Ttll4 (tubulin tyrosine ligase like 4) - Rat Genome Database

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Gene: Ttll4 (tubulin tyrosine ligase like 4) Heterocephalus glaber
Analyze
Symbol: Ttll4
Name: tubulin tyrosine ligase like 4
RGD ID: 18932980
Description: ENCODES a protein that exhibits protein-glutamic acid ligase activity (ortholog); INVOLVED IN regulation of blastocyst development (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); cerebrotendinous xanthomatosis (ortholog); myofibrillar myopathy 1 (ortholog); FOUND IN 9+0 non-motile cilium (ortholog); ciliary basal body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tubulin polyglutamylase TTLL4; tubulin tyrosine ligase-like family, member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,310,738 - 6,352,333 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,314,177 - 6,352,236 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Ttll4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,310,738 - 6,352,333 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,314,177 - 6,352,236 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TTLL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,710,835 - 218,759,724 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,710,835 - 218,755,416 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,575,558 - 219,620,139 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,283,887 - 219,327,652 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,401,147 - 219,444,913NCBI
Celera2213,343,326 - 213,387,891 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,428,803 - 211,473,377 (+)NCBIHuRef
CHM1_12219,582,524 - 219,627,056 (+)NCBICHM1_1
T2T-CHM13v2.02219,197,391 - 219,244,038 (+)NCBIT2T-CHM13v2.0
Ttll4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,700,804 - 74,740,991 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,700,904 - 74,742,889 (+)EnsemblGRCm39 Ensembl
GRCm38174,661,645 - 74,701,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,661,745 - 74,703,730 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,708,328 - 74,744,547 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,594,961 - 74,631,180 (+)NCBIMGSCv36mm8
Celera175,216,789 - 75,252,776 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
Ttll4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,670,788 - 83,706,891 (+)NCBIGRCr8
mRatBN7.2976,221,659 - 76,258,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,221,796 - 76,251,301 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0981,925,363 - 81,961,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,940,630 - 81,954,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,687,817 - 81,724,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,011,065 - 74,025,699 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera973,794,152 - 73,830,671 (+)NCBICelera
Cytogenetic Map9q33NCBI
Ttll4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545314,679,945 - 14,720,025 (-)NCBIChiLan1.0ChiLan1.0
TTLL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,339,077 - 121,388,881 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,356,017 - 121,403,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,968,840 - 106,016,034 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,563,626 - 224,610,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,563,691 - 224,610,431 (+)Ensemblpanpan1.1panPan2
TTLL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,303,818 - 25,341,315 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,273,110 - 25,340,512 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,123,846 - 26,160,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,319,791 - 25,356,071 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,319,910 - 25,356,002 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,224,607 - 25,260,995 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,158,861 - 25,195,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,179,670 - 25,216,226 (+)NCBIUU_Cfam_GSD_1.0
Ttll4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,810,537 - 174,859,089 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,153,447 - 1,194,269 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,153,376 - 1,201,704 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTLL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,773,185 - 120,793,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,748,537 - 120,791,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,817,235 - 133,820,673 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTLL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,612,946 - 104,656,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,613,026 - 104,656,622 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,745,779 - 94,790,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000022132   ⟹   ENSHGLP00000021922
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248236,310,738 - 6,352,333 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000022133   ⟹   ENSHGLP00000021923
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248236,310,738 - 6,344,627 (-)Ensembl
RefSeq Acc Id: XM_021244198   ⟹   XP_021099857
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,314,177 - 6,352,236 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021099857 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021922
  ENSHGLP00000021923
Reference Protein Sequences
RefSeq Acc Id: XP_021099857   ⟸   XM_021244198
- UniProtKB: G5AKL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000021923   ⟸   ENSHGLT00000022133
RefSeq Acc Id: ENSHGLP00000021922   ⟸   ENSHGLT00000022132


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015642 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000022132 ENTREZGENE
  ENSHGLT00000022133 UniProtKB/TrEMBL
Gene3D-CATH ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro TTL/TTLL_fam UniProtKB/TrEMBL
NCBI Gene Ttll4 ENTREZGENE
PANTHER TUBULIN POLYGLUTAMYLASE UniProtKB/TrEMBL
  TUBULIN POLYGLUTAMYLASE TTLL4 UniProtKB/TrEMBL
Pfam TTL UniProtKB/TrEMBL
PROSITE TTL UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
UniProt G5AKL8 ENTREZGENE, UniProtKB/TrEMBL