Mef2c (myocyte enhancer factor 2C) - Rat Genome Database

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Gene: Mef2c (myocyte enhancer factor 2C) Rattus norvegicus
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Symbol: Mef2c
Name: myocyte enhancer factor 2C
RGD ID: 1563119
Description: Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including dentate gyrus development; response to ischemia; and transdifferentiation. Located in cytosol; nucleus; and sarcomere. Used to study myocardial infarction. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language. Orthologous to human MEF2C (myocyte enhancer factor 2C); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC499497; LOC685671; myocyte-specific enhancer factor 2C; RGD1563119; similar to MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C); similar to myocyte enhancer factor 2C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8215,708,732 - 15,871,639 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl215,708,924 - 15,871,640 (+)EnsemblGRCr8
mRatBN7.2213,973,299 - 14,136,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl213,993,438 - 14,132,880 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx221,055,034 - 21,197,306 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0219,155,243 - 19,297,527 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0213,828,879 - 13,971,209 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0211,658,534 - 11,822,788 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl211,658,568 - 11,822,787 (+)Ensemblrn6Rnor6.0
Rnor_5.0211,521,053 - 11,684,949 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4212,331,078 - 12,346,520 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera210,288,159 - 10,449,731 (+)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acadesine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
caffeine  (EXP)
cannabidiol  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dantrolene  (EXP)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
gentamycin  (EXP)
Goe 6976  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
isoxazoles  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
metformin  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
resveratrol  (ISO)
rimonabant  (ISO)
rofecoxib  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spermine  (ISO)
streptozocin  (ISO)
succimer  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
AMPA selective glutamate receptor signaling pathway  (ISO,ISS)
apoptotic process  (IEA)
axon guidance  (ISO)
B cell homeostasis  (ISO,ISS)
B cell proliferation  (ISO,ISS)
B cell receptor signaling pathway  (ISO,ISS)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac ventricle formation  (ISO)
cartilage morphogenesis  (ISO)
cell differentiation  (IBA,IEA)
cell fate commitment  (ISO)
cell morphogenesis involved in neuron differentiation  (ISO,ISS)
cellular response to calcium ion  (ISO,ISS)
cellular response to fluid shear stress  (ISO,ISS)
cellular response to glucose stimulus  (IEP)
cellular response to growth factor stimulus  (IDA)
cellular response to lipopolysaccharide  (ISO,ISS)
cellular response to parathyroid hormone stimulus  (ISO,ISS)
cellular response to retinoic acid  (IDA)
cellular response to transforming growth factor beta stimulus  (ISO,ISS)
cellular response to trichostatin A  (ISO,ISS)
cellular response to xenobiotic stimulus  (ISO,ISS)
chondrocyte differentiation  (ISO)
dentate gyrus development  (IEP)
DNA-templated transcription  (IEA)
embryonic heart tube development  (ISO)
embryonic skeletal system morphogenesis  (ISO)
embryonic viscerocranium morphogenesis  (ISO)
endochondral ossification  (ISO)
epithelial cell proliferation involved in renal tubule morphogenesis  (ISO,ISS)
excitatory postsynaptic potential  (ISO,ISS)
gene expression  (ISO)
germinal center formation  (ISO,ISS)
glomerulus morphogenesis  (ISO,ISS)
heart development  (IBA,IEA,IEP,ISO)
heart looping  (ISO,ISS)
humoral immune response  (ISO,ISS)
learning or memory  (ISO,ISS)
MAPK cascade  (ISO,ISS)
melanocyte differentiation  (ISO,ISS)
monocyte differentiation  (ISO)
muscle cell fate determination  (ISO)
myotube differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO,ISS)
negative regulation of neuron apoptotic process  (IDA,ISO,ISS)
negative regulation of ossification  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
nephron tubule epithelial cell differentiation  (ISO,ISS)
nervous system development  (IEA)
neural crest cell differentiation  (ISO,ISS)
neuron development  (ISO,ISS)
neuron differentiation  (ISO,ISS)
neuron migration  (ISO,ISS)
NMDA selective glutamate receptor signaling pathway  (ISO,ISS)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
platelet formation  (ISO,ISS)
positive regulation of B cell proliferation  (ISO,ISS)
positive regulation of behavioral fear response  (ISO,ISS)
positive regulation of bone mineralization  (ISO,ISS)
positive regulation of cardiac muscle cell differentiation  (ISO,ISS)
positive regulation of cardiac muscle cell proliferation  (ISO,ISS)
positive regulation of cardiac muscle hypertrophy  (IMP)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of DNA-templated transcription  (IDA,IEA,IMP,ISO)
positive regulation of gene expression  (ISO)
positive regulation of macrophage apoptotic process  (ISO,ISS)
positive regulation of MAPK cascade  (IDA)
positive regulation of myoblast differentiation  (ISO,ISS)
positive regulation of neuron differentiation  (ISO,ISS)
positive regulation of osteoblast differentiation  (ISO,ISS)
positive regulation of skeletal muscle cell differentiation  (ISO,ISS)
positive regulation of skeletal muscle tissue development  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,IMP,ISO,ISS)
primary heart field specification  (ISO,ISS)
regulation of dendritic spine development  (ISO,ISS)
regulation of DNA-templated transcription  (ISO)
regulation of germinal center formation  (ISO,ISS)
regulation of megakaryocyte differentiation  (ISO,ISS)
regulation of neuron apoptotic process  (ISO,ISS)
regulation of neurotransmitter secretion  (ISO,ISS)
regulation of sarcomere organization  (ISO)
regulation of synapse assembly  (ISO)
regulation of synaptic activity  (ISO,ISS)
regulation of synaptic plasticity  (ISO,ISS)
regulation of synaptic transmission, glutamatergic  (ISO)
renal tubule morphogenesis  (ISO,ISS)
response to ischemia  (IDA)
response to nutrient levels  (IEP)
response to vitamin E  (IEP)
roof of mouth development  (ISO)
secondary heart field specification  (ISO,ISS)
semaphorin-plexin signaling pathway  (ISO)
sinoatrial valve morphogenesis  (ISO,ISS)
skeletal muscle cell differentiation  (ISO)
skeletal muscle tissue development  (ISO)
smooth muscle cell differentiation  (ISO)
sympathetic neuron axon guidance  (ISO)
transdifferentiation  (IMP)
ventricular cardiac muscle cell differentiation  (ISO,ISS)

Cellular Component
cytoplasm  (ISO)
cytosol  (IDA)
nuclear speck  (ISO)
nucleus  (IDA,IEA,ISO)
postsynapse  (IEA)
protein-containing complex  (ISO,ISS)
sarcomere  (IDA)
sarcoplasm  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Obesogenic high fat western diet induces oxidative stress and apoptosis in rat heart. Ballal K, etal., Mol Cell Biochem. 2010 Nov;344(1-2):221-30. Epub 2010 Jul 31.
2. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Feng B, etal., Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1119-26. Epub 2008 Apr 15.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57. Kobarg CB, etal., FEBS Lett. 2005 May 9;579(12):2615-22. Epub 2005 Apr 8.
5. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Leupin O, etal., J Bone Miner Res. 2007 Dec;22(12):1957-67.
6. The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling. Munoz JP, etal., Biochem Biophys Res Commun. 2009 Oct 9;388(1):155-60. Epub 2009 Aug 3.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice. Pereira AH, etal., PLoS One. 2009 Dec 29;4(12):e8472.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Poizat C, etal., Mol Cell Biol. 2000 Dec;20(23):8643-54.
11. Activation of p38/MEF2C pathway by all-trans retinoic acid in cardiac myoblasts. Ren X, etal., Life Sci. 2007 Jun 20;81(2):89-96. Epub 2007 May 13.
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Vitamin E in heart transplantation: effects on cardiac gene expression. Schulte I, etal., Transplantation. 2006 Mar 15;81(5):736-45.
15. Myocyte-specific enhancer binding factor 2C (MEF2C) expression in the dentate gyrus during development and after pilocarpine-induced status epilepticus: a preliminary report. Scorza CA, etal., Arq Neuropsiquiatr. 2008 Sep;66(3B):731-5.
16. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. Suzaki Y, etal., J Biol Chem. 2002 Mar 15;277(11):9614-21. Epub 2002 Jan 8.
17. The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats. Wang RM, etal., Brain Res. 2009 Feb 19;1255:32-41. doi: 10.1016/j.brainres.2008.12.011. Epub 2008 Dec 11.
18. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. Xu J, etal., J Biol Chem. 2006 Apr 7;281(14):9152-62. Epub 2006 Feb 9.
19. Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2C regulates myocardial gene expression. Zang MX, etal., J Biol Chem. 2004 Dec 24;279(52):54258-63. Epub 2004 Oct 14.
20. Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C. Zang MX, etal., J Cell Biochem. 2004 Dec 15;93(6):1255-66.
21. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Zhang Y, etal., Aquat Toxicol. 2013 Jul 29;142-143C:26-32. doi: 10.1016/j.aquatox.2013.07.014.
Additional References at PubMed
PMID:7677753   PMID:7760790   PMID:8035824   PMID:8455629   PMID:8506376   PMID:8668199   PMID:8900141   PMID:9162005   PMID:9738004   PMID:9770491   PMID:9778514   PMID:9857019  
PMID:9858528   PMID:10395786   PMID:10458488   PMID:10531040   PMID:10983972   PMID:11081517   PMID:11160896   PMID:11554755   PMID:11744164   PMID:12130539   PMID:14515274   PMID:14762206  
PMID:15735306   PMID:15743821   PMID:15890826   PMID:15998798   PMID:16043483   PMID:16140986   PMID:16510869   PMID:16680724   PMID:16775627   PMID:16818234   PMID:17336904   PMID:17352741  
PMID:17420000   PMID:17786239   PMID:17875930   PMID:18079734   PMID:18086704   PMID:18093911   PMID:18278031   PMID:18326819   PMID:18438409   PMID:18579729   PMID:18599437   PMID:18599438  
PMID:18955699   PMID:19035347   PMID:19169261   PMID:19204083   PMID:19211936   PMID:19477969   PMID:19796622   PMID:20181743   PMID:20399744   PMID:20691899   PMID:21170291   PMID:21556048  
PMID:21610032   PMID:21652706   PMID:21954104   PMID:22147266   PMID:22275376   PMID:22496871   PMID:23328440   PMID:23632743   PMID:24008018   PMID:25287062   PMID:25931508   PMID:26184978  
PMID:27427476   PMID:28473466   PMID:28799067  


Genomics

Comparative Map Data
Mef2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8215,708,732 - 15,871,639 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl215,708,924 - 15,871,640 (+)EnsemblGRCr8
mRatBN7.2213,973,299 - 14,136,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl213,993,438 - 14,132,880 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx221,055,034 - 21,197,306 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0219,155,243 - 19,297,527 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0213,828,879 - 13,971,209 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0211,658,534 - 11,822,788 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl211,658,568 - 11,822,787 (+)Ensemblrn6Rnor6.0
Rnor_5.0211,521,053 - 11,684,949 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4212,331,078 - 12,346,520 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera210,288,159 - 10,449,731 (+)NCBICelera
Cytogenetic Map2q11NCBI
MEF2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38588,717,117 - 88,904,105 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl588,717,117 - 88,904,257 (-)Ensemblhg38GRCh38
GRCh37588,012,934 - 88,199,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36588,051,922 - 88,214,780 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34588,051,921 - 88,214,780NCBI
Celera583,907,023 - 84,092,551 (-)NCBICelera
Cytogenetic Map5q14.3NCBI
HuRef583,218,989 - 83,404,187 (-)NCBIHuRef
CHM1_1587,447,103 - 87,632,656 (-)NCBICHM1_1
T2T-CHM13v2.0589,198,250 - 89,385,215 (-)NCBIT2T-CHM13v2.0
Mef2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391383,652,136 - 83,815,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1383,652,153 - 83,815,199 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381383,504,017 - 83,667,079 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1383,504,034 - 83,667,080 (+)Ensemblmm10GRCm38
MGSCv371383,643,033 - 83,806,684 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361383,981,532 - 84,141,286 (+)NCBIMGSCv36mm8
Celera1385,760,645 - 85,921,930 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1343.68NCBI
Mef2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541822,537,285 - 22,701,434 (+)Ensembl
ChiLan1.0NW_00495541822,537,388 - 22,701,434 (+)NCBIChiLan1.0ChiLan1.0
MEF2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2426,505,226 - 26,675,705 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1524,658,850 - 24,829,329 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0526,480,489 - 26,650,813 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1526,620,837 - 26,786,426 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl526,681,700 - 26,786,426 (+)EnsemblpanPan2panpan1.1
MEF2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1319,778,997 - 19,948,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl319,779,007 - 19,943,852 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha321,145,574 - 21,314,826 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0319,687,661 - 19,856,893 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl319,687,680 - 19,856,891 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1319,665,907 - 19,834,881 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0319,629,618 - 19,798,838 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0319,916,077 - 20,085,117 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mef2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213175,400,303 - 175,565,279 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364697,060,480 - 7,204,661 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364697,060,480 - 7,225,497 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEF2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl296,124,168 - 96,296,810 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1296,122,407 - 96,296,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2298,794,388 - 98,885,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MEF2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1482,702,378 - 82,887,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl482,706,738 - 82,788,152 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604931,746,488 - 31,916,073 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mef2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247438,072,673 - 8,235,252 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247438,072,871 - 8,235,174 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mef2c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13212,020,968 - 212,165,328 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mef2c
1047 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:112
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000041296, ENSRNOT00000041538, ENSRNOT00000047689
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358125054526Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat

Markers in Region
AU047435  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2213,978,829 - 13,978,972 (+)MAPPERmRatBN7.2
Rnor_6.0211,664,081 - 11,664,223NCBIRnor6.0
Rnor_5.0211,526,561 - 11,526,703UniSTSRnor5.0
RGSC_v3.4212,104,196 - 12,104,338UniSTSRGSC3.4
Celera210,293,706 - 10,293,848UniSTS
Cytogenetic Map2q11UniSTS
RH133929  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2214,133,156 - 14,133,367 (+)MAPPERmRatBN7.2
Rnor_6.0211,819,881 - 11,820,091NCBIRnor6.0
Rnor_5.0211,682,042 - 11,682,252UniSTSRnor5.0
RGSC_v3.4212,329,295 - 12,329,505UniSTSRGSC3.4
Celera210,446,824 - 10,447,034UniSTS
Cytogenetic Map2q11UniSTS
AV011172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2214,133,156 - 14,133,298 (+)MAPPERmRatBN7.2
Rnor_6.0211,819,881 - 11,820,022NCBIRnor6.0
Rnor_5.0211,682,042 - 11,682,183UniSTSRnor5.0
Celera210,446,824 - 10,446,965UniSTS
Cytogenetic Map2q11UniSTS
G10647  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2214,132,095 - 14,132,332 (+)MAPPERmRatBN7.2
Rnor_6.0211,818,820 - 11,819,056NCBIRnor6.0
Rnor_5.0211,680,981 - 11,681,217UniSTSRnor5.0
RGSC_v3.4212,330,330 - 12,330,566UniSTSRGSC3.4
Celera210,445,763 - 10,445,999UniSTS
Cytogenetic Map2q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001399397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000075931   ⟹   ENSRNOP00000067970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl215,708,924 - 15,871,638 (+)Ensembl
mRatBN7.2 Ensembl213,993,438 - 14,132,614 (+)Ensembl
Rnor_6.0 Ensembl211,658,568 - 11,819,436 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076084   ⟹   ENSRNOP00000068421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl211,658,568 - 11,820,093 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076136   ⟹   ENSRNOP00000068094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl215,729,051 - 15,871,638 (+)Ensembl
mRatBN7.2 Ensembl213,993,438 - 14,132,614 (+)Ensembl
Rnor_6.0 Ensembl211,658,568 - 11,819,436 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076230   ⟹   ENSRNOP00000068527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl213,993,466 - 14,132,880 (+)Ensembl
Rnor_6.0 Ensembl211,658,568 - 11,820,093 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076239   ⟹   ENSRNOP00000068373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl211,658,568 - 11,822,787 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076408   ⟹   ENSRNOP00000068328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl211,658,568 - 11,818,308 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076416   ⟹   ENSRNOP00000068323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl211,658,568 - 11,818,308 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076481   ⟹   ENSRNOP00000067963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl215,728,513 - 15,871,640 (+)Ensembl
mRatBN7.2 Ensembl213,993,438 - 14,132,614 (+)Ensembl
Rnor_6.0 Ensembl211,658,568 - 11,820,075 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076710   ⟹   ENSRNOP00000068307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl211,658,568 - 11,820,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076992   ⟹   ENSRNOP00000067948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl215,708,924 - 15,871,638 (+)Ensembl
mRatBN7.2 Ensembl213,993,438 - 14,132,235 (+)Ensembl
Rnor_6.0 Ensembl211,658,568 - 11,818,989 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122974   ⟹   ENSRNOP00000099728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl215,708,924 - 15,871,638 (+)Ensembl
RefSeq Acc Id: NM_001399397   ⟹   NP_001386326
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,729,015 - 15,871,639 (+)NCBI
mRatBN7.2213,993,426 - 14,136,065 (+)NCBI
RefSeq Acc Id: NM_001399399   ⟹   NP_001386328
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,729,015 - 15,871,639 (+)NCBI
mRatBN7.2213,993,426 - 14,136,065 (+)NCBI
RefSeq Acc Id: XM_006231733   ⟹   XP_006231795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,777,758 - 15,871,639 (+)NCBI
mRatBN7.2214,042,155 - 14,131,584 (+)NCBI
Rnor_6.0211,727,917 - 11,822,788 (+)NCBI
Rnor_5.0211,521,053 - 11,684,949 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591163   ⟹   XP_017446652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,708,732 - 15,871,639 (+)NCBI
mRatBN7.2213,973,302 - 14,131,584 (+)NCBI
Rnor_6.0211,658,535 - 11,822,788 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103393   ⟹   XP_038959321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,797 - 15,871,639 (+)NCBI
mRatBN7.2213,993,205 - 14,131,584 (+)NCBI
RefSeq Acc Id: XM_039103394   ⟹   XP_038959322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,708,732 - 15,871,639 (+)NCBI
mRatBN7.2213,973,299 - 14,131,584 (+)NCBI
RefSeq Acc Id: XM_039103395   ⟹   XP_038959323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,748 - 15,871,639 (+)NCBI
mRatBN7.2213,993,215 - 14,136,065 (+)NCBI
RefSeq Acc Id: XM_039103397   ⟹   XP_038959325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,748 - 15,871,639 (+)NCBI
mRatBN7.2213,993,213 - 14,131,584 (+)NCBI
RefSeq Acc Id: XM_039103399   ⟹   XP_038959327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,802 - 15,871,639 (+)NCBI
mRatBN7.2213,993,212 - 14,136,065 (+)NCBI
RefSeq Acc Id: XM_039103401   ⟹   XP_038959329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,797 - 15,871,639 (+)NCBI
mRatBN7.2213,993,206 - 14,131,584 (+)NCBI
RefSeq Acc Id: XM_039103403   ⟹   XP_038959331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,800 - 15,871,639 (+)NCBI
mRatBN7.2213,993,208 - 14,131,584 (+)NCBI
RefSeq Acc Id: XM_063282314   ⟹   XP_063138384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,777,762 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282315   ⟹   XP_063138385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,523 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282316   ⟹   XP_063138386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,708,732 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282317   ⟹   XP_063138387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,708,732 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282318   ⟹   XP_063138388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,777,704 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282319   ⟹   XP_063138389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,500 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282320   ⟹   XP_063138390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,708,732 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282321   ⟹   XP_063138391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,708,732 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282322   ⟹   XP_063138392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,708,732 - 15,871,639 (+)NCBI
RefSeq Acc Id: XM_063282323   ⟹   XP_063138393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8215,728,799 - 15,871,639 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386326 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386328 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231795 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446652 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959321 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959322 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959323 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959325 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959327 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959329 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959331 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138384 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138385 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138386 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138387 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138388 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138389 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138390 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138391 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138392 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138393 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A096MJY4 (Get FASTA)   NCBI Sequence Viewer  
  EDM09957 (Get FASTA)   NCBI Sequence Viewer  
  EDM09958 (Get FASTA)   NCBI Sequence Viewer  
  EDM09959 (Get FASTA)   NCBI Sequence Viewer  
  EDM09960 (Get FASTA)   NCBI Sequence Viewer  
  EDM09961 (Get FASTA)   NCBI Sequence Viewer  
  EDM09962 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067948
  ENSRNOP00000067963
  ENSRNOP00000067970
  ENSRNOP00000068094
  ENSRNOP00000099728
RefSeq Acc Id: XP_006231795   ⟸   XM_006231733
- Peptide Label: isoform X1
- UniProtKB: A0A096MJY4 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446652   ⟸   XM_017591163
- Peptide Label: isoform X1
- UniProtKB: A0A096MJY4 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067970   ⟸   ENSRNOT00000075931
Ensembl Acc Id: ENSRNOP00000067948   ⟸   ENSRNOT00000076992
Ensembl Acc Id: ENSRNOP00000068373   ⟸   ENSRNOT00000076239
Ensembl Acc Id: ENSRNOP00000068527   ⟸   ENSRNOT00000076230
Ensembl Acc Id: ENSRNOP00000068094   ⟸   ENSRNOT00000076136
Ensembl Acc Id: ENSRNOP00000068421   ⟸   ENSRNOT00000076084
Ensembl Acc Id: ENSRNOP00000068307   ⟸   ENSRNOT00000076710
Ensembl Acc Id: ENSRNOP00000067963   ⟸   ENSRNOT00000076481
Ensembl Acc Id: ENSRNOP00000068323   ⟸   ENSRNOT00000076416
Ensembl Acc Id: ENSRNOP00000068328   ⟸   ENSRNOT00000076408
RefSeq Acc Id: XP_038959322   ⟸   XM_039103394
- Peptide Label: isoform X2
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959321   ⟸   XM_039103393
- Peptide Label: isoform X2
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959329   ⟸   XM_039103401
- Peptide Label: isoform X8
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959331   ⟸   XM_039103403
- Peptide Label: isoform X10
- UniProtKB: A0A096MJD9 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959327   ⟸   XM_039103399
- Peptide Label: isoform X7
- UniProtKB: A0A096MJ29 (UniProtKB/TrEMBL),   A6I4K4 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959325   ⟸   XM_039103397
- Peptide Label: isoform X5
- UniProtKB: A0A096MJ23 (UniProtKB/TrEMBL),   A6I4J9 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959323   ⟸   XM_039103395
- Peptide Label: isoform X3
- UniProtKB: A6I4K3 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386326   ⟸   NM_001399397
- Peptide Label: isoform 1
- UniProtKB: A0A096MJY4 (UniProtKB/Swiss-Prot),   A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386328   ⟸   NM_001399399
- Peptide Label: isoform 2
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138387   ⟸   XM_063282317
- Peptide Label: isoform X6
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138386   ⟸   XM_063282316
- Peptide Label: isoform X4
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138390   ⟸   XM_063282320
- Peptide Label: isoform X7
- UniProtKB: A0A096MJ29 (UniProtKB/TrEMBL),   A6I4K4 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138391   ⟸   XM_063282321
- Peptide Label: isoform X9
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138392   ⟸   XM_063282322
- Peptide Label: isoform X11
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138389   ⟸   XM_063282319
- Peptide Label: isoform X6
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138385   ⟸   XM_063282315
- Peptide Label: isoform X3
- UniProtKB: A6I4K3 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138393   ⟸   XM_063282323
- Peptide Label: isoform X12
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138388   ⟸   XM_063282318
- Peptide Label: isoform X6
- UniProtKB: A0A096MKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138384   ⟸   XM_063282314
- Peptide Label: isoform X3
- UniProtKB: A6I4K3 (UniProtKB/TrEMBL),   A0A096MKI4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099728   ⟸   ENSRNOT00000122974
Protein Domains
MADS-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MJY4-F1-model_v2 AlphaFold A0A096MJY4 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691064
Promoter ID:EPDNEW_R1572
Type:initiation region
Name:Mef2c_1
Description:myocyte enhancer factor 2C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0211,658,583 - 11,658,643EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563119 AgrOrtholog
BioCyc Gene G2FUF-54978 BioCyc
Ensembl Genes ENSRNOG00000033134 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000075931 ENTREZGENE
  ENSRNOT00000076136 ENTREZGENE
  ENSRNOT00000076481 ENTREZGENE
  ENSRNOT00000076992 ENTREZGENE
  ENSRNOT00000122974 ENTREZGENE
Gene3D-CATH 3.40.1810.10 UniProtKB/Swiss-Prot
InterPro HJURP_C UniProtKB/Swiss-Prot
  MADS_MEF2-like UniProtKB/Swiss-Prot
  TF_MADSbox UniProtKB/Swiss-Prot
  TF_MADSbox_sf UniProtKB/Swiss-Prot
NCBI Gene 499497 ENTREZGENE
PANTHER MADS BOX PROTEIN UniProtKB/Swiss-Prot
  MYOCYTE-SPECIFIC ENHANCER FACTOR 2 UniProtKB/Swiss-Prot
Pfam HJURP_C UniProtKB/Swiss-Prot
  SRF-TF UniProtKB/Swiss-Prot
PhenoGen Mef2c PhenoGen
PRINTS MADSDOMAIN UniProtKB/Swiss-Prot
PROSITE MADS_BOX_1 UniProtKB/Swiss-Prot
  MADS_BOX_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033134 RatGTEx
SMART MADS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55455 UniProtKB/Swiss-Prot
UniProt A0A096MJ09_RAT UniProtKB/TrEMBL
  A0A096MJ23 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MJ29 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MJD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MJY4 ENTREZGENE
  A0A096MKI4 ENTREZGENE
  A0ABK0L6U2_RAT UniProtKB/TrEMBL
  A6I4J9 ENTREZGENE, UniProtKB/TrEMBL
  A6I4K3 ENTREZGENE, UniProtKB/TrEMBL
  A6I4K4 ENTREZGENE, UniProtKB/TrEMBL
  MEF2C_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Mef2c  myocyte enhancer factor 2C  LOC685671  similar to myocyte enhancer factor 2C  Data merged from RGD:1591342 737654 PROVISIONAL
2008-03-07 Mef2c  myocyte enhancer factor 2C  RGD1563119_predicted  similar to MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685671  similar to myocyte enhancer factor 2C      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-10 RGD1563119_predicted  similar to MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) (predicted)      Name updated 1299863 APPROVED
2006-03-07 RGD1563119_predicted  similar to MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) (predicted)  LOC499497  similar to MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499497  similar to MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)      Symbol and Name status set to provisional 70820 PROVISIONAL