Phlpp2 (PH domain and leucine rich repeat protein phosphatase 2) - Rat Genome Database

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Gene: Phlpp2 (PH domain and leucine rich repeat protein phosphatase 2) Rattus norvegicus
Analyze
Symbol: Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
RGD ID: 1562857
Description: Enables protein serine/threonine phosphatase activity. Involved in hippocampus development. Located in photoreceptor inner segment and photoreceptor outer segment membrane. Orthologous to human PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498949; PH domain and leucine rich repeat protein phosphatase-like; PH domain leucine-rich repeat-containing protein phosphatase 2; Phlppl; RGD1562857; similar to KIAA0931 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,744,581 - 54,811,258 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1954,744,581 - 54,812,259 (+)EnsemblGRCr8
mRatBN7.21937,835,125 - 37,901,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,835,125 - 37,905,513 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1944,647,457 - 44,714,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,300,799 - 45,367,461 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,610,415 - 47,677,073 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,731,845 - 41,798,451 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,731,646 - 41,798,383 (-)Ensemblrn6Rnor6.0
Rnor_5.01952,555,245 - 52,621,851 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41939,741,655 - 39,808,301 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1937,238,682 - 37,305,396 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PHLiPPing the switch on Akt and protein kinase C signaling. Brognard J and Newton AC, Trends Endocrinol Metab. 2008 Aug;19(6):223-30. Epub 2008 May 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PHLPP1 splice variants differentially regulate AKT and PKCalpha signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus. Jackson TC, etal., J Neurochem. 2010 Nov;115(4):941-55. doi: 10.1111/j.1471-4159.2010.06984.x. Epub 2010 Sep 28.
4. Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. Kanan Y, etal., J Neurochem. 2010 Apr;113(2):477-88. Epub 2010 Jan 20.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Signaling specificity in the Akt pathway in biology and disease. Toker A and Marmiroli S, Adv Biol Regul. 2014 May;55:28-38. doi: 10.1016/j.jbior.2014.04.001. Epub 2014 Apr 19.
Additional References at PubMed
PMID:19450723   PMID:24675471   PMID:26286854   PMID:29628444  


Genomics

Comparative Map Data
Phlpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,744,581 - 54,811,258 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1954,744,581 - 54,812,259 (+)EnsemblGRCr8
mRatBN7.21937,835,125 - 37,901,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,835,125 - 37,905,513 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1944,647,457 - 44,714,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,300,799 - 45,367,461 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,610,415 - 47,677,073 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,731,845 - 41,798,451 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,731,646 - 41,798,383 (-)Ensemblrn6Rnor6.0
Rnor_5.01952,555,245 - 52,621,851 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41939,741,655 - 39,808,301 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1937,238,682 - 37,305,396 (+)NCBICelera
Cytogenetic Map19q12NCBI
PHLPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381671,644,924 - 71,724,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1671,637,835 - 71,724,701 (-)Ensemblhg38GRCh38
GRCh371671,678,827 - 71,758,604 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,236,353 - 70,306,205 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1655,994,913 - 56,064,759 (-)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,446,695 - 57,516,253 (-)NCBIHuRef
CHM1_11673,091,614 - 73,161,535 (-)NCBICHM1_1
T2T-CHM13v2.01677,462,088 - 77,541,847 (-)NCBIT2T-CHM13v2.0
Phlpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,595,149 - 110,671,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,595,174 - 110,671,303 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388109,868,517 - 109,944,671 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,868,542 - 109,944,671 (+)Ensemblmm10GRCm38
MGSCv378112,392,503 - 112,468,571 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368112,757,671 - 112,830,037 (+)NCBIMGSCv36mm8
Celera8114,090,251 - 114,166,622 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.33NCBI
Phlpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,353,950 - 4,420,873 (-)Ensembl
ChiLan1.0NW_0049554844,353,950 - 4,419,891 (-)NCBIChiLan1.0ChiLan1.0
PHLPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,436,073 - 82,514,656 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,363,906 - 88,445,484 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01653,287,549 - 53,366,113 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,481,605 - 71,562,793 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,481,605 - 71,562,793 (-)EnsemblpanPan2panpan1.1
PHLPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,428,587 - 77,506,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,432,517 - 77,565,801 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha577,394,012 - 77,467,228 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0577,871,556 - 77,945,286 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl577,869,730 - 78,028,575 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1577,691,632 - 77,765,295 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,514,784 - 77,588,272 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,013,711 - 78,087,473 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Phlpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,450,806 - 37,514,518 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647522,074,568 - 22,138,334 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647522,074,620 - 22,138,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHLPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,633,751 - 14,715,965 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1614,633,756 - 14,715,921 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PHLPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1554,767,935 - 54,845,700 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl554,767,941 - 54,845,527 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604717,569,921 - 17,646,703 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phlpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474613,919,557 - 13,994,182 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474613,917,070 - 13,994,212 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Phlpp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11729,579,212 - 29,649,334 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Phlpp2
592 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:54
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000021744
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat

Markers in Region
RH136743  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,851,821 - 37,851,973 (-)MAPPERmRatBN7.2
Rnor_6.01941,781,596 - 41,781,747NCBIRnor6.0
Rnor_5.01952,604,996 - 52,605,147UniSTSRnor5.0
RGSC_v3.41939,758,352 - 39,758,503UniSTSRGSC3.4
Celera1937,255,465 - 37,255,616UniSTS
Cytogenetic Map19q12UniSTS
RH130264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,886,653 - 37,886,865 (-)MAPPERmRatBN7.2
Rnor_6.01941,746,783 - 41,746,994NCBIRnor6.0
Rnor_5.01952,570,183 - 52,570,394UniSTSRnor5.0
RGSC_v3.41939,793,151 - 39,793,362UniSTSRGSC3.4
Celera1937,290,248 - 37,290,459UniSTS
RH 3.4 Map19427.6UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021744   ⟹   ENSRNOP00000021745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1954,744,581 - 54,812,259 (+)Ensembl
mRatBN7.2 Ensembl1937,835,125 - 37,905,513 (+)Ensembl
Rnor_6.0 Ensembl1941,731,646 - 41,798,383 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101587   ⟹   ENSRNOP00000085796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,866,645 - 37,905,513 (+)Ensembl
RefSeq Acc Id: NM_001109131   ⟹   NP_001102601
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,744,581 - 54,811,258 (+)NCBI
mRatBN7.21937,835,125 - 37,901,804 (+)NCBI
Rnor_6.01941,731,845 - 41,798,451 (-)NCBI
Rnor_5.01952,555,245 - 52,621,851 (-)NCBI
RGSC_v3.41939,741,655 - 39,808,301 (+)RGD
Celera1937,238,682 - 37,305,396 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102601 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92516 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021745
  ENSRNOP00000021745.7
RefSeq Acc Id: NP_001102601   ⟸   NM_001109131
- UniProtKB: D4A254 (UniProtKB/TrEMBL),   A6IZ38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021745   ⟸   ENSRNOT00000021744
Ensembl Acc Id: ENSRNOP00000085796   ⟸   ENSRNOT00000101587
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A254-F1-model_v2 AlphaFold D4A254 1-1190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701133
Promoter ID:EPDNEW_R11657
Type:initiation region
Name:Phlpp2_1
Description:PH domain and leucine rich repeat protein phosphatase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01941,798,398 - 41,798,458EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562857 AgrOrtholog
BioCyc Gene G2FUF-5704 BioCyc
Ensembl Genes ENSRNOG00000016108 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021744 ENTREZGENE
  ENSRNOT00000021744.8 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_domain-containing UniProtKB/TrEMBL
  PP2C-related UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  RA_PHLPP-like UniProtKB/TrEMBL
KEGG Report rno:498949 UniProtKB/TrEMBL
NCBI Gene 498949 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT-CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR48051 UniProtKB/TrEMBL
Pfam LRR_6 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  PP2C UniProtKB/TrEMBL
  RA_3 UniProtKB/TrEMBL
PhenoGen Phlpp2 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016108 RatGTEx
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  PP2C-related UniProtKB/TrEMBL
UniProt A6IZ38 ENTREZGENE, UniProtKB/TrEMBL
  D4A254 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Phlpp2  PH domain and leucine rich repeat protein phosphatase 2  Phlppl  PH domain and leucine rich repeat protein phosphatase-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Phlppl  PH domain and leucine rich repeat protein phosphatase-like  RGD1562857_predicted  similar to KIAA0931 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562857_predicted  similar to KIAA0931 protein (predicted)  LOC498949  similar to KIAA0931 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498949  similar to KIAA0931 protein      Symbol and Name status set to provisional 70820 PROVISIONAL