Hus1b (HUS1 checkpoint clamp component B) - Rat Genome Database

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Gene: Hus1b (HUS1 checkpoint clamp component B) Rattus norvegicus
Analyze
Symbol: Hus1b
Name: HUS1 checkpoint clamp component B
RGD ID: 1585035
Description: Orthologous to human HUS1B (HUS1 checkpoint clamp component B); INTERACTS WITH bisphenol A; benzo[a]pyrene (ortholog); butanal (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: checkpoint protein HUS1B; HUS1 checkpoint homolog b; HUS1 checkpoint homolog b (S. pombe); LOC691382; similar to Hus1 checkpoint homolog b
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81733,742,690 - 33,743,857 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21733,534,032 - 33,535,199 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1733,378,629 - 33,379,459 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01734,982,500 - 34,983,330 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,374,446 - 33,375,276 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,424,018 - 35,424,848 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,424,011 - 35,425,104 (+)Ensemblrn6Rnor6.0
Rnor_5.01738,707,452 - 38,708,282 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41739,978,923 - 39,979,753 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1733,078,922 - 33,079,752 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:21873635  


Genomics

Comparative Map Data
Hus1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81733,742,690 - 33,743,857 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21733,534,032 - 33,535,199 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1733,378,629 - 33,379,459 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01734,982,500 - 34,983,330 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,374,446 - 33,375,276 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,424,018 - 35,424,848 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,424,011 - 35,425,104 (+)Ensemblrn6Rnor6.0
Rnor_5.01738,707,452 - 38,708,282 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41739,978,923 - 39,979,753 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1733,078,922 - 33,079,752 (+)NCBICelera
Cytogenetic Map17p12NCBI
HUS1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386655,939 - 657,100 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6655,939 - 657,100 (-)Ensemblhg38GRCh38
GRCh376655,939 - 657,100 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366600,939 - 601,964 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346600,939 - 601,944NCBI
Celera61,883,309 - 1,884,334 (-)NCBICelera
Cytogenetic Map6p25.3NCBI
HuRef6526,023 - 527,048 (-)NCBIHuRef
CHM1_16658,066 - 659,091 (-)NCBICHM1_1
T2T-CHM13v2.06515,149 - 516,310 (-)NCBIT2T-CHM13v2.0
Hus1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391331,130,559 - 31,131,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1331,130,556 - 31,131,742 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381330,946,576 - 30,947,761 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,946,573 - 30,947,759 (-)Ensemblmm10GRCm38
MGSCv371331,038,713 - 31,039,543 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361330,954,309 - 30,955,139 (-)NCBIMGSCv36mm8
Celera1331,159,693 - 31,160,523 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.33NCBI
HUS1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2515,263,730 - 15,304,170 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1611,257,795 - 11,261,530 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06466,508 - 469,590 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16601,123 - 602,138 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6601,288 - 602,124 (-)EnsemblpanPan2panpan1.1
Hus1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494624,799,523 - 24,800,636 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366331,820,063 - 1,821,150 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HUS1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11771,502,951 - 71,504,134 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666044581,645 - 584,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hus1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11449,985,275 - 49,988,870 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hus1b
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:323
Count of miRNA genes:129
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000072505, ENSRNOT00000074097
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
RH131719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21733,534,738 - 33,534,952 (+)MAPPERmRatBN7.2
Rnor_6.01735,424,644 - 35,424,857NCBIRnor6.0
Rnor_6.01734,694,230 - 34,694,443NCBIRnor6.0
Rnor_5.01736,739,684 - 36,739,897UniSTSRnor5.0
Rnor_5.01738,707,443 - 38,707,656UniSTSRnor5.0
RGSC_v3.41739,979,549 - 39,979,762UniSTSRGSC3.4
Celera1733,079,548 - 33,079,761UniSTS
Cytogenetic Map17p12UniSTS
UniSTS:493122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21733,534,112 - 33,534,943 (+)MAPPERmRatBN7.2
Rnor_6.01735,424,018 - 35,424,848NCBIRnor6.0
Rnor_6.01734,693,604 - 34,694,434NCBIRnor6.0
Rnor_5.01736,739,058 - 36,739,888UniSTSRnor5.0
Rnor_5.01738,707,452 - 38,708,282UniSTSRnor5.0
RGSC_v3.41739,978,923 - 39,979,753UniSTSRGSC3.4
Celera1733,078,922 - 33,079,752UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
1 14 22 7 7 7 40 7 89 61 7 24 21 15 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000086985   ⟹   ENSRNOP00000069298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1735,424,011 - 35,425,104 (+)Ensembl
RefSeq Acc Id: NM_001134846   ⟹   NP_001128318
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81733,742,690 - 33,743,857 (+)NCBI
mRatBN7.21733,534,032 - 33,535,199 (+)NCBI
Rnor_6.01735,424,018 - 35,424,848 (+)NCBI
Rnor_5.01738,707,452 - 38,708,282 (-)NCBI
RGSC_v3.41739,978,923 - 39,979,753 (+)RGD
Celera1733,078,922 - 33,079,752 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128318 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98362 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001128318   ⟸   NM_001134846
- UniProtKB: A6J7L1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069298   ⟸   ENSRNOT00000086985

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585035 AgrOrtholog
BioCyc Gene G2FUF-9546 BioCyc
Ensembl Genes ENSRNOG00000055922 Ensembl
Gene3D-CATH 3.70.10.10 UniProtKB/TrEMBL
InterPro Cell_cycle_HUS1 UniProtKB/TrEMBL
  Hus1/Mec3 UniProtKB/TrEMBL
KEGG Report rno:691382 UniProtKB/TrEMBL
NCBI Gene 691382 ENTREZGENE
PANTHER CHECKPOINT PROTEIN HUS1B UniProtKB/TrEMBL
  MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1 UniProtKB/TrEMBL
Pfam Hus1 UniProtKB/TrEMBL
PhenoGen Hus1b PhenoGen
PIRSF Cell_cycle_HUS1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055922 RatGTEx
UniProt A6J7L1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Hus1b  HUS1 checkpoint clamp component B  Hus1b  HUS1 checkpoint homolog b (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-17 Hus1b  HUS1 checkpoint homolog b (S. pombe)  LOC683826  similar to Hus1 checkpoint homolog b  Data merged from RGD:1597853 1643240 APPROVED
2008-03-06 Hus1b  HUS1 checkpoint homolog b (S. pombe)  LOC691382  similar to Hus1 checkpoint homolog b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC683826  similar to Hus1 checkpoint homolog b      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691382  similar to Hus1 checkpoint homolog b      Symbol and Name status set to provisional 70820 PROVISIONAL