669
- Peptide Label: isoform 2
- UniProtKB: Q8K3G3 (UniProtKB/TrEMBL),   F8WFH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029098   ⟸   NM_001033926
- Peptide Label: isoform 1
- UniProtKB: Q6P792 (UniProtKB/TrEMBL),   A0A8I6A745 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258128   ⟸   NM_001271199
- Peptide Label: isoform 3
- UniProtKB: Q9WUH4 (UniProtKB/Swiss-Prot),   A6KSP3 (UniProtKB/TrEMBL),   A0A8I6A745 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258129   ⟸   NM_001271200
- Peptide Label: isoform 3
- UniProtKB: Q9WUH4 (UniProtKB/Swiss-Prot),   A6KSP3 (UniProtKB/TrEMBL),   A0A8I6A745 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258130   ⟸   NM_001271201
- Peptide Label: isoform 4
- UniProtKB: A6KSP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257738   ⟸   XM_006257676
- Peptide Label: isoform X2
- UniProtKB: A6KSP6 (UniProtKB/TrEMBL),   A0A8L2R9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257736   ⟸   XM_006257674
- Peptide Label: isoform X2
- UniProtKB: A6KSP6 (UniProtKB/TrEMBL),   A0A8L2R9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257734   ⟸   XM_006257672
- Peptide Label: isoform X2
- UniProtKB: A6KSP6 (UniProtKB/TrEMBL),   A0A8L2R9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257735   ⟸   XM_006257673
- Peptide Label: isoform X2
- UniProtKB: A6KSP6 (UniProtKB/TrEMBL),   A0A8L2R9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257733   ⟸   XM_006257671
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K338 (UniProtKB/TrEMBL),   A0A8L2R9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257737   ⟸   XM_006257675
- Peptide Label: isoform X2
- UniProtKB: A6KSP6 (UniProtKB/TrEMBL),   A0A8L2R9G0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049677   ⟸   ENSRNOT00000043820
Ensembl Acc Id: ENSRNOP00000074052   ⟸   ENSRNOT00000084594
Ensembl Acc Id: ENSRNOP00000074817   ⟸   ENSRNOT00000087274
Ensembl Acc Id: ENSRNOP00000072490   ⟸   ENSRNOT00000083502
Ensembl Acc Id: ENSRNOP00000001169   ⟸   ENSRNOT00000001169
Ensembl Acc Id: ENSRNOP00000088085   ⟸   ENSRNOT00000110431
Ensembl Acc Id: ENSRNOP00000110147   ⟸   ENSRNOT00000141257
Ensembl Acc Id: ENSRNOP00000100750   ⟸   ENSRNOT00000170371
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUH4-F1-model_v2 AlphaFold Q9WUH4 1-280 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702068
Promoter ID:EPDNEW_R12592
Type:initiation region
Name:Fhl1_2
Description:four and a half LIM domains 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12594  EPDNEW_R12593  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X159,112,812 - 159,112,872EPDNEW
RGD ID:13702076
Promoter ID:EPDNEW_R12593
Type:multiple initiation site
Name:Fhl1_1
Description:four and a half LIM domains 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12592  EPDNEW_R12594  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X159,158,220 - 159,158,280EPDNEW
RGD ID:13702070
Promoter ID:EPDNEW_R12594
Type:multiple initiation site
Name:Fhl1_3
Description:four and a half LIM domains 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12592  EPDNEW_R12593  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X159,165,184 - 159,165,244EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2615 AgrOrtholog
BioCyc Gene G2FUF-917 BioCyc
Ensembl Genes ENSRNOG00000000875 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001169 ENTREZGENE
  ENSRNOT00000043820 ENTREZGENE
  ENSRNOT00000083502 ENTREZGENE
  ENSRNOT00000084594 ENTREZGENE
  ENSRNOT00000084594.2 UniProtKB/Swiss-Prot
  ENSRNOT00000087274 ENTREZGENE
  ENSRNOT00000110431 ENTREZGENE
  ENSRNOT00000170371 ENTREZGENE
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623247 IMAGE-MGC_LOAD
InterPro Fhl1 UniProtKB/Swiss-Prot
  LIM_FHL1/2/3/5_N UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report rno:25177 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72291 IMAGE-MGC_LOAD
NCBI Gene 25177 ENTREZGENE
PANTHER FOUR AND A HALF LIM DOMAINS PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR47029 UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
  LIM_FHL2-3_N UniProtKB/Swiss-Prot
PhenoGen Fhl1 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000875 RatGTEx
SMART LIM UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
UniProt A0A0G2K338 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A745 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R9G0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L7K4_RAT UniProtKB/TrEMBL
  A0ABK0M1V0_RAT UniProtKB/TrEMBL
  A6KSP3 ENTREZGENE, UniProtKB/TrEMBL
  A6KSP6 ENTREZGENE, UniProtKB/TrEMBL
  A6KSP7 ENTREZGENE, UniProtKB/TrEMBL
  F7F3F1_RAT UniProtKB/TrEMBL
  F8WFH4 ENTREZGENE, UniProtKB/TrEMBL
  FHL1_RAT UniProtKB/Swiss-Prot
  Q6P792 ENTREZGENE, UniProtKB/TrEMBL
  Q8K3G3 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUH4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Fhl1  four and a half LIM domains 1    Four and a half LIM domains 1 (skeletal muscle LIM-protein 1)  Name updated 625702 APPROVED
2002-06-10 Fhl1  Four and a half LIM domains 1 (skeletal muscle LIM-protein 1)      Symbol and Name status set to approved 70586 APPROVED