Socs5 (suppressor of cytokine signaling 5) - Rat Genome Database

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Gene: Socs5 (suppressor of cytokine signaling 5) Rattus norvegicus
Analyze
Symbol: Socs5
Name: suppressor of cytokine signaling 5
RGD ID: 1564914
Description: Predicted to enable epidermal growth factor receptor binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including cellular response to low-density lipoprotein particle stimulus; regulation of T-helper cell differentiation; and regulation of macromolecule metabolic process. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Orthologous to human SOCS5 (suppressor of cytokine signaling 5); PARTICIPATES IN interleukin-4 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC500616; RGD1564914; similar to Suppressor of cytokine signaling 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,235,157 - 13,266,161 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl613,234,062 - 13,273,883 (-)EnsemblGRCr8
mRatBN7.267,481,039 - 7,512,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,481,095 - 7,514,834 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,762,496 - 7,793,102 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,071,907 - 8,102,513 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,599,021 - 7,629,627 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd614,659,475 - 14,690,081 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive614,099,444 - 14,130,050 (-)NCBILyon_Normotensive
Lyon_Hypertensive611,886,200 - 11,916,871 (-)NCBILyon_Hypertensive
F344_StmMcwi611,023,732 - 11,054,403 (-)NCBIF344_StmMcwi
Rnor_6.0610,671,311 - 10,705,610 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,674,371 - 10,704,977 (+)Ensemblrn6Rnor6.0
Rnor_5.0620,659,713 - 20,697,182 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4610,552,177 - 10,582,783 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera67,217,143 - 7,247,749 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Inhibitors of cytokine signal transduction. Wormald S and Hilton DJ, J Biol Chem 2004 Jan 9;279(2):821-4. Epub 2003 Nov 7.
Additional References at PubMed
PMID:12242343   PMID:15590694   PMID:15695332   PMID:17464217   PMID:19176113   PMID:24255059  


Genomics

Comparative Map Data
Socs5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,235,157 - 13,266,161 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl613,234,062 - 13,273,883 (-)EnsemblGRCr8
mRatBN7.267,481,039 - 7,512,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,481,095 - 7,514,834 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,762,496 - 7,793,102 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,071,907 - 8,102,513 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,599,021 - 7,629,627 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd614,659,475 - 14,690,081 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive614,099,444 - 14,130,050 (-)NCBILyon_Normotensive
Lyon_Hypertensive611,886,200 - 11,916,871 (-)NCBILyon_Hypertensive
F344_StmMcwi611,023,732 - 11,054,403 (-)NCBIF344_StmMcwi
Rnor_6.0610,671,311 - 10,705,610 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,674,371 - 10,704,977 (+)Ensemblrn6Rnor6.0
Rnor_5.0620,659,713 - 20,697,182 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4610,552,177 - 10,582,783 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera67,217,143 - 7,247,749 (-)NCBICelera
Cytogenetic Map6q12NCBI
SOCS5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38246,698,937 - 46,763,129 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl246,698,423 - 46,780,245 (+)Ensemblhg38GRCh38
GRCh37246,926,076 - 46,990,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,779,603 - 46,843,431 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34246,837,999 - 46,901,578NCBI
Celera246,764,784 - 46,828,608 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef246,663,409 - 46,727,912 (+)NCBIHuRef
CHM1_1246,856,418 - 46,920,225 (+)NCBICHM1_1
T2T-CHM13v2.0246,703,485 - 46,767,961 (+)NCBIT2T-CHM13v2.0
Socs5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,414,707 - 87,445,153 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,415,107 - 87,445,267 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381787,107,278 - 87,137,647 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,107,679 - 87,137,839 (+)Ensemblmm10GRCm38
MGSCv371787,507,019 - 87,536,925 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361787,016,005 - 87,045,911 (+)NCBIMGSCv36mm8
Celera1791,484,878 - 91,514,794 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.93NCBI
Socs5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,593,342 - 13,657,389 (+)Ensembl
ChiLan1.0NW_00495544113,593,342 - 13,657,389 (+)NCBIChiLan1.0ChiLan1.0
SOCS5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21279,514,383 - 79,691,607 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A79,631,595 - 79,696,153 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A46,813,589 - 46,878,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A47,745,216 - 47,808,566 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A47,804,431 - 47,806,041 (+)EnsemblpanPan2panpan1.1
SOCS5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,916,446 - 48,977,183 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,972,842 - 48,974,452 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1048,769,314 - 48,830,770 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01049,786,401 - 49,847,931 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1049,786,357 - 49,845,694 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,494,260 - 49,555,954 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01049,784,343 - 49,845,789 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,967,638 - 50,029,159 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Socs5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,102,393 - 34,159,407 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,531,002 - 5,587,549 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,531,002 - 5,588,022 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,783,964 - 93,925,863 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1393,777,402 - 93,925,859 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,869,650 - 99,940,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103220335
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,330,192 - 60,335,477 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,431,401 - 60,433,011 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl1460,431,401 - 60,433,011 (-)NCBIChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604551,352,938 - 51,515,428 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,150,664 - 28,216,389 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473828,150,004 - 28,217,850 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Socs5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v175,857,803 - 5,889,851 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Socs5
226 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:324
Count of miRNA genes:178
Interacting mature miRNAs:239
Transcripts:ENSRNOT00000020337
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020337   ⟹   ENSRNOP00000020346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl613,234,736 - 13,265,974 (-)Ensembl
mRatBN7.2 Ensembl67,481,672 - 7,512,277 (-)Ensembl
Rnor_6.0 Ensembl610,674,371 - 10,704,977 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094405   ⟹   ENSRNOP00000084063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl613,234,062 - 13,266,247 (-)Ensembl
mRatBN7.2 Ensembl67,481,340 - 7,511,781 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108488   ⟹   ENSRNOP00000087303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl613,234,513 - 13,270,709 (-)Ensembl
mRatBN7.2 Ensembl67,481,095 - 7,514,834 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134939   ⟹   ENSRNOP00000110665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl613,234,545 - 13,273,883 (-)Ensembl
RefSeq Acc Id: NM_001109274   ⟹   NP_001102744
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8613,235,225 - 13,265,831 (-)NCBI
mRatBN7.267,481,672 - 7,512,277 (-)NCBI
Dahl_SR_JrHsd614,659,475 - 14,690,081 (-)NCBI
Lyon_Normotensive614,099,444 - 14,130,050 (-)NCBI
Lyon_Hypertensive611,886,200 - 11,916,871 (-)NCBI
F344_StmMcwi611,023,732 - 11,054,403 (-)NCBI
Rnor_6.0610,674,371 - 10,704,977 (+)NCBI
Rnor_5.0620,659,713 - 20,697,182 (+)NCBI
RGSC_v3.4610,552,177 - 10,582,783 (+)RGD
Celera67,217,143 - 7,247,749 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239718   ⟹   XP_006239780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8613,235,157 - 13,266,161 (-)NCBI
mRatBN7.267,481,039 - 7,512,644 (-)NCBI
Rnor_6.0610,671,311 - 10,705,610 (+)NCBI
Rnor_5.0620,659,713 - 20,697,182 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063262285   ⟹   XP_063118355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8613,235,157 - 13,266,142 (-)NCBI
RefSeq Acc Id: XM_063262286   ⟹   XP_063118356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8613,235,157 - 13,265,441 (-)NCBI
RefSeq Acc Id: NP_001102744   ⟸   NM_001109274
- UniProtKB: D3ZUE4 (UniProtKB/TrEMBL),   A6H9E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239780   ⟸   XM_006239718
- Peptide Label: isoform X1
- UniProtKB: D3ZUE4 (UniProtKB/TrEMBL),   A6H9E6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020346   ⟸   ENSRNOT00000020337
Ensembl Acc Id: ENSRNOP00000084063   ⟸   ENSRNOT00000094405
Ensembl Acc Id: ENSRNOP00000087303   ⟸   ENSRNOT00000108488
RefSeq Acc Id: XP_063118355   ⟸   XM_063262285
- Peptide Label: isoform X1
- UniProtKB: A6H9E6 (UniProtKB/TrEMBL),   D3ZUE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118356   ⟸   XM_063262286
- Peptide Label: isoform X1
- UniProtKB: A6H9E6 (UniProtKB/TrEMBL),   D3ZUE4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110665   ⟸   ENSRNOT00000134939
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUE4-F1-model_v2 AlphaFold D3ZUE4 1-536 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694391
Promoter ID:EPDNEW_R4916
Type:multiple initiation site
Name:Socs5_1
Description:suppressor of cytokine signaling 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0610,674,364 - 10,674,424EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564914 AgrOrtholog
BioCyc Gene G2FUF-38714 BioCyc
Ensembl Genes ENSRNOG00000028504 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020337.6 UniProtKB/TrEMBL
  ENSRNOT00000094405 ENTREZGENE
  ENSRNOT00000094405.2 UniProtKB/TrEMBL
  ENSRNOT00000108488.2 UniProtKB/TrEMBL
  ENSRNOT00000134939 ENTREZGENE
  ENSRNOT00000134939.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS5_SOCS UniProtKB/TrEMBL
  SOCS_box_dom_like UniProtKB/TrEMBL
  SOCS_C UniProtKB/TrEMBL
KEGG Report rno:500616 UniProtKB/TrEMBL
NCBI Gene 500616 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/TrEMBL
  PTHR10155:SF15 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PhenoGen Socs5 PhenoGen
PROSITE SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028504 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A6H9E6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUE4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Socs5  suppressor of cytokine signaling 5  RGD1564914_predicted  similar to Suppressor of cytokine signaling 5 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564914_predicted  similar to Suppressor of cytokine signaling 5 (predicted)  LOC500616  similar to Suppressor of cytokine signaling 5  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500616  similar to Suppressor of cytokine signaling 5      Symbol and Name status set to provisional 70820 PROVISIONAL