Fanca (FA complementation group A) - Rat Genome Database

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Gene: Fanca (FA complementation group A) Rattus norvegicus
Analyze
Symbol: Fanca
Name: FA complementation group A
RGD ID: 1311380
Description: Predicted to be involved in regulation of regulatory T cell differentiation. Predicted to act upstream of or within several processes, including gonad development; regulation of CD40 signaling pathway; and regulation of germ cell proliferation. Predicted to be located in chromatin and nucleus. Predicted to be part of Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); cervical cancer; esophagus squamous cell carcinoma; ovarian disease (multiple); and skin melanoma. Orthologous to human FANCA (FA complementation group A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fanconi anemia group A protein homolog; Fanconi anemia, complementation group A; LOC103690042; LOC361435
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,210,562 - 68,271,080 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1968,212,643 - 68,271,019 (-)EnsemblGRCr8
mRatBN7.21951,304,126 - 51,362,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,304,021 - 51,362,527 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1958,099,010 - 58,156,795 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,779,050 - 58,837,262 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,997,616 - 61,055,403 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,067,548 - 56,126,075 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,067,548 - 56,126,063 (-)Ensemblrn6Rnor6.0
Rnor_5.01967,115,679 - 67,132,939 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01966,772,525 - 66,837,134 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41953,587,849 - 53,647,780 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1950,539,880 - 50,598,370 (-)NCBICelera
RGSC_v3.11953,592,974 - 53,652,636 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
furan  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methimazole  (EXP)
monocrotaline  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
quinoline yellow  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
Fanconi anaemia nuclear complex  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mutations in Fanconi anemia genes and the risk of esophageal cancer. Akbari MR, etal., Hum Genet. 2011 May;129(5):573-82. doi: 10.1007/s00439-011-0951-7. Epub 2011 Jan 30.
2. Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations. Bouchlaka C, etal., J Hum Genet. 2003;48(7):352-61. Epub 2003 Jun 24.
3. Mice with a targeted disruption of the Fanconi anemia homolog Fanca. Cheng NC, etal., Hum Mol Genet. 2000 Jul 22;9(12):1805-11.
4. Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. Faivre L, etal., Blood. 2000 Dec 15;96(13):4064-70.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Evaluation of Fanconi anaemia genes FANCA, FANCC and FANCL in cervical cancer susceptibility. Juko-Pecirep I, etal., Gynecol Oncol. 2011 Aug;122(2):377-81. doi: 10.1016/j.ygyno.2011.04.014. Epub 2011 May 4.
8. Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Li J, etal., Antioxid Redox Signal. 2012 Oct 15;17(8):1083-98. doi: 10.1089/ars.2011.4417. Epub 2012 Jun 25.
9. Polymorphic variations in the FANCA gene in high-risk non-BRCA1/2 breast cancer individuals from the French Canadian population. Litim N, etal., Mol Oncol. 2013 Feb;7(1):85-100. doi: 10.1016/j.molonc.2012.08.002. Epub 2012 Sep 11.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Michiels S, etal., Carcinogenesis. 2009 May;30(5):763-8. doi: 10.1093/carcin/bgp046. Epub 2009 Feb 23.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Polymorphisms within the FANCA gene associate with premature ovarian failure in Korean women. Pyun JA, etal., Menopause. 2014 May;21(5):530-3. doi: 10.1097/GME.0b013e3182a4323e.
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Genetics of the FANCA gene in familial pancreatic cancer. Rogers CD, etal., J Med Genet. 2004 Dec;41(12):e126.
18. A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer. Thompson E, etal., BMC Cancer. 2005 Apr 29;5:43.
19. Deletion and reduced expression of the Fanconi anemia FANCA gene in sporadic acute myeloid leukemia. Tischkowitz MD, etal., Leukemia. 2004 Mar;18(3):420-5.
20. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. Wang SS, etal., J Infect Dis. 2009 Jan 1;199(1):20-30. doi: 10.1086/595563.
21. Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population. Yagasaki H, etal., Hum Mutat. 2004 Dec;24(6):481-90.
22. Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival. Yin J, etal., J Invest Dermatol. 2015 Feb;135(2):542-50. doi: 10.1038/jid.2014.416. Epub 2014 Sep 22.
Additional References at PubMed
PMID:11726552   PMID:12913077   PMID:20347428   PMID:22266823   PMID:22343915   PMID:22705371   PMID:24501220  


Genomics

Comparative Map Data
Fanca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,210,562 - 68,271,080 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1968,212,643 - 68,271,019 (-)EnsemblGRCr8
mRatBN7.21951,304,126 - 51,362,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,304,021 - 51,362,527 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1958,099,010 - 58,156,795 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,779,050 - 58,837,262 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,997,616 - 61,055,403 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,067,548 - 56,126,075 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,067,548 - 56,126,063 (-)Ensemblrn6Rnor6.0
Rnor_5.01967,115,679 - 67,132,939 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01966,772,525 - 66,837,134 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41953,587,849 - 53,647,780 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1950,539,880 - 50,598,370 (-)NCBICelera
RGSC_v3.11953,592,974 - 53,652,636 (-)NCBI
Cytogenetic Map19q12NCBI
FANCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381689,737,549 - 89,816,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1689,726,683 - 89,816,977 (-)Ensemblhg38GRCh38
GRCh371689,803,957 - 89,883,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,331,460 - 88,410,566 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341688,331,459 - 88,410,555NCBI
Celera1674,868,202 - 74,947,293 (-)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,499,171 - 75,578,023 (-)NCBIHuRef
CHM1_11691,215,162 - 91,294,341 (-)NCBICHM1_1
T2T-CHM13v2.01695,822,301 - 95,901,198 (-)NCBIT2T-CHM13v2.0
Fanca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,993,033 - 124,045,390 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,995,039 - 124,045,315 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388123,266,294 - 123,318,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,268,300 - 123,318,576 (-)Ensemblmm10GRCm38
MGSCv378125,792,144 - 125,842,476 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368126,154,390 - 126,204,666 (-)NCBIMGSCv36mm8
Celera8127,507,685 - 127,559,921 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.1NCBI
Fanca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555413,273,022 - 3,320,052 (-)Ensembl
ChiLan1.0NW_0049555413,272,936 - 3,320,229 (-)NCBIChiLan1.0ChiLan1.0
FANCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21899,585,370 - 99,668,686 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116105,473,180 - 105,555,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01670,495,310 - 70,579,275 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11690,162,900 - 90,245,190 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1690,163,950 - 90,245,147 (-)EnsemblpanPan2panpan1.1
FANCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,778,149 - 63,838,869 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,778,212 - 63,838,823 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha563,791,001 - 63,853,152 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0564,006,193 - 64,068,100 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,006,249 - 64,066,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,026,242 - 64,086,986 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,863,551 - 63,925,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,270,126 - 64,332,344 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fanca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,527,532 - 24,567,237 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641281,073 - 324,053 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936641281,119 - 319,796 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FANCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6253,207 - 300,152 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16253,207 - 300,159 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26378,761 - 425,687 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FANCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1575,073,161 - 75,149,110 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl575,073,358 - 75,148,591 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666047286,358 - 422,323 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fanca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746215,193 - 252,569 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624746206,069 - 253,473 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fanca
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11742,874,091 - 42,930,708 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:81
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000022658
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
D19Got113  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,344,675 - 51,344,847 (+)MAPPERmRatBN7.2
Rnor_6.01956,403,073 - 56,403,260NCBIRnor6.0
Rnor_6.01956,108,196 - 56,108,383NCBIRnor6.0
Rnor_5.01966,818,965 - 66,819,152UniSTSRnor5.0
Rnor_5.01967,115,072 - 67,115,259UniSTSRnor5.0
RGSC_v3.41953,629,913 - 53,630,100UniSTSRGSC3.4
Celera1950,580,443 - 50,580,615UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:238171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,304,339 - 51,305,154 (+)MAPPERmRatBN7.2
Rnor_6.01956,067,867 - 56,068,681NCBIRnor6.0
Rnor_5.01966,772,739 - 66,773,553UniSTSRnor5.0
RGSC_v3.41953,588,168 - 53,588,982UniSTSRGSC3.4
Celera1950,540,199 - 50,541,013UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 87 59 6 351 187 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022658   ⟹   ENSRNOP00000022659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1968,212,643 - 68,271,019 (-)Ensembl
mRatBN7.2 Ensembl1951,304,021 - 51,362,527 (-)Ensembl
Rnor_6.0 Ensembl1956,067,548 - 56,126,063 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101339   ⟹   ENSRNOP00000083808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1968,253,444 - 68,271,019 (-)Ensembl
mRatBN7.2 Ensembl1951,344,934 - 51,362,527 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107501   ⟹   ENSRNOP00000092075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1968,212,643 - 68,271,019 (-)Ensembl
mRatBN7.2 Ensembl1951,304,021 - 51,362,527 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134755   ⟹   ENSRNOP00000105081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1968,213,097 - 68,271,019 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000141062   ⟹   ENSRNOP00000105869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1968,212,643 - 68,271,019 (-)Ensembl
RefSeq Acc Id: NM_001401252   ⟹   NP_001388181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,212,643 - 68,271,019 (-)NCBI
mRatBN7.21951,304,126 - 51,362,509 (-)NCBI
RefSeq Acc Id: XM_039097888   ⟹   XP_038953816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,213,297 - 68,271,079 (-)NCBI
mRatBN7.21951,304,776 - 51,362,573 (-)NCBI
RefSeq Acc Id: XM_039097889   ⟹   XP_038953817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,210,562 - 68,269,117 (-)NCBI
mRatBN7.21951,304,126 - 51,360,278 (-)NCBI
RefSeq Acc Id: XM_039097892   ⟹   XP_038953820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,215,626 - 68,271,079 (-)NCBI
mRatBN7.21951,307,476 - 51,362,576 (-)NCBI
RefSeq Acc Id: XM_063278163   ⟹   XP_063134233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,210,562 - 68,246,542 (-)NCBI
RefSeq Acc Id: XR_005496676
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,229,943 - 68,271,080 (-)NCBI
mRatBN7.21951,321,425 - 51,362,582 (-)NCBI
RefSeq Acc Id: XR_010060017
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,232,008 - 68,271,080 (-)NCBI
Ensembl Acc Id: ENSRNOP00000022659   ⟸   ENSRNOT00000022658
RefSeq Acc Id: XP_038953817   ⟸   XM_039097889
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AGX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953816   ⟸   XM_039097888
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953820   ⟸   XM_039097892
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGX8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083808   ⟸   ENSRNOT00000101339
Ensembl Acc Id: ENSRNOP00000092075   ⟸   ENSRNOT00000107501
RefSeq Acc Id: NP_001388181   ⟸   NM_001401252
- UniProtKB: A0A8I6AGX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134233   ⟸   XM_063278163
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000105869   ⟸   ENSRNOT00000141062
Ensembl Acc Id: ENSRNOP00000105081   ⟸   ENSRNOT00000134755
Protein Domains
Fanconi anaemia group A protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQL0-F1-model_v2 AlphaFold D3ZQL0 1-1190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311380 AgrOrtholog
BioCyc Gene G2FUF-5331 BioCyc
Ensembl Genes ENSRNOG00000016706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022658.9 UniProtKB/TrEMBL
  ENSRNOT00000101339.2 UniProtKB/TrEMBL
  ENSRNOT00000107501 ENTREZGENE
  ENSRNOT00000107501.2 UniProtKB/TrEMBL
  ENSRNOT00000134755 ENTREZGENE
  ENSRNOT00000134755.1 UniProtKB/TrEMBL
  ENSRNOT00000141062.1 UniProtKB/TrEMBL
InterPro FANCA_arcN UniProtKB/TrEMBL
  FANCA_helical UniProtKB/TrEMBL
  Fanconi_A_C UniProtKB/TrEMBL
  Fanconi_A_N UniProtKB/TrEMBL
  Fanconia UniProtKB/TrEMBL
NCBI Gene 361435 ENTREZGENE
PANTHER FANCONI ANEMIA GROUP A PROTEIN UniProtKB/TrEMBL
  PTHR12047 UniProtKB/TrEMBL
Pfam FANCA_arcN UniProtKB/TrEMBL
  FANCA_helical UniProtKB/TrEMBL
  Fanconi_A UniProtKB/TrEMBL
  Fanconi_A_N UniProtKB/TrEMBL
PhenoGen Fanca PhenoGen
PRINTS FANCONIAGENE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016706 RatGTEx
UniProt A0A8I5ZXD8_RAT UniProtKB/TrEMBL
  A0A8I6AGX8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L5K0_RAT UniProtKB/TrEMBL
  A0ABK0LRP5_RAT UniProtKB/TrEMBL
  D3ZQL0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fanca  FA complementation group A  LOC103690042  Fanconi anemia group A protein homolog  Data merged from RGD:9109459 737654 PROVISIONAL
2018-05-25 Fanca  FA complementation group A  Fanca  Fanconi anemia, complementation group A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690042  Fanconi anemia group A protein homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Fanca  Fanconi anemia, complementation group A   Fanca_predicted  Fanconi anemia, complementation group A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fanca_predicted  Fanconi anemia, complementation group A (predicted)      Symbol and Name status set to approved 70820 APPROVED