Mrpl40 (mitochondrial ribosomal protein L40) - Rat Genome Database

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Pathways
Gene: Mrpl40 (mitochondrial ribosomal protein L40) Rattus norvegicus
Analyze
Symbol: Mrpl40
Name: mitochondrial ribosomal protein L40
RGD ID: 1565444
Description: Located in mitochondrial ribosome. Orthologous to human MRPL40 (mitochondrial ribosomal protein L40); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 39S ribosomal protein L40, mitochondrial; L40mt; large ribosomal subunit protein mL40; MRP-L40
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,637,751 - 95,643,587 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1195,637,712 - 95,643,586 (+)EnsemblGRCr8
mRatBN7.21182,133,398 - 82,139,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,133,398 - 82,139,233 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,862,860 - 90,868,698 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,524,080 - 83,529,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,577,348 - 82,583,186 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,276,616 - 86,282,452 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,276,616 - 86,282,451 (+)Ensemblrn6Rnor6.0
Rnor_5.01189,378,582 - 89,384,418 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1180,914,027 - 80,919,719 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, etal., J Biol Chem. 1998 Dec 25;273(52):34828-36.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:18614015   PMID:18775783   PMID:22681889   PMID:25278503   PMID:28892042  


Genomics

Comparative Map Data
Mrpl40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,637,751 - 95,643,587 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1195,637,712 - 95,643,586 (+)EnsemblGRCr8
mRatBN7.21182,133,398 - 82,139,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,133,398 - 82,139,233 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,862,860 - 90,868,698 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,524,080 - 83,529,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,577,348 - 82,583,186 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,276,616 - 86,282,452 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,276,616 - 86,282,451 (+)Ensemblrn6Rnor6.0
Rnor_5.01189,378,582 - 89,384,418 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1180,914,027 - 80,919,719 (+)NCBICelera
Cytogenetic Map11q23NCBI
MRPL40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,432,545 - 19,436,075 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,432,467 - 19,436,077 (+)Ensemblhg38GRCh38
GRCh372219,420,068 - 19,423,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,800,036 - 17,803,598 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342217,794,589 - 17,798,148NCBI
Celera223,272,293 - 3,275,855 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,040,849 - 3,044,411 (+)NCBIHuRef
CHM1_12219,419,610 - 19,423,172 (+)NCBICHM1_1
T2T-CHM13v2.02219,809,376 - 19,812,906 (+)NCBIT2T-CHM13v2.0
Mrpl40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,690,767 - 18,695,875 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,690,768 - 18,695,612 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381618,872,018 - 18,876,637 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,872,018 - 18,876,862 (-)Ensemblmm10GRCm38
MGSCv371618,872,111 - 18,876,730 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361618,785,780 - 18,790,200 (-)NCBIMGSCv36mm8
Celera1619,446,075 - 19,450,694 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.69NCBI
Mrpl40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,577,952 - 18,580,517 (-)Ensembl
ChiLan1.0NW_00495544218,578,107 - 18,580,517 (-)NCBIChiLan1.0ChiLan1.0
MRPL40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22329,057,340 - 29,061,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,604,620 - 31,608,737 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,191,187 - 2,195,350 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12217,865,992 - 17,870,539 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2217,866,322 - 17,870,539 (+)EnsemblpanPan2panpan1.1
MRPL40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,773,397 - 29,777,104 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,773,403 - 29,777,073 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2629,728,768 - 29,732,471 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02631,175,195 - 31,178,901 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,174,164 - 31,180,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,222,488 - 29,226,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,847,911 - 28,851,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,934,840 - 29,938,543 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mrpl40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,369,421 - 139,373,206 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,380,335 - 3,384,600 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,380,957 - 3,384,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPL40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,102,613 - 51,105,767 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11451,102,900 - 51,105,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,669,933 - 54,672,802 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRPL40
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,319,745 - 6,323,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,319,263 - 6,323,799 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666085610,117 - 613,937 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrpl40
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474796,418 - 100,913 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474796,411 - 99,490 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mrpl40
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v144,117,405 - 4,123,366 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:649
Count of miRNA genes:279
Interacting mature miRNAs:345
Transcripts:ENSRNOT00000071159
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
Mrpl40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,249,761 - 48,250,175 (+)MAPPERmRatBN7.2
mRatBN7.2259,471,127 - 59,471,615 (+)MAPPERmRatBN7.2
Rnor_6.01554,961,080 - 54,961,493NCBIRnor6.0
Rnor_6.0260,471,065 - 60,471,552NCBIRnor6.0
Rnor_5.01558,683,336 - 58,683,749UniSTSRnor5.0
RGSC_v3.4259,847,412 - 59,847,899UniSTSRGSC3.4
RGSC_v3.41553,706,993 - 53,707,406UniSTSRGSC3.4
Celera1547,899,572 - 47,899,985UniSTS
Cytogenetic Map2q16UniSTS
Cytogenetic Map11p12UniSTS
RH128570  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,137,452 - 82,137,640 (+)MAPPERmRatBN7.2
mRatBN7.21548,250,193 - 48,250,381 (+)MAPPERmRatBN7.2
Rnor_6.01554,961,512 - 54,961,699NCBIRnor6.0
Rnor_6.01186,280,671 - 86,280,858NCBIRnor6.0
Rnor_5.01189,382,637 - 89,382,824UniSTSRnor5.0
Rnor_5.01558,683,768 - 58,683,955UniSTSRnor5.0
RGSC_v3.41553,707,425 - 53,707,612UniSTSRGSC3.4
Celera1547,900,004 - 47,900,191UniSTS
Celera1180,918,082 - 80,918,269UniSTS
Cytogenetic Map11p12UniSTS
AI715998  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,139,031 - 82,139,163 (+)MAPPERmRatBN7.2
mRatBN7.21548,251,770 - 48,251,889 (+)MAPPERmRatBN7.2
Rnor_6.01554,963,089 - 54,963,207NCBIRnor6.0
Rnor_6.01186,282,250 - 86,282,381NCBIRnor6.0
Rnor_5.01558,685,345 - 58,685,463UniSTSRnor5.0
Rnor_5.01189,384,216 - 89,384,347UniSTSRnor5.0
RGSC_v3.41553,709,002 - 53,709,120UniSTSRGSC3.4
Celera1547,901,581 - 47,901,699UniSTS
Celera1180,919,517 - 80,919,648UniSTS
RH 3.4 Map349.3UniSTS
Cytogenetic Map11p12UniSTS
Hira  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,132,470 - 82,132,627 (+)MAPPERmRatBN7.2
Rnor_6.01186,275,689 - 86,275,845NCBIRnor6.0
Rnor_5.01189,377,655 - 89,377,811UniSTSRnor5.0
Celera1180,913,100 - 80,913,256UniSTS
Cytogenetic Map11p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071159   ⟹   ENSRNOP00000065376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1195,637,712 - 95,643,586 (+)Ensembl
mRatBN7.2 Ensembl1182,133,398 - 82,139,233 (+)Ensembl
Rnor_6.0 Ensembl1186,276,616 - 86,282,451 (+)Ensembl
RefSeq Acc Id: NM_001024865   ⟹   NP_001020036
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,637,751 - 95,643,587 (+)NCBI
mRatBN7.21182,133,398 - 82,139,234 (+)NCBI
Rnor_6.01186,276,616 - 86,282,452 (+)NCBI
Rnor_5.01189,378,582 - 89,384,418 (+)NCBI
Celera1180,914,027 - 80,919,719 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020036 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97472 (Get FASTA)   NCBI Sequence Viewer  
  EDL77962 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065376
  ENSRNOP00000065376.1
GenBank Protein P83565 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020036   ⟸   NM_001024865
- Peptide Label: precursor
- UniProtKB: Q4V8A4 (UniProtKB/Swiss-Prot),   P83565 (UniProtKB/Swiss-Prot),   A6JSE5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065376   ⟸   ENSRNOT00000071159

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83565-F1-model_v2 AlphaFold P83565 1-206 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698293
Promoter ID:EPDNEW_R8818
Type:initiation region
Name:Mrpl40_1
Description:mitochondrial ribosomal protein L40
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,276,690 - 86,276,750EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565444 AgrOrtholog
BioCyc Gene G2FUF-20675 BioCyc
Ensembl Genes ENSRNOG00000049686 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071159 ENTREZGENE
  ENSRNOT00000071159.2 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.3440 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7457772 IMAGE-MGC_LOAD
InterPro MRPL40 UniProtKB/Swiss-Prot
  Ribosomal_L28_mit UniProtKB/Swiss-Prot
KEGG Report rno:287962 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114537 IMAGE-MGC_LOAD
NCBI Gene 287962 ENTREZGENE
PANTHER 39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR13359 UniProtKB/Swiss-Prot
Pfam MRP-L28 UniProtKB/Swiss-Prot
PhenoGen Mrpl40 PhenoGen
RatGTEx ENSRNOG00000049686 RatGTEx
UniProt A6JSE5 ENTREZGENE, UniProtKB/TrEMBL
  P83565 ENTREZGENE
  Q4V8A4 ENTREZGENE
  RM40_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4V8A4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mrpl40  mitochondrial ribosomal protein L40      Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Mrpl40  mitochondrial ribosomal protein L40      Symbol and Name status set to provisional 70820 PROVISIONAL