Itch (itchy E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Itch (itchy E3 ubiquitin protein ligase) Rattus norvegicus
Analyze
Symbol: Itch
Name: itchy E3 ubiquitin protein ligase
RGD ID: 1359556
Description: Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin-like protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Predicted to be involved in several processes, including negative regulation of defense response to virus; negative regulation of intracellular signal transduction; and protein ubiquitination. Predicted to act upstream of or within several processes, including CXCL12-activated CXCR4 signaling pathway; negative regulation of CD4-positive, alpha-beta T cell proliferation; and positive regulation of T cell anergy. Predicted to be located in several cellular components, including cell cortex; early endosome; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase); PARTICIPATES IN Notch signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 17beta-estradiol; acetamide; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase Itchy homolog; itch E3 ubiquitin ligase; itchy E3 ubiquitin protein ligase homolog; itchy E3 ubiquitin protein ligase homolog (mouse); itchy homolog E3 ubiquitin protein ligase; itchy homolog E3 ubiquitin protein ligase (mouse); itchy, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,102,490 - 164,193,932 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,105,812 - 164,193,932 (+)EnsemblGRCr8
mRatBN7.23143,642,348 - 143,733,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,645,637 - 143,733,543 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3147,511,691 - 147,599,817 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,128,969 - 156,217,097 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,868,517 - 153,956,642 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,660,665 - 150,752,016 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,686,638 - 150,749,827 (+)Ensemblrn6Rnor6.0
Rnor_5.03157,055,848 - 157,117,955 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43145,644,315 - 145,707,190 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,396,380 - 142,459,141 (+)NCBICelera
RGSC_v3.13145,549,936 - 145,612,812 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
defense response to virus  (IEA)
immune system process  (IEA)
innate immune response  (IEA)
negative regulation of alpha-beta T cell proliferation  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of cytoplasmic pattern recognition receptor signaling pathway  (IEA,ISO)
negative regulation of defense response to virus  (IEA,ISO)
negative regulation of immune system process  (IEA)
negative regulation of intracellular signal transduction  (IEA)
negative regulation of JNK cascade  (IEA,ISO)
negative regulation of multicellular organismal process  (IEA)
positive regulation of catabolic process  (IEA)
positive regulation of immune system process  (IEA)
positive regulation of macromolecule metabolic process  (IEA)
positive regulation of protein catabolic process  (ISO)
positive regulation of receptor catabolic process  (IEA,ISO)
positive regulation of T cell anergy  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IBA,IEA,ISO)
protein autoubiquitination  (IEA,ISO)
protein branched polyubiquitination  (IEA,ISO)
protein K29-linked ubiquitination  (IEA,ISO)
protein K48-linked ubiquitination  (IEA,ISO)
protein K63-linked ubiquitination  (IEA,ISO)
protein monoubiquitination  (IEA,ISO)
protein polyubiquitination  (ISO)
protein ubiquitination  (IEA,ISO)
receptor internalization  (IEA,ISO)
regulation of protein deubiquitination  (IEA,ISO)
ubiquitin-dependent protein catabolic process  (IEA,ISO)

Cellular Component
cell cortex  (IEA,ISO)
cell periphery  (IEA)
cytoplasm  (IBA,IEA,ISO)
cytoplasmic vesicle  (IEA,ISO)
cytosol  (IEA)
early endosome  (IEA,ISO)
early endosome membrane  (IEA)
membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IEA,ISO)
protein-containing complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Regulation of NF-kappaB by ubiquitination. Chen J and Chen ZJ, Curr Opin Immunol. 2013 Feb;25(1):4-12. doi: 10.1016/j.coi.2012.12.005. Epub 2013 Jan 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Deubiquitinases in the regulation of NF-kappaB signaling. Harhaj EW and Dixit VM, Cell Res. 2011 Jan;21(1):22-39. doi: 10.1038/cr.2010.166. Epub 2010 Nov 30.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Perry WL, etal., Nat Genet 1998 Feb;18(2):143-6.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11555636   PMID:14602072   PMID:14973438   PMID:15605377   PMID:15678106   PMID:17028573   PMID:17137798   PMID:17592138   PMID:18246070   PMID:18628966   PMID:18718448   PMID:19116316  
PMID:19592251   PMID:19881509   PMID:19946888   PMID:20068034   PMID:22871113   PMID:23146885   PMID:23533145   PMID:23886940   PMID:24790097   PMID:25518932   PMID:25631046   PMID:26796253  
PMID:37306338  


Genomics

Comparative Map Data
Itch
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,102,490 - 164,193,932 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,105,812 - 164,193,932 (+)EnsemblGRCr8
mRatBN7.23143,642,348 - 143,733,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,645,637 - 143,733,543 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3147,511,691 - 147,599,817 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,128,969 - 156,217,097 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,868,517 - 153,956,642 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,660,665 - 150,752,016 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,686,638 - 150,749,827 (+)Ensemblrn6Rnor6.0
Rnor_5.03157,055,848 - 157,117,955 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43145,644,315 - 145,707,190 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,396,380 - 142,459,141 (+)NCBICelera
RGSC_v3.13145,549,936 - 145,612,812 (+)NCBI
Cytogenetic Map3q41NCBI
ITCH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,363,273 - 34,511,773 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,363,235 - 34,511,773 (+)Ensemblhg38GRCh38
GRCh372032,951,079 - 33,099,578 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,414,745 - 32,562,858 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342032,414,744 - 32,562,858NCBI
Celera2029,700,532 - 29,848,669 (+)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,732,695 - 29,880,133 (+)NCBIHuRef
CHM1_12032,852,140 - 33,000,398 (+)NCBICHM1_1
T2T-CHM13v2.02036,086,401 - 36,234,950 (+)NCBIT2T-CHM13v2.0
Itch
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,975,401 - 155,068,775 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,975,429 - 155,068,775 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382155,133,481 - 155,226,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,133,509 - 155,226,855 (+)Ensemblmm10GRCm38
MGSCv372154,959,217 - 155,052,590 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362154,821,645 - 154,918,295 (+)NCBIMGSCv36mm8
Celera2161,062,175 - 161,159,103 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.94NCBI
Itch
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,809,972 - 26,887,123 (-)Ensembl
ChiLan1.0NW_00495542226,810,829 - 26,918,517 (-)NCBIChiLan1.0ChiLan1.0
ITCH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,093,373 - 40,244,925 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,086,459 - 40,238,028 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02030,690,172 - 30,840,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,822,496 - 31,971,945 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,852,203 - 31,971,945 (+)EnsemblpanPan2panpan1.1
ITCH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,476,619 - 23,630,574 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,476,736 - 23,627,469 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2423,124,607 - 23,276,323 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02424,168,489 - 24,321,093 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,168,521 - 24,320,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,456,967 - 23,608,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,551,074 - 23,703,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,990,143 - 24,142,586 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itch
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,483,787 - 172,608,613 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,140,234 - 6,265,767 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,140,236 - 6,265,734 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITCH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,810,235 - 37,918,209 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11737,810,113 - 37,918,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,398,530 - 42,404,580 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITCH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1238,671,170 - 38,808,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl238,701,396 - 38,805,005 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605088,023,258 - 88,160,983 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itch
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248424,842,419 - 4,935,699 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248424,840,848 - 4,977,785 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Itch
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15134,494,345 - 134,582,451 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itch
1261 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:105
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000024411
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078235   ⟹   ENSRNOP00000075116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,105,812 - 164,193,909 (+)Ensembl
mRatBN7.2 Ensembl3143,645,637 - 143,733,543 (+)Ensembl
Rnor_6.0 Ensembl3150,686,638 - 150,749,827 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105016   ⟹   ENSRNOP00000083747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,668,084 - 143,733,543 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106366   ⟹   ENSRNOP00000092387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,134,005 - 164,193,932 (+)Ensembl
mRatBN7.2 Ensembl3143,673,816 - 143,733,543 (+)Ensembl
RefSeq Acc Id: NM_001005887   ⟹   NP_001005887
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,105,796 - 164,193,932 (+)NCBI
mRatBN7.23143,645,604 - 143,733,745 (+)NCBI
Rnor_6.03150,686,759 - 150,749,629 (+)NCBI
Rnor_5.03157,055,848 - 157,117,955 (+)NCBI
RGSC_v3.43145,644,315 - 145,707,190 (+)RGD
Celera3142,396,380 - 142,459,141 (+)RGD
Sequence:
RefSeq Acc Id: XM_008762336   ⟹   XP_008760558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,102,490 - 164,193,931 (+)NCBI
mRatBN7.23143,642,348 - 143,733,745 (+)NCBI
Rnor_6.03150,660,665 - 150,752,016 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001005887 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760558 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT46068 (Get FASTA)   NCBI Sequence Viewer  
  EDL85936 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075116
  ENSRNOP00000075116.2
  ENSRNOP00000092387.1
RefSeq Acc Id: NP_001005887   ⟸   NM_001005887
- UniProtKB: A0A0G2K9T1 (UniProtKB/TrEMBL),   A6KI19 (UniProtKB/TrEMBL),   Q5YB86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760558   ⟸   XM_008762336
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9T1 (UniProtKB/TrEMBL),   A6KI19 (UniProtKB/TrEMBL),   Q5YB86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075116   ⟸   ENSRNOT00000078235
Ensembl Acc Id: ENSRNOP00000083747   ⟸   ENSRNOT00000105016
Ensembl Acc Id: ENSRNOP00000092387   ⟸   ENSRNOT00000106366
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9T1-F1-model_v2 AlphaFold A0A0G2K9T1 1-882 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359556 AgrOrtholog
BioCyc Gene G2FUF-47148 BioCyc
Ensembl Genes ENSRNOG00000059043 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078235 ENTREZGENE
  ENSRNOT00000078235.3 UniProtKB/TrEMBL
  ENSRNOT00000106366.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  E3_ubiq-protein_ligase UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:311567 UniProtKB/TrEMBL
NCBI Gene 311567 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Itch PhenoGen
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059043 RatGTEx
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0A0G2K9T1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AVL7_RAT UniProtKB/TrEMBL
  A6KI19 ENTREZGENE, UniProtKB/TrEMBL
  Q5YB86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-18 Itch  itchy E3 ubiquitin protein ligase  Itch  itchy E3 ubiquitin protein ligase homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Itch  itchy E3 ubiquitin protein ligase homolog (mouse)  Itch  itchy, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Itch  itchy, E3 ubiquitin protein ligase  Itch  itchy homolog E3 ubiquitin protein ligase (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Itch  itchy homolog E3 ubiquitin protein ligase (mouse)    itchy homolog E3 ubiquitin protein ligase  Name updated 1299863 APPROVED
2005-07-29 Itch  itchy homolog E3 ubiquitin protein ligase      Symbol and Name status set to provisional 70820 PROVISIONAL