Cdc73 (cell division cycle 73) - Rat Genome Database

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Gene: Cdc73 (cell division cycle 73) Rattus norvegicus
Analyze
Symbol: Cdc73
Name: cell division cycle 73
RGD ID: 1311766
Description: Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in several processes, including negative regulation of cell population proliferation; regulation of RNA metabolic process; and regulation of cell cycle G1/S phase transition. Predicted to act upstream of or within negative regulation of apoptotic process; regulation of cell growth; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cdc73/Paf1 complex. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73); PARTICIPATES IN RNA polymerase I transcription pathway; RNA polymerase II transcription elongation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); cell division cycle protein 73 homolog; Hrpt2; hyperparathyroidism 2 (with jaw tumor); hyperparathyroidism 2 protein homolog; LOC304832; parafibromin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81357,897,924 - 58,000,031 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1357,883,983 - 57,999,978 (-)EnsemblGRCr8
mRatBN7.21355,357,226 - 55,449,690 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,357,226 - 55,449,656 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1357,920,582 - 58,012,922 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,192,881 - 59,285,299 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,477,724 - 56,570,082 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,403,771 - 60,496,511 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,403,771 - 60,496,511 (-)Ensemblrn6Rnor6.0
Rnor_5.01365,392,579 - 65,485,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41357,441,674 - 57,534,385 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1355,444,707 - 55,537,113 (-)NCBICelera
RGSC_v3.11357,455,753 - 57,548,465 (-)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Cdc73/Paf1 complex  (IBA,IEA,ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Carpten JD, etal., Nat Genet. 2002 Dec;32(4):676-80. Epub 2002 Nov 18.
2. Significance of Parafibromin Expression in Laryngeal Squamous Cell Carcinomas. Cho I, etal., J Pathol Transl Med. 2016 Jul;50(4):264-9. doi: 10.4132/jptm.2016.04.24. Epub 2016 Jun 23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Parafibromin, APC, and MIB-1 Are Useful Markers for Distinguishing Parathyroid Carcinomas From Adenomas. Hosny Mohammed K, etal., Appl Immunohistochem Mol Morphol. 2017 Nov/Dec;25(10):731-735. doi: 10.1097/PAI.0000000000000378.
5. The Paf1 complex: platform or player in RNA polymerase II transcription? Jaehning JA Biochim Biophys Acta. 2010 May-Jun;1799(5-6):379-88. doi: 10.1016/j.bbagrm.2010.01.001. Epub 2010 Jan 12.
6. Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics. Rather MI, etal., J Biol Chem. 2014 Jan 10;289(2):968-76. doi: 10.1074/jbc.M113.483255. Epub 2013 Nov 20.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. Shattuck TM, etal., N Engl J Med. 2003 Oct 30;349(18):1722-9.
12. Parafibromin expression in lung normal tissue and carcinoma: its comparison with clinicopathological parameters of carcinoma. Xia P, etal., Histol Histopathol. 2011 Aug;26(8):1039-47. doi: 10.14670/HH-26.1039.
13. The clinicopathological significances and biological functions of parafibromin expression in head and neck squamous cell carcinomas. Zhang Z, etal., Tumour Biol. 2015 Dec;36(12):9487-97. doi: 10.1007/s13277-015-3618-5. Epub 2015 Jul 1.
14. Parafibromin expression is an independent prognostic factor for colorectal carcinomas. Zheng HC, etal., Hum Pathol. 2011 Aug;42(8):1089-102. doi: 10.1016/j.humpath.2010.10.024. Epub 2011 Feb 11.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:15923622   PMID:16307923   PMID:16630820   PMID:16989776   PMID:17911113   PMID:18212049   PMID:18987311   PMID:19135898   PMID:19136632   PMID:19345177  
PMID:20178742   PMID:20541477   PMID:21329879   PMID:31505169  


Genomics

Comparative Map Data
Cdc73
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81357,897,924 - 58,000,031 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1357,883,983 - 57,999,978 (-)EnsemblGRCr8
mRatBN7.21355,357,226 - 55,449,690 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,357,226 - 55,449,656 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1357,920,582 - 58,012,922 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,192,881 - 59,285,299 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,477,724 - 56,570,082 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,403,771 - 60,496,511 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,403,771 - 60,496,511 (-)Ensemblrn6Rnor6.0
Rnor_5.01365,392,579 - 65,485,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41357,441,674 - 57,534,385 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1355,444,707 - 55,537,113 (-)NCBICelera
RGSC_v3.11357,455,753 - 57,548,465 (-)NCBI
Cytogenetic Map13q21NCBI
CDC73
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381193,122,031 - 193,254,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1193,115,732 - 193,264,613 (+)Ensemblhg38GRCh38
GRCh371193,091,161 - 193,223,945 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,357,784 - 191,487,679 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341189,822,817 - 189,952,713NCBI
Celera1166,200,694 - 166,333,560 (+)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1164,326,911 - 164,459,852 (+)NCBIHuRef
CHM1_11194,512,977 - 194,645,669 (+)NCBICHM1_1
T2T-CHM13v2.01192,469,240 - 192,602,060 (+)NCBIT2T-CHM13v2.0
Cdc73
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,479,014 - 143,578,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,474,538 - 143,578,631 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381143,603,276 - 143,702,893 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,598,800 - 143,702,893 (-)Ensemblmm10GRCm38
MGSCv371145,454,629 - 145,549,814 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361145,369,717 - 145,464,902 (-)NCBIMGSCv36mm8
Celera1146,186,403 - 146,281,769 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.52NCBI
Cdc73
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,533,060 - 30,665,812 (+)Ensembl
ChiLan1.0NW_00495540630,533,919 - 30,665,812 (+)NCBIChiLan1.0ChiLan1.0
CDC73
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2156,534,616 - 56,670,750 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1156,190,589 - 56,334,645 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,581,730 - 168,710,915 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,875,365 - 173,004,942 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,875,365 - 173,004,934 (+)EnsemblpanPan2panpan1.1
CDC73
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,826,209 - 5,937,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl385,805,916 - 5,938,111 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha385,923,156 - 6,034,975 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0385,842,156 - 5,954,484 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl385,841,856 - 5,954,492 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,841,710 - 5,953,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,206,980 - 6,319,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,435,831 - 6,547,946 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdc73
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934480,662,470 - 80,779,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366381,365,648 - 1,483,277 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366381,365,457 - 1,482,497 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC73
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl10575,075 - 667,432 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.110575,075 - 667,618 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,279,054 - 2,305,137 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC73
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,167,482 - 36,302,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,170,134 - 36,302,812 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605537,127,006 - 37,251,142 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc73
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624814299,444 - 460,391 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624814298,015 - 460,314 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdc73
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11023,534,471 - 23,625,982 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdc73
829 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:27
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000004495
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat

Markers in Region
RH142331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,357,192 - 55,357,392 (+)MAPPERmRatBN7.2
Rnor_6.01360,403,738 - 60,403,937NCBIRnor6.0
Rnor_5.01365,392,546 - 65,392,745UniSTSRnor5.0
RGSC_v3.41357,441,641 - 57,441,840UniSTSRGSC3.4
Celera1355,444,674 - 55,444,873UniSTS
Cytogenetic Map13q21UniSTS
RH142465  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,396,472 - 55,396,616 (+)MAPPERmRatBN7.2
Rnor_6.01360,443,011 - 60,443,154NCBIRnor6.0
Rnor_5.01365,431,675 - 65,431,818UniSTSRnor5.0
RGSC_v3.41357,481,196 - 57,481,339UniSTSRGSC3.4
Celera1355,483,931 - 55,484,074UniSTS
Cytogenetic Map13q21UniSTS
UniSTS:495935  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,395,168 - 55,395,782 (+)MAPPERmRatBN7.2
Rnor_6.01360,441,707 - 60,442,320NCBIRnor6.0
Rnor_5.01365,430,371 - 65,430,984UniSTSRnor5.0
RGSC_v3.41357,479,892 - 57,480,505UniSTSRGSC3.4
Celera1355,482,627 - 55,483,240UniSTS
Cytogenetic Map13q21UniSTS
B3galt2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,394,689 - 55,395,113 (+)MAPPERmRatBN7.2
Rnor_6.01360,441,228 - 60,441,651NCBIRnor6.0
Rnor_5.01365,429,892 - 65,430,315UniSTSRnor5.0
Celera1355,482,148 - 55,482,571UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000004495   ⟹   ENSRNOP00000004495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1357,907,543 - 57,999,978 (-)Ensembl
mRatBN7.2 Ensembl1355,357,226 - 55,449,656 (-)Ensembl
Rnor_6.0 Ensembl1360,403,771 - 60,496,511 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127869   ⟹   ENSRNOP00000100085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1357,883,983 - 57,999,978 (-)Ensembl
RefSeq Acc Id: NM_001024769   ⟹   NP_001019940
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81357,907,543 - 57,999,978 (-)NCBI
mRatBN7.21355,357,226 - 55,449,656 (-)NCBI
Rnor_6.01360,403,771 - 60,496,511 (-)NCBI
Rnor_5.01365,392,579 - 65,485,175 (-)NCBI
RGSC_v3.41357,441,674 - 57,534,385 (-)RGD
Celera1355,444,707 - 55,537,113 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090729   ⟹   XP_038946657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81357,917,418 - 58,000,031 (-)NCBI
mRatBN7.21355,365,839 - 55,449,690 (-)NCBI
RefSeq Acc Id: XM_063272314   ⟹   XP_063128384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81357,897,924 - 57,976,488 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001019940 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946657 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128384 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97445 (Get FASTA)   NCBI Sequence Viewer  
  EDM09609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004495
GenBank Protein Q4V8C8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019940   ⟸   NM_001024769
- UniProtKB: Q4V8C8 (UniProtKB/Swiss-Prot),   A6ICN7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004495   ⟸   ENSRNOT00000004495
RefSeq Acc Id: XP_038946657   ⟸   XM_039090729
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128384   ⟸   XM_063272314
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100085   ⟸   ENSRNOT00000127869
Protein Domains
Cell division control protein 73 C-terminal   Paf1 complex subunit Cdc73 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8C8-F1-model_v2 AlphaFold Q4V8C8 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698871
Promoter ID:EPDNEW_R9396
Type:initiation region
Name:Cdc73_1
Description:cell division cycle 73
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01360,496,557 - 60,496,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311766 AgrOrtholog
BioCyc Gene G2FUF-18032 BioCyc
Ensembl Genes ENSRNOG00000003258 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000004495 ENTREZGENE
Gene3D-CATH 3.40.50.11990 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7456471 IMAGE-MGC_LOAD
InterPro Cdc73/Parafibromin UniProtKB/Swiss-Prot
  CDC73_C UniProtKB/Swiss-Prot
  CDC73_C_sf UniProtKB/Swiss-Prot
  Cdc73_N UniProtKB/Swiss-Prot
KEGG Report rno:304832 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114504 IMAGE-MGC_LOAD
NCBI Gene 304832 ENTREZGENE
PANTHER PARAFIBROMIN UniProtKB/Swiss-Prot
  PTHR12466 UniProtKB/Swiss-Prot
Pfam CDC73_C UniProtKB/Swiss-Prot
  CDC73_N UniProtKB/Swiss-Prot
PhenoGen Cdc73 PhenoGen
RatGTEx ENSRNOG00000003258 RatGTEx
UniProt A0ABK0KYG2_RAT UniProtKB/TrEMBL
  A6ICN7 ENTREZGENE, UniProtKB/TrEMBL
  CDC73_RAT UniProtKB/Swiss-Prot
  F2Z3T0_RAT UniProtKB/TrEMBL
  Q4V8C8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc73  cell division cycle 73  Cdc73  cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Cdc73  cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cdc73  cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)  Hrpt2  hyperparathyroidism 2 (with jaw tumor)  Symbol and Name updated 1299863 APPROVED
2005-12-06 Hrpt2  hyperparathyroidism 2 (with jaw tumor)  Hrpt2_predicted  hyperparathyroidism 2 (with jaw tumor) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hrpt2_predicted  hyperparathyroidism 2 (with jaw tumor) (predicted)      Symbol and Name status set to approved 70820 APPROVED