Pou2af2 (POU class 2 homeobox associating factor 2) - Rat Genome Database

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Gene: Pou2af2 (POU class 2 homeobox associating factor 2) Rattus norvegicus
Analyze
Symbol: Pou2af2
Name: POU class 2 homeobox associating factor 2
RGD ID: 1562914
Description: Predicted to enable sequence-specific DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human POU2AF2 (POU class 2 homeobox associating factor 2); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC500997; POU domain class 2-associating factor 2; POU domain, class 2, associating factor 2; RGD1562914; uncharacterized protein C11orf53 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8860,504,292 - 60,544,996 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl860,504,152 - 60,545,000 (-)EnsemblGRCr8
mRatBN7.2851,607,780 - 51,648,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,607,763 - 51,648,628 (-)EnsemblmRatBN7.2
Rnor_6.0855,693,820 - 55,696,856 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,694,804 - 55,696,601 (-)Ensemblrn6Rnor6.0
Rnor_5.0854,288,887 - 54,330,073 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4854,621,532 - 54,642,099 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera851,152,414 - 51,155,450 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Pou2af2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8860,504,292 - 60,544,996 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl860,504,152 - 60,545,000 (-)EnsemblGRCr8
mRatBN7.2851,607,780 - 51,648,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,607,763 - 51,648,628 (-)EnsemblmRatBN7.2
Rnor_6.0855,693,820 - 55,696,856 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,694,804 - 55,696,601 (-)Ensemblrn6Rnor6.0
Rnor_5.0854,288,887 - 54,330,073 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4854,621,532 - 54,642,099 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera851,152,414 - 51,155,450 (-)NCBICelera
Cytogenetic Map8q23NCBI
POU2AF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,245,725 - 111,286,401 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,245,725 - 111,286,401 (+)Ensemblhg38GRCh38
GRCh3711111,116,450 - 111,157,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,631,917 - 110,662,183 (+)NCBIBuild 36Build 36hg18NCBI36
Celera11108,279,889 - 108,310,160 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,051,423 - 107,081,652 (+)NCBIHuRef
CHM1_111111,009,837 - 111,040,110 (+)NCBICHM1_1
T2T-CHM13v2.011111,255,953 - 111,296,584 (+)NCBIT2T-CHM13v2.0
Pou2af2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,200,986 - 51,240,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,200,986 - 51,240,224 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38951,289,686 - 51,328,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,289,686 - 51,328,924 (-)Ensemblmm10GRCm38
MGSCv37951,097,791 - 51,137,022 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36951,041,924 - 51,081,147 (-)NCBIMGSCv36mm8
Celera948,576,872 - 48,616,362 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map928.05NCBI
Pou2af2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541213,076,854 - 13,079,095 (+)NCBIChiLan1.0ChiLan1.0
POU2AF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29111,999,701 - 112,030,008 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,091,755 - 113,122,077 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,125,675 - 106,165,907 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111109,981,398 - 110,011,080 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11109,971,255 - 110,011,080 (+)EnsemblpanPan2panpan1.1
POU2AF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,749,430 - 21,785,996 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,749,786 - 21,785,287 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha521,671,004 - 21,707,571 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0521,775,350 - 21,811,914 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,775,711 - 21,811,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,835,943 - 21,872,425 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,736,068 - 21,772,622 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,785,293 - 21,821,811 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pou2af2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494793,549,146 - 93,587,542 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366123,118,236 - 3,123,305 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366123,118,204 - 3,123,279 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POU2AF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,024,631 - 39,062,684 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1939,024,067 - 39,065,379 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2943,922,254 - 43,962,911 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POU2AF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11102,591,385 - 102,625,441 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604323,345,939 - 23,452,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pou2af2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247846,356,269 - 6,410,924 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pou2af2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1845,726,943 - 45,767,386 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pou2af2
505 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:85
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000016127
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
D8Rat38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,618,801 - 51,618,922 (+)MAPPERmRatBN7.2
Rnor_6.0855,705,491 - 55,705,611NCBIRnor6.0
Rnor_5.0854,300,274 - 54,300,394UniSTSRnor5.0
RGSC_v3.4854,632,219 - 54,632,339UniSTSRGSC3.4
RGSC_v3.4854,632,218 - 54,632,339RGDRGSC3.4
Celera851,164,085 - 51,164,205UniSTS
RGSC_v3.1854,651,273 - 54,651,393RGD
RH 3.4 Map8551.7RGD
RH 3.4 Map8551.7UniSTS
RH 2.0 Map8410.8RGD
SHRSP x BN Map838.1RGD
FHH x ACI Map846.8499RGD
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 20 50 33 34 3 41 3 4 126 81 1 34 18 33 31 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000016127   ⟹   ENSRNOP00000016127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl860,504,152 - 60,545,000 (-)Ensembl
mRatBN7.2 Ensembl851,607,763 - 51,648,628 (-)Ensembl
Rnor_6.0 Ensembl855,694,804 - 55,696,601 (-)Ensembl
RefSeq Acc Id: XM_008766355   ⟹   XP_008764577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8860,504,292 - 60,544,996 (-)NCBI
mRatBN7.2851,607,780 - 51,648,790 (-)NCBI
Rnor_6.0855,693,820 - 55,696,856 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001420314 (Get FASTA)   NCBI Sequence Viewer  
  XP_008764577 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95498 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016127
  ENSRNOP00000016127.3
RefSeq Acc Id: XP_008764577   ⟸   XM_008766355
- Sequence:
Ensembl Acc Id: ENSRNOP00000016127   ⟸   ENSRNOT00000016127
Protein Domains
OCA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M541-F1-model_v2 AlphaFold F1M541 1-234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562914 AgrOrtholog
BioCyc Gene G2FUF-30501 BioCyc
Ensembl Genes ENSRNOG00000012022 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016127 ENTREZGENE
  ENSRNOT00000016127.5 UniProtKB/TrEMBL
InterPro C11orf53 UniProtKB/TrEMBL
  OCA UniProtKB/TrEMBL
NCBI Gene 500997 ENTREZGENE
PANTHER PTHR28376 UniProtKB/TrEMBL
  RGD1562914 UniProtKB/TrEMBL
Pfam DUF5566 UniProtKB/TrEMBL
PhenoGen Pou2af2 PhenoGen
PROSITE OCA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012022 RatGTEx
UniProt A6J4H5 ENTREZGENE, UniProtKB/TrEMBL
  F1M541 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Pou2af2  POU class 2 homeobox associating factor 2  Pou2af2  POU domain, class 2, associating factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-05-19 Pou2af2  POU domain, class 2, associating factor 2  RGD1562914  RGD1562914  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1562914  RGD1562914   RGD1562914_predicted  RGD1562914 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562914_predicted  RGD1562914 (predicted)  LOC500997  LOC500997  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500997  LOC500997      Symbol and Name status set to provisional 70820 PROVISIONAL