RGD Reference Report - Upregulation of CSPG3 accompanies neuronal progenitor proliferation and migration in EAE. - Rat Genome Database

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Upregulation of CSPG3 accompanies neuronal progenitor proliferation and migration in EAE.

Authors: Sajad, M  Zargan, J  Chawla, R  Umar, S  Khan, HA 
Citation: Sajad M, etal., J Mol Neurosci. 2011 Mar;43(3):531-40. Epub 2010 Nov 25.
RGD ID: 6483335
Pubmed: PMID:21107918   (View Abstract at PubMed)
DOI: DOI:10.1007/s12031-010-9476-0   (Journal Full-text)

The molecular identities of signals that regulate the CNS lesion remodeling remain unclear. Herein, we report for the first time that extracellular matrix chondroitin sulphate proteoglycan, CSPG3 (neurocan) is upregulated after primary inflammatory injury. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) (35-55) which was characterized by massive polymorphonuclear cell infiltration and loss of myelin basic protein expression along with steep decrease of CNPase. Periventricular white matter (PVWM) and cortex presented with astrogliosis evidenced by increased Glial fibrillary acidic protein (GFAP) immunoreactivity 20 days post immunization (p.i). Neuronal progenitor cell (NPC) proliferation increased after first acute episode in the subventricular zone (SVZ), corpus callosum, and cortex, indicating migration of cells to structures other than rostral migration stream and olfactory bulb, which is indicative of cell recruitment for repair process and was confirmed by presence of thin myelin sheaths in the shadow plaques. Earlier CSPG3 has been demonstrated to impede regeneration. We observed neuroinflammation-induced up-regulation of the CSPG3 expression in two most affected regions viz. PVWM and cortex after proliferation and migration of NPCs. Our results show possible role of reactive astrogliosis in lesion remodeling and redefine the relation between inflammation and endogenous cellular repair which can aid in designing of newer therapeutic strategies.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Encephalomyelitis  ISOCnp (Rattus norvegicus)6483335; 6483335 RGD 
Experimental Autoimmune Encephalomyelitis  IDA 6483335 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cnp  (2',3'-cyclic nucleotide 3' phosphodiesterase)

Genes (Mus musculus)
Cnp  (2',3'-cyclic nucleotide 3' phosphodiesterase)

Genes (Homo sapiens)
CNP  (2',3'-cyclic nucleotide 3' phosphodiesterase)


Additional Information