RGD Reference Report - Deubiquitinases in the regulation of NF-kappaB signaling. - Rat Genome Database

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Deubiquitinases in the regulation of NF-kappaB signaling.

Authors: Harhaj, EW  Dixit, VM 
Citation: Harhaj EW and Dixit VM, Cell Res. 2011 Jan;21(1):22-39. doi: 10.1038/cr.2010.166. Epub 2010 Nov 30.
RGD ID: 7800735
Pubmed: PMID:21119682   (View Abstract at PubMed)
PMCID: PMC3075605   (View Article at PubMed Central)
DOI: DOI:10.1038/cr.2010.166   (Journal Full-text)

Nuclear factor-kappa B (NF-kappaB) is a critical regulator of multiple biological functions including innate and adaptive immunity and cell survival. Activation of NF-kappaB is tightly regulated to preclude chronic signaling that may lead to persistent inflammation and cancer. Ubiquitination of key signaling molecules by E3 ubiquitin ligases has emerged as an important regulatory mechanism for NF-kappaB signaling. Deubiquitinases (DUBs) counteract E3 ligases and therefore play a prominent role in the downregulation of NF-kappaB signaling and homeostasis. Understanding the mechanisms of NF-kappaB downregulation by specific DUBs such as A20 and CYLD may provide therapeutic opportunities for the treatment of chronic inflammatory diseases and cancer.

Objects Annotated

Genes (Rattus norvegicus)
Cyld  (CYLD lysine 63 deubiquitinase)
Itch  (itchy E3 ubiquitin protein ligase)
Tax1bp1  (Tax1 binding protein 1)
Tnfaip3  (TNF alpha induced protein 3)

Genes (Mus musculus)
Cyld  (CYLD lysine 63 deubiquitinase)
Itch  (itchy, E3 ubiquitin protein ligase)
Rnf11  (ring finger protein 11)
Tax1bp1  (Tax1 (human T cell leukemia virus type I) binding protein 1)
Tnfaip3  (tumor necrosis factor, alpha-induced protein 3)

Genes (Homo sapiens)
CYLD  (CYLD lysine 63 deubiquitinase)
ITCH  (itchy E3 ubiquitin protein ligase)
RNF11  (ring finger protein 11)
TAX1BP1  (Tax1 binding protein 1)
TNFAIP3  (TNF alpha induced protein 3)


Additional Information