Ctrb1 (chymotrypsinogen B1) - Rat Genome Database

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Gene: Ctrb1 (chymotrypsinogen B1) Rattus norvegicus
Analyze
Symbol: Ctrb1
Name: chymotrypsinogen B1
RGD ID: 2444
Description: Enables serine-type endopeptidase activity. Involved in several processes, including positive regulation of apoptotic process; response to food; and response to peptide hormone. Predicted to be located in extracellular region. Biomarker of pancreatitis. Orthologous to human CTRB1 (chymotrypsinogen B1) and CTRB2 (chymotrypsinogen B2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Chymotrypsin B; chymotrypsin B1; chymotrypsinogen B; Ctrb
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau8
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,562,220 - 56,566,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,562,220 - 56,566,978 (-)EnsemblGRCr8
mRatBN7.21939,652,931 - 39,657,689 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,652,933 - 39,657,688 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,452,364 - 46,457,060 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01947,105,694 - 47,110,390 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,409,869 - 49,414,515 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,906,344 - 43,911,020 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,906,292 - 43,911,057 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,714,015 - 54,718,691 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,611,382 - 41,616,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1939,014,471 - 39,018,472 (-)NCBICelera
RGSC_v3.11941,616,262 - 41,620,939 (-)NCBI
RH 3.4 Map19492.9RGD
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
pancreatitis  (IEP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Isolation and sequence of a rat chymotrypsin B gene. Bell GI, etal., J Biol Chem 1984 Nov 25;259(22):14265-70.
2. Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin. Bodi A, etal., Eur J Biochem. 2001 Dec;268(23):6238-46.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Regulation of proteolytic enzyme activities and mRNA concentrations in rat pancreas by food content. Giorgi D, etal., Biochem Biophys Res Commun. 1985 Mar 29;127(3):937-42.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Pancreatic gene expression is altered during acute experimental pancreatitis in the rat. Iovanna JL, etal., Am J Physiol. 1991 Sep;261(3 Pt 1):G485-9.
7. Changes in pancreatic trophism and gene expression during a prolonged fasting period in rats. Iovanna JL, etal., Int J Pancreatol. 1991 Feb;8(2):177-86.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Pseudomonas aeruginosa cytotoxin stimulates secretion of amylase and protease zymogens with a concomitant decrease of mRNA levels in isolated rat pancreatic acini. Lau PP, etal., Biochem Biophys Res Commun. 1988 Apr 29;152(2):688-94.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway. Miao Q, etal., J Biol Chem. 2008 Mar 28;283(13):8218-28. Epub 2008 Jan 22.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Procarboxypeptidase in rat pancreas. Overall characterization and comparison of the activation processes. Oppezzo O, etal., Eur J Biochem. 1994 May 15;222(1):55-63.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Pancreatic digestive enzyme gene expression: effects of CCK and soybean trypsin inhibitor. Rosewicz S, etal., Am J Physiol. 1989 Apr;256(4 Pt 1):G733-8.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Attempts to convert chymotrypsin to trypsin. Venekei I, etal., FEBS Lett. 1996 Jan 29;379(2):143-7.
Additional References at PubMed
PMID:1820020  


Genomics

Comparative Map Data
Ctrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,562,220 - 56,566,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1956,562,220 - 56,566,978 (-)EnsemblGRCr8
mRatBN7.21939,652,931 - 39,657,689 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,652,933 - 39,657,688 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1946,452,364 - 46,457,060 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01947,105,694 - 47,110,390 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,409,869 - 49,414,515 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,906,344 - 43,911,020 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,906,292 - 43,911,057 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,714,015 - 54,718,691 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41941,611,382 - 41,616,058 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1939,014,471 - 39,018,472 (-)NCBICelera
RGSC_v3.11941,616,262 - 41,620,939 (-)NCBI
RH 3.4 Map19492.9RGD
Cytogenetic Map19q12NCBI
CTRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381675,204,103 - 75,207,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1675,204,103 - 75,207,161 (-)Ensemblhg38GRCh38
GRCh371675,238,001 - 75,241,059 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,795,495 - 73,798,573 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1659,531,248 - 59,537,102 (-)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1660,988,698 - 60,994,552 (-)NCBIHuRef
CHM1_11676,650,109 - 76,653,201 (-)NCBICHM1_1
T2T-CHM13v2.01681,250,834 - 81,253,906 (-)NCBIT2T-CHM13v2.0
Ctrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,413,142 - 112,417,642 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8112,413,151 - 112,417,642 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388111,686,510 - 111,691,010 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,686,519 - 111,691,010 (-)Ensemblmm10GRCm38
MGSCv378114,210,410 - 114,214,910 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368114,573,194 - 114,577,683 (-)NCBIMGSCv36mm8
Celera8115,914,394 - 115,918,860 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.98NCBI
LOC479649
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1575,504,232 - 75,507,650 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha575,481,049 - 75,484,466 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0575,861,031 - 75,864,450 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl575,861,031 - 75,864,450 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1575,753,262 - 75,756,675 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0575,588,381 - 75,591,799 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,079,524 - 76,082,941 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CTRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1612,420,976 - 12,426,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,256,439 - 12,268,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,685,302 - 60,691,548 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604715,369,684 - 15,375,225 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ctrb1
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000026017
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
D19Wox7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01954,715,401 - 54,715,514NCBIRnor5.0
RGSC_v3.41941,612,769 - 41,612,881RGDRGSC3.4
RGSC_v3.11941,617,650 - 41,617,762RGD
RH 2.0 Map19548.0RGD


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 10 60 113 62 64 38 67 38 1 257 148 7 103 51 81 26 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000026017   ⟹   ENSRNOP00000026017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1956,562,220 - 56,566,978 (-)Ensembl
mRatBN7.2 Ensembl1939,652,935 - 39,657,688 (-)Ensembl
Rnor_6.0 Ensembl1943,906,292 - 43,911,057 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115260   ⟹   ENSRNOP00000094061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1956,562,220 - 56,565,174 (-)Ensembl
mRatBN7.2 Ensembl1939,652,933 - 39,655,500 (-)Ensembl
RefSeq Acc Id: NM_012536   ⟹   NP_036668
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,562,220 - 56,566,978 (-)NCBI
mRatBN7.21939,652,931 - 39,657,689 (-)NCBI
Rnor_6.01943,906,344 - 43,911,020 (-)NCBI
Rnor_5.01954,714,015 - 54,718,691 (-)NCBI
RGSC_v3.41941,611,382 - 41,616,058 (-)RGD
Celera1939,014,471 - 39,018,472 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097467   ⟹   XP_038953395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,562,220 - 56,565,603 (-)NCBI
mRatBN7.21939,652,931 - 39,656,241 (-)NCBI
Protein Sequences
Protein RefSeqs NP_036668 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953395 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98732 (Get FASTA)   NCBI Sequence Viewer  
  EDL92581 (Get FASTA)   NCBI Sequence Viewer  
  EDL92582 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026017
GenBank Protein P07338 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036668   ⟸   NM_012536
- Peptide Label: precursor
- UniProtKB: P07338 (UniProtKB/Swiss-Prot),   F1MA56 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026017   ⟸   ENSRNOT00000026017
RefSeq Acc Id: XP_038953395   ⟸   XM_039097467
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000094061   ⟸   ENSRNOT00000115260
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07338-F1-model_v2 AlphaFold P07338 1-263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6849844
Promoter ID:EP16053
Type:single initiation site
Name:RN_CTRB
Description:Chymotrypsin B, CTRB1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:exocrine pancreas
Experiment Methods:RNA sequencing by primer extension
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41941,616,080 - 41,616,140EPD
RGD ID:13701151
Promoter ID:EPDNEW_R11675
Type:multiple initiation site
Name:Ctrb1_1
Description:chymotrypsinogen B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,911,042 - 43,911,102EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2444 AgrOrtholog
BioCyc Gene G2FUF-5643 BioCyc
Ensembl Genes ENSRNOG00000019068 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026017 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:24291 UniProtKB/Swiss-Prot
NCBI Gene 24291 ENTREZGENE
PANTHER CHYMOTRYPSIN-RELATED UniProtKB/Swiss-Prot
  CHYMOTRYPSINOGEN B UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Ctrb1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019068 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
TIGR TC229312
UniProt A0A8I6AKT9_RAT UniProtKB/TrEMBL
  CTRB1_RAT UniProtKB/Swiss-Prot
  F1MA56 ENTREZGENE, UniProtKB/TrEMBL
  P07338 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Ctrb1  chymotrypsinogen B1  Ctrb  Chymotrypsinogen B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Ctrb  Chymotrypsinogen B  LOC687247  similar to Chymotrypsinogen B precursor  Data merged from RGD:1587731 1643240 APPROVED
2006-11-19 LOC687247  similar to Chymotrypsinogen B precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Ctrb  Chymotrypsinogen B    chymotrypsinogen B  Symbol and Name updated 629477 APPROVED
2003-03-06 Ctrb  Chymotrypsinogen B  Ctrb1  chymotrypsinogen B1  Data merged from RGD:67393 628472 PROVISIONAL
2002-06-10 Ctrb  Chymotrypsin B      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Ctrb1  chymotrypsinogen B1      Symbol and Name status set to approved 70586 APPROVED
2001-10-22 Ctrb1  chymotrypsinogen B      Name updated 68916 RESERVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pancreas 1298832
gene_function predicted to cleave peptide bonds 1298832