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Gene: Smc6 (structural maintenance of chromosomes 6) Rattus norvegicus

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Symbol:

Smc6

Name:

structural maintenance of chromosomes 6

RGD ID:

1311214

Description:

Predicted to enable DNA binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including DNA recombination; cellular senescence; and host-mediated suppression of viral genome replication. Predicted to be located in chromosome; mitotic spindle pole; and nuclear body. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SMC6 (structural maintenance of chromosomes 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC313961; SMC6 structural maintenance of chromosomes 6-like 1; SMC6 structural maintenance of chromosomes 6-like 1 (yeast); Smc6l1; structural maintenance of chromosomes protein 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SMC6 (structural maintenance of chromosomes 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Smc6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Smc6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SMC6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SMC6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Smc6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SMC6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SMC6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Smc6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Smc6 (structural maintenance of chromosomes 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SMC6 (structural maintenance of chromosomes 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SMC6 (structural maintenance of chromosomes 6)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Smc6 (structural maintenance of chromosomes 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Smc6 (structural maintenance of chromosomes 6)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	smc6 (structural maintenance of chromosomes 6)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	si:dkey-119f1.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-119f1.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C23H4.6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C23H4.6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SMC6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SMC6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	jnj	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	jnj	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	smc-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	smc-6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	smc6.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100496941	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100496941	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	39,697,810 - 39,752,275 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	39,697,811 - 39,752,279 (+)	Ensembl				GRCr8
mRatBN7.2	6	33,978,730 - 34,033,201 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	33,978,716 - 34,031,746 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	34,271,336 - 34,324,302 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	34,587,277 - 34,640,243 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	34,058,056 - 34,111,010 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	36,941,233 - 36,995,920 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	36,941,233 - 36,995,138 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	46,691,346 - 46,746,033 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	34,710,177 - 34,763,158 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	33,379,218 - 33,432,201 (+)	NCBI		Celera
RGSC_v3.1	6	34,718,849 - 34,765,945 (+)	NCBI
Cytogenetic Map	6	q15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Laterality Defects, Autosomal Dominant (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

dicrotophos (ISO)

diuron (ISO)

ethanol (ISO)

flutamide (EXP)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glafenine (EXP)

gold atom (ISO)

gold(0) (ISO)

ivermectin (ISO)

ketamine (EXP)

kojic acid (ISO)

L-ascorbic acid (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylparaben (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nefazodone (EXP)

nimesulide (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

quercetin (ISO)

resveratrol (ISO)

senecionine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

succimer (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

vincristine (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular senescence (IEA,ISO)

DNA damage response (IEA,ISO)

DNA recombination (IEA)

DNA repair (IEA)

double-strand break repair (IEA)

double-strand break repair via homologous recombination (IBA)

host-mediated suppression of viral genome replication (IEA,ISO)

positive regulation of chromosome segregation (IEA,ISO)

telomere maintenance via recombination (IEA,ISO)

Cellular Component

chromosomal region (IEA)

chromosome, centromeric region (IEA,ISO)

chromosome, telomeric region (IEA,ISO)

interchromatin granule (IEA,ISO)

mitotic spindle pole (IEA,ISO)

nuclear speck (IEA)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

PML body (IEA,ISO)

sex chromosome (IEA,ISO)

site of double-strand break (IBA,IEA,ISO)

Smc5-Smc6 complex (IBA,IEA,ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

damaged DNA binding (IBA)

DNA secondary structure binding (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

single-stranded DNA binding (IBA)

ubiquitin protein ligase binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11408570	PMID:17589526	PMID:18086888	PMID:25931565

Genomics

Comparative Map Data

Smc6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	39,697,810 - 39,752,275 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	39,697,811 - 39,752,279 (+)	Ensembl				GRCr8
mRatBN7.2	6	33,978,730 - 34,033,201 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	33,978,716 - 34,031,746 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	34,271,336 - 34,324,302 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	34,587,277 - 34,640,243 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	34,058,056 - 34,111,010 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	36,941,233 - 36,995,920 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	36,941,233 - 36,995,138 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	46,691,346 - 46,746,033 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	34,710,177 - 34,763,158 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	33,379,218 - 33,432,201 (+)	NCBI		Celera
RGSC_v3.1	6	34,718,849 - 34,765,945 (+)	NCBI
Cytogenetic Map	6	q15	NCBI

SMC6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	17,663,812 - 17,753,810 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	17,663,583 - 17,800,242 (-)	Ensembl			hg38	GRCh38
GRCh37	2	17,845,079 - 17,935,077 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	17,708,562 - 17,798,541 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	17,766,708 - 17,856,688	NCBI
Celera	2	17,724,884 - 17,815,383 (-)	NCBI		Celera
Cytogenetic Map	2	p24.2	NCBI
HuRef	2	17,620,169 - 17,710,162 (-)	NCBI		HuRef
CHM1_1	2	17,774,474 - 17,864,475 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	17,695,556 - 17,785,539 (-)	NCBI		T2T-CHM13v2.0

Smc6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	11,315,887 - 11,369,786 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	11,315,887 - 11,369,786 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	11,265,886 - 11,319,785 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	11,265,886 - 11,319,785 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	11,272,692 - 11,326,591 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	11,292,229 - 11,346,128 (+)	NCBI		MGSCv36	mm8
Celera	12	11,610,123 - 11,665,032 (+)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	5.58	NCBI

Smc6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	453,353 - 552,279 (-)	Ensembl
ChiLan1.0	NW_004955469	456,023 - 552,794 (-)	NCBI	ChiLan1.0	ChiLan1.0

SMC6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	108,728,947 - 108,861,156 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	108,732,913 - 108,874,819 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	17,648,371 - 17,735,910 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	17,774,590 - 17,861,920 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	17,776,276 - 17,854,052 (-)	Ensembl			panPan2	panpan1.1

SMC6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	13,132,945 - 13,201,214 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	13,133,236 - 13,201,759 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	13,085,159 - 13,153,159 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	13,269,396 - 13,337,856 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	13,269,693 - 13,337,904 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	13,127,707 - 13,196,134 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	13,138,902 - 13,207,328 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	13,165,157 - 13,233,234 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Smc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	57,587,323 - 57,648,207 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	13,191,455 - 13,252,578 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	13,191,389 - 13,250,788 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SMC6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	120,097,379 - 120,170,971 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	120,097,361 - 120,170,974 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	128,245,265 - 128,318,831 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SMC6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	89,917,621 - 90,005,604 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	89,917,518 - 90,000,088 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	22,208,586 - 22,296,770 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Smc6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	614,402 - 681,430 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	612,758 - 689,191 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Smc6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	31,250,066 - 31,302,985 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Smc6
179 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	187
Count of miRNA genes:	144
Interacting mature miRNAs:	156
Transcripts:	ENSRNOT00000007073
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	39028659	63457441	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	1	40163351	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	39028659	86867923	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat

Markers in Region

RH143232

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	34,027,678 - 34,027,817 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	36,990,398 - 36,990,536	NCBI	Rnor6.0
Rnor_5.0	6	46,740,511 - 46,740,649	UniSTS	Rnor5.0
RGSC_v3.4	6	34,759,091 - 34,759,229	UniSTS	RGSC3.4
Celera	6	33,428,134 - 33,428,272	UniSTS
RH 3.4 Map	6	144.2	UniSTS
Cytogenetic Map	6	q14	UniSTS

RH143724

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	33,977,895 - 33,978,065 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	36,940,363 - 36,940,532	NCBI	Rnor6.0
Rnor_5.0	6	46,690,476 - 46,690,645	UniSTS	Rnor5.0
RGSC_v3.4	6	34,709,307 - 34,709,476	UniSTS	RGSC3.4
Celera	6	33,378,348 - 33,378,517	UniSTS
RH 3.4 Map	6	145.4	UniSTS
Cytogenetic Map	6	q14	UniSTS

BF387143

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	33,979,868 - 33,980,064 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	36,942,336 - 36,942,531	NCBI	Rnor6.0
Rnor_5.0	6	46,692,449 - 46,692,644	UniSTS	Rnor5.0
RGSC_v3.4	6	34,711,280 - 34,711,475	UniSTS	RGSC3.4
Celera	6	33,380,321 - 33,380,516	UniSTS
Cytogenetic Map	6	q14	UniSTS

RH139846

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	34,032,829 - 34,033,011 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	36,995,549 - 36,995,730	NCBI	Rnor6.0
Rnor_5.0	6	46,745,662 - 46,745,843	UniSTS	Rnor5.0
RGSC_v3.4	6	34,764,242 - 34,764,423	UniSTS	RGSC3.4
Celera	6	33,433,285 - 33,433,466	UniSTS
RH 3.4 Map	6	143.8	UniSTS
Cytogenetic Map	6	q14	UniSTS

AA850777

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	34,031,404 - 34,031,598 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	36,994,124 - 36,994,317	NCBI	Rnor6.0
Rnor_5.0	6	46,744,237 - 46,744,430	UniSTS	Rnor5.0
RGSC_v3.4	6	34,762,817 - 34,763,010	UniSTS	RGSC3.4
Celera	6	33,431,860 - 33,432,053	UniSTS
RH 3.4 Map	6	144.5	UniSTS
Cytogenetic Map	6	q14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007073 ⟹ ENSRNOP00000007073

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,697,811 - 39,752,279 (+)	Ensembl
mRatBN7.2 Ensembl	6	33,978,716 - 34,031,739 (+)	Ensembl
Rnor_6.0 Ensembl	6	36,941,233 - 36,994,465 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083383 ⟹ ENSRNOP00000070408

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,697,811 - 39,752,279 (+)	Ensembl
mRatBN7.2 Ensembl	6	33,978,716 - 34,031,739 (+)	Ensembl
Rnor_6.0 Ensembl	6	36,941,596 - 36,995,138 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110833 ⟹ ENSRNOP00000078251

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	39,697,811 - 39,752,279 (+)	Ensembl
mRatBN7.2 Ensembl	6	33,984,057 - 34,031,746 (+)	Ensembl

RefSeq Acc Id:

NM_001108014 ⟹ NP_001101484

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,697,845 - 39,750,826 (+)	NCBI
mRatBN7.2	6	33,978,766 - 34,031,746 (+)	NCBI
Rnor_6.0	6	36,941,233 - 36,994,465 (+)	NCBI
Rnor_5.0	6	46,691,346 - 46,746,033 (+)	NCBI
RGSC_v3.4	6	34,710,177 - 34,763,158 (+)	RGD
Celera	6	33,379,218 - 33,432,201 (+)	RGD

Sequence:

show sequence

ATTCGGGCGGGTGTGCCCTGCTTGGCGGCCGAGCGGTGGCCGAGGTCCGACGCCCTTAGGGTGG
CCTTCGTGTCGTGACAGCCGTGCGGACTAGCTTCCCCGAGGTGACCGCGACTTGTTGGAGATCT
GATGGCCAAAAGAAAGGAAGAAAATTTTTGCTCTCCTGAAAATGCTAAAAGACCAAGACAGGAA
GAACTGGAAGATTTTGATAAAGATGGAGATGAGGATGAATGTACAATTTCTTTCACAAATGGAA
CCTCCACTTTGACTGCAGCAGAAGTTGGAATAATTGAGAGTATTCAGCTAAGAAATTTCATGTG
CCATTCAATGCTTGGACCTTTTAAGTTTGGTTCTAATGTCAACTTTGTGGTTGGCAATAATGGA
AGTGGGAAGAGTGCTGTGCTCACTGCACTCATAGTTGGTCTTGGTGGAAAAGCAGTTGCTACTA
ACAGAGGATCCTCTTTAAAAGGTTTTGTGAAAGCTGGACAGAACTCAGCAGATATCTCAATAAC
ATTAAGGAACAGAGGAGATGATGCCTTCAGGGCAAACGTGTATGGTGACTCCATAGTTGTGCAA
CAACACATTAGCGTGGATGGAAGTCGATCTTACAAACTAAAAAGTGAAAAAGGCACCGTGGTTT
CTACAAGGAAGGAAGAGCTGATCGCAATTCTTGACCATTTTAACATCCAGGTGGATAATCCAGT
TTCCGTTTTAACACAAGAGATGAGCAAGCAATTCTTACAATCCAAAAATGAGGGAGACAAATAC
AAATTCTTCATGAAAGCAACCCAATTGGAACAGATGAAGGAAGATTATTCATATATTATGGAAA
CGAAAGAAAGAACAAAGGAGCAAATAAATCAGGGAGAAGAGCGACTTACTGAGCTAAAGCGCCA
GTGCTTGGAGAAAGAGGAACGTTTTCAAAATATTGCTGGTTTAAGTACAATGAAGACGAATTTA
GAGTATTTGAAACATGAAATGGCATGGGCTGTGGTCAATGAAATTGAAAAACAGTTGAATGCTA
TTCGAGATAATATCAAAATTGGAGAAGAACGCGCTGCCAAACTTGACAGGAAAATGGAAGAGCA
GCAGGTCAGACTTAATGATGCAGAAAAAAAATACAAAGATATACAAGATAAACTAGAAAAAATT
AGTGAAGAGACAAATGCACGAGCACCAGAATGTATGGCCTTGAAAACAGATGTCATTGCAAGAA
CAAGAGCCTTTAATGATGCTGAGGTTTTATATAATCGTTCCCTAAATGAATATAAAGCATTAAA
AAAAGATGGTGAACAGCTTTGTAAAAGAATTGAAGAGCTGAAGAAAAGTACCGACCAGTCATTA
GAACCAGAGCGATTGGAAAGGCAAAAAAGGATCTGCTGGTTAAAAGAGAAAGTAAAGGCCTTAC
AGGATCAGGAAAATACAGTCAATCAGGAGGTTGAACAGTTCGAGCAAGCCATAGAAAAGGACAA
ACAAGAACACGTCCGAATTAAGAGAGAAGATGTAGAAGTGAGACATACACTCAGCTATAATCAG
AGACAATTGAAAGAACTGAAAGATAGTAAAACTGATCGACTAAAAAGATTTGGTCCTCATGTTC
CAGCTCTTCTGGAAGCAATAGATGATGCTTACAGACGGAGACAGTTTACCCATAAACCTATTGG
CCCTTTAGGTGCTTGCATTCATCTACGGGACCCTGAACTTGCATTGGCCATTGAGTCTTGCTTA
AAAGGACTTCTGCAAGCCTATTGCTGCCATAATCATGCTGATGAAAGAGTACTTCAGTCATTGA
TGAAAAAGTTTTATCCACCAGGGACCTCTCGACCACAGATAATCGTTTCGGAATTTCGGAATGA
GGTATATGATGTGAGACTCAGAGCTGCTTACCATCCAGAGTTTCCAACTGTTCTGACAGCTTTA
GAAATAGACAATGCTGTTGTTGCAAACAGTCTGATTGACATGCGGAGCATAGAGACAGTGCTGC
TGATCAAAAATAATTCTGTAGCTCGTGCAGTCATGCAGTCCCAAAAGCCACCCAAAAATTGTAG
AGAAGCTTTTACTGCTGACGGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAGTACA
AGACCCAAGTTTCTAAGCAGAGATGTGGATTCTGAAATAAGTGACTTGGAAACTGAGATTGAAA
ATAAAAAGGGCCACATAATGAACCTTCAGCACCGTCTGTCTGCTCTTGAGAAGGATATTAAACG
CAATGAAGAACTTCTTAAAAGGTGCCAACTACATTATAAAGAAATAAAGATGAAAATAAGAAAA
AATATTTCTGAAATTCGGGAACTTGAGAACATAGAAGAACACCAATCTGTAGATATTGCAACCT
TGGAAGATGAAGCGGAGGAAAATAAAATAAAAATGCAAATGGTGGAGAAAAATATGGAGCAACA
AAAAGAAAACATGGAGAATCTTAAAACTCTAAAAATTGAAGCAGAAAACAAGTATGATACAATT
AAATTGAAGATTAATCAGCTATCAGAGCTAGCAGATCCACTTAAGGATGAATTAAATCTTGCTG
ACTCTGAAGTGGATAGCCAGAAACGGGGAAAGCAGCATTATGAAGATAAACAGAAAGAACATAT
GGATACCCTAAATAAAAAGAGAAGAGAGCTTGACATGAAGGAAAAGGAGCTACAGGAGAAAATG
TCGCAAGCAAGACAGATCTGCCCAGAACGCATAGAAGTAAAAAAATCTGCATCAATTCTAGACA
AAGAAATTAATCGATTAAGACAAAAAATTCAGGCAGAACATGCTAGTCATGGAGATCGGGAAGA
AATAATGAAGCAGTACCAGGAAGCAAGAGAAACCTATCTTGATCTGGATAGTAAAGTAAGGACT
TTAAGAAGGTTCATTAAATTACTTGAAGAAATAATGACCCATAGGTACAAAACATACCAACAAT
TTAGAAGGTGTCTGACACTACGATGCAAGTTATACTTTGACAACTTATTATCTCAGCGTGCTTA
TTGTGGAAAAATGAATTTTGACCACAAGAATGAAACTCTTAGTATATCAGTTCAGCCCGGAGAG
GGAAACAAAGCCTCCTTCAATGACATGCGTGCTTTGTCCGGCGGCGAGCGCTCTTTTTCCACAG
TGTGCTTCATTCTTTCCCTGTGGTCCATTGCTGAATCACCTTTCAGATGCCTGGATGAGTTTGA
TGTCTACATGGATATGGTTAATAGGAGAATTGCGATGGACATGATCCTTAAGATGGCAGATTCC
CAACGTTTTAGACAGTTTATCTTGCTTACCCCTCAAAGCATGAGCTCACTTCCTTCAAGTAAAC
TGATTCGAATTCTTCGAATGTCTGACCCTGAAAGAGGGCAAACCACCTTGCCCTTCCGACCTGT
GACTCAAGAAGAAGATGACAGTGCAAGCTGACAGCTTAGTGCCTTGCCCTCGTACTGAAAGATT
GTGAGGGGAATAATCTGGACTGGTGGATGAAGTAAAGTGGGATGAGAGGTACTCTGAAATAAAG
AAGCTCCTTTAATATGACCTATCAAAAGTGTAAATAAGCCTAGAAAACCAGCTGCTGCCAAGAG
TTTAAAATTATGATTGCTTTTCCTTGTGAAAATCAGTTTCATAATACTGGTTTTAAATCTTTTT
CTGTTTGTTTGCTTTGGAGTTTCTGTATTTCGTTTGTTGTTTTTACCATCTACTTTTATAAATT
TTTTCAGGAGTAAAATTTTGTACATAATGCACATGTACATATCTGTTCAGTTTGGGTTCATTTC
TATAGTATTTTGTAAGAATTTAAATAAAAGTCTGAGCACCTGA

hide sequence

RefSeq Acc Id:

XM_006239898 ⟹ XP_006239960

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,698,222 - 39,752,275 (+)	NCBI
mRatBN7.2	6	33,979,143 - 34,031,676 (+)	NCBI
Rnor_6.0	6	36,941,659 - 36,995,920 (+)	NCBI
Rnor_5.0	6	46,691,346 - 46,746,033 (+)	NCBI

Sequence:

show sequence

GTGTGTGGGGGGGCTGGAAATGCCGCTGAAATCTGAATTTGCCGTTAAATCCAGTTTCCCTGAA
AGACCACTCGGATGAACCAGACTAGAATCTGATGGCCAAAAGAAAGGAAGAAAATTTTTGCTCT
CCTGAAAATGCTAAAAGACCAAGACAGGAAGAACTGGAAGATTTTGATAAAGATGGAGATGAGG
ATGAATGTACAATTTCTTTCACAAATGGAACCTCCACTTTGACTGCAGCAGAAGTTGGAATAAT
TGAGAGTATTCAGCTAAGAAATTTCATGTGCCATTCAATGCTTGGACCTTTTAAGTTTGGTTCT
AATGTCAACTTTGTGGTTGGCAATAATGGAAGTGGGAAGAGTGCTGTGCTCACTGCACTCATAG
TTGGTCTTGGTGGAAAAGCAGTTGCTACTAACAGAGGATCCTCTTTAAAAGGTTTTGTGAAAGC
TGGACAGAACTCAGCAGATATCTCAATAACATTAAGGAACAGAGGAGATGATGCCTTCAGGGCA
AACGTGTATGGTGACTCCATAGTTGTGCAACAACACATTAGCGTGGATGGAAGTCGATCTTACA
AACTAAAAAGTGAAAAAGGCACCGTGGTTTCTACAAGGAAGGAAGAGCTGATCGCAATTCTTGA
CCATTTTAACATCCAGGTGGATAATCCAGTTTCCGTTTTAACACAAGAGATGAGCAAGCAATTC
TTACAATCCAAAAATGAGGGAGACAAATACAAATTCTTCATGAAAGCAACCCAATTGGAACAGA
TGAAGGAAGATTATTCATATATTATGGAAACGAAAGAAAGAACAAAGGAGCAAATAAATCAGGG
AGAAGAGCGACTTACTGAGCTAAAGCGCCAGTGCTTGGAGAAAGAGGAACGTTTTCAAAATATT
GCTGGTTTAAGTACAATGAAGACGAATTTAGAGTATTTGAAACATGAAATGGCATGGGCTGTGG
TCAATGAAATTGAAAAACAGTTGAATGCTATTCGAGATAATATCAAAATTGGAGAAGAACGCGC
TGCCAAACTTGACAGGAAAATGGAAGAGCAGCAGGTCAGACTTAATGATGCAGAAAAAAAATAC
AAAGATATACAAGATAAACTAGAAAAAATTAGTGAAGAGACAAATGCACGAGCACCAGAATGTA
TGGCCTTGAAAACAGATGTCATTGCAAGAACAAGAGCCTTTAATGATGCTGAGGTTTTATATAA
TCGTTCCCTAAATGAATATAAAGCATTAAAAAAAGATGGTGAACAGCTTTGTAAAAGAATTGAA
GAGCTGAAGAAAAGTACCGACCAGTCATTAGAACCAGAGCGATTGGAAAGGCAAAAAAGGATCT
GCTGGTTAAAAGAGAAAGTAAAGGCCTTACAGGATCAGGAAAATACAGTCAATCAGGAGGTTGA
ACAGTTCGAGCAAGCCATAGAAAAGGACAAACAAGAACACGTCCGAATTAAGAGAGAAGATGTA
GAAGTGAGACATACACTCAGCTATAATCAGAGACAATTGAAAGAACTGAAAGATAGTAAAACTG
ATCGACTAAAAAGATTTGGTCCTCATGTTCCAGCTCTTCTGGAAGCAATAGATGATGCTTACAG
ACGGAGACAGTTTACCCATAAACCTATTGGCCCTTTAGGTGCTTGCATTCATCTACGGGACCCT
GAACTTGCATTGGCCATTGAGTCTTGCTTAAAAGGACTTCTGCAAGCCTATTGCTGCCATAATC
ATGCTGATGAAAGAGTACTTCAGTCATTGATGAAAAAGTTTTATCCACCAGGGACCTCTCGACC
ACAGATAATCGTTTCGGAATTTCGGAATGAGGTATATGATGTGAGACTCAGAGCTGCTTACCAT
CCAGAGTTTCCAACTGTTCTGACAGCTTTAGAAATAGACAATGCTGTTGTTGCAAACAGTCTGA
TTGACATGCGGAGCATAGAGACAGTGCTGCTGATCAAAAATAATTCTGTAGCTCGTGCAGTCAT
GCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGACGGTGATCAAGTTTTT
GCAGGACGTTATTATTCATCTGAAAGTACAAGACCCAAGTTTCTAAGCAGAGATGTGGATTCTG
AAATAAGTGACTTGGAAACTGAGATTGAAAATAAAAAGGGCCACATAATGAACCTTCAGCACCG
TCTGTCTGCTCTTGAGAAGGATATTAAACGCAATGAAGAACTTCTTAAAAGGTGCCAACTACAT
TATAAAGAAATAAAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATAG
AAGAACACCAATCTGTAGATATTGCAACCTTGGAAGATGAAGCGGAGGAAAATAAAATAAAAAT
GCAAATGGTGGAGAAAAATATGGAGCAACAAAAAGAAAACATGGAGAATCTTAAAACTCTAAAA
ATTGAAGCAGAAAACAAGTATGATACAATTAAATTGAAGATTAATCAGCTATCAGAGCTAGCAG
ATCCACTTAAGGATGAATTAAATCTTGCTGACTCTGAAGTGGATAGCCAGAAACGGGGAAAGCA
GCATTATGAAGATAAACAGAAAGAACATATGGATACCCTAAATAAAAAGAGAAGAGAGCTTGAC
ATGAAGGAAAAGGAGCTACAGGAGAAAATGTCGCAAGCAAGACAGATCTGCCCAGAACGCATAG
AAGTAAAAAAATCTGCATCAATTCTAGACAAAGAAATTAATCGATTAAGACAAAAAATTCAGGC
AGAACATGCTAGTCATGGAGATCGGGAAGAAATAATGAAGCAGTACCAGGAAGCAAGAGAAACC
TATCTTGATCTGGATAGTAAAGTAAGGACTTTAAGAAGGTTCATTAAATTACTTGAAGAAATAA
TGACCCATAGGTACAAAACATACCAACAATTTAGAAGGTGTCTGACACTACGATGCAAGTTATA
CTTTGACAACTTATTATCTCAGCGTGCTTATTGTGGAAAAATGAATTTTGACCACAAGAATGAA
ACTCTTAGTATATCAGTTCAGCCCGGAGAGGGAAACAAAGCCTCCTTCAATGACATGCGTGCTT
TGTCCGGCGGCGAGCGCTCTTTTTCCACAGTGTGCTTCATTCTTTCCCTGTGGTCCATTGCTGA
ATCACCTTTCAGATGCCTGGATGAGTTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCG
ATGGACATGATCCTTAAGATGGCAGATTCCCAACGTTTTAGACAGTTTATCTTGCTTACCCCTC
AAAGCATGAGCTCACTTCCTTCAAGTAAACTGATTCGAATTCTTCGAATGTCTGACCCTGAAAG
AGGGCAAACCACCTTGCCCTTCCGACCTGTGACTCAAGAAGAAGATGACAGTGCAAGCTGACAG
CTTAGTGCCTTGCCCTCGTACTGAAAGATTGTGAGGGGAATAATCTGGACTGGTGGATGAAGTA
AAGTGGGATGAGAGGTACTCTGAAATAAAGAAGCTCCTTTAATATGACCTATCAAAAGTGTAAA
TAAGCCTAGAAAACCAGCTGCTGCCAAGAGTTTAAAATTATGATTGCTTTTCCTTGTGAAAATC
AGTTTCATAATACTGGTTTTAAATCTTTTTCTGTTTGTTTGCTTTGGAGTTTCTGTATTTCGTT
TGTTGTTTTTACCATCTACTTTTATAAATTTTTTCAGGAGTAAAATTTTGTACATAATGCACAT
GTACATATCTGTTCAGTTTGGGTTCATTTCTATAGTATTTTGTAAGAATTTAAATAAAAGTCTG
AGCACCTGATGTTTAGTTTTGCGTTTCCAGGTTGTTACAGCCTAGTTTTAAAACTTAGCAAATG
TCTGTGGAAAGAGCAGTCTCAGTATGGGACAGGGGGATGCAGTGAAGGAGAACTGGTTAGGCCG
GACGCACTGATGTTTACATGTAGAGGTCTGCATAAGGCTGCTGGTACTGCAGAATCTCTACTTA
CCATTGTTTTTAACCCTGGGGTACAACCATAGATTTGGATACAGTTTTTAATCACTATACTTAA
TCAGTTATAAGATGGTCTTCACTAGACACTTTTATGCAGCCCTGAAGCACTGCCAGTTGTGACA
AGTACTTTCTTTCTCCTTTGTCCTTTAACTATTCTCCATTCAAGAAAGAACGGGCCATGGCTGT
GACACACTTTCCACTTTGACCTGTAGCAGTGACCAAGTTGTAAAAGCCCTCAGCTTTTGGTGGT
GTACCACTAGGGTTTTAGATGCAAGATTTCAAGTTCTAGACCTGCCTGGGCTATAGAGTGAATT
CAAGGCCAGCCTGGACAGCTTAGACCCTGTCTCAAAATGAAAGAGAAATCGAGGCCTGAAAATA
CAGCCTAGTGGTAGAGCAGGGCTGAAAAAGCCAGAGGATAAGTGCCTGCGGTCAGAGCCAGTAG
CTGCGTGAGGCAAAATCTACACCTCATGACCTCATGGGAGATGGTATAAGTCACACCCTGAATT
TAGAGATATTAAAATGTTTCTGTAATGATCAGTTTACAGTAAAATTTGGTATTTGTGATTTTTT
TTTTTTTTTAAAGAAAACAGTGTATTTGTGCCTGTGTTGTTTCATACTAGGTTTAGGGCTAACC
TTTAAATTTTGACTAGCAGCAAGAAGCATCCCTTTATTACCAGCAATAAATTAGAATACATATT
TATGAACTTGAAAAGAAAGTATTTTAAGAAAAGTACTATTTTTCAAAGCAAGTATAATTCTATA
ATTATTAATTAAAACTGAGTTTTGTTTTGGTGGGGGAAGAGAATGTATTCTTAGAATACAATAG
TTGCCAAAAATCCAAAAGCATTCTAGTCTAAGAACATAGAAAGAAGAAAACTAATGTTTTAAAC
TTTCCCCACCAACAATAAGCAGTATAACTCATTTGTATCAGAACTATTTTAACATACATACATT
TTTTTCAAATAAATAAAAATGAAGTGAGACCAGTGCATTAATTTTAATTAGCTCAGGAGTTTCG
ATGTTTTGAGGTTTTGTGGTAGTTTTAAATGTGCTTCTACAGAATGAGAAACGCAGCCCTCAGA
TCCTGAGCGTCTCCTGCTGAAGACACTACATTGATTTGGCCTCAGAAAGCTTTGGTTTCAATCA
TAAGTGAAGTCTTCATCTAGTGTTCTAAGGAGTAATAACATCCATTGGAAAACAAGAAAAAACT
ATTGTTCTTTTAAAGTATGTGTAACTTCCAAAAATAAAACTTAAACTGTACATGTA

hide sequence

RefSeq Acc Id:

XM_039112188 ⟹ XP_038968116

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,697,810 - 39,752,275 (+)	NCBI
mRatBN7.2	6	33,978,730 - 34,031,676 (+)	NCBI

RefSeq Acc Id:

XM_039112189 ⟹ XP_038968117

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,705,838 - 39,752,275 (+)	NCBI
mRatBN7.2	6	33,986,772 - 34,031,676 (+)	NCBI

RefSeq Acc Id:

XM_039112190 ⟹ XP_038968118

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,719,241 - 39,752,275 (+)	NCBI
mRatBN7.2	6	34,000,158 - 34,033,201 (+)	NCBI

RefSeq Acc Id:

XM_039112191 ⟹ XP_038968119

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	39,716,332 - 39,752,275 (+)	NCBI
mRatBN7.2	6	33,999,513 - 34,033,201 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101484	(Get FASTA)	NCBI Sequence Viewer
	XP_006239960	(Get FASTA)	NCBI Sequence Viewer
	XP_038968116	(Get FASTA)	NCBI Sequence Viewer
	XP_038968117	(Get FASTA)	NCBI Sequence Viewer
	XP_038968118	(Get FASTA)	NCBI Sequence Viewer
	XP_038968119	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM03101	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007073
	ENSRNOP00000007073.4
	ENSRNOP00000070408.2
	ENSRNOP00000078251
	ENSRNOP00000078251.2

RefSeq Acc Id:

NP_001101484 ⟸ NM_001108014

- UniProtKB:

D4AB26 (UniProtKB/TrEMBL), A6HAP6 (UniProtKB/TrEMBL), A0A0G2JXU6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAKRKEENFCSPENAKRPRQEELEDFDKDGDEDECTISFTNGTSTLTAAEVGIIESIQLRNFMC
HSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSLKGFVKAGQNSADISIT
LRNRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEELIAILDHFNIQVDNPV
SVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQINQGEERLTELKRQ
CLEKEERFQNIAGLSTMKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKIGEERAAKLDRKMEEQ
QVRLNDAEKKYKDIQDKLEKISEETNARAPECMALKTDVIARTRAFNDAEVLYNRSLNEYKALK
KDGEQLCKRIEELKKSTDQSLEPERLERQKRICWLKEKVKALQDQENTVNQEVEQFEQAIEKDK
QEHVRIKREDVEVRHTLSYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTHKPIG
PLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQSLMKKFYPPGTSRPQIIVSEFRNE
VYDVRLRAAYHPEFPTVLTALEIDNAVVANSLIDMRSIETVLLIKNNSVARAVMQSQKPPKNCR
EAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLETEIENKKGHIMNLQHRLSALEKDIKR
NEELLKRCQLHYKEIKMKIRKNISEIRELENIEEHQSVDIATLEDEAEENKIKMQMVEKNMEQQ
KENMENLKTLKIEAENKYDTIKLKINQLSELADPLKDELNLADSEVDSQKRGKQHYEDKQKEHM
DTLNKKRRELDMKEKELQEKMSQARQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREE
IMKQYQEARETYLDLDSKVRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAY
CGKMNFDHKNETLSISVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFD
VYMDMVNRRIAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPV
TQEEDDSAS

hide sequence

RefSeq Acc Id:	XP_006239960 ⟸ XM_006239898
- Peptide Label:	isoform X1
- UniProtKB:	D4AB26 (UniProtKB/TrEMBL), A6HAP6 (UniProtKB/TrEMBL), A0A0G2JXU6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAKRKEENFCSPENAKRPRQEELEDFDKDGDEDECTISFTNGTSTLTAAEVGIIESIQLRNFMC HSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSLKGFVKAGQNSADISIT LRNRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEELIAILDHFNIQVDNPV SVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQINQGEERLTELKRQ CLEKEERFQNIAGLSTMKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKIGEERAAKLDRKMEEQ QVRLNDAEKKYKDIQDKLEKISEETNARAPECMALKTDVIARTRAFNDAEVLYNRSLNEYKALK KDGEQLCKRIEELKKSTDQSLEPERLERQKRICWLKEKVKALQDQENTVNQEVEQFEQAIEKDK QEHVRIKREDVEVRHTLSYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTHKPIG PLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQSLMKKFYPPGTSRPQIIVSEFRNE VYDVRLRAAYHPEFPTVLTALEIDNAVVANSLIDMRSIETVLLIKNNSVARAVMQSQKPPKNCR EAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLETEIENKKGHIMNLQHRLSALEKDIKR NEELLKRCQLHYKEIKMKIRKNISEIRELENIEEHQSVDIATLEDEAEENKIKMQMVEKNMEQQ KENMENLKTLKIEAENKYDTIKLKINQLSELADPLKDELNLADSEVDSQKRGKQHYEDKQKEHM DTLNKKRRELDMKEKELQEKMSQARQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREE IMKQYQEARETYLDLDSKVRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAY CGKMNFDHKNETLSISVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFD VYMDMVNRRIAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPV TQEEDDSAS hide sequence

Ensembl Acc Id:

ENSRNOP00000070408 ⟸ ENSRNOT00000083383

Ensembl Acc Id:

ENSRNOP00000007073 ⟸ ENSRNOT00000007073

RefSeq Acc Id:	XP_038968116 ⟸ XM_039112188
- Peptide Label:	isoform X1
- UniProtKB:	D4AB26 (UniProtKB/TrEMBL), A6HAP6 (UniProtKB/TrEMBL), A0A0G2JXU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968117 ⟸ XM_039112189
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2JXU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038968119 ⟸ XM_039112191
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038968118 ⟸ XM_039112190
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000078251 ⟸ ENSRNOT00000110833

Protein Domains

Rad50/SbcC-type AAA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AB26-F1-model_v2	AlphaFold	D4AB26	1-1097	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694494

Promoter ID:

EPDNEW_R5019

Type:

initiation region

Name:

Smc6_1

Description:

structural maintenance of chromosomes 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	36,941,218 - 36,941,278	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311214	AgrOrtholog
BioCyc Gene	G2FUF-38143	BioCyc
Ensembl Genes	ENSRNOG00000004908	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007073	ENTREZGENE
	ENSRNOT00000007073.7	UniProtKB/TrEMBL
	ENSRNOT00000083383.3	UniProtKB/TrEMBL
	ENSRNOT00000110833	ENTREZGENE
	ENSRNOT00000110833.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Rad50/SbcC_AAA	UniProtKB/TrEMBL
KEGG Report	rno:313961	UniProtKB/TrEMBL
NCBI Gene	313961	ENTREZGENE
PANTHER	STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6	UniProtKB/TrEMBL
	STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6	UniProtKB/TrEMBL
Pfam	AAA_23	UniProtKB/TrEMBL
PhenoGen	Smc6	PhenoGen
RatGTEx	ENSRNOG00000004908	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0G2JXU6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZKI2_RAT	UniProtKB/TrEMBL
	A6HAP6	ENTREZGENE, UniProtKB/TrEMBL
	D4AB26	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-05-05	Smc6	structural maintenance of chromosomes 6	Smc6l1	SMC6 structural maintenance of chromosomes 6-like 1 (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Smc6l1	SMC6 structural maintenance of chromosomes 6-like 1 (yeast)	Smc6l1_predicted	SMC6 structural maintenance of chromosomes 6-like 1 (yeast) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Smc6l1_predicted	SMC6 structural maintenance of chromosomes 6-like 1 (yeast) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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