Dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2) - Rat Genome Database

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Gene: Dyrk2 (dual specificity tyrosine phosphorylation regulated kinase 2) Rattus norvegicus
Analyze
Symbol: Dyrk2
Name: dual specificity tyrosine phosphorylation regulated kinase 2
RGD ID: 1312039
Description: Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and positive regulation of glycogen biosynthetic process. Predicted to be part of ribonucleoprotein complex and ubiquitin ligase complex. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; LOC314862
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8756,235,276 - 56,265,741 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl756,235,276 - 56,265,942 (-)EnsemblGRCr8
mRatBN7.2754,348,724 - 54,381,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl754,349,610 - 54,380,106 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx756,256,148 - 56,268,568 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,459,275 - 58,471,695 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0758,237,109 - 58,249,529 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,785,423 - 61,816,775 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,786,309 - 61,798,729 (-)Ensemblrn6Rnor6.0
Rnor_5.0761,775,902 - 61,807,168 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4758,114,127 - 58,126,547 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera751,116,337 - 51,128,757 (-)NCBICelera
RGSC_v3.1758,138,697 - 58,149,260 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-diaminotoluene  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrobenzaldehyde  (ISO)
5-iodotubercidin  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
endosulfan  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hexestrol  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (EXP,ISO)
maneb  (ISO)
menadione  (ISO)
mestranol  (ISO)
methapyrilene  (EXP)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9748265   PMID:11311121   PMID:16511445   PMID:17349958   PMID:18455992   PMID:19287380   PMID:19965871   PMID:21709260  


Genomics

Comparative Map Data
Dyrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8756,235,276 - 56,265,741 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl756,235,276 - 56,265,942 (-)EnsemblGRCr8
mRatBN7.2754,348,724 - 54,381,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl754,349,610 - 54,380,106 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx756,256,148 - 56,268,568 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,459,275 - 58,471,695 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0758,237,109 - 58,249,529 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,785,423 - 61,816,775 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,786,309 - 61,798,729 (-)Ensemblrn6Rnor6.0
Rnor_5.0761,775,902 - 61,807,168 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4758,114,127 - 58,126,547 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera751,116,337 - 51,128,757 (-)NCBICelera
RGSC_v3.1758,138,697 - 58,149,260 (-)NCBI
Cytogenetic Map7q22NCBI
DYRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381267,648,745 - 67,665,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1267,647,913 - 67,665,406 (+)Ensemblhg38GRCh38
GRCh371268,042,525 - 68,059,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,328,779 - 66,342,711 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341266,329,020 - 66,340,410NCBI
Celera1267,706,515 - 67,720,446 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1265,093,416 - 65,107,347 (+)NCBIHuRef
CHM1_11268,010,112 - 68,024,043 (+)NCBICHM1_1
T2T-CHM13v2.01267,628,264 - 67,644,920 (+)NCBIT2T-CHM13v2.0
Dyrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,691,507 - 118,725,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,691,508 - 118,706,114 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl10118,688,786 - 118,725,168 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810118,855,602 - 118,889,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,855,603 - 118,870,209 (-)Ensemblmm10GRCm38
MGSCv3710118,296,405 - 118,305,959 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610118,262,342 - 118,271,896 (-)NCBIMGSCv36mm8
Celera10121,236,125 - 121,244,887 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.75NCBI
Dyrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545814,193,303 - 14,218,957 (+)Ensembl
ChiLan1.0NW_00495545814,199,912 - 14,201,712 (+)NCBIChiLan1.0ChiLan1.0
DYRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21026,689,217 - 26,704,660 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11226,685,982 - 26,701,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01221,241,325 - 21,260,321 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11221,751,119 - 21,766,602 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1221,757,436 - 21,767,505 (-)EnsemblpanPan2panpan1.1
DYRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1109,982,245 - 9,994,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl109,980,080 - 9,991,934 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha109,915,768 - 9,929,155 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01010,099,203 - 10,112,645 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,098,813 - 10,108,970 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1109,974,467 - 9,987,896 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01010,221,581 - 10,234,975 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01010,343,266 - 10,356,687 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dyrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494548,553,639 - 48,567,246 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365455,542,803 - 5,554,136 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365455,542,873 - 5,555,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,047,643 - 32,064,222 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1532,047,614 - 32,064,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,120,816 - 110,124,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11163,294,035 - 63,308,008 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,294,444 - 63,304,080 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037182,403,669 - 182,420,416 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dyrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624802650,119 - 660,005 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624802643,783 - 660,603 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dyrk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11196,815,645 - 196,828,812 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dyrk2
204 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1232
Count of miRNA genes:346
Interacting mature miRNAs:493
Transcripts:ENSRNOT00000010283
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH140100  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2754,350,813 - 54,351,028 (+)MAPPERmRatBN7.2
Rnor_6.0761,787,513 - 61,787,727NCBIRnor6.0
Rnor_5.0761,777,992 - 61,778,206UniSTSRnor5.0
RGSC_v3.4758,115,331 - 58,115,545UniSTSRGSC3.4
Celera751,117,541 - 51,117,755UniSTS
Cytogenetic Map7q22UniSTS
Dyrk2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2754,354,743 - 54,355,240 (+)MAPPERmRatBN7.2
Rnor_6.0761,791,443 - 61,791,939NCBIRnor6.0
Rnor_5.0761,781,922 - 61,782,418UniSTSRnor5.0
Celera751,121,471 - 51,121,967UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010283   ⟹   ENSRNOP00000010283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl756,235,276 - 56,248,660 (-)Ensembl
mRatBN7.2 Ensembl754,349,610 - 54,365,153 (-)Ensembl
Rnor_6.0 Ensembl761,786,309 - 61,798,729 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104850   ⟹   ENSRNOP00000079967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl756,238,318 - 56,265,942 (-)Ensembl
mRatBN7.2 Ensembl754,353,456 - 54,380,106 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138059   ⟹   ENSRNOP00000111431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl756,235,276 - 56,249,724 (-)Ensembl
RefSeq Acc Id: NM_001108100   ⟹   NP_001101570
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8756,235,276 - 56,248,660 (-)NCBI
mRatBN7.2754,349,608 - 54,362,992 (-)NCBI
Rnor_6.0761,786,309 - 61,798,729 (-)NCBI
Rnor_5.0761,775,902 - 61,807,168 (-)NCBI
RGSC_v3.4758,114,127 - 58,126,547 (-)RGD
Celera751,116,337 - 51,128,757 (-)RGD
Sequence:
RefSeq Acc Id: XM_063263497   ⟹   XP_063119567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8756,235,276 - 56,265,741 (-)NCBI
RefSeq Acc Id: XM_063263498   ⟹   XP_063119568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8756,235,276 - 56,263,077 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101570 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119567 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119568 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16591 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010283
  ENSRNOP00000010283.6
  ENSRNOP00000079967
  ENSRNOP00000079967.1
  ENSRNOP00000111431.1
RefSeq Acc Id: NP_001101570   ⟸   NM_001108100
- UniProtKB: F1LYY7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010283   ⟸   ENSRNOT00000010283
Ensembl Acc Id: ENSRNOP00000079967   ⟸   ENSRNOT00000104850
RefSeq Acc Id: XP_063119567   ⟸   XM_063263497
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119568   ⟸   XM_063263498
- Peptide Label: isoform X2
- UniProtKB: A6IGV7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111431   ⟸   ENSRNOT00000138059
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LYY7-F1-model_v2 AlphaFold F1LYY7 1-527 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695220
Promoter ID:EPDNEW_R5745
Type:single initiation site
Name:Dyrk2_1
Description:dual specificity tyrosine phosphorylation regulated kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0761,798,733 - 61,798,793EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312039 AgrOrtholog
BioCyc Gene G2FUF-33938 BioCyc
Ensembl Genes ENSRNOG00000007821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010283 ENTREZGENE
  ENSRNOT00000010283.7 UniProtKB/TrEMBL
  ENSRNOT00000104850 ENTREZGENE
  ENSRNOT00000104850.2 UniProtKB/TrEMBL
  ENSRNOT00000138059.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.10.30 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DYRK UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser_Thr_dual-spec_kinase UniProtKB/TrEMBL
KEGG Report rno:314862 UniProtKB/TrEMBL
NCBI Gene 314862 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/TrEMBL
  DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Dyrk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007821 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZS28 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M2L3_RAT UniProtKB/TrEMBL
  A6IGV7 ENTREZGENE, UniProtKB/TrEMBL
  F1LYY7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Dyrk2  dual specificity tyrosine phosphorylation regulated kinase 2  Dyrk2  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dyrk2  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2   Dyrk2_predicted  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dyrk2_predicted  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED