Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | H2bc12 | Rat | (-)-demecolcine | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Demecolcine results in increased expression of H2BC12 mRNA | CTD | PMID:23649840 | H2bc12 | Rat | 17beta-estradiol | affects expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Estradiol affects the expression of H2BC12 mRNA | CTD | PMID:22574217 | H2bc12 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of H2BC12 mRNA | CTD | PMID:32109520 | H2bc12 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | H2bc12 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression more ... | CTD | PMID:25975270 | H2bc12 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | H2bc12 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of H2BC12 mRNA | CTD | PMID:21570461|PMID:24680724 | H2bc12 | Rat | 2-hydroxypropanoic acid | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of H2BC12 mRNA | CTD | PMID:30851411 | H2bc12 | Rat | 5-fluorouracil | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Fluorouracil results in decreased expression of H2BC12 mRNA | CTD | PMID:16101138 | H2bc12 | Rat | 5-fluorouracil | affects response to substance | ISO | H2BC12 (Homo sapiens) | 6480464 | H2BC12 protein affects the susceptibility to Fluorouracil | CTD | PMID:15352031|PMID:16217747 | H2bc12 | Rat | 5-fluorouracil | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Fluorouracil results in increased expression of H2BC12 protein | CTD | PMID:15352031 | H2bc12 | Rat | acrylamide | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of H2BC12 mRNA | CTD | PMID:32763439 | H2bc12 | Rat | aflatoxin B1 | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of H2BC12 mRNA | CTD | PMID:27153756 | H2bc12 | Rat | all-trans-retinoic acid | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of H2BC12 mRNA | CTD | PMID:21934132|PMID:23724009 | H2bc12 | Rat | all-trans-retinoic acid | multiple interactions | ISO | H2bc12 (Mus musculus) | 6480464 | [bisphenol A co-treated with Tretinoin] results in decreased expression of H2BC12 mRNA | CTD | PMID:30951980 | H2bc12 | Rat | aminoglutethimide | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Aminoglutethimide results in increased expression of H2BC12 protein | CTD | PMID:26102013 | H2bc12 | Rat | aristolochic acid A | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of H2BC12 mRNA | CTD | PMID:33212167 | H2bc12 | Rat | Aroclor 1254 | increases expression | ISO | H2bc12 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of H2BC12 mRNA | CTD | PMID:23650126 | H2bc12 | Rat | belinostat | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | H2bc12 | Rat | belinostat | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | belinostat results in decreased expression of H2BC12 mRNA | CTD | PMID:26272509|PMID:27188386 | H2bc12 | Rat | benzene | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Benzene results in decreased expression of H2BC12 mRNA | CTD | PMID:19162166 | H2bc12 | Rat | benzo[a]pyrene | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of H2BC12 mRNA; Benzo(a)pyrene results in increased expression of H2BC12 more ... | CTD | PMID:20106945|PMID:33044785 | H2bc12 | Rat | benzo[a]pyrene | affects methylation | ISO | H2BC12 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of H2BC12 3' UTR; Benzo(a)pyrene affects the methylation of H2BC12 promoter | CTD | PMID:27901495 | H2bc12 | Rat | benzo[a]pyrene | increases expression | ISO | H2bc12 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of H2BC12 mRNA | CTD | PMID:22228805|PMID:22610609 | H2bc12 | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of H2BC12 mRNA | CTD | PMID:20382639 | H2bc12 | Rat | berberine | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Berberine results in decreased expression of H2BC12 mRNA | CTD | PMID:27311644 | H2bc12 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of H2BC12 mRNA | CTD | PMID:32145629 | H2bc12 | Rat | bisphenol A | multiple interactions | ISO | H2bc12 (Mus musculus) | 6480464 | [bisphenol A co-treated with Tretinoin] results in decreased expression of H2BC12 mRNA | CTD | PMID:30951980 | H2bc12 | Rat | bisphenol A | decreases methylation | ISO | H2BC12 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of H2BC12 gene | CTD | PMID:31601247 | H2bc12 | Rat | bisphenol A | increases expression | ISO | H2bc12 (Mus musculus) | 6480464 | bisphenol A results in increased expression of H2BC12 mRNA | CTD | PMID:33221593 | H2bc12 | Rat | bleomycin A5 | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | bleomycetin results in decreased expression of H2BC12 mRNA | CTD | PMID:21040473 | H2bc12 | Rat | cadmium atom | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Cadmium results in increased expression of H2BC12 mRNA | CTD | PMID:24376830 | H2bc12 | Rat | cadmium dichloride | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of H2BC12 protein | CTD | PMID:38185225 | H2bc12 | Rat | CGP 52608 | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to H2BC12 gene] | CTD | PMID:28238834 | H2bc12 | Rat | chloropicrin | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | chloropicrin results in decreased expression of H2BC12 mRNA | CTD | PMID:26352163 | H2bc12 | Rat | ciguatoxin CTX1B | affects expression | ISO | H2bc12 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of H2BC12 mRNA | CTD | PMID:18353800 | H2bc12 | Rat | cisplatin | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of H2BC12 mRNA | CTD | PMID:27594783 | H2bc12 | Rat | cobalt dichloride | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of H2BC12 mRNA | CTD | PMID:19320972 | H2bc12 | Rat | copper atom | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of H2BC12 mRNA | CTD | PMID:24690739 | H2bc12 | Rat | copper(0) | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of H2BC12 mRNA | CTD | PMID:24690739 | H2bc12 | Rat | copper(II) sulfate | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of H2BC12 mRNA | CTD | PMID:19549813 | H2bc12 | Rat | coumestrol | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of H2BC12 mRNA | CTD | PMID:19167446 | H2bc12 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of H2BC12 mRNA | CTD | PMID:26577399 | H2bc12 | Rat | cyclosporin A | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of H2BC12 mRNA | CTD | PMID:20106945 | H2bc12 | Rat | cyclosporin A | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of H2BC12 mRNA | CTD | PMID:27989131 | H2bc12 | Rat | DDE | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of H2BC12 mRNA | CTD | PMID:38568856 | H2bc12 | Rat | deguelin | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | deguelin results in increased expression of H2BC12 mRNA | CTD | PMID:33512557 | H2bc12 | Rat | dioxygen | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of H2BC12 mRNA | CTD | PMID:26516004 | H2bc12 | Rat | disulfiram | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of H2BC12 mRNA | CTD | PMID:24690739 | H2bc12 | Rat | dorsomorphin | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | H2bc12 | Rat | doxorubicin | affects expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Doxorubicin affects the expression of H2BC12 protein | CTD | PMID:29385562 | H2bc12 | Rat | doxorubicin | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of H2BC12 mRNA | CTD | PMID:29803840 | H2bc12 | Rat | entinostat | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | H2bc12 | Rat | entinostat | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | entinostat results in decreased expression of H2BC12 mRNA | CTD | PMID:26272509 | H2bc12 | Rat | epoxiconazole | increases expression | ISO | H2bc12 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of H2BC12 mRNA | CTD | PMID:35436446 | H2bc12 | Rat | ethanol | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Ethanol results in decreased expression of H2BC12 mRNA | CTD | PMID:23378141 | H2bc12 | Rat | ethanol | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [Ethanol co-treated with Folic Acid] results in decreased expression of H2BC12 mRNA | CTD | PMID:23378141 | H2bc12 | Rat | folic acid | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [Ethanol co-treated with Folic Acid] results in decreased expression of H2BC12 mRNA | CTD | PMID:23378141 | H2bc12 | Rat | formaldehyde | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of H2BC12 mRNA | CTD | PMID:23649840 | H2bc12 | Rat | hydrogen peroxide | affects expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of H2BC12 mRNA | CTD | PMID:21179406 | H2bc12 | Rat | isotretinoin | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Isotretinoin results in decreased expression of H2BC12 mRNA | CTD | PMID:20436886 | H2bc12 | Rat | Licochalcone B | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of H2BC12 mRNA | CTD | PMID:33647349 | H2bc12 | Rat | methyl methacrylate | increases expression | ISO | H2bc12 (Mus musculus) | 6480464 | Methylmethacrylate results in increased expression of H2BC12 mRNA | CTD | PMID:16916219 | H2bc12 | Rat | methyl methanesulfonate | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of H2BC12 mRNA | CTD | PMID:23649840 | H2bc12 | Rat | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC12 mRNA | CTD | PMID:19013360 | H2bc12 | Rat | N-methyl-4-phenylpyridinium | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of H2BC12 mRNA; 1-Methyl-4-phenylpyridinium results in decreased expression of H2BC12 more ... | CTD | PMID:24806433|PMID:24810058 | H2bc12 | Rat | okadaic acid | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of H2BC12 mRNA | CTD | PMID:38832940 | H2bc12 | Rat | panobinostat | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Panobinostat results in decreased expression of H2BC12 mRNA | CTD | PMID:26272509 | H2bc12 | Rat | panobinostat | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | H2bc12 | Rat | paracetamol | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of H2BC12 mRNA | CTD | PMID:21420995|PMID:38614205 | H2bc12 | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of H2BC12 mRNA | CTD | PMID:32680482 | H2bc12 | Rat | pirinixic acid | increases expression | ISO | H2bc12 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of H2BC12 mRNA | CTD | PMID:23811191 | H2bc12 | Rat | potassium chromate | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of H2BC12 mRNA | CTD | PMID:22714537 | H2bc12 | Rat | pyrimidifen | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | pyrimidifen results in increased expression of H2BC12 mRNA | CTD | PMID:33512557 | H2bc12 | Rat | rac-lactic acid | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of H2BC12 mRNA | CTD | PMID:30851411 | H2bc12 | Rat | SB 431542 | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | H2bc12 | Rat | silicon dioxide | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of H2BC12 mRNA | CTD | PMID:23806026 | H2bc12 | Rat | sodium arsenite | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of H2BC12 mRNA | CTD | PMID:22714537|PMID:28595984|PMID:34032870|PMID:38568856 | H2bc12 | Rat | temozolomide | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of H2BC12 mRNA | CTD | PMID:31758290 | H2bc12 | Rat | tert-butyl hydroperoxide | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of H2BC12 mRNA | CTD | PMID:15336504 | H2bc12 | Rat | thalidomide | decreases expression | ISO | H2bc12 (Mus musculus) | 6480464 | Thalidomide results in decreased expression of H2BC12 mRNA | CTD | PMID:26217789 | H2bc12 | Rat | thiram | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Thiram results in increased expression of H2BC12 mRNA | CTD | PMID:38568856 | H2bc12 | Rat | trichostatin A | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of H2BC12 mRNA | CTD | PMID:24935251|PMID:26272509 | H2bc12 | Rat | trichostatin A | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | H2bc12 | Rat | troglitazone | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Troglitazone results in increased expression of H2BC12 mRNA | CTD | PMID:19140230 | H2bc12 | Rat | urethane | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Urethane results in increased expression of H2BC12 mRNA | CTD | PMID:28818685 | H2bc12 | Rat | valproic acid | affects expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of H2BC12 mRNA | CTD | PMID:25979313 | H2bc12 | Rat | valproic acid | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of H2BC12 mRNA | CTD | PMID:28001369 | H2bc12 | Rat | valproic acid | multiple interactions | ISO | H2BC12 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | H2bc12 | Rat | valproic acid | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of H2BC12 mRNA | CTD | PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509|PMID:29154799 | H2bc12 | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of H2BC12 mRNA | CTD | PMID:23034163 | H2bc12 | Rat | vincristine | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Vincristine results in increased expression of H2BC12 mRNA | CTD | PMID:23649840 | H2bc12 | Rat | zinc sulfate | decreases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Zinc Sulfate results in decreased expression of H2BC12 mRNA | CTD | PMID:19013360 | H2bc12 | Rat | zoledronic acid | increases expression | ISO | H2BC12 (Homo sapiens) | 6480464 | Zoledronic Acid results in increased expression of H2BC12 mRNA | CTD | PMID:24714768 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















