Pjvk (pejvakin) - Rat Genome Database

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Gene: Pjvk (pejvakin) Rattus norvegicus
Analyze
Symbol: Pjvk
Name: pejvakin
RGD ID: 1587131
Description: Predicted to be involved in several processes, including pexophagy; programmed cell death in response to reactive oxygen species; and regulation of peroxisome organization. Predicted to act upstream of or within detection of mechanical stimulus involved in sensory perception of sound and stereocilium maintenance. Predicted to be located in cytoskeleton; peroxisomal membrane; and stereocilium base. Predicted to be active in cytoplasm and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 59. Orthologous to human PJVK (pejvakin); INTERACTS WITH bisphenol A; N-methyl-4-phenylpyridinium; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: deafness, autosomal recessive 59; deafness, autosomal recessive 59 (human); Dfnb59; LOC679552; similar to Nonsyndromic hearing impairment protein 5 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8382,002,106 - 82,012,273 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl382,002,368 - 82,012,451 (+)EnsemblGRCr8
mRatBN7.2361,594,644 - 61,605,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl361,596,641 - 61,605,045 (+)EnsemblmRatBN7.2
Rnor_6.0363,508,386 - 63,518,163 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl363,510,293 - 63,518,147 (+)Ensemblrn6Rnor6.0
Rnor_5.0370,083,296 - 70,091,353 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4359,348,728 - 59,356,706 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera361,080,528 - 61,090,733 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16804542   PMID:17329413  


Genomics

Comparative Map Data
Pjvk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8382,002,106 - 82,012,273 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl382,002,368 - 82,012,451 (+)EnsemblGRCr8
mRatBN7.2361,594,644 - 61,605,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl361,596,641 - 61,605,045 (+)EnsemblmRatBN7.2
Rnor_6.0363,508,386 - 63,518,163 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl363,510,293 - 63,518,147 (+)Ensemblrn6Rnor6.0
Rnor_5.0370,083,296 - 70,091,353 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4359,348,728 - 59,356,706 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera361,080,528 - 61,090,733 (+)NCBICelera
Cytogenetic Map3q24NCBI
PJVK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382178,451,378 - 178,462,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2178,451,346 - 178,462,102 (+)Ensemblhg38GRCh38
GRCh372179,316,105 - 179,326,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362179,026,351 - 179,034,310 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2172,919,049 - 172,928,999 (+)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2171,186,847 - 171,196,797 (+)NCBIHuRef
CHM1_12179,322,170 - 179,332,144 (+)NCBICHM1_1
T2T-CHM13v2.02178,934,171 - 178,944,894 (+)NCBIT2T-CHM13v2.0
Pjvk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39276,480,617 - 76,488,898 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl276,478,820 - 76,488,900 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38276,650,273 - 76,658,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl276,648,476 - 76,658,556 (+)Ensemblmm10GRCm38
MGSCv37276,488,330 - 76,496,613 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36276,449,338 - 76,459,395 (+)NCBIMGSCv36mm8
Celera278,311,949 - 78,320,233 (+)NCBICelera
Cytogenetic Map2C3NCBI
cM Map245.08NCBI
Pjvk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540318,386,705 - 18,393,771 (-)Ensembl
ChiLan1.0NW_00495540318,386,705 - 18,393,771 (-)NCBIChiLan1.0ChiLan1.0
PJVK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21381,098,713 - 81,111,146 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B81,113,687 - 81,124,634 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B65,708,635 - 65,725,766 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B183,413,375 - 183,423,503 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B183,413,265 - 183,423,224 (+)EnsemblpanPan2panpan1.1
PJVK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13622,080,574 - 22,087,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3622,040,303 - 22,092,249 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3622,099,201 - 22,106,550 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03622,224,490 - 22,231,855 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3622,183,736 - 22,231,259 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13622,333,855 - 22,341,196 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03622,296,525 - 22,303,268 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03622,412,988 - 22,420,325 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pjvk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303139,115,170 - 139,124,763 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365097,670,325 - 7,677,581 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365097,670,557 - 7,677,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PJVK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1584,158,639 - 84,165,906 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11584,157,864 - 84,165,763 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21593,691,740 - 93,699,282 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PJVK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11064,004,113 - 64,013,025 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1064,005,259 - 64,014,571 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040135,561,744 - 135,613,400 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pjvk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624844426,636 - 433,043 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624844424,903 - 432,841 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pjvk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1553,999,475 - 54,007,956 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pjvk
51 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:109
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000058093
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 3 42 139 48 53 24 55 24 3 234 117 10 129 81 91 29 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000058093   ⟹   ENSRNOP00000054901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl382,002,368 - 82,012,451 (+)Ensembl
mRatBN7.2 Ensembl361,596,641 - 61,605,045 (+)Ensembl
Rnor_6.0 Ensembl363,510,293 - 63,518,147 (+)Ensembl
RefSeq Acc Id: XM_039106435   ⟹   XP_038962363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8382,002,106 - 82,012,273 (+)NCBI
mRatBN7.2361,594,644 - 61,605,051 (+)NCBI
RefSeq Acc Id: XM_063284883   ⟹   XP_063140953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8382,003,778 - 82,012,273 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038962363 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140953 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79231 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054901
  ENSRNOP00000054901.5
Ensembl Acc Id: ENSRNOP00000054901   ⟸   ENSRNOT00000058093
RefSeq Acc Id: XP_038962363   ⟸   XM_039106435
- UniProtKB: D3ZSE6 (UniProtKB/TrEMBL),   A6HMI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140953   ⟸   XM_063284883
- UniProtKB: A6HMI0 (UniProtKB/TrEMBL),   D3ZSE6 (UniProtKB/TrEMBL)
Protein Domains
Gasdermin pore forming

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSE6-F1-model_v2 AlphaFold D3ZSE6 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587131 AgrOrtholog
BioCyc Gene G2FUF-49278 BioCyc
Ensembl Genes ENSRNOG00000038165 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058093 ENTREZGENE
  ENSRNOT00000058093.6 UniProtKB/TrEMBL
InterPro Gasdermin_pore UniProtKB/TrEMBL
  GSDME UniProtKB/TrEMBL
NCBI Gene 679552 ENTREZGENE
PANTHER NONSYNDROMIC HEARING IMPAIRMENT PROTEIN UniProtKB/TrEMBL
  PEJVAKIN UniProtKB/TrEMBL
Pfam Gasdermin UniProtKB/TrEMBL
PhenoGen Pjvk PhenoGen
RatGTEx ENSRNOG00000038165 RatGTEx
UniProt A6HMI0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSE6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-05 Pjvk  pejvakin  Dfnb59  deafness, autosomal recessive 59  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-10 Dfnb59  deafness, autosomal recessive 59  Dfnb59  deafness, autosomal recessive 59 (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-08 Dfnb59  deafness, autosomal recessive 59 (human)  Dfnb59  deafness, autosomal recessive 59  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Dfnb59  deafness, autosomal recessive 59  LOC679552  similar to Nonsyndromic hearing impairment protein 5 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679552  similar to Nonsyndromic hearing impairment protein 5 homolog  LOC683391  similar to Nonsyndromic hearing impairment protein 5 homolog  Data merged from RGD:1587980 1643240 APPROVED
2006-11-19 LOC679552  similar to Nonsyndromic hearing impairment protein 5 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683391  similar to Nonsyndromic hearing impairment protein 5 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL