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Gene: Ttll4 (tubulin tyrosine ligase like 4) Rattus norvegicus

Analyze

Symbol:

Ttll4

Name:

tubulin tyrosine ligase like 4

RGD ID:

1594742

Description:

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within regulation of blastocyst development. Predicted to be located in 9+0 non-motile cilium. Predicted to be active in ciliary basal body. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC690512; similar to tubulin tyrosine ligase-like family, member 4; tubulin monoglutamylase TTLL4; tubulin polyglutamylase TTLL4; tubulin tyrosine ligase-like family, member 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TTLL4 (tubulin tyrosine ligase like 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ttll4 (tubulin tyrosine ligase-like family, member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ttll4 (tubulin tyrosine ligase like 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TTLL4 (tubulin tyrosine ligase like 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TTLL4 (tubulin tyrosine ligase like 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ttll4 (tubulin tyrosine ligase like 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TTLL4 (tubulin tyrosine ligase like 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TTLL4 (tubulin tyrosine ligase like 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ttll4 (tubulin tyrosine ligase like 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ttll4 (tubulin tyrosine ligase like 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TTLL4 (tubulin tyrosine ligase like 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ttll4 (tubulin tyrosine ligase-like family, member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ttll4 (tubulin tyrosine ligase-like family, member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	TTLL4A	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ttll-4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	TTLL4B	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ttll4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ttll4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,670,788 - 83,706,891 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	83,681,025 - 83,700,404 (+)	Ensembl				GRCr8
mRatBN7.2	9	76,221,659 - 76,258,219 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	76,221,796 - 76,251,301 (+)	Ensembl				mRatBN7.2
Rnor_6.0	9	81,925,363 - 81,961,882 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,940,630 - 81,954,686 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	81,687,817 - 81,724,261 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	74,011,065 - 74,025,699 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	73,794,152 - 73,830,671 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebrotendinous xanthomatosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

formaldehyde (ISO)

gentamycin (EXP)

methamphetamine (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

rotenone (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

microtubule cytoskeleton organization (IBA)

peptidyl-glutamic acid modification (ISO)

protein polyglutamylation (ISO)

regulation of blastocyst development (ISO)

Cellular Component

9+0 non-motile cilium (IEA,ISO)

ciliary basal body (IBA,IEA,ISO)

microtubule (IEA)

Molecular Function

ATP binding (IEA)

ligase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein-glutamic acid ligase activity (IEA,ISO)

tubulin binding (IBA,IEA,ISO)

tubulin-glutamic acid ligase activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17499049	PMID:20530212	PMID:21074048	PMID:26829768	PMID:29593216

Genomics

Comparative Map Data

Ttll4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,670,788 - 83,706,891 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	83,681,025 - 83,700,404 (+)	Ensembl				GRCr8
mRatBN7.2	9	76,221,659 - 76,258,219 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	76,221,796 - 76,251,301 (+)	Ensembl				mRatBN7.2
Rnor_6.0	9	81,925,363 - 81,961,882 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,940,630 - 81,954,686 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	81,687,817 - 81,724,261 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	74,011,065 - 74,025,699 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	73,794,152 - 73,830,671 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

TTLL4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,710,835 - 218,759,724 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,710,809 - 218,755,416 (+)	Ensembl			hg38	GRCh38
GRCh37	2	219,575,558 - 219,620,139 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	219,283,887 - 219,327,652 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	219,401,147 - 219,444,913	NCBI
Celera	2	213,343,326 - 213,387,891 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	211,428,803 - 211,473,377 (+)	NCBI		HuRef
CHM1_1	2	219,582,524 - 219,627,056 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	219,197,391 - 219,244,038 (+)	NCBI		T2T-CHM13v2.0

Ttll4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	74,700,804 - 74,740,991 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	74,700,904 - 74,742,889 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	74,661,645 - 74,701,832 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	74,661,745 - 74,703,730 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	74,708,328 - 74,744,547 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	74,594,961 - 74,631,180 (+)	NCBI		MGSCv36	mm8
Celera	1	75,216,789 - 75,252,776 (+)	NCBI		Celera
Cytogenetic Map	1	C4	NCBI
cM Map	1	38.54	NCBI

Ttll4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	14,680,923 - 14,720,599 (-)	Ensembl
ChiLan1.0	NW_004955453	14,679,945 - 14,720,025 (-)	NCBI	ChiLan1.0	ChiLan1.0

TTLL4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	121,339,077 - 121,388,881 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	121,356,017 - 121,403,846 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	105,968,840 - 106,016,034 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	224,563,626 - 224,610,511 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	224,563,691 - 224,610,431 (+)	Ensembl			panPan2	panpan1.1

TTLL4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	25,303,818 - 25,341,315 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	25,273,110 - 25,340,512 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	26,123,846 - 26,160,606 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	25,319,791 - 25,356,071 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	25,319,910 - 25,356,002 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	25,224,607 - 25,260,995 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	25,158,861 - 25,195,634 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	25,179,670 - 25,216,226 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ttll4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	174,810,537 - 174,859,089 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936569	1,153,447 - 1,194,269 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936569	1,153,376 - 1,201,704 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TTLL4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	120,773,185 - 120,793,194 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	120,748,537 - 120,791,825 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	133,817,235 - 133,820,673 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TTLL4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	104,612,946 - 104,656,926 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	104,613,026 - 104,656,622 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	94,745,779 - 94,790,597 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ttll4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624823	6,310,738 - 6,352,333 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624823	6,314,177 - 6,352,236 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ttll4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	148,086,070 - 148,122,439 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ttll4
304 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	67
Count of miRNA genes:	54
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000023067
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56047863	101047863	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	82168823	86720295	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	83161999	118999486	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	54506504	99506504	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002727234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023067 ⟹ ENSRNOP00000023067

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	83,681,025 - 83,700,404 (+)	Ensembl
mRatBN7.2 Ensembl	9	76,221,796 - 76,251,301 (+)	Ensembl
Rnor_6.0 Ensembl	9	81,940,630 - 81,954,686 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105220 ⟹ ENSRNOP00000093298

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	83,681,025 - 83,700,404 (+)	Ensembl
mRatBN7.2 Ensembl	9	76,221,796 - 76,251,301 (+)	Ensembl

RefSeq Acc Id:

NM_001427082 ⟹ NP_001414011

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	83,670,788 - 83,706,891 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414011	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023067
	ENSRNOP00000023067.5
	ENSRNOP00000093298.1

Ensembl Acc Id:

ENSRNOP00000023067 ⟸ ENSRNOT00000023067

Ensembl Acc Id:

ENSRNOP00000093298 ⟸ ENSRNOT00000105220

RefSeq Acc Id:	NP_001414011 ⟸ NM_001427082
- UniProtKB:	D4A331 (UniProtKB/TrEMBL), A0A8I6AJT5 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A331-F1-model_v2	AlphaFold	D4A331	1-1193	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1594742	AgrOrtholog
BioCyc Gene	G2FUF-27120	BioCyc
Ensembl Genes	ENSRNOG00000017129	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023067	ENTREZGENE
	ENSRNOT00000023067.6	UniProtKB/TrEMBL
	ENSRNOT00000105220.2	UniProtKB/TrEMBL
Gene3D-CATH	ATP-grasp fold, B domain	UniProtKB/TrEMBL
InterPro	Tub_tyr_ligase	UniProtKB/TrEMBL
NCBI Gene	690512	ENTREZGENE
PANTHER	TUBULIN POLYGLUTAMYLASE	UniProtKB/TrEMBL
	TUBULIN POLYGLUTAMYLASE TTLL4	UniProtKB/TrEMBL
Pfam	TTL	UniProtKB/TrEMBL
PhenoGen	Ttll4	PhenoGen
PROSITE	TTL	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017129	RatGTEx
Superfamily-SCOP	Glutathione synthetase ATP-binding domain-like	UniProtKB/TrEMBL
UniProt	A0A8I6AJT5	ENTREZGENE, UniProtKB/TrEMBL
	D4A331	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Ttll4	tubulin tyrosine ligase like 4	Ttll4	tubulin tyrosine ligase-like family, member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Ttll4	tubulin tyrosine ligase-like family, member 4	LOC690512	similar to tubulin tyrosine ligase-like family, member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC690512	similar to tubulin tyrosine ligase-like family, member 4	LOC681499	similar to tubulin tyrosine ligase-like family, member 4	Data merged from RGD:1595337	1643240	APPROVED
2006-11-20	LOC690512	similar to tubulin tyrosine ligase-like family, member 4			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-20	LOC681499	similar to tubulin tyrosine ligase-like family, member 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar