SOCS5 (suppressor of cytokine signaling 5) - Rat Genome Database

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Gene: SOCS5 (suppressor of cytokine signaling 5) Homo sapiens
Analyze
Symbol: SOCS5
Name: suppressor of cytokine signaling 5
RGD ID: 1346055
HGNC Page HGNC:16852
Description: Enables receptor tyrosine kinase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CIS-6; CIS6; Cish5; CISH6; cytokine-inducible SH2 protein 6; cytokine-inducible SH2-containing protein 5; KIAA0671; SOCS-5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC100420748   SOCS5P1   SOCS5P2   SOCS5P3   SOCS5P4   SOCS5P5  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38246,698,937 - 46,763,129 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl246,698,952 - 46,780,245 (+)EnsemblGRCh38hg38GRCh38
GRCh37246,926,076 - 46,990,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,779,603 - 46,843,431 (+)NCBINCBI36Build 36hg18NCBI36
Build 34246,837,999 - 46,901,578NCBI
Celera246,764,784 - 46,828,608 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef246,663,409 - 46,727,912 (+)NCBIHuRef
CHM1_1246,856,418 - 46,920,225 (+)NCBICHM1_1
T2T-CHM13v2.0246,703,485 - 46,767,961 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Lynch syndrome  (IAGP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Inhibitors of cytokine signal transduction. Wormald S and Hilton DJ, J Biol Chem 2004 Jan 9;279(2):821-4. Epub 2003 Nov 7.
Additional References at PubMed
PMID:9419338   PMID:9734811   PMID:10773671   PMID:11230166   PMID:11553846   PMID:11835308   PMID:11837794   PMID:12076535   PMID:12242343   PMID:12477932   PMID:14707129   PMID:14968112  
PMID:15489334   PMID:15590694   PMID:15695332   PMID:16210657   PMID:20137421   PMID:20802378   PMID:20881960   PMID:21048031   PMID:21145461   PMID:21244100   PMID:21685187   PMID:21832049  
PMID:21873635   PMID:21988832   PMID:22081311   PMID:22423360   PMID:22773185   PMID:22973453   PMID:23314748   PMID:23990909   PMID:24255059   PMID:24340963   PMID:24376456   PMID:24728074  
PMID:25017311   PMID:27317770   PMID:28195529   PMID:28196747   PMID:28196914   PMID:28514442   PMID:29117863   PMID:30191950   PMID:30292646   PMID:30974024   PMID:31094455   PMID:31200002  
PMID:31233116   PMID:31406106   PMID:31473323   PMID:31539118   PMID:31741433   PMID:31900314   PMID:32155348   PMID:32211804   PMID:32393512   PMID:32844573   PMID:32894543   PMID:33391546  
PMID:33961781   PMID:34666613   PMID:35121374   PMID:35730472   PMID:37646261   PMID:37672963   PMID:37828534  


Genomics

Comparative Map Data
SOCS5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38246,698,937 - 46,763,129 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl246,698,952 - 46,780,245 (+)EnsemblGRCh38hg38GRCh38
GRCh37246,926,076 - 46,990,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,779,603 - 46,843,431 (+)NCBINCBI36Build 36hg18NCBI36
Build 34246,837,999 - 46,901,578NCBI
Celera246,764,784 - 46,828,608 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef246,663,409 - 46,727,912 (+)NCBIHuRef
CHM1_1246,856,418 - 46,920,225 (+)NCBICHM1_1
T2T-CHM13v2.0246,703,485 - 46,767,961 (+)NCBIT2T-CHM13v2.0
Socs5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,414,707 - 87,445,153 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,415,107 - 87,445,267 (+)EnsemblGRCm39 Ensembl
GRCm381787,107,278 - 87,137,647 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,107,679 - 87,137,839 (+)EnsemblGRCm38mm10GRCm38
MGSCv371787,507,019 - 87,536,925 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361787,016,005 - 87,045,911 (+)NCBIMGSCv36mm8
Celera1791,484,878 - 91,514,794 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.93NCBI
Socs5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,235,157 - 13,266,161 (-)NCBIGRCr8
mRatBN7.267,481,039 - 7,512,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,481,095 - 7,514,834 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx67,762,496 - 7,793,102 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,071,907 - 8,102,513 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,599,021 - 7,629,627 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0610,671,311 - 10,705,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,674,371 - 10,704,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0620,659,713 - 20,697,182 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,552,177 - 10,582,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera67,217,143 - 7,247,749 (-)NCBICelera
Cytogenetic Map6q12NCBI
Socs5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,593,342 - 13,657,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544113,593,342 - 13,657,389 (+)NCBIChiLan1.0ChiLan1.0
SOCS5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21279,514,383 - 79,691,607 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A79,631,595 - 79,696,153 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A46,813,589 - 46,878,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A47,745,216 - 47,808,566 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A47,804,431 - 47,806,041 (+)Ensemblpanpan1.1panPan2
SOCS5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,916,446 - 48,977,183 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,972,842 - 48,974,452 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1048,769,314 - 48,830,770 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01049,786,401 - 49,847,931 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1049,786,357 - 49,845,694 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,494,260 - 49,555,954 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01049,784,343 - 49,845,789 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,967,638 - 50,029,159 (+)NCBIUU_Cfam_GSD_1.0
Socs5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,102,393 - 34,159,407 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,531,002 - 5,587,549 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,531,002 - 5,588,022 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,783,964 - 93,925,863 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1393,777,402 - 93,925,859 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,869,650 - 99,940,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOCS5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,330,192 - 60,335,477 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,431,401 - 60,433,011 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
ChlSab1.1 Ensembl1460,431,401 - 60,433,011 (-)NCBIChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604551,352,938 - 51,515,428 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,150,664 - 28,216,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473828,150,004 - 28,217,850 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SOCS5
37 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1		 pathogenic
GRCh38/hg38 2p22.1-16.1(chr2:40738282-57863821)x3 copy number gain See cases [RCV000052943] Chr2:40738282..57863821 [GRCh38]
Chr2:40965422..58090956 [GRCh37]
Chr2:40818926..57944460 [NCBI36]
Chr2:2p22.1-16.1		 pathogenic
NM_014011.4(SOCS5):c.404C>T (p.Ser135Leu) single nucleotide variant Malignant melanoma [RCV000065611] Chr2:46758934 [GRCh38]
Chr2:46986073 [GRCh37]
Chr2:46839577 [NCBI36]
Chr2:2p21		 not provided
GRCh38/hg38 2p21(chr2:46592232-47488001)x3 copy number gain See cases [RCV000137575] Chr2:46592232..47488001 [GRCh38]
Chr2:46819371..47715140 [GRCh37]
Chr2:46672875..47568644 [NCBI36]
Chr2:2p21		 likely benign
GRCh38/hg38 2p21-16.3(chr2:46415109-48203207)x3 copy number gain See cases [RCV000141883] Chr2:46415109..48203207 [GRCh38]
Chr2:46642248..48430346 [GRCh37]
Chr2:46495752..48283850 [NCBI36]
Chr2:2p21-16.3		 uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p21(chr2:46573689-46732838)x3 copy number gain See cases [RCV000142598] Chr2:46573689..46732838 [GRCh38]
Chr2:46800828..46959977 [GRCh37]
Chr2:46654332..46813481 [NCBI36]
Chr2:2p21		 benign
GRCh37/hg19 2p23.3-16.1(chr2:27861707-60790985)x3 copy number gain See cases [RCV000454271] Chr2:27861707..60790985 [GRCh37]
Chr2:2p23.3-16.1		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NC_000002.11:g.38121110_47669522inv inversion Hereditary nonpolyposis colorectal neoplasms [RCV002231155] Chr2:38121110..47669522 [GRCh37]
Chr2:2p22.2-21		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_144949.3(SOCS5):c.94A>G (p.Met32Val) single nucleotide variant not specified [RCV004321485] Chr2:46758624 [GRCh38]
Chr2:46985763 [GRCh37]
Chr2:2p21		 uncertain significance
GRCh37/hg19 2p22.3-16.1(chr2:34792916-56676541)x3 copy number gain not provided [RCV000682169] Chr2:34792916..56676541 [GRCh37]
Chr2:2p22.3-16.1		 pathogenic
GRCh37/hg19 2p21-16.3(chr2:46978055-48131152)x3 copy number gain not provided [RCV000682118] Chr2:46978055..48131152 [GRCh37]
Chr2:2p21-16.3		 uncertain significance
GRCh37/hg19 2p21(chr2:46557702-47744377)x3 copy number gain not provided [RCV000682119] Chr2:46557702..47744377 [GRCh37]
Chr2:2p21		 uncertain significance
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3		 likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p24.1-16.3(chr2:22665048-52850368)x3 copy number gain not provided [RCV000752875] Chr2:22665048..52850368 [GRCh37]
Chr2:2p24.1-16.3		 pathogenic
NM_144949.3(SOCS5):c.57C>T (p.Phe19=) single nucleotide variant not provided [RCV000893300] Chr2:46758587 [GRCh38]
Chr2:46985726 [GRCh37]
Chr2:2p21		 benign
NM_144949.3(SOCS5):c.1476C>T (p.Ile492=) single nucleotide variant not provided [RCV000966796] Chr2:46760006 [GRCh38]
Chr2:46987145 [GRCh37]
Chr2:2p21		 benign
NM_144949.3(SOCS5):c.1140C>A (p.Pro380=) single nucleotide variant not provided [RCV000883637] Chr2:46759670 [GRCh38]
Chr2:46986809 [GRCh37]
Chr2:2p21		 benign
GRCh37/hg19 2p21(chr2:46179259-47646894)x3 copy number gain not provided [RCV001005255] Chr2:46179259..47646894 [GRCh37]
Chr2:2p21		 uncertain significance
NC_000002.12:g.46722010_46985532dup duplication not specified [RCV001568393] Chr2:46722010..46985532 [GRCh38]
Chr2:2p21		 not provided
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NC_000002.11:g.(?_38121051)_(47710088_?)dup duplication Hereditary nonpolyposis colorectal neoplasms [RCV003122260] Chr2:38121051..47710088 [GRCh37]
Chr2:2p22.2-21		 uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
NM_144949.3(SOCS5):c.17A>G (p.Lys6Arg) single nucleotide variant not specified [RCV004194409] Chr2:46758547 [GRCh38]
Chr2:46985686 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.941G>A (p.Ser314Asn) single nucleotide variant not specified [RCV004242476] Chr2:46759471 [GRCh38]
Chr2:46986610 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.614A>G (p.Lys205Arg) single nucleotide variant not specified [RCV004218521] Chr2:46759144 [GRCh38]
Chr2:46986283 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.499G>A (p.Val167Ile) single nucleotide variant not specified [RCV004242167] Chr2:46759029 [GRCh38]
Chr2:46986168 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.58G>C (p.Gly20Arg) single nucleotide variant not specified [RCV004193602] Chr2:46758588 [GRCh38]
Chr2:46985727 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.584G>A (p.Ser195Asn) single nucleotide variant not specified [RCV004240646] Chr2:46759114 [GRCh38]
Chr2:46986253 [GRCh37]
Chr2:2p21		 likely benign
NM_144949.3(SOCS5):c.854A>G (p.His285Arg) single nucleotide variant not specified [RCV004167717] Chr2:46759384 [GRCh38]
Chr2:46986523 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.472G>C (p.Val158Leu) single nucleotide variant not specified [RCV004078343] Chr2:46759002 [GRCh38]
Chr2:46986141 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.415G>C (p.Asp139His) single nucleotide variant not specified [RCV004106918] Chr2:46758945 [GRCh38]
Chr2:46986084 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.172C>A (p.Pro58Thr) single nucleotide variant not specified [RCV004121663] Chr2:46758702 [GRCh38]
Chr2:46985841 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.151A>G (p.Thr51Ala) single nucleotide variant not specified [RCV004188485] Chr2:46758681 [GRCh38]
Chr2:46985820 [GRCh37]
Chr2:2p21		 likely benign
NM_144949.3(SOCS5):c.1033G>A (p.Gly345Arg) single nucleotide variant not specified [RCV004105223] Chr2:46759563 [GRCh38]
Chr2:46986702 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.244T>G (p.Cys82Gly) single nucleotide variant not specified [RCV004241530] Chr2:46758774 [GRCh38]
Chr2:46985913 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.283G>A (p.Glu95Lys) single nucleotide variant not specified [RCV004091339] Chr2:46758813 [GRCh38]
Chr2:46985952 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.472G>A (p.Val158Ile) single nucleotide variant not specified [RCV004078866] Chr2:46759002 [GRCh38]
Chr2:46986141 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.401G>A (p.Ser134Asn) single nucleotide variant not specified [RCV004147150] Chr2:46758931 [GRCh38]
Chr2:46986070 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.1240C>A (p.Leu414Ile) single nucleotide variant not specified [RCV004116060] Chr2:46759770 [GRCh38]
Chr2:46986909 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.126G>C (p.Glu42Asp) single nucleotide variant not specified [RCV004077679] Chr2:46758656 [GRCh38]
Chr2:46985795 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.1358C>A (p.Thr453Lys) single nucleotide variant not specified [RCV004280918] Chr2:46759888 [GRCh38]
Chr2:46987027 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.182A>C (p.Glu61Ala) single nucleotide variant not specified [RCV004324521] Chr2:46758712 [GRCh38]
Chr2:46985851 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.1510C>T (p.Leu504Phe) single nucleotide variant not specified [RCV004265231] Chr2:46760040 [GRCh38]
Chr2:46987179 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.527C>G (p.Ser176Cys) single nucleotide variant not specified [RCV004337459] Chr2:46759057 [GRCh38]
Chr2:46986196 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.56T>A (p.Phe19Tyr) single nucleotide variant not specified [RCV004347067] Chr2:46758586 [GRCh38]
Chr2:46985725 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.1021C>T (p.Arg341Cys) single nucleotide variant not specified [RCV004363888] Chr2:46759551 [GRCh38]
Chr2:46986690 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.502T>G (p.Ser168Ala) single nucleotide variant not specified [RCV004464780] Chr2:46759032 [GRCh38]
Chr2:46986171 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.1532A>T (p.Gln511Leu) single nucleotide variant not specified [RCV004464777] Chr2:46760062 [GRCh38]
Chr2:46987201 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.985A>G (p.Thr329Ala) single nucleotide variant not specified [RCV004464788] Chr2:46759515 [GRCh38]
Chr2:46986654 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.533G>C (p.Arg178Thr) single nucleotide variant not specified [RCV004464781] Chr2:46759063 [GRCh38]
Chr2:46986202 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.953C>T (p.Pro318Leu) single nucleotide variant not specified [RCV004464787] Chr2:46759483 [GRCh38]
Chr2:46986622 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.1031C>T (p.Ser344Phe) single nucleotide variant not specified [RCV004464776] Chr2:46759561 [GRCh38]
Chr2:46986700 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.883C>T (p.Pro295Ser) single nucleotide variant not specified [RCV004464785] Chr2:46759413 [GRCh38]
Chr2:46986552 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.433A>G (p.Thr145Ala) single nucleotide variant not specified [RCV004464779] Chr2:46758963 [GRCh38]
Chr2:46986102 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.613A>G (p.Lys205Glu) single nucleotide variant not specified [RCV004464783] Chr2:46759143 [GRCh38]
Chr2:46986282 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.1027A>T (p.Ile343Leu) single nucleotide variant not specified [RCV004464775] Chr2:46759557 [GRCh38]
Chr2:46986696 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.842A>G (p.Asn281Ser) single nucleotide variant not specified [RCV004464784] Chr2:46759372 [GRCh38]
Chr2:46986511 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.1448G>A (p.Ser483Asn) single nucleotide variant not specified [RCV004349863] Chr2:46759978 [GRCh38]
Chr2:46987117 [GRCh37]
Chr2:2p21		 uncertain significance
NM_144949.3(SOCS5):c.58G>A (p.Gly20Ser) single nucleotide variant not specified [RCV004286052] Chr2:46758588 [GRCh38]
Chr2:46985727 [GRCh37]
Chr2:2p21		 likely benign
NM_144949.3(SOCS5):c.313G>A (p.Gly105Arg) single nucleotide variant not specified [RCV004256227] Chr2:46758843 [GRCh38]
Chr2:46985982 [GRCh37]
Chr2:2p21		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1807
Count of miRNA genes:633
Interacting mature miRNAs:716
Transcripts:ENST00000306503, ENST00000394861
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH69870  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37246,989,238 - 46,989,401UniSTSGRCh37
Build 36246,842,742 - 46,842,905RGDNCBI36
Celera246,827,919 - 46,828,082RGD
Cytogenetic Map2p21UniSTS
HuRef246,727,223 - 46,727,386UniSTS
GeneMap99-GB4 RH Map2142.44UniSTS
SHGC-144045  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37246,942,055 - 46,942,245UniSTSGRCh37
Build 36246,795,559 - 46,795,749RGDNCBI36
Celera246,780,740 - 46,780,930RGD
Cytogenetic Map2p21UniSTS
HuRef246,679,558 - 46,679,748UniSTS
TNG Radiation Hybrid Map29981.0UniSTS
SOCS5_1721  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37246,987,926 - 46,988,796UniSTSGRCh37
Build 36246,841,430 - 46,842,300RGDNCBI36
Celera246,826,607 - 46,827,477RGD
HuRef246,725,911 - 46,726,781UniSTS
RH69691  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37246,989,375 - 46,989,533UniSTSGRCh37
Build 36246,842,879 - 46,843,037RGDNCBI36
Celera246,828,056 - 46,828,214RGD
Cytogenetic Map2p21UniSTS
HuRef246,727,360 - 46,727,518UniSTS
GeneMap99-GB4 RH Map2142.44UniSTS
NCBI RH Map2291.6UniSTS
A009L30  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37246,942,235 - 46,942,339UniSTSGRCh37
Build 36246,795,739 - 46,795,843RGDNCBI36
Celera246,780,920 - 46,781,024RGD
Cytogenetic Map2p21UniSTS
HuRef246,679,738 - 46,679,842UniSTS
GeneMap99-GB4 RH Map2142.44UniSTS
NCBI RH Map2291.6UniSTS
G32655  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37246,942,235 - 46,942,339UniSTSGRCh37
Celera246,780,920 - 46,781,024UniSTS
Cytogenetic Map2p21UniSTS
HuRef246,679,738 - 46,679,842UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1698 1492 1042 191 525 83 2747 935 1663 242 1295 1469 121 1088 1614 2
Low 740 1441 684 433 1369 381 1609 1261 2071 176 163 144 54 1 116 1174 3 2
Below cutoff 57 57 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000306503   ⟹   ENSP00000305133
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl246,698,952 - 46,763,129 (+)Ensembl
RefSeq Acc Id: ENST00000394861   ⟹   ENSP00000378330
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl246,699,295 - 46,763,129 (+)Ensembl
RefSeq Acc Id: ENST00000568862
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl246,777,783 - 46,780,245 (+)Ensembl
RefSeq Acc Id: ENST00000650009   ⟹   ENSP00000497526
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl246,759,747 - 46,780,244 (+)Ensembl
RefSeq Acc Id: NM_014011   ⟹   NP_054730
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38246,698,937 - 46,763,129 (+)NCBI
GRCh37246,926,099 - 46,989,927 (+)ENTREZGENE
Build 36246,779,603 - 46,843,431 (+)NCBI Archive
HuRef246,663,409 - 46,727,912 (+)ENTREZGENE
CHM1_1246,856,418 - 46,920,225 (+)NCBI
T2T-CHM13v2.0246,703,485 - 46,767,961 (+)NCBI
Sequence:
RefSeq Acc Id: NM_144949   ⟹   NP_659198
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38246,699,295 - 46,763,129 (+)NCBI
GRCh37246,926,099 - 46,989,927 (+)ENTREZGENE
Build 36246,779,853 - 46,843,431 (+)NCBI Archive
HuRef246,663,409 - 46,727,912 (+)ENTREZGENE
CHM1_1246,856,668 - 46,920,225 (+)NCBI
T2T-CHM13v2.0246,703,843 - 46,767,961 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_054730   ⟸   NM_014011
- UniProtKB: Q53SD4 (UniProtKB/Swiss-Prot),   Q8IYZ4 (UniProtKB/Swiss-Prot),   O75159 (UniProtKB/Swiss-Prot),   B4DL10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_659198   ⟸   NM_144949
- UniProtKB: Q53SD4 (UniProtKB/Swiss-Prot),   Q8IYZ4 (UniProtKB/Swiss-Prot),   O75159 (UniProtKB/Swiss-Prot),   B4DL10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000305133   ⟸   ENST00000306503
RefSeq Acc Id: ENSP00000497526   ⟸   ENST00000650009
RefSeq Acc Id: ENSP00000378330   ⟸   ENST00000394861
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O75159-F1-model_v2 AlphaFold O75159 1-536 view protein structure

Promoters
RGD ID:6860238
Promoter ID:EPDNEW_H3284
Type:initiation region
Name:SOCS5_1
Description:suppressor of cytokine signaling 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3285  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38246,698,937 - 46,698,997EPDNEW
RGD ID:6860240
Promoter ID:EPDNEW_H3285
Type:initiation region
Name:SOCS5_2
Description:suppressor of cytokine signaling 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3284  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38246,699,249 - 46,699,309EPDNEW
RGD ID:6798218
Promoter ID:HG_KWN:32525
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000250791,   OTTHUMT00000323197
Position:
Human AssemblyChrPosition (strand)Source
Build 36246,779,326 - 46,780,082 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16852 AgrOrtholog
COSMIC SOCS5 COSMIC
Ensembl Genes ENSG00000171150 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000306503 ENTREZGENE
  ENST00000306503.5 UniProtKB/Swiss-Prot
  ENST00000394861 ENTREZGENE
  ENST00000394861.3 UniProtKB/Swiss-Prot
  ENST00000650009.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000171150 GTEx
HGNC ID HGNC:16852 ENTREZGENE
Human Proteome Map SOCS5 Human Proteome Map
InterPro SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS4/SOCS5_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS5_SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9655 UniProtKB/Swiss-Prot
NCBI Gene 9655 ENTREZGENE
OMIM 607094 OMIM
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10155:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134884627 PharmGKB
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SOCS box-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B3ISP4_HUMAN UniProtKB/TrEMBL
  B4DL10 ENTREZGENE, UniProtKB/TrEMBL
  O75159 ENTREZGENE
  Q53SD4 ENTREZGENE
  Q8IYZ4 ENTREZGENE
  SOCS5_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q53SD4 UniProtKB/Swiss-Prot
  Q8IYZ4 UniProtKB/Swiss-Prot