Ca5b (carbonic anhydrase 5B) - Rat Genome Database

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Pathways
Gene: Ca5b (carbonic anhydrase 5B) Rattus norvegicus
Analyze
Symbol: Ca5b (Ensembl: Car5b)
Name: carbonic anhydrase 5B
RGD ID: 1549783
Description: Predicted to enable carbonate dehydratase activity. Predicted to act upstream of or within response to bacterium. Predicted to be active in mitochondrion. Orthologous to human CA5B (carbonic anhydrase 5B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CA-VB; Car5b; carbonate dehydratase VB; carbonic anhydrase 5B, mitochondrial; carbonic anhydrase VB, mitochondrial; MGC93720
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X34,106,553 - 34,166,651 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX34,067,403 - 34,166,653 (+)EnsemblGRCr8
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,474,784 - 30,533,837 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX31,520,092 - 31,566,687 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,957,057 - 35,003,669 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X31,144,294 - 31,190,893 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,232,106 - 32,291,124 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,232,142 - 32,292,072 (+)Ensemblrn6Rnor6.0
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X51,241,437 - 51,290,433 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX30,830,281 - 30,876,988 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10677517   PMID:15489334   PMID:18614015   PMID:23012479  


Genomics

Comparative Map Data
Ca5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X34,106,553 - 34,166,651 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX34,067,403 - 34,166,653 (+)EnsemblGRCr8
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,474,784 - 30,533,837 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX31,520,092 - 31,566,687 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,957,057 - 35,003,669 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X31,144,294 - 31,190,893 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,232,106 - 32,291,124 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,232,142 - 32,292,072 (+)Ensemblrn6Rnor6.0
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X51,241,437 - 51,290,433 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX30,830,281 - 30,876,988 (+)NCBICelera
Cytogenetic MapXq14NCBI
CA5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,738,270 - 15,788,411 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,688,830 - 15,788,411 (+)Ensemblhg38GRCh38
GRCh37X15,756,393 - 15,806,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,666,333 - 15,715,669 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X15,516,081 - 15,562,315NCBI
CeleraX19,872,853 - 19,923,232 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,510,606 - 13,559,489 (+)NCBIHuRef
CHM1_1X15,787,366 - 15,836,721 (+)NCBICHM1_1
T2T-CHM13v2.0X15,321,214 - 15,371,343 (+)NCBIT2T-CHM13v2.0
Car5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,759,818 - 162,811,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,759,818 - 162,810,993 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X163,976,822 - 164,028,010 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX163,976,822 - 164,027,997 (-)Ensemblmm10GRCm38
MGSCv37X160,414,754 - 160,465,942 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X159,323,196 - 159,372,102 (-)NCBIMGSCv36mm8
CeleraX147,196,469 - 147,247,766 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.03NCBI
Ca5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,412,289 - 2,455,280 (-)Ensembl
ChiLan1.0NW_0049555192,415,722 - 2,455,052 (-)NCBIChiLan1.0ChiLan1.0
CA5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,527,320 - 17,581,111 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,525,852 - 17,584,497 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X8,325,881 - 8,410,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,629,967 - 15,678,112 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,658,816 - 15,764,323 (+)EnsemblpanPan2panpan1.1
PanPan1.1 EnsemblX15,658,816 - 15,764,323 (+)NCBIpanPan2panpan1.1
CA5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,908,426 - 12,042,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,930,884 - 12,040,221 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX11,809,477 - 11,892,620 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,869,327 - 12,003,333 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,953,590 - 12,003,322 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,932,374 - 12,072,571 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,926,678 - 12,059,951 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,951,875 - 12,085,347 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ca5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X5,184,444 - 5,230,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364705,184,483 - 5,230,214 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364705,184,489 - 5,227,855 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,224,159 - 12,365,025 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X12,295,393 - 12,332,283 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,188,075 - 13,222,663 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,197,561 - 14,240,294 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,197,651 - 14,243,626 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605615,985,256 - 16,095,069 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829457,244 - 571,168 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624829455,731 - 572,603 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ca5b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X24,563,966 - 24,599,773 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ca5b
228 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:134
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000047354
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 89 59 6 353 189 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000047354   ⟹   ENSRNOP00000043235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,112,827 - 34,166,617 (+)Ensembl
mRatBN7.2 EnsemblX30,474,803 - 30,533,837 (+)Ensembl
Rnor_6.0 EnsemblX32,232,142 - 32,292,072 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101751   ⟹   ENSRNOP00000080254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,104,383 - 34,166,653 (+)Ensembl
mRatBN7.2 EnsemblX30,474,784 - 30,533,837 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121599   ⟹   ENSRNOP00000106083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,067,403 - 34,166,653 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000135180   ⟹   ENSRNOP00000106421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX34,112,827 - 34,148,619 (+)Ensembl
RefSeq Acc Id: NM_001005551   ⟹   NP_001005551
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,119,026 - 34,165,641 (+)NCBI
mRatBN7.2X30,487,172 - 30,533,787 (+)NCBI
Rnor_6.0X32,244,448 - 32,291,063 (+)NCBI
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBI
RGSC_v3.4X51,241,437 - 51,290,433 (+)RGD
CeleraX30,830,281 - 30,876,988 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256859   ⟹   XP_006256921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,106,553 - 34,166,651 (+)NCBI
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBI
Rnor_6.0X32,232,106 - 32,291,124 (+)NCBI
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099656   ⟹   XP_038955584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,112,797 - 34,166,651 (+)NCBI
mRatBN7.2X30,480,943 - 30,534,797 (+)NCBI
RefSeq Acc Id: XM_039099657   ⟹   XP_038955585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,106,553 - 34,166,651 (+)NCBI
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBI
RefSeq Acc Id: NP_001005551   ⟸   NM_001005551
- Peptide Label: precursor
- UniProtKB: Q66HG6 (UniProtKB/Swiss-Prot),   A6K2L9 (UniProtKB/TrEMBL),   A0A8I5ZPN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256921   ⟸   XM_006256859
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000043235   ⟸   ENSRNOT00000047354
RefSeq Acc Id: XP_038955585   ⟸   XM_039099657
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955584   ⟸   XM_039099656
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000080254   ⟸   ENSRNOT00000101751
Ensembl Acc Id: ENSRNOP00000106421   ⟸   ENSRNOT00000135180
Ensembl Acc Id: ENSRNOP00000106083   ⟸   ENSRNOT00000121599
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HG6-F1-model_v2 AlphaFold Q66HG6 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701799
Promoter ID:EPDNEW_R12323
Type:initiation region
Name:Ca5b_1
Description:carbonic anhydrase 5B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,232,136 - 32,232,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549783 AgrOrtholog
BioCyc Gene G2FUF-2571 BioCyc
Ensembl Genes ENSRNOG00000029330 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047354 ENTREZGENE
  ENSRNOT00000047354.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106842 IMAGE-MGC_LOAD
InterPro CA_dom UniProtKB/Swiss-Prot
  CA_dom_sf UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
KEGG Report rno:302669 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93720 IMAGE-MGC_LOAD
NCBI Gene 302669 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot
  PTHR18952:SF25 UniProtKB/Swiss-Prot
Pfam Carb_anhydrase UniProtKB/Swiss-Prot
PhenoGen Ca5b PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029330 RatGTEx
SMART Carb_anhydrase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot
UniProt A0A8I5ZPN0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LKD6_RAT UniProtKB/TrEMBL
  A0ABK0LX98_RAT UniProtKB/TrEMBL
  A6K2L9 ENTREZGENE, UniProtKB/TrEMBL
  CAH5B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-04-28 Ca5b  carbonic anhydrase 5B  Car5b  carbonic anhydrase 5B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-18 Car5b  carbonic anhydrase 5B  Ca5b  carbonic anhydrase 5B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-16 Ca5b  carbonic anhydrase 5B  Car5b  carbonic anhydrase 5B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-03-16 Car5b  carbonic anhydrase 5B  Ca5b  carbonic anhydrase 5B  Symbol changed 629549 APPROVED
2016-05-20 Ca5b  carbonic anhydrase 5B  Car5b  carbonic anhydrase 5B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-18 Car5b  carbonic anhydrase 5B  Car5b  carbonic anhydrase 5B, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-05-14 Car5b  carbonic anhydrase 5B, mitochondrial  Car5b  carbonic anhydrase 5b, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-20 Car5b  carbonic anhydrase 5B, mitochondrial  Ca5b  carbonic anhydrase VB, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 Ca5b  carbonic anhydrase VB, mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL