Tubb2a (tubulin, beta 2A class IIa) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tubb2a (tubulin, beta 2A class IIa) Rattus norvegicus
Analyze
Symbol: Tubb2a
Name: tubulin, beta 2A class IIa
RGD ID: 1588452
Description: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization; mitotic cell cycle; and nervous system development. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 5. Orthologous to human TUBB2A (tubulin beta 2A class IIa); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC108348176; LOC498736; similar to tubulin, beta 2; T beta-15; Tubb2b; tubulin beta-2A chain; tubulin beta-2A chain pseudogene; Tubulin beta-2B chain; tubulin, beta 2A
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,002,186 - 31,006,057 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1730,983,387 - 31,006,838 (+)EnsemblGRCr8
mRatBN7.21730,796,842 - 30,800,713 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,747,503 - 30,800,714 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1730,610,793 - 30,614,662 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,214,539 - 32,218,408 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,606,536 - 30,610,405 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01731,493,145 - 31,496,827 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1731,493,107 - 31,498,651 (+)Ensemblrn6Rnor6.0
Rnor_5.01733,390,589 - 33,391,837 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41737,139,177 - 37,143,049 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1730,361,117 - 30,364,988 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
glucose  (ISO)
graphene oxide  (ISO)
HC toxin  (ISO)
hexadecanoic acid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone undecanoate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
ciliary tip  (IEA,ISO)
cilium  (IEA,ISO)
cytoplasm  (IBA)
cytoskeleton  (IEA)
intercellular bridge  (IEA,ISO)
microtubule  (IBA,IEA,ISO)
microtubule cytoskeleton  (IEA,ISO)
mitotic spindle  (IEA,ISO)
sperm end piece  (IEA,ISO)
sperm principal piece  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2868892   PMID:15057822   PMID:15865439   PMID:19056867   PMID:21525035   PMID:21630459   PMID:22871113   PMID:24625528   PMID:24769233   PMID:25931508   PMID:29476059   PMID:31505169  
PMID:31904090  


Genomics

Comparative Map Data
Tubb2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,002,186 - 31,006,057 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1730,983,387 - 31,006,838 (+)EnsemblGRCr8
mRatBN7.21730,796,842 - 30,800,713 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,747,503 - 30,800,714 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1730,610,793 - 30,614,662 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,214,539 - 32,218,408 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,606,536 - 30,610,405 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01731,493,145 - 31,496,827 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1731,493,107 - 31,498,651 (+)Ensemblrn6Rnor6.0
Rnor_5.01733,390,589 - 33,391,837 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41737,139,177 - 37,143,049 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1730,361,117 - 30,364,988 (+)NCBICelera
Cytogenetic Map17p12NCBI
TUBB2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3863,153,666 - 3,157,544 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl63,153,497 - 3,157,544 (-)Ensemblhg38GRCh38
GRCh3763,153,900 - 3,157,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3663,098,899 - 3,102,782 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3463,098,902 - 3,102,759NCBI
Celera64,382,770 - 4,386,674 (-)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef63,024,011 - 3,027,895 (-)NCBIHuRef
CHM1_163,153,792 - 3,157,676 (-)NCBICHM1_1
T2T-CHM13v2.063,020,886 - 3,024,765 (-)NCBIT2T-CHM13v2.0
Tubb2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391334,258,261 - 34,261,991 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1334,258,257 - 34,261,990 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381334,074,278 - 34,078,008 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1334,074,274 - 34,078,007 (-)Ensemblmm10GRCm38
MGSCv371334,166,147 - 34,169,877 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361334,081,743 - 34,085,453 (-)NCBIMGSCv36mm8
Celera1335,203,665 - 35,207,395 (-)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.03NCBI
TUBB2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,787,003 - 17,790,900 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,786,855 - 13,790,770 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,993,653 - 2,997,570 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.163,083,230 - 3,085,242 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl63,080,751 - 3,255,882 (-)EnsemblpanPan2panpan1.1
TUBB2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,448,402 - 3,450,783 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,448,435 - 3,452,091 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha353,456,142 - 3,460,841 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,505,153 - 3,509,899 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,505,153 - 3,558,836 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,380,360 - 3,384,881 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,402,361 - 3,407,093 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,734,869 - 4,739,525 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TUBB2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,026,112 - 69,030,000 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1769,026,130 - 69,029,801 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660443,078,918 - 3,096,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tubb2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11452,646,114 - 52,649,786 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tubb2a
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:14
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000023611
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
RH141796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,797,428 - 30,797,622 (+)MAPPERmRatBN7.2
Rnor_6.01731,493,732 - 31,493,925NCBIRnor6.0
Rnor_5.01733,386,918 - 33,387,111UniSTSRnor5.0
RGSC_v3.41737,139,765 - 37,139,958UniSTSRGSC3.4
Celera1730,361,704 - 30,361,897UniSTS
RH 3.4 Map17326.32UniSTS
Cytogenetic Map17p12UniSTS
Tubb2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,800,424 - 30,800,619 (+)MAPPERmRatBN7.2
Rnor_6.01731,498,363 - 31,498,557NCBIRnor6.0
Rnor_5.01733,391,549 - 33,391,743UniSTSRnor5.0
RGSC_v3.41737,142,761 - 37,142,955UniSTSRGSC3.4
Celera1730,364,700 - 30,364,894UniSTS
Cytogenetic Map17p12UniSTS
MARC_26445-26446:1030655521:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,749,123 - 30,749,576 (+)MAPPERmRatBN7.2
mRatBN7.21730,798,685 - 30,799,569 (+)MAPPERmRatBN7.2
Rnor_6.01731,494,989 - 31,495,872NCBIRnor6.0
Rnor_6.01731,443,030 - 31,443,482NCBIRnor6.0
Rnor_5.01733,388,175 - 33,389,058UniSTSRnor5.0
Rnor_5.01733,337,455 - 33,337,907UniSTSRnor5.0
RGSC_v3.41737,089,312 - 37,089,764UniSTSRGSC3.4
RGSC_v3.41737,141,022 - 37,141,905UniSTSRGSC3.4
Celera1730,362,961 - 30,363,844UniSTS
Celera1730,313,507 - 30,313,959UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023582   ⟹   ENSRNOP00000023582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1730,747,503 - 30,800,703 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000023611   ⟹   ENSRNOP00000023611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1730,991,696 - 31,006,055 (+)Ensembl
mRatBN7.2 Ensembl1730,798,942 - 30,800,668 (+)Ensembl
Rnor_6.0 Ensembl1731,493,107 - 31,496,825 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083705   ⟹   ENSRNOP00000073323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1730,991,094 - 31,006,055 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086264   ⟹   ENSRNOP00000071729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1730,983,387 - 31,006,057 (+)Ensembl
mRatBN7.2 Ensembl1730,796,841 - 30,800,714 (+)Ensembl
Rnor_6.0 Ensembl1731,493,145 - 31,498,651 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099483   ⟹   ENSRNOP00000093166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,003,702 - 31,006,057 (+)Ensembl
mRatBN7.2 Ensembl1730,796,841 - 30,800,708 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000142247   ⟹   ENSRNOP00000104951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1730,991,080 - 31,006,838 (+)Ensembl
RefSeq Acc Id: NM_001109119   ⟹   NP_001102589
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,002,186 - 31,006,057 (+)NCBI
mRatBN7.21730,796,842 - 30,800,713 (+)NCBI
Rnor_6.01731,493,145 - 31,496,827 (+)NCBI
Rnor_5.01733,390,589 - 33,391,837 (+)NCBI
RGSC_v3.41737,139,177 - 37,143,049 (+)RGD
Celera1730,361,117 - 30,364,988 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102589 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA27067 (Get FASTA)   NCBI Sequence Viewer  
  EDL98318 (Get FASTA)   NCBI Sequence Viewer  
  P85108 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102589   ⟸   NM_001109119
- UniProtKB: P85108 (UniProtKB/Swiss-Prot),   A6J7G7 (UniProtKB/TrEMBL),   A0A8L2R4U4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023611   ⟸   ENSRNOT00000023611
Ensembl Acc Id: ENSRNOP00000071729   ⟸   ENSRNOT00000086264
Ensembl Acc Id: ENSRNOP00000093166   ⟸   ENSRNOT00000099483
Ensembl Acc Id: ENSRNOP00000023582   ⟸   ENSRNOT00000023582
Ensembl Acc Id: ENSRNOP00000073323   ⟸   ENSRNOT00000083705
Ensembl Acc Id: ENSRNOP00000104951   ⟸   ENSRNOT00000142247
Protein Domains
Tubulin/FtsZ 2-layer sandwich   Tubulin/FtsZ GTPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P85108-F1-model_v2 AlphaFold P85108 1-445 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700420
Promoter ID:EPDNEW_R10936
Type:single initiation site
Name:Tubb2a_1
Description:tubulin, beta 2A class IIa
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01731,493,144 - 31,493,204EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588452 AgrOrtholog
BioCyc Gene G2FUF-9600 BioCyc
Ensembl Genes ENSRNOG00000017558 Ensembl
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot
  3.30.1330.20 UniProtKB/Swiss-Prot
  3.40.50.1440 UniProtKB/Swiss-Prot
InterPro Beta-tubulin_BS UniProtKB/Swiss-Prot
  Beta_tubulin UniProtKB/Swiss-Prot
  Tub_FtsZ_C UniProtKB/Swiss-Prot
  Tubulin UniProtKB/Swiss-Prot
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
  Tubulin/FtsZ_GTPase_sf UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
  Tubulin_CS UniProtKB/Swiss-Prot
  Tubulin_FtsZ_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:498736 UniProtKB/Swiss-Prot
NCBI Gene 498736 ENTREZGENE
PANTHER PTHR11588 UniProtKB/Swiss-Prot
Pfam Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
PhenoGen Tubb2a PhenoGen
PRINTS BETATUBULIN UniProtKB/Swiss-Prot
  TUBULIN UniProtKB/Swiss-Prot
PROSITE TUBULIN UniProtKB/Swiss-Prot
  TUBULIN_B_AUTOREG UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017558 RatGTEx
SMART Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52490 UniProtKB/Swiss-Prot
  SSF55307 UniProtKB/Swiss-Prot
UniProt A0A8I6AFA2_RAT UniProtKB/TrEMBL
  A0A8L2QD97_RAT UniProtKB/TrEMBL
  A0A8L2R4U4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R7U3_RAT UniProtKB/TrEMBL
  A0ABK0L596_RAT UniProtKB/TrEMBL
  A6J7G7 ENTREZGENE, UniProtKB/TrEMBL
  P85108 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tubb2a  tubulin, beta 2A class IIa  LOC108348176  tubulin beta-2A chain pseudogene  Data merged from RGD:11388883 737654 PROVISIONAL
2016-08-02 LOC108348176  tubulin beta-2A chain pseudogene      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-10-19 Tubb2a  tubulin, beta 2A class IIa  Tubb2a  tubulin, beta 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-12 Tubb2a  tubulin, beta 2A  Tubb2a  tubulin, beta 2A class IIa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-10 Tubb2a  tubulin, beta 2A class IIa  Tubb2a  tubulin, beta 2a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Tubb2a  tubulin, beta 2a  LOC498736  similar to tubulin, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC498736  similar to tubulin, beta 2      Symbol and Name status set to provisional 70820 PROVISIONAL