Akr1c2 (aldo-keto reductase family 1, member C2) - Rat Genome Database

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Gene: Akr1c2 (aldo-keto reductase family 1, member C2) Rattus norvegicus
Analyze
Symbol: Akr1c2
Name: aldo-keto reductase family 1, member C2
RGD ID: 1311841
Description: Predicted to enable several functions, including NADP binding activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including cellular response to prostaglandin D stimulus; glycoside metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C2 (aldo-keto reductase family 1 member C2); INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; 3,4,5,3',4',5'-Hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; Akr1c21; aldo-keto reductase family 1 member C21; aldo-keto reductase family 1, member C21; LOC291283; RAKg
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,669,684 - 70,717,935 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1770,669,710 - 70,685,686 (-)EnsemblGRCr8
mRatBN7.21765,759,778 - 65,808,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,255,523 - 69,303,728 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,084,375 - 73,132,581 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,127,357 - 67,175,563 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,388,337 - 69,435,160 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)Ensemblrn6Rnor6.0
Rnor_5.01771,102,094 - 71,148,911 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,034,737 - 77,081,406 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,292,033 - 65,339,839 (-)NCBICelera
RGSC_v3.11777,045,579 - 77,092,239 (-)NCBI
Cytogenetic Map17q12.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (ISO)
(E)-cinnamyl alcohol  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-phenyl-1,2-propanedione  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dimethoxyphenol  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-aminophenol  (ISO)
2-hexenal  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxybenzoic acid  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-nitrobenzyl bromide  (ISO)
5-alpha-THDOC  (ISO)
5-fluorouracil  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
9,10-phenanthroquinone  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
ampicillin  (ISO)
androstane-3,17-diol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzyl cinnamate  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
citral  (ISO)
clodronic acid  (ISO)
Clofop  (ISO)
cloxazolam  (ISO)
cobalt dichloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclopentanol  (ISO)
cyclopentanone  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
dibenzo[a,l]pyrene  (ISO)
dienogest  (ISO)
diethyl maleate  (ISO)
diethyl sulfate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
estazolam  (ISO)
Ethyl acrylate  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol dimethacrylate  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
farnesal  (ISO)
fenamic acid  (ISO)
fenofibrate  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
gedunin  (ISO)
geranial  (ISO)
glipizide  (ISO)
glyburide  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyoxal  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexestrol  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
imidurea  (ISO)
indometacin  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
linalool  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
malathion  (ISO)
meclofenamic acid  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methyl methanesulfonate  (ISO)
methyl non-2-ynoate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
n-propyl gallate  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
nitrazepam  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
octyl gallate  (ISO)
oxcarbazepine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
Panaxytriol  (ISO)
para-Cresidine  (ISO)
paracetamol  (ISO)
Paraoxon-methyl  (ISO)
parathion-methyl  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenolphthalein  (ISO)
Phenyl glycidyl ether  (ISO)
phenylacetaldehyde  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
progesterone  (ISO)
prostaglandin F2alpha  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
reactive oxygen species  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP)
salicylic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-isoeugenol  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8573067   PMID:15577209   PMID:17034817   PMID:17442338   PMID:18508192   PMID:19487289   PMID:20124700   PMID:20837989   PMID:21232532   PMID:21492153   PMID:21851338  


Genomics

Comparative Map Data
Akr1c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,669,684 - 70,717,935 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1770,669,710 - 70,685,686 (-)EnsemblGRCr8
mRatBN7.21765,759,778 - 65,808,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,255,523 - 69,303,728 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,084,375 - 73,132,581 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,127,357 - 67,175,563 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,388,337 - 69,435,160 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)Ensemblrn6Rnor6.0
Rnor_5.01771,102,094 - 71,148,911 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,034,737 - 77,081,406 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,292,033 - 65,339,839 (-)NCBICelera
RGSC_v3.11777,045,579 - 77,092,239 (-)NCBI
Cytogenetic Map17q12.2NCBI
AKR1C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38104,987,775 - 5,018,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl104,987,775 - 5,018,031 (-)Ensemblhg38GRCh38
GRCh37105,029,967 - 5,060,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,021,965 - 5,050,207 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34105,021,965 - 5,050,207NCBI
Celera104,972,245 - 5,000,184 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef104,920,321 - 4,955,422 (+)NCBIHuRef
CHM1_1105,030,308 - 5,060,576 (-)NCBICHM1_1
T2T-CHM13v2.0104,988,109 - 5,018,344 (-)NCBIT2T-CHM13v2.0
Akr1c21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,624,074 - 4,636,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,624,074 - 4,636,540 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38134,574,075 - 4,586,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,574,075 - 4,586,541 (+)Ensemblmm10GRCm38
MGSCv37134,573,321 - 4,585,789 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36134,573,321 - 4,585,787 (+)NCBIMGSCv36mm8
Celera134,543,969 - 4,562,535 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.56NCBI

Variants

.
Variants in Akr1c2
592 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:140
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000051342, ENSRNOT00000066282
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 10 12 43 56 55 31 20 31 6 133 50 1 25 38 36 24 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000051342   ⟹   ENSRNOP00000045355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,669,710 - 70,685,686 (-)Ensembl
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)Ensembl
Rnor_6.0 Ensembl1769,388,347 - 69,404,323 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066282   ⟹   ENSRNOP00000063166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,669,710 - 70,685,686 (-)Ensembl
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)Ensembl
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160073   ⟹   ENSRNOP00000107623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,669,710 - 70,685,686 (-)Ensembl
RefSeq Acc Id: NM_001013057   ⟹   NP_001013075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,700 - 70,717,880 (-)NCBI
mRatBN7.21765,759,778 - 65,807,957 (-)NCBI
Rnor_6.01769,388,337 - 69,435,148 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
RGSC_v3.41777,034,737 - 77,081,406 (-)RGD
Celera1765,292,033 - 65,339,839 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254183   ⟹   XP_006254245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,935 (-)NCBI
mRatBN7.21765,759,895 - 65,808,013 (-)NCBI
Rnor_6.01769,388,374 - 69,435,160 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254185   ⟹   XP_006254247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,935 (-)NCBI
mRatBN7.21765,759,895 - 65,808,013 (-)NCBI
Rnor_6.01769,388,375 - 69,435,160 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095531   ⟹   XP_038951459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,897 (-)NCBI
mRatBN7.21765,759,895 - 65,807,943 (-)NCBI
RefSeq Acc Id: XM_063276235   ⟹   XP_063132305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,897 (-)NCBI
RefSeq Acc Id: NP_001013075   ⟸   NM_001013057
- UniProtKB: Q6AYQ2 (UniProtKB/Swiss-Prot),   F1LQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254247   ⟸   XM_006254185
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006254245   ⟸   XM_006254183
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000045355   ⟸   ENSRNOT00000051342
Ensembl Acc Id: ENSRNOP00000063166   ⟸   ENSRNOT00000066282
RefSeq Acc Id: XP_038951459   ⟸   XM_039095531
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132305   ⟸   XM_063276235
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000107623   ⟸   ENSRNOT00000160073
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYQ2-F1-model_v2 AlphaFold Q6AYQ2 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311841 AgrOrtholog
BioCyc Gene G2FUF-8841 BioCyc
Ensembl Genes ENSRNOG00000029844 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051342 ENTREZGENE
  ENSRNOT00000160073 ENTREZGENE
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110806 IMAGE-MGC_LOAD
InterPro AKR1C UniProtKB/Swiss-Prot
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:291283 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93821 IMAGE-MGC_LOAD
NCBI Gene 291283 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot
PhenoGen Akr1c2 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot
PROSITE ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029844 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot
UniProt A0A387KBL1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LAS3_RAT UniProtKB/TrEMBL
  AK1CL_RAT UniProtKB/Swiss-Prot
  F1LQ80 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYQ2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-15 Akr1c2  aldo-keto reductase family 1, member C2  Akr1c21  aldo-keto reductase family 1, member C21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Akr1c21  aldo-keto reductase family 1, member C21  Akr1c21_predicted  aldo-keto reductase family 1, member C21 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Akr1c21_predicted  aldo-keto reductase family 1, member C21 (predicted)      Symbol and Name status set to approved 70820 APPROVED