Btbd6 (BTB domain containing 6) - Rat Genome Database

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Gene: Btbd6 (BTB domain containing 6) Rattus norvegicus
Analyze
Symbol: Btbd6
Name: BTB domain containing 6
RGD ID: 1597323
Description: Predicted to be involved in neurogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human BTBD6 (BTB domain containing 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BTB (POZ) domain containing 6; BTB/POZ domain-containing protein 6; MGC156832; similar to BTB/POZ domain containing protein 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,879,202 - 137,881,662 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,879,162 - 137,881,652 (+)EnsemblGRCr8
mRatBN7.26132,058,094 - 132,060,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,058,096 - 132,060,587 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6132,227,690 - 132,230,150 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,517,505 - 132,519,965 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,892,617 - 131,895,077 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,785,662 - 137,788,442 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,785,982 - 137,788,434 (+)Ensemblrn6Rnor6.0
Rnor_5.06146,782,104 - 146,784,624 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,983,974 - 137,986,434 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,596,008 - 129,598,468 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
neurogenesis  (IBA)

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15326124  


Genomics

Comparative Map Data
Btbd6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,879,202 - 137,881,662 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,879,162 - 137,881,652 (+)EnsemblGRCr8
mRatBN7.26132,058,094 - 132,060,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,058,096 - 132,060,587 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6132,227,690 - 132,230,150 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,517,505 - 132,519,965 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,892,617 - 131,895,077 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,785,662 - 137,788,442 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,785,982 - 137,788,434 (+)Ensemblrn6Rnor6.0
Rnor_5.06146,782,104 - 146,784,624 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,983,974 - 137,986,434 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,596,008 - 129,598,468 (+)NCBICelera
Cytogenetic Map6q32NCBI
BTBD6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,248,533 - 105,251,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,248,533 - 105,251,110 (+)Ensemblhg38GRCh38
GRCh3714105,714,870 - 105,717,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,786,053 - 104,788,474 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3414104,786,052 - 104,788,475NCBI
Celera1485,764,120 - 85,766,668 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,905,116 - 85,914,632 (+)NCBIHuRef
CHM1_114105,644,856 - 105,647,407 (+)NCBICHM1_1
T2T-CHM13v2.01499,495,394 - 99,497,954 (+)NCBIT2T-CHM13v2.0
Btbd6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,937,880 - 112,943,113 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,940,102 - 112,942,565 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812112,974,260 - 112,979,493 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,976,482 - 112,978,945 (+)Ensemblmm10GRCm38
MGSCv3712114,214,693 - 114,217,151 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612113,424,371 - 113,426,748 (+)NCBIMGSCv36mm8
Celera12114,186,511 - 114,188,971 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.5NCBI
Btbd6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,494,946 - 3,500,783 (+)Ensembl
ChiLan1.0NW_0049555383,494,950 - 3,496,888 (+)NCBIChiLan1.0ChiLan1.0
BTBD6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,420,635 - 106,423,180 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,637,137 - 105,639,682 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,883,988 - 85,886,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,665,258 - 105,667,031 (+)NCBIPanPan1.1PanPan1.1panPan2
BTBD6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,605,715 - 72,607,189 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,605,516 - 72,607,023 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha872,116,307 - 72,118,424 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0872,892,008 - 72,894,130 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,891,341 - 72,893,965 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,572,640 - 72,574,760 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,623,608 - 72,625,718 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0873,013,585 - 73,015,722 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Btbd6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,467,750 - 1,475,220 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621300,503 - 304,183 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936621301,879 - 304,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTBD6
(Sus scrofa - pig)		 No map positions available.
BTBD6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,147,794 - 83,150,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605370,592,041 - 70,594,592 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btbd6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734255,564 - 257,375 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624734255,182 - 257,494 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Btbd6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17130,581,393 - 130,584,059 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Btbd6
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:137
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000019768
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
AI072236  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86137,880,939 - 137,881,132 (+)Marker Load Pipeline
mRatBN7.26132,059,867 - 132,060,060 (+)MAPPERmRatBN7.2
Rnor_6.06137,787,720 - 137,787,912NCBIRnor6.0
Rnor_5.06146,783,902 - 146,784,094UniSTSRnor5.0
RGSC_v3.46137,985,712 - 137,985,904UniSTSRGSC3.4
Celera6129,597,746 - 129,597,938UniSTS
RH 3.4 Map6783.1UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019768   ⟹   ENSRNOP00000019768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,879,202 - 137,881,652 (+)Ensembl
mRatBN7.2 Ensembl6132,058,130 - 132,060,580 (+)Ensembl
Rnor_6.0 Ensembl6137,785,982 - 137,788,434 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110669   ⟹   ENSRNOP00000083242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,879,162 - 137,879,999 (+)Ensembl
mRatBN7.2 Ensembl6132,058,096 - 132,060,587 (+)Ensembl
RefSeq Acc Id: NM_001077683   ⟹   NP_001071151
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,879,202 - 137,881,662 (+)NCBI
mRatBN7.26132,058,130 - 132,060,590 (+)NCBI
Rnor_6.06137,785,982 - 137,788,442 (+)NCBI
Rnor_5.06146,782,104 - 146,784,624 (+)NCBI
RGSC_v3.46137,983,974 - 137,986,434 (+)RGD
Celera6129,596,008 - 129,598,468 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001071151 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27549 (Get FASTA)   NCBI Sequence Viewer  
  EDL97409 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019768
  ENSRNOP00000019768.5
  ENSRNOP00000083242.2
RefSeq Acc Id: NP_001071151   ⟸   NM_001077683
- UniProtKB: F1M7U0 (UniProtKB/TrEMBL),   A0A8I5ZW64 (UniProtKB/TrEMBL),   A6KBX4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019768   ⟸   ENSRNOT00000019768
Ensembl Acc Id: ENSRNOP00000083242   ⟸   ENSRNOT00000110669
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7U0-F1-model_v2 AlphaFold F1M7U0 1-539 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694859
Promoter ID:EPDNEW_R5382
Type:multiple initiation site
Name:Btbd6_1
Description:BTB domain containing 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06137,785,953 - 137,786,013EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597323 AgrOrtholog
BioCyc Gene G2FUF-35767 BioCyc
Ensembl Genes ENSRNOG00000014693 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019768 ENTREZGENE
  ENSRNOT00000019768.7 UniProtKB/TrEMBL
  ENSRNOT00000110669.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.60.120.820 UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7365801 IMAGE-MGC_LOAD
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  BTB_POZ_BTBD6 UniProtKB/TrEMBL
  PHR UniProtKB/TrEMBL
  PHR_sf UniProtKB/TrEMBL
KEGG Report rno:690367 UniProtKB/TrEMBL
MGC_CLONE MGC:156832 IMAGE-MGC_LOAD
NCBI Gene 690367 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING UniProtKB/TrEMBL
  BTB/POZ DOMAIN-CONTAINING PROTEIN 6 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  PHR UniProtKB/TrEMBL
PhenoGen Btbd6 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014693 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
UniProt A0A8I5ZW64 ENTREZGENE, UniProtKB/TrEMBL
  A0JPR1_RAT UniProtKB/TrEMBL
  A6KBX4 ENTREZGENE, UniProtKB/TrEMBL
  F1M7U0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Btbd6  BTB domain containing 6  Btbd6  BTB (POZ) domain containing 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Btbd6  BTB (POZ) domain containing 6  MGC156832  similar to BTB/POZ domain containing protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 MGC156832  similar to BTB/POZ domain containing protein 6  LOC684566  similar to BTB/POZ domain containing protein 6  Data merged from RGD:1589119 1643240 APPROVED
2006-11-20 MGC156832  similar to BTB/POZ domain containing protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684566  similar to BTB/POZ domain containing protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL