Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase) - Rat Genome Database

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Gene: Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase) Rattus norvegicus
Analyze
Symbol: Cnp
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
RGD ID: 2368
Description: Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity and cyclic nucleotide binding activity. Involved in forebrain development; regulation of mitochondrial membrane permeability; and response to lipopolysaccharide. Located in several cellular components, including mitochondrial membrane; myelin sheath abaxonal region; and myelin sheath adaxonal region. Used to study carotid stenosis. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2',3'-cyclic-nucleotide 3'-phosphodiesterase; 2'3'- Cyclic nucleotide 3'-phosphodiesterase; 2,3- Cyclic nucleotide 3-phosphodiesterase; 23- cyclic nucleotide 3-phosphodiesterase; Cnp1; CNPase; CNPF; CNPI; CNPII; cyclic nucleotide phosphodiesterase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,011,504 - 86,018,063 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,011,495 - 86,018,063 (+)EnsemblGRCr8
mRatBN7.21085,511,164 - 85,517,723 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,511,160 - 85,517,720 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,548,000 - 90,554,559 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,026,520 - 90,033,080 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,419,429 - 85,425,988 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,490,798 - 88,497,357 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,490,798 - 88,497,356 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,284,045 - 88,290,604 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,519,421 - 89,525,978 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,227,529 - 84,234,088 (+)NCBICelera
RGSC_v3.11089,533,790 - 89,540,348 (+)NCBI
RH 3.4 Map10859.8RGD
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
atrazine  (EXP)
beauvericin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
corticotropin  (EXP)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyldithiocarbamic acid  (EXP)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
haloperidol  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phencyclidine  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
SR 144528  (ISO)
sunitinib  (ISO)
Temsirolimus  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ca2+-dependent permeability transition regulation in rat brain mitochondria by 2',3'-cyclic nucleotides and 2',3'-cyclic nucleotide 3'-phosphodiesterase. Azarashvili T, etal., Am J Physiol Cell Physiol. 2009 Jun;296(6):C1428-39. Epub 2009 Apr 8.
2. 2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin. Bifulco M, etal., Proc Natl Acad Sci U S A 2002 Feb 19;99(4):1807-12. Epub 2002 Feb 12.
3. Age-related changes of the oligodendrocytes in rat subcortical white matter. Chen L, etal., Anat Rec (Hoboken). 2011 Mar;294(3):487-93. doi: 10.1002/ar.21332. Epub 2011 Jan 31.
4. Allopregnanolone promotes regeneration and reduces beta-amyloid burden in a preclinical model of Alzheimer's disease. Chen S, etal., PLoS One. 2011;6(8):e24293. Epub 2011 Aug 30.
5. Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome. Connor JR, etal., Sleep Med. 2011 Jun;12(6):614-9. Epub 2011 May 12.
6. Passive transfer of experimental autoimmune encephalomyelitis in Wistar rats: dissociation of clinical symptoms and biochemical alterations. Degano AL and Roth GA, J Neurosci Res. 2000 Jan 15;59(2):283-90.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Georgieva L, etal., Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12469-74. Epub 2006 Aug 4.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. A myelin gene causative of a catatonia-depression syndrome upon aging. Hagemeyer N, etal., EMBO Mol Med. 2012 Apr 4. doi: 10.1002/emmm.201200230.
11. Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxic-ischemic brain injury. Huang Z, etal., Brain Res. 2009 Dec 8;1301:100-9. Epub 2009 Sep 10.
12. Abundant extracellular myelin in the meninges of patients with multiple sclerosis. Kooi EJ, etal., Neuropathol Appl Neurobiol. 2009 Jun;35(3):283-95. Epub 2008 Sep 17.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Concurrent administration of cilostazol with donepezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoperfusion in rats. Lee JH, etal., Brain Res. 2007 Dec 14;1185:246-55. Epub 2007 Sep 20.
15. Expression of MBP, PLP, MAG, CNP, and GFAP in the Human Alcoholic Brain. Lewohl JM, etal., Alcohol Clin Exp Res. 2005 Sep;29(9):1698-705.
16. Induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of BALB/c mice caused by Angiostrongylus cantonensis. Lin KY and Lai SC, J Comp Pathol. 2009 Nov;141(4):248-53. Epub 2009 Jul 9.
17. Transketolase and 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I isoforms are specifically recognized by IgG autoantibodies in multiple sclerosis patients. Lovato L, etal., Mol Cell Proteomics. 2008 Dec;7(12):2337-49. Epub 2008 Jul 31.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Peirce TR, etal., Arch Gen Psychiatry. 2006 Jan;63(1):18-24.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Postnatal inflammatory rat model for cerebral palsy: too different from humans. Roberson R, etal., Am J Obstet Gynecol. 2006 Oct;195(4):1038-44.
25. Upregulation of CSPG3 accompanies neuronal progenitor proliferation and migration in EAE. Sajad M, etal., J Mol Neurosci. 2011 Mar;43(3):531-40. Epub 2010 Nov 25.
26. Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure. Svetlov SI, etal., J Trauma. 2010 Oct;69(4):795-804.
27. Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population. Tang F, etal., Neurosci Lett. 2007 Apr 12;416(2):113-6. Epub 2007 Jan 30.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Limited remyelination in Theiler's murine encephalomyelitis due to insufficient oligodendroglial differentiation of nerve/glial antigen 2 (NG2)-positive putative oligodendroglial progenitor cells. Ulrich R, etal., Neuropathol Appl Neurobiol. 2008 Dec;34(6):603-20. Epub 2008 May 5.
30. Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the amoeboid microglial cells in the developing rat brain. Wu CY, etal., Neuroscience. 2006 Oct 13;142(2):333-41. Epub 2006 Jul 28.
31. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
32. Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Yao DL, etal., Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6190-4.
33. Juxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking. Zhang B, etal., Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11527-32. Epub 2005 Jul 28.
Additional References at PubMed
PMID:3040924   PMID:7932861   PMID:11885989   PMID:12379507   PMID:12477932   PMID:12590258   PMID:12898532   PMID:12947117   PMID:14503857   PMID:14749525   PMID:15535987   PMID:16103231  
PMID:16786579   PMID:17634366   PMID:18094118   PMID:19021295   PMID:19056867   PMID:19139271   PMID:19199708   PMID:19292454   PMID:19946888   PMID:20131911   PMID:20233944   PMID:20578039  
PMID:21525035   PMID:22068741   PMID:22313968   PMID:22871113   PMID:22926577   PMID:23376485   PMID:23533145   PMID:24101522   PMID:24808540   PMID:25277077   PMID:25931508   PMID:25936639  
PMID:28251676   PMID:29350434   PMID:29476059   PMID:30405014   PMID:31885393   PMID:32357304   PMID:34330062  


Genomics

Comparative Map Data
Cnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,011,504 - 86,018,063 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,011,495 - 86,018,063 (+)EnsemblGRCr8
mRatBN7.21085,511,164 - 85,517,723 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,511,160 - 85,517,720 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,548,000 - 90,554,559 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,026,520 - 90,033,080 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,419,429 - 85,425,988 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,490,798 - 88,497,357 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,490,798 - 88,497,356 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,284,045 - 88,290,604 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,519,421 - 89,525,978 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,227,529 - 84,234,088 (+)NCBICelera
RGSC_v3.11089,533,790 - 89,540,348 (+)NCBI
RH 3.4 Map10859.8RGD
Cytogenetic Map10q31NCBI
CNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,966,795 - 41,977,740 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,966,763 - 41,977,740 (+)Ensemblhg38GRCh38
GRCh371740,118,813 - 40,129,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,372,285 - 37,383,280 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341737,372,284 - 37,383,280NCBI
Celera1736,773,458 - 36,784,455 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,884,123 - 35,895,118 (+)NCBIHuRef
CHM1_11740,354,523 - 40,365,518 (+)NCBICHM1_1
T2T-CHM13v2.01742,823,292 - 42,834,237 (+)NCBIT2T-CHM13v2.0
Cnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,465,765 - 100,472,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,465,730 - 100,482,555 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811100,574,909 - 100,591,875 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,574,904 - 100,591,729 (+)Ensemblmm10GRCm38
MGSCv3711100,436,253 - 100,443,053 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611100,391,065 - 100,397,815 (+)NCBIMGSCv36mm8
Celera11111,195,104 - 111,201,904 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Cnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,114,454 - 16,118,622 (+)Ensembl
ChiLan1.0NW_00495545116,115,137 - 16,119,261 (+)NCBIChiLan1.0ChiLan1.0
CNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,008,706 - 23,017,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,898,864 - 24,907,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,338,085 - 15,349,089 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,560,056 - 15,569,108 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,560,056 - 15,568,916 (-)EnsemblpanPan2panpan1.1
CNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,888,350 - 20,896,139 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,886,574 - 20,896,079 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha920,349,053 - 20,356,835 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0921,606,902 - 21,614,689 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,594,095 - 21,614,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,392,407 - 20,400,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,659,216 - 20,666,990 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,762,355 - 20,770,140 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,233,405 - 20,240,592 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,834,540 - 16,841,810 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,834,570 - 16,841,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,758,083 - 20,765,553 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11220,758,081 - 20,765,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,048,293 - 21,055,830 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,288,583 - 64,296,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,289,828 - 64,296,922 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607735,106,165 - 35,114,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,855,992 - 1,861,053 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247951,856,455 - 1,861,142 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cnp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1959,876,598 - 59,883,302 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cnp
33 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:423
Count of miRNA genes:220
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000023872
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH129321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,517,570 - 85,517,722 (+)MAPPERmRatBN7.2
Rnor_6.01088,497,205 - 88,497,356NCBIRnor6.0
Rnor_5.01088,290,452 - 88,290,603UniSTSRnor5.0
RGSC_v3.41089,525,826 - 89,525,977UniSTSRGSC3.4
Celera1084,233,936 - 84,234,087UniSTS
RH 3.4 Map10859.5UniSTS
Cytogenetic Map10q32.1UniSTS
RH127905  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,517,409 - 85,517,627 (+)MAPPERmRatBN7.2
Rnor_6.01088,497,044 - 88,497,261NCBIRnor6.0
Rnor_5.01088,290,291 - 88,290,508UniSTSRnor5.0
RGSC_v3.41089,525,665 - 89,525,882UniSTSRGSC3.4
Celera1084,233,775 - 84,233,992UniSTS
Cytogenetic Map10q32.1UniSTS
RH94388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,517,527 - 85,517,693 (+)MAPPERmRatBN7.2
Rnor_6.01088,497,162 - 88,497,327NCBIRnor6.0
Rnor_5.01088,290,409 - 88,290,574UniSTSRnor5.0
RGSC_v3.41089,525,783 - 89,525,948UniSTSRGSC3.4
Celera1084,233,893 - 84,234,058UniSTS
RH 3.4 Map10859.8UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023872   ⟹   ENSRNOP00000023875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,012,449 - 86,018,063 (+)Ensembl
mRatBN7.2 Ensembl1085,511,160 - 85,517,720 (+)Ensembl
Rnor_6.0 Ensembl1088,490,798 - 88,497,356 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103289   ⟹   ENSRNOP00000080276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,011,495 - 86,018,062 (+)Ensembl
mRatBN7.2 Ensembl1085,511,160 - 85,517,717 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111402   ⟹   ENSRNOP00000077498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,512,109 - 85,517,717 (+)Ensembl
RefSeq Acc Id: NM_012809   ⟹   NP_036941
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,011,504 - 86,018,063 (+)NCBI
mRatBN7.21085,511,164 - 85,517,723 (+)NCBI
Rnor_6.01088,490,798 - 88,497,357 (+)NCBI
Rnor_5.01088,284,045 - 88,290,604 (+)NCBI
RGSC_v3.41089,519,421 - 89,525,978 (+)RGD
Celera1084,227,529 - 84,234,088 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036941   ⟸   NM_012809
- UniProtKB: Q4V796 (UniProtKB/Swiss-Prot),   Q64575 (UniProtKB/Swiss-Prot),   P13233 (UniProtKB/Swiss-Prot),   A6HJ42 (UniProtKB/TrEMBL),   A0A8I5Y1M7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023875   ⟸   ENSRNOT00000023872
Ensembl Acc Id: ENSRNOP00000077498   ⟸   ENSRNOT00000111402
Ensembl Acc Id: ENSRNOP00000080276   ⟸   ENSRNOT00000103289
Protein Domains
Cyclic nucleotide phosphodiesterase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13233-F1-model_v2 AlphaFold P13233 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697725
Promoter ID:EPDNEW_R8250
Type:initiation region
Name:Cnp_1
Description:2',3'-cyclic nucleotide 3' phosphodiesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,490,789 - 88,490,849EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2368 AgrOrtholog
BioCyc Gene G2FUF-23229 BioCyc
Ensembl Genes ENSRNOG00000017496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000103289 ENTREZGENE
  ENSRNOT00000103289.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7458826 IMAGE-MGC_LOAD
InterPro CNPase UniProtKB/Swiss-Prot
  CNPase_cat UniProtKB/Swiss-Prot
  cNuc_Pdiesterase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:25275 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116229 IMAGE-MGC_LOAD
NCBI Gene 25275 ENTREZGENE
PANTHER 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE UniProtKB/Swiss-Prot
  PTHR10156 UniProtKB/Swiss-Prot
Pfam AAA_33 UniProtKB/Swiss-Prot
  CNPase UniProtKB/Swiss-Prot
PhenoGen Cnp PhenoGen
PIRSF CNPase UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017496 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF55144 UniProtKB/Swiss-Prot
TIGR TC204961
UniProt A0A097BVJ5_RAT UniProtKB/TrEMBL
  A0A8I5Y1M7 ENTREZGENE
  A0A8L2QCQ2_RAT UniProtKB/TrEMBL
  A6HJ42 ENTREZGENE, UniProtKB/TrEMBL
  CN37_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V796 ENTREZGENE
  Q64575 ENTREZGENE
UniProt Secondary Q4V796 UniProtKB/Swiss-Prot
  Q64575 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Cnp1  cyclic nucleotide phosphodiesterase 1  Cnp  2,3- Cyclic nucleotide 3-phosphodiesterase  Symbol and Name updated 625702 APPROVED
2002-06-10 Cnp  2,3- Cyclic nucleotide 3-phosphodiesterase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization membrane-bound microtubule-associated protein 1298767
gene_expression expressed in brain and FRTL-5 thyroid cells 1298767
gene_process promotes microtubule assembly at low mole ratios 1298767
gene_process may regulate cellular distribution of microtubules 1298767
gene_process C-terminus essential for microtubule assembly function 1298767
gene_regulation phosphorylation of protein interferes with microtubule assemby function 1298767
gene_transcript may be alternatively spliced to produce different products in nervous and lymphoid tissues 1298766