Setd7 (SET domain containing 7, histone lysine methyltransferase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Setd7 (SET domain containing 7, histone lysine methyltransferase) Rattus norvegicus
Analyze
Symbol: Setd7
Name: SET domain containing 7, histone lysine methyltransferase
RGD ID: 1586346
Description: Enables chromatin binding activity. Involved in positive regulation of DNA-templated transcription and response to ethanol. Predicted to be active in chromosome and nucleus. Used to study extrahepatic cholestasis. Biomarker of fetal alcohol spectrum disorder. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase); PARTICIPATES IN carnitine biosynthetic pathway; histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone-lysine N-methyltransferase SETD7; LOC689954; SET domain containing (lysine methyltransferase) 7; similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82137,713,545 - 137,756,319 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2137,713,545 - 137,756,319 (-)EnsemblGRCr8
mRatBN7.22135,562,683 - 135,605,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,562,683 - 135,605,468 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2142,138,563 - 142,181,343 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02140,250,828 - 140,293,610 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02134,882,909 - 134,925,676 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02140,576,188 - 140,618,405 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,576,188 - 140,618,405 (-)Ensemblrn6Rnor6.0
Rnor_5.02160,051,126 - 160,093,343 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42140,413,802 - 140,456,579 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2130,058,161 - 130,100,836 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bisphenol AF  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
glucose  (EXP)
isoflurane  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
Nutlin-3  (ISO)
orphenadrine  (EXP)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IBA,IEA,ISO)
nucleolus  (IEA,ISO)
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in beta-endorphin-producing POMC neurons of the hypothalamus. Bekdash RA, etal., Alcohol Clin Exp Res. 2013 Jul;37(7):1133-42. doi: 10.1111/acer.12082. Epub 2013 Feb 15.
2. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Targeting protein lysine methylation and demethylation in cancers. He Y, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):70-9. doi: 10.1093/abbs/gmr109.
6. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Epigenetic histone methylation regulates transforming growth factor beta-1 expression following bile duct ligation in rats. Sheen-Chen SM, etal., J Gastroenterol. 2014 Aug;49(8):1285-97. doi: 10.1007/s00535-013-0892-0. Epub 2013 Oct 6.
13. Epigenetic histone methylation modulates fibrotic gene expression. Sun G, etal., J Am Soc Nephrol. 2010 Dec;21(12):2069-80. doi: 10.1681/ASN.2010060633. Epub 2010 Oct 7.
Additional References at PubMed
PMID:16415881   PMID:17108971   PMID:17707234   PMID:23509280   PMID:27652271   PMID:28762861   PMID:29684621   PMID:30119254   PMID:31505256   PMID:32448511   PMID:34592314   PMID:35259059  


Genomics

Comparative Map Data
Setd7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82137,713,545 - 137,756,319 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2137,713,545 - 137,756,319 (-)EnsemblGRCr8
mRatBN7.22135,562,683 - 135,605,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,562,683 - 135,605,468 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2142,138,563 - 142,181,343 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02140,250,828 - 140,293,610 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02134,882,909 - 134,925,676 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02140,576,188 - 140,618,405 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,576,188 - 140,618,405 (-)Ensemblrn6Rnor6.0
Rnor_5.02160,051,126 - 160,093,343 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42140,413,802 - 140,456,579 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2130,058,161 - 130,100,836 (-)NCBICelera
Cytogenetic Map2q26NCBI
SETD7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384139,492,974 - 139,556,219 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4139,492,974 - 139,606,699 (-)Ensemblhg38GRCh38
GRCh374140,414,128 - 140,477,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364140,646,642 - 140,697,027 (-)NCBIBuild 36Build 36hg18NCBI36
Celera4137,759,367 - 137,809,746 (-)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4136,156,561 - 136,206,720 (-)NCBIHuRef
CHM1_14140,404,455 - 140,454,786 (-)NCBICHM1_1
T2T-CHM13v2.04142,812,640 - 142,875,826 (-)NCBIT2T-CHM13v2.0
Setd7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39351,422,740 - 51,468,519 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl351,422,740 - 51,468,300 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38351,515,318 - 51,560,823 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl351,515,319 - 51,560,879 (-)Ensemblmm10GRCm38
MGSCv37351,319,240 - 51,364,745 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36351,603,247 - 51,648,752 (-)NCBIMGSCv36mm8
Celera351,246,288 - 51,292,035 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map322.5NCBI
Setd7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554284,131,103 - 4,178,250 (+)Ensembl
ChiLan1.0NW_0049554284,131,431 - 4,178,250 (+)NCBIChiLan1.0ChiLan1.0
SETD7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23137,379,578 - 137,432,801 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14137,756,847 - 137,825,326 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04131,869,999 - 131,921,342 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14143,167,190 - 143,227,731 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4143,167,190 - 143,227,732 (-)EnsemblpanPan2panpan1.1
SETD7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,186,620 - 3,229,305 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,186,906 - 3,224,113 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha193,427,673 - 3,478,217 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0193,250,127 - 3,300,591 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl193,250,143 - 3,298,678 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,182,575 - 3,232,096 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,543,515 - 3,593,766 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,907,163 - 3,957,479 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Setd7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530150,657,144 - 50,705,771 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365358,094,178 - 8,137,580 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365358,094,479 - 8,143,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SETD7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl887,478,173 - 87,527,188 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1887,478,266 - 87,527,190 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2893,131,742 - 93,168,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SETD7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1786,476,101 - 86,528,146 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl786,481,726 - 86,527,779 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603765,998,142 - 66,050,297 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Setd7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477719,768,698 - 19,814,506 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477719,764,383 - 19,812,804 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Setd7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13102,891,089 - 102,933,274 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Setd7
115 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:374
Count of miRNA genes:212
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000017736
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
BM387085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22135,591,509 - 135,591,696 (+)MAPPERmRatBN7.2
Rnor_6.02140,604,447 - 140,604,633NCBIRnor6.0
Rnor_5.02160,079,385 - 160,079,571UniSTSRnor5.0
RGSC_v3.42140,442,619 - 140,442,805UniSTSRGSC3.4
Celera2130,086,884 - 130,087,070UniSTS
RH 3.4 Map2848.1UniSTS
Cytogenetic Map2q26UniSTS
AU046527  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22135,581,256 - 135,581,468 (+)MAPPERmRatBN7.2
Rnor_6.02140,594,204 - 140,594,415NCBIRnor6.0
Rnor_5.02160,069,142 - 160,069,353UniSTSRnor5.0
RGSC_v3.42140,432,377 - 140,432,588UniSTSRGSC3.4
Celera2130,076,736 - 130,076,947UniSTS
Cytogenetic Map2q26UniSTS
AI011764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22135,595,954 - 135,596,191 (+)MAPPERmRatBN7.2
Rnor_6.02140,608,892 - 140,609,128NCBIRnor6.0
Rnor_5.02160,083,830 - 160,084,066UniSTSRnor5.0
RGSC_v3.42140,447,064 - 140,447,300UniSTSRGSC3.4
Celera2130,091,329 - 130,091,565UniSTS
RH 3.4 Map2859.1UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
25 14 99 260 91 90 59 225 59 6 605 377 33 237 136 152 31 51 51

Sequence


Ensembl Acc Id: ENSRNOT00000017736   ⟹   ENSRNOP00000017736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2137,713,545 - 137,756,319 (-)Ensembl
mRatBN7.2 Ensembl2135,562,683 - 135,605,468 (-)Ensembl
Rnor_6.0 Ensembl2140,576,188 - 140,618,405 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103869   ⟹   ENSRNOP00000090313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,562,683 - 135,586,215 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111366   ⟹   ENSRNOP00000084831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2137,713,545 - 137,746,066 (-)Ensembl
mRatBN7.2 Ensembl2135,562,683 - 135,595,209 (-)Ensembl
RefSeq Acc Id: NM_001109558   ⟹   NP_001103028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,713,545 - 137,756,319 (-)NCBI
mRatBN7.22135,562,683 - 135,605,468 (-)NCBI
Rnor_6.02140,576,188 - 140,618,405 (-)NCBI
Rnor_5.02160,051,126 - 160,093,343 (-)NCBI
RGSC_v3.42140,413,802 - 140,456,579 (-)RGD
Celera2130,058,161 - 130,100,836 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017736
  ENSRNOP00000017736.5
  ENSRNOP00000084831.1
RefSeq Acc Id: NP_001103028   ⟸   NM_001109558
- UniProtKB: D4ADE5 (UniProtKB/TrEMBL),   A6JV72 (UniProtKB/TrEMBL),   A0A8I6A0F7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017736   ⟸   ENSRNOT00000017736
Ensembl Acc Id: ENSRNOP00000090313   ⟸   ENSRNOT00000103869
Ensembl Acc Id: ENSRNOP00000084831   ⟸   ENSRNOT00000111366
Protein Domains
SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADE5-F1-model_v2 AlphaFold D4ADE5 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691320
Promoter ID:EPDNEW_R1845
Type:initiation region
Name:Setd7_1
Description:SET domain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02140,618,379 - 140,618,439EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586346 AgrOrtholog
BioCyc Gene G2FUF-53128 BioCyc
Ensembl Genes ENSRNOG00000013045 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017736 ENTREZGENE
  ENSRNOT00000017736.8 UniProtKB/TrEMBL
  ENSRNOT00000111366.2 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
  Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain UniProtKB/TrEMBL
InterPro Hist-Lys_N-MeTrfase_SET UniProtKB/TrEMBL
  MORN UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  SETD7_N UniProtKB/TrEMBL
  SETD7_SET UniProtKB/TrEMBL
KEGG Report rno:689954 UniProtKB/TrEMBL
NCBI Gene 689954 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE SETD7 UniProtKB/TrEMBL
  HISTONE-LYSINE N-METHYLTRANSFERASE SETD7 UniProtKB/TrEMBL
Pfam MORN UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  SET7_N UniProtKB/TrEMBL
PhenoGen Setd7 PhenoGen
PIRSF Histone_Lys_mtfrase_SET UniProtKB/TrEMBL
PROSITE SAM_MT43_13 UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013045 RatGTEx
Superfamily-SCOP Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A8I6A0F7 ENTREZGENE, UniProtKB/TrEMBL
  A6JV72 ENTREZGENE, UniProtKB/TrEMBL
  D4ADE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-04 Setd7  SET domain containing 7, histone lysine methyltransferase  Setd7  SET domain containing (lysine methyltransferase) 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Setd7  SET domain containing (lysine methyltransferase) 7  LOC689954  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689954  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)  LOC679429  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)  Data merged from RGD:1588334 1643240 APPROVED
2006-11-19 LOC689954  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679429  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)      Symbol and Name status set to provisional 70820 PROVISIONAL