Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6) - Rat Genome Database

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Gene: Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6) Rattus norvegicus
Analyze
Symbol: Arhgef6
Name: Rac/Cdc42 guanine nucleotide exchange factor 6
RGD ID: 1359674
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to be located in cell-cell junction. Predicted to be active in cytoplasm and lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6); PARTICIPATES IN ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; rho guanine nucleotide exchange factor 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X140,182,734 - 140,302,812 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX140,182,734 - 140,344,458 (-)EnsemblGRCr8
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX135,146,786 - 135,275,304 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX137,344,314 - 137,461,067 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X140,901,995 - 141,018,759 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X138,471,394 - 138,588,158 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X159,722,031 - 159,841,344 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,723,866 - 159,841,072 (-)Ensemblrn6Rnor6.0
Rnor_5.0X154,351,133 - 154,467,649 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X141,946,362 - 142,068,557 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX143,180,944 - 143,297,823 (-)NCBICelera
RGSC_v3.1X142,019,794 - 142,141,990 (-)NCBI
Cytogenetic MapXq36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel dichloride  (EXP)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IBA)
lamellipodium  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. Kutsche K, etal., Nat Genet. 2000 Oct;26(2):247-50.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16641100   PMID:18325335   PMID:19261846   PMID:22554054   PMID:23793062   PMID:25450678  


Genomics

Comparative Map Data
Arhgef6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X140,182,734 - 140,302,812 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX140,182,734 - 140,344,458 (-)EnsemblGRCr8
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX135,146,786 - 135,275,304 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX137,344,314 - 137,461,067 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X140,901,995 - 141,018,759 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X138,471,394 - 138,588,158 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X159,722,031 - 159,841,344 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,723,866 - 159,841,072 (-)Ensemblrn6Rnor6.0
Rnor_5.0X154,351,133 - 154,467,649 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X141,946,362 - 142,068,557 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX143,180,944 - 143,297,823 (-)NCBICelera
RGSC_v3.1X142,019,794 - 142,141,990 (-)NCBI
Cytogenetic MapXq36NCBI
ARHGEF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,665,550 - 136,780,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX136,665,547 - 136,781,688 (-)Ensemblhg38GRCh38
GRCh37X135,747,709 - 135,863,091 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,575,375 - 135,691,169 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X135,473,232 - 135,589,023NCBI
CeleraX136,111,384 - 136,227,182 (-)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX125,018,703 - 125,134,374 (-)NCBIHuRef
CHM1_1X135,659,375 - 135,775,269 (-)NCBICHM1_1
T2T-CHM13v2.0X134,974,276 - 135,089,655 (-)NCBIT2T-CHM13v2.0
Arhgef6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,276,845 - 56,384,119 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX56,276,845 - 56,384,089 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X57,231,485 - 57,338,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,231,485 - 57,338,729 (-)Ensemblmm10GRCm38
MGSCv37X54,484,662 - 54,591,906 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X53,578,271 - 53,685,513 (-)NCBIMGSCv36mm8
CeleraX43,709,095 - 43,814,976 (-)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.26NCBI
Arhgef6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,360,072 - 8,459,377 (+)Ensembl
ChiLan1.0NW_0049554898,360,027 - 8,459,309 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X136,083,897 - 136,200,099 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X136,087,494 - 136,203,400 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X125,794,158 - 125,909,809 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X136,060,652 - 136,176,571 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX136,058,879 - 136,176,110 (-)EnsemblpanPan2panpan1.1
ARHGEF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X107,031,586 - 107,133,402 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX107,034,118 - 107,133,082 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX92,853,143 - 92,954,592 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X109,011,566 - 109,112,628 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX109,011,570 - 109,112,366 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X106,152,309 - 106,253,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X108,343,657 - 108,445,068 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,985,467 - 108,087,145 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgef6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X105,016,252 - 105,126,029 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651310,488,532 - 10,598,493 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651310,488,525 - 10,598,366 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,796,485 - 111,917,174 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X111,796,485 - 111,917,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,658,249 - 127,763,452 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232641
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X111,672,701 - 111,793,597 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX111,672,713 - 111,792,856 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606549,359,175 - 49,486,195 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480810,319,793 - 10,465,514 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480810,320,388 - 10,464,081 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgef6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X117,668,249 - 117,786,048 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgef6
442 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:51
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000001158
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
DXRat141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X135,183,402 - 135,183,610 (+)MAPPERmRatBN7.2
Rnor_6.0X159,760,012 - 159,760,219NCBIRnor6.0
Rnor_5.0X154,385,788 - 154,385,995UniSTSRnor5.0
RGSC_v3.4X141,982,743 - 141,982,950RGDRGSC3.4
RGSC_v3.4X141,982,744 - 141,982,951UniSTSRGSC3.4
CeleraX143,216,854 - 143,217,061UniSTS
RGSC_v3.1X142,056,176 - 142,056,383RGD
SHRSP x BN MapX44.63UniSTS
SHRSP x BN MapX44.63RGD
Cytogenetic MapXq36UniSTS
RH144315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X135,186,611 - 135,186,721 (+)MAPPERmRatBN7.2
Rnor_6.0X159,763,221 - 159,763,330NCBIRnor6.0
Rnor_5.0X154,388,997 - 154,389,106UniSTSRnor5.0
RGSC_v3.4X141,985,953 - 141,986,062UniSTSRGSC3.4
CeleraX143,220,057 - 143,220,166UniSTS
RH 3.4 MapX958.1UniSTS
Cytogenetic MapXq36UniSTS
px-17e5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X135,154,816 - 135,154,940 (+)MAPPERmRatBN7.2
Rnor_6.0X159,731,400 - 159,731,523NCBIRnor6.0
Rnor_5.0X154,357,999 - 154,358,122UniSTSRnor5.0
RGSC_v3.4X141,954,095 - 141,954,218UniSTSRGSC3.4
CeleraX143,188,244 - 143,188,367UniSTS
Cytogenetic MapXq36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY725848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001158   ⟹   ENSRNOP00000001158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX140,182,734 - 140,301,754 (-)Ensembl
mRatBN7.2 EnsemblX135,146,786 - 135,275,304 (-)Ensembl
Rnor_6.0 EnsemblX159,723,866 - 159,841,072 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096866   ⟹   ENSRNOP00000096317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX140,182,734 - 140,234,838 (-)Ensembl
mRatBN7.2 EnsemblX135,146,786 - 135,197,390 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103631   ⟹   ENSRNOP00000084113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX140,182,734 - 140,344,458 (-)Ensembl
mRatBN7.2 EnsemblX135,146,789 - 135,275,304 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111102   ⟹   ENSRNOP00000088717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX140,182,734 - 140,312,565 (-)Ensembl
mRatBN7.2 EnsemblX135,146,786 - 135,275,304 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115452   ⟹   ENSRNOP00000083356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX135,146,786 - 135,197,390 (-)Ensembl
RefSeq Acc Id: NM_001005565   ⟹   NP_001005565
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,301,577 (-)NCBI
mRatBN7.2X135,145,447 - 135,264,270 (-)NCBI
Rnor_6.0X159,724,065 - 159,840,804 (-)NCBI
Rnor_5.0X154,351,133 - 154,467,649 (-)NCBI
RGSC_v3.4X141,946,362 - 142,068,557 (-)RGD
CeleraX143,180,944 - 143,297,823 (-)RGD
Sequence:
RefSeq Acc Id: XM_008773651   ⟹   XP_008771873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,302,812 (-)NCBI
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
Rnor_6.0X159,722,031 - 159,841,343 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773652   ⟹   XP_008771874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,302,812 (-)NCBI
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
Rnor_6.0X159,722,031 - 159,841,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773653   ⟹   XP_008771875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,302,812 (-)NCBI
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
Rnor_6.0X159,722,031 - 159,841,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773654   ⟹   XP_008771876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,290,093 (-)NCBI
mRatBN7.2X135,147,481 - 135,252,810 (-)NCBI
Rnor_6.0X159,724,065 - 159,829,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602114   ⟹   XP_017457603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,290,851 (-)NCBI
mRatBN7.2X135,147,481 - 135,253,556 (-)NCBI
Rnor_6.0X159,724,065 - 159,830,107 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099906   ⟹   XP_038955834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,302,812 (-)NCBI
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
RefSeq Acc Id: XM_039099907   ⟹   XP_038955835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,302,812 (-)NCBI
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
RefSeq Acc Id: XM_039099908   ⟹   XP_038955836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,302,812 (-)NCBI
mRatBN7.2X135,145,447 - 135,264,636 (-)NCBI
RefSeq Acc Id: XM_039099909   ⟹   XP_038955837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,262,967 (-)NCBI
mRatBN7.2X135,147,481 - 135,225,668 (-)NCBI
RefSeq Acc Id: XM_039099910   ⟹   XP_038955838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,290,093 (-)NCBI
mRatBN7.2X135,147,481 - 135,252,810 (-)NCBI
RefSeq Acc Id: XM_039099911   ⟹   XP_038955839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,234,737 (-)NCBI
mRatBN7.2X135,145,447 - 135,197,425 (-)NCBI
RefSeq Acc Id: XM_063280154   ⟹   XP_063136224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,290,853 (-)NCBI
RefSeq Acc Id: XM_063280155   ⟹   XP_063136225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,290,094 (-)NCBI
RefSeq Acc Id: XM_063280156   ⟹   XP_063136226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,234,737 (-)NCBI
RefSeq Acc Id: XM_063280157   ⟹   XP_063136227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,234,737 (-)NCBI
RefSeq Acc Id: XM_063280158   ⟹   XP_063136228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X140,182,734 - 140,234,737 (-)NCBI
RefSeq Acc Id: NP_001005565   ⟸   NM_001005565
- UniProtKB: Q5XXR3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008771874   ⟸   XM_008773652
- Peptide Label: isoform X4
- UniProtKB: D3ZWQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771873   ⟸   XM_008773651
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZX43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771875   ⟸   XM_008773653
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GGI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771876   ⟸   XM_008773654
- Peptide Label: isoform X7
- UniProtKB: Q5XXR3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457603   ⟸   XM_017602114
- Peptide Label: isoform X7
- UniProtKB: Q5XXR3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001158   ⟸   ENSRNOT00000001158
RefSeq Acc Id: XP_038955836   ⟸   XM_039099908
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GGI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955835   ⟸   XM_039099907
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZX43 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955834   ⟸   XM_039099906
- Peptide Label: isoform X2
- UniProtKB: D3ZWQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955839   ⟸   XM_039099911
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038955838   ⟸   XM_039099910
- Peptide Label: isoform X7
- UniProtKB: Q5XXR3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038955837   ⟸   XM_039099909
- Peptide Label: isoform X7
- UniProtKB: Q5XXR3 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000084113   ⟸   ENSRNOT00000103631
Ensembl Acc Id: ENSRNOP00000088717   ⟸   ENSRNOT00000111102
Ensembl Acc Id: ENSRNOP00000096317   ⟸   ENSRNOT00000096866
Ensembl Acc Id: ENSRNOP00000083356   ⟸   ENSRNOT00000115452
RefSeq Acc Id: XP_063136224   ⟸   XM_063280154
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063136225   ⟸   XM_063280155
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063136228   ⟸   XM_063280158
- Peptide Label: isoform X13
- UniProtKB: A0A8I6G8W1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136227   ⟸   XM_063280157
- Peptide Label: isoform X12
- UniProtKB: A0A8I6APF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136226   ⟸   XM_063280156
- Peptide Label: isoform X11
Protein Domains
Calponin-homology (CH)   DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XXR3-F1-model_v2 AlphaFold Q5XXR3 1-772 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359674 AgrOrtholog
BioCyc Gene G2FUF-906 BioCyc
Ensembl Genes ENSRNOG00000000869 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001158 ENTREZGENE
  ENSRNOT00000096866 ENTREZGENE
  ENSRNOT00000103631 ENTREZGENE
  ENSRNOT00000111102 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  L1 transposable element, trimerization domain UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro AlphaPIX_SH3 UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  GDS_CDC24_CS UniProtKB/Swiss-Prot
  GEF_CC UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_Cool_Pix UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:363509 UniProtKB/Swiss-Prot
NCBI Gene 363509 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 UniProtKB/Swiss-Prot
  RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F UniProtKB/Swiss-Prot
Pfam betaPIX_CC UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  PF00307 UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  RhoGEF67_u1 UniProtKB/Swiss-Prot
  RhoGEF67_u2 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PhenoGen Arhgef6 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE DH_1 UniProtKB/Swiss-Prot
  DH_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PS50021 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000869 RatGTEx
SMART RhoGEF UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  SM00033 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47576 UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A8I5ZX43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G8W1 ENTREZGENE
  A0A8I6GGI3 ENTREZGENE, UniProtKB/TrEMBL
  ARHG6_RAT UniProtKB/Swiss-Prot
  D3ZWQ8 ENTREZGENE, UniProtKB/TrEMBL
  Q5XXR3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef6  Rac/Cdc42 guanine nucleotide exchange factor 6  Arhgef6  Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Arhgef6  Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6  arhgef6  rac/cdc42 guanine nucleotide exchange factor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 arhgef6  rac/cdc42 guanine nucleotide exchange factor 6      Symbol and Name status set to provisional 70820 PROVISIONAL