Ca5b (carbonic anhydrase 5B) - Rat Genome Database

Name: Ca5b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Ca5b (carbonic anhydrase 5B) Chinchilla lanigera

Analyze

Symbol:

Ca5b

Name:

carbonic anhydrase 5B

RGD ID:

8737604

Description:

ENCODES a protein that exhibits carbonate dehydratase activity (ortholog); INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Fanconi anemia (ortholog); multiple congenital anomalies-hypotonia-seizures syndrome 2 (ortholog); FOUND IN mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

carbonic anhydrase 5B, mitochondrial; carbonic anhydrase VB, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CA5B (carbonic anhydrase 5B)	NCBI	Ortholog
Mus musculus (house mouse):	Car5b (carbonic anhydrase 5b, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Car5b (carbonic anhydrase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CA5B (carbonic anhydrase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CA5B (carbonic anhydrase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ca5b (carbonic anhydrase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CA5B (carbonic anhydrase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CA5B (carbonic anhydrase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ca5b (carbonic anhydrase 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955519	2,412,289 - 2,455,280 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955519	2,415,722 - 2,455,052 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Fanconi anemia (ISO)

multiple congenital anomalies-hypotonia-seizures syndrome 2 (ISO)

Neurodevelopmental Disorders (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

response to bacterium (ISO)

Cellular Component

mitochondrion (ISO)

Molecular Function

carbonate dehydratase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ca5b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955519	2,412,289 - 2,455,280 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955519	2,415,722 - 2,455,052 (-)	NCBI	ChiLan1.0	ChiLan1.0

CA5B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	15,738,270 - 15,788,411 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	15,688,830 - 15,788,411 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	15,756,393 - 15,806,534 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	15,666,333 - 15,715,669 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	15,516,081 - 15,562,315	NCBI
Celera	X	19,872,853 - 19,923,232 (+)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	13,510,606 - 13,559,489 (+)	NCBI		HuRef
CHM1_1	X	15,787,366 - 15,836,721 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	15,321,214 - 15,371,343 (+)	NCBI		T2T-CHM13v2.0

Car5b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	162,759,818 - 162,811,006 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	162,759,818 - 162,810,993 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	163,976,822 - 164,028,010 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	163,976,822 - 164,027,997 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	160,414,754 - 160,465,942 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	159,323,196 - 159,372,102 (-)	NCBI		MGSCv36	mm8
Celera	X	147,196,469 - 147,247,766 (-)	NCBI		Celera
Cytogenetic Map	X	F5	NCBI
cM Map	X	76.03	NCBI

Car5b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	34,106,553 - 34,166,651 (+)	NCBI		GRCr8
mRatBN7.2	X	30,474,697 - 30,534,797 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	30,474,784 - 30,533,837 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	31,520,092 - 31,566,687 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	34,957,057 - 35,003,669 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	31,144,294 - 31,190,893 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	32,232,106 - 32,291,124 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	32,232,142 - 32,292,072 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	32,597,409 - 32,652,981 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	51,241,437 - 51,290,433 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	30,830,281 - 30,876,988 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

CA5B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	17,527,320 - 17,581,111 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	17,525,852 - 17,584,497 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	8,325,881 - 8,410,506 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	15,629,967 - 15,678,112 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	15,658,816 - 15,764,323 (+)	Ensembl	panpan1.1		panPan2
PanPan1.1 Ensembl	X	15,658,816 - 15,764,323 (+)	NCBI	panpan1.1		panPan2

CA5B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	11,908,426 - 12,042,327 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	11,930,884 - 12,040,221 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	11,809,477 - 11,892,620 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	11,869,327 - 12,003,333 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	11,932,374 - 12,072,571 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	11,926,678 - 12,059,951 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	11,951,875 - 12,085,347 (+)	NCBI		UU_Cfam_GSD_1.0

Ca5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	5,184,444 - 5,230,212 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	5,184,483 - 5,230,214 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	5,184,489 - 5,227,855 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CA5B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	12,224,159 - 12,365,025 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	12,295,393 - 12,332,283 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	13,188,075 - 13,222,663 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CA5B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	14,197,561 - 14,240,294 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	14,197,651 - 14,243,626 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	15,985,256 - 16,095,069 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ca5b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	457,244 - 571,168 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	455,731 - 572,603 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005409159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01067929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01067930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01067931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01169072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000003025 ⟹ ENSCLAP00000002963

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955519	2,412,289 - 2,455,280 (-)	Ensembl

RefSeq Acc Id:

XM_005409159 ⟹ XP_005409216

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955519	2,415,722 - 2,455,052 (-)	NCBI

Sequence:

show sequence

GCGGGTAGAGGGCTGGCAAAGTCTGGAGGGGCATGGCCAGCGCTGTAGGTTTGGAAGTAGCGGG
CACGAACGCCTGATGGGGGCGTGTTCCCGCGCGAGGGGCGGGGCCCGGGTACGAGGGTGGTGAA
AGGGTTCCGGGCGCGCGACTCCCGAGTCCTGGAAAGTGAGCGAGCGGAGAGATTAGTGCTGTAA
AGGAAACGCTCAGGGTTTTAGGTTCCTGTGCATTATTTGGCAGCTGATCAGGATTTCAAGCTGA
GGATGATGATGCTGAACAGCCTGAGAGTTATTCGGCAAGGGTCCCCCTGCAAATGGCTGTGGAG
GAGGGTCCCGGTTCCCAGATCCATGCCGGTGAGACCCTGCAGTCTGTATACTTGCACCTATAGA
ACCCGGAACCGAGCCTTGCATCCTCTCTGGGAAAGCATGGACCTTGTTCCAGCAGGTGACAGAC
AGTCACCCATTAACATCCGGTGGAAGGACAGCGTTTATGACCCGGGCTTAAAACCACTCACGAT
CTCTTATGACCCGACCACTTGCCTGCATATCTGGAATAATGGATACTCTTTCCTCGTGGAATTT
GAAGACTCTAAGGATAGATCAGTGATCAAGGGAGGACCTCTGGAACACAACTACCGATTGAAGC
AGTTCCATTTTCACTGGGGGGCCATTGATGCCTGGGGTTCCGAGCACACTGTGGACAGCAAATT
CTACCCAGCAGAGCTGCATTTGGTGCATTGGAACGCAGTCAAATTTGAAAGCTTCGAGGATGCG
GCCCAGGAAGAAAACGGTTTGGCTGTGATAGGAGTATTTTTAAAGCTAGGCAAACATCATAAAG
AGCTACAGAACTTGCTGGACACTTTGCCATCAATTAAGCATAAGGACACCCTTGTGGAACTTGG
GTCCTTTGACCCCGCCTGCCTGATGCCTGCCTGCCCTGATTACTGGACCTACTCAGGGTCTCTG
ACTACCCCACCTCTCTCAGAGTCTGTCACCTGGATCATTAAGAAGCAGCCAGTAGAGGTCGATC
ACGATCAGCTTGAGCAATTTCGGACCCTACTCTTCACTTCTGAGGGAGAAAAAGAGAAAAAAAT
GGTGGACAACTTTCGCCCCCTTCAGCCCCTGATGAATCGCACTGTTCGCTCGTCCTTCCGCCAT
GACTATGTGCTGAACATACAAGCGAAACCCAAGCCATCGGCCAGCCAAGTGACCCCCTAAGGTG
TCCGTACCTAGGCAATATTTTGCTTCTTTTAGCTTTTTAAAACATTGTTTAAACTATTTTAAAT
ACCTGCACTAATAATATTTATAGAATATATAATTCTTTTTTGACATTTCCAAGTCACTACCCTT
GTAAGGCTGGAACAGGGAGACAGGAACAATTGGAAAATAACTGATTGGCTAACATCAGGCTACT
TTAGGTGACCATTTGTTTGTGAGGATTAAGGCAGAGAGGACTTCATTACTATTGCCAATTGAAA
CTGGCCCGTTTGGGAAAGTTGGCTGTCATCTCTCTAATCTTGCTTTTTGAGAAGGTCAGATAAG
TAATTTAGTTTCTGTTTGGTAAAGTGGAACTTTATTTGGTATGAGTGATTCCATTTTGAGTTTG
AGCCTGGTCTGCTGCAGCCTAGTACAGCAGCTCAGTTTAAAACAATGGCCTCCTGTAATTTTTA
TTTAACAATTTTCCGGTTTTGATCAGGCTCTCACAGCCTTAGAGTCTTAGTGTCACTCTTAGTT
ACCATCATTTTGGGCTTCAGGTATTAACATGTCATTCATAGGTTAGATGTGCATTTATTGGCAT
GAAAGCGCTTTATAAATCTTTGAAAAATCTATTTGGTAAACAGATTCTTTCTTTGGTTGATAAT
AGTACTTATCACTAAAATATCAGCAAGAGGTACAAGTTTCTTTTACAGCAACTTATTGGTAACT
GTAATGTCTTTTTATGTCTGACATTTTTGAGCATTCTTTTTATATTTCCCAGTCAATAGTCCCA
TAGAGTTATAAGTAGGGATTATATTCAAAATGTTTAATAAATGGTAGAGGTAGAGACACTGATC
ACATAGAACAGCGGCCTTTTAGAAATGGCCATAGGGCCCAGACTGGTCCTTTCTGGCTGAAGAC
TGACCATGGTTTTAGGTGTACTTTCTTTCAAAATGGGAATGTATATTCTTTTATTAGGGTTCCT
CAATAAATATGTTTGCTCCACTTTTTAGTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005409216	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000002963
	ENSCLAP00000002963.1

RefSeq Acc Id:

XP_005409216 ⟸ XM_005409159

- UniProtKB:

A0A8C2YJD5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMMLNSLRVIRQGSPCKWLWRRVPVPRSMPVRPCSLYTCTYRTRNRALHPLWESMDLVPAGDRQ
SPINIRWKDSVYDPGLKPLTISYDPTTCLHIWNNGYSFLVEFEDSKDRSVIKGGPLEHNYRLKQ
FHFHWGAIDAWGSEHTVDSKFYPAELHLVHWNAVKFESFEDAAQEENGLAVIGVFLKLGKHHKE
LQNLLDTLPSIKHKDTLVELGSFDPACLMPACPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDH
DQLEQFRTLLFTSEGEKEKKMVDNFRPLQPLMNRTVRSSFRHDYVLNIQAKPKPSASQVTP

hide sequence

RefSeq Acc Id:

ENSCLAP00000002963 ⟸ ENSCLAT00000003025

Protein Domains

Alpha-carbonic anhydrase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002128	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000003025	ENTREZGENE
	ENSCLAT00000003025.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.200.10	UniProtKB/TrEMBL
InterPro	CA_dom	UniProtKB/TrEMBL
	CA_dom_sf	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class_CS	UniProtKB/TrEMBL
NCBI Gene	Ca5b	ENTREZGENE
PANTHER	PTHR18952	UniProtKB/TrEMBL
	PTHR18952:SF25	UniProtKB/TrEMBL
Pfam	Carb_anhydrase	UniProtKB/TrEMBL
PROSITE	ALPHA_CA_1	UniProtKB/TrEMBL
	ALPHA_CA_2	UniProtKB/TrEMBL
SMART	Carb_anhydrase	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51069	UniProtKB/TrEMBL
UniProt	A0A8C2YJD5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Ca5b	carbonic anhydrase 5B		carbonic anhydrase VB, mitochondrial	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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