Gadd45g (growth arrest and DNA-damage-inducible, gamma) - Rat Genome Database

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Gene: Gadd45g (growth arrest and DNA-damage-inducible, gamma) Rattus norvegicus
Analyze
Symbol: Gadd45g
Name: growth arrest and DNA-damage-inducible, gamma
RGD ID: 1311796
Description: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including positive regulation of MAPK cascade; positive regulation of apoptotic process; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in cytoplasm and nucleus. Biomarker of mesangial proliferative glomerulonephritis. Orthologous to human GADD45G (growth arrest and DNA damage inducible gamma); PARTICIPATES IN interleukin-12 signaling pathway; p38 MAPK signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (S)-colchicine; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GADD45gamma; growth arrest and DNA damage inducible; growth arrest and DNA damage-inducible protein GADD45 gamma; growth arrest and DNA-damage-inducible 45 gamma; growth arrest and DNA-damage-inducible protein GADD45 gamma; LOC291005
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,528,606 - 13,530,351 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1713,528,610 - 13,530,369 (-)EnsemblGRCr8
mRatBN7.21713,376,842 - 13,378,587 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,376,839 - 13,378,610 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1713,306,579 - 13,308,325 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01714,916,605 - 14,918,351 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,233,590 - 13,235,336 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,391,474 - 13,393,219 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,391,467 - 13,393,243 (-)Ensemblrn6Rnor6.0
Rnor_5.01715,469,297 - 15,471,042 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41719,230,896 - 19,232,641 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1713,134,806 - 13,136,551 (-)NCBICelera
RGSC_v3.11719,230,892 - 19,312,040 (-)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-nitropropane  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylcoumarin  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
abexinostat  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenic trichloride  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
febuxostat  (ISO)
fenpyroximate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
furan  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucose  (ISO)
glycidol  (EXP)
glycine betaine  (ISO)
glyphosate  (EXP,ISO)
graphene oxide  (ISO)
GSK-J4  (ISO)
hydrogen cyanide  (ISO)
hydrogen sulfide  (ISO)
hypochlorous acid  (ISO)
idarubicin  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
irinotecan  (EXP)
iron dichloride  (ISO)
isoprenaline  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
miconazole  (ISO)
microcystin-LR  (ISO)
milrinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
myristicin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
neomycin  (ISO)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
phosphoramide mustard  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
ritodrine  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sorafenib  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
Xanthatin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GADD45¿ regulates the thermogenic capacity of brown adipose tissue. Gantner ML, etal., Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11870-5. doi: 10.1073/pnas.1406638111. Epub 2014 Jul 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Gene expression profile and overexpression of apoptosis-related genes (NGFI-B and Gadd 45 gamma) in early phase of Thy-1 nephritis model. Xu JH, etal., Cell Tissue Res. 2006 Oct;326(1):159-68. doi: 10.1007/s00441-006-0214-4. Epub 2006 May 31.
Additional References at PubMed
PMID:9827804   PMID:10100865   PMID:12124778   PMID:12213961   PMID:12477932   PMID:18445651   PMID:19882653   PMID:27086974   PMID:32828305  


Genomics

Comparative Map Data
Gadd45g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,528,606 - 13,530,351 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1713,528,610 - 13,530,369 (-)EnsemblGRCr8
mRatBN7.21713,376,842 - 13,378,587 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,376,839 - 13,378,610 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1713,306,579 - 13,308,325 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01714,916,605 - 14,918,351 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,233,590 - 13,235,336 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,391,474 - 13,393,219 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,391,467 - 13,393,243 (-)Ensemblrn6Rnor6.0
Rnor_5.01715,469,297 - 15,471,042 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41719,230,896 - 19,232,641 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1713,134,806 - 13,136,551 (-)NCBICelera
RGSC_v3.11719,230,892 - 19,312,040 (-)NCBI
Cytogenetic Map17p14NCBI
GADD45G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38989,605,012 - 89,606,555 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl989,605,012 - 89,606,555 (+)Ensemblhg38GRCh38
GRCh37992,219,927 - 92,221,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36991,409,748 - 91,411,290 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34989,449,481 - 89,451,021NCBI
Celera962,803,226 - 62,804,769 (+)NCBICelera
Cytogenetic Map9q22.2NCBI
HuRef962,051,611 - 62,053,154 (+)NCBIHuRef
CHM1_1992,368,717 - 92,370,261 (+)NCBICHM1_1
T2T-CHM13v2.09101,768,936 - 101,770,479 (+)NCBIT2T-CHM13v2.0
Gadd45g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391352,000,711 - 52,002,511 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1352,000,714 - 52,002,504 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381351,846,675 - 51,848,475 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1351,846,678 - 51,848,468 (+)Ensemblmm10GRCm38
MGSCv371351,942,044 - 51,943,844 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361351,859,189 - 51,860,971 (+)NCBIMGSCv36mm8
Celera1352,922,160 - 52,923,960 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1326.36NCBI
Gadd45g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555152,422,998 - 2,424,851 (-)Ensembl
ChiLan1.0NW_0049555152,423,137 - 2,424,851 (-)NCBIChiLan1.0ChiLan1.0
GADD45G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21149,854,190 - 49,855,744 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1949,856,577 - 49,858,126 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0960,695,307 - 60,696,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1988,740,411 - 88,741,965 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl988,740,411 - 88,741,958 (+)EnsemblpanPan2panpan1.1
GADD45G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1196,745,001 - 96,746,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl196,744,985 - 96,746,520 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha197,197,788 - 97,199,313 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0197,346,707 - 97,348,232 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl197,346,691 - 97,348,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1196,974,994 - 96,976,519 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0196,693,996 - 96,695,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0197,452,325 - 97,453,850 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gadd45g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494411,357,046 - 11,358,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936780501,681 - 503,305 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936780501,452 - 503,272 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl141,165,982 - 1,167,529 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1141,166,000 - 1,167,538 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2141,421,152 - 1,422,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GADD45G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112100,097,990 - 100,099,541 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12100,097,967 - 100,099,697 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603888,422,292 - 88,423,839 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gadd45g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476522,959,373 - 22,961,491 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476522,959,751 - 22,961,371 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gadd45g
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11470,216,781 - 70,218,635 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gadd45g
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:175
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000018252
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
C86281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21713,376,871 - 13,377,056 (+)MAPPERmRatBN7.2
Rnor_6.01713,391,504 - 13,391,688NCBIRnor6.0
Rnor_5.01715,469,327 - 15,469,511UniSTSRnor5.0
RGSC_v3.41719,230,926 - 19,231,110UniSTSRGSC3.4
Celera1713,134,836 - 13,135,020UniSTS
Cytogenetic Map17p14UniSTS
PMC86941P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21713,377,064 - 13,377,420 (+)MAPPERmRatBN7.2
Rnor_6.01713,391,697 - 13,392,052NCBIRnor6.0
Rnor_5.01715,469,520 - 15,469,875UniSTSRnor5.0
RGSC_v3.41719,231,119 - 19,231,474UniSTSRGSC3.4
Celera1713,135,029 - 13,135,384UniSTS
Cytogenetic Map17p14UniSTS
UniSTS:237015  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81713,528,693 - 13,528,892 (+)Marker Load Pipeline
mRatBN7.21713,376,929 - 13,377,128 (+)MAPPERmRatBN7.2
Rnor_6.01713,391,562 - 13,391,760NCBIRnor6.0
Rnor_5.01715,469,385 - 15,469,583UniSTSRnor5.0
RGSC_v3.41719,230,984 - 19,231,182UniSTSRGSC3.4
Celera1713,134,894 - 13,135,092UniSTS
Cytogenetic Map17p14UniSTS
UniSTS:546781  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81713,529,695 - 13,530,291 (+)Marker Load Pipeline
mRatBN7.21713,377,931 - 13,378,527 (+)MAPPERmRatBN7.2
Rnor_6.01713,392,564 - 13,393,159NCBIRnor6.0
Rnor_5.01715,470,387 - 15,470,982UniSTSRnor5.0
Celera1713,135,896 - 13,136,491UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018252   ⟹   ENSRNOP00000018251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1713,528,610 - 13,530,369 (-)Ensembl
mRatBN7.2 Ensembl1713,376,839 - 13,378,610 (-)Ensembl
Rnor_6.0 Ensembl1713,391,467 - 13,393,243 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106900   ⟹   ENSRNOP00000086432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1713,376,839 - 13,378,610 (-)Ensembl
RefSeq Acc Id: NM_001077640   ⟹   NP_001071108
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,528,606 - 13,530,351 (-)NCBI
mRatBN7.21713,376,842 - 13,378,587 (-)NCBI
Rnor_6.01713,391,474 - 13,393,219 (-)NCBI
Rnor_5.01715,469,297 - 15,471,042 (-)NCBI
RGSC_v3.41719,230,896 - 19,232,641 (-)RGD
Celera1713,134,806 - 13,136,551 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001071108 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68643 (Get FASTA)   NCBI Sequence Viewer  
  BAA78094 (Get FASTA)   NCBI Sequence Viewer  
  EDL98082 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018251
  ENSRNOP00000018251.4
GenBank Protein Q9WTQ7 (Get FASTA)   NCBI Sequence Viewer  
  QST78375 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001071108   ⟸   NM_001077640
- UniProtKB: Q9WTQ7 (UniProtKB/Swiss-Prot),   B5DEF0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018251   ⟸   ENSRNOT00000018252
Ensembl Acc Id: ENSRNOP00000086432   ⟸   ENSRNOT00000106900
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTQ7-F1-model_v2 AlphaFold Q9WTQ7 1-159 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700337
Promoter ID:EPDNEW_R10860
Type:single initiation site
Name:Gadd45g_1
Description:growth arrest and DNA-damage-inducible, gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01713,393,237 - 13,393,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311796 AgrOrtholog
BioCyc Gene G2FUF-10076 BioCyc
Ensembl Genes ENSRNOG00000013090 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018252 ENTREZGENE
  ENSRNOT00000018252.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1330.30 UniProtKB/Swiss-Prot
InterPro GADD45 UniProtKB/Swiss-Prot
  L30e-like UniProtKB/Swiss-Prot
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/Swiss-Prot
KEGG Report rno:291005 UniProtKB/Swiss-Prot
NCBI Gene 291005 ENTREZGENE
PANTHER GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA UniProtKB/Swiss-Prot
  PTHR10411 UniProtKB/Swiss-Prot
Pfam Ribosomal_L7Ae UniProtKB/Swiss-Prot
PhenoGen Gadd45g PhenoGen
RatGTEx ENSRNOG00000013090 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/Swiss-Prot
UniProt B5DEF0 ENTREZGENE, UniProtKB/TrEMBL
  GA45G_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Gadd45g  growth arrest and DNA-damage-inducible, gamma  Gadd45g  growth arrest and DNA-damage-inducible 45 gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gadd45g  growth arrest and DNA-damage-inducible 45 gamma  Gadd45g_predicted  growth arrest and DNA-damage-inducible 45 gamma (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gadd45g_predicted  growth arrest and DNA-damage-inducible 45 gamma (predicted)      Symbol and Name status set to approved 70820 APPROVED