Smc6 (structural maintenance of chromosomes 6) - Rat Genome Database

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Gene: Smc6 (structural maintenance of chromosomes 6) Mus musculus
Analyze
Symbol: Smc6
Name: structural maintenance of chromosomes 6
RGD ID: 1322556
MGI Page MGI
Description: Predicted to enable DNA binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including DNA recombination; cellular senescence; and negative regulation by host of viral genome replication. Predicted to act upstream of or within DNA recombination and DNA repair. Located in chromosome; mitotic spindle pole; and nucleus. Part of Smc5-Smc6 complex. Is expressed in central nervous system; embryo; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human SMC6 (structural maintenance of chromosomes 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2810489L22Rik; 3830418C19Rik; AA990493; AU018782; AW742439; D19Mgi1; KIAA4103; MGC96146; mKIAA4103; mSMC6; SMC protein 6; SMC-6; SMC6 structural maintenance of chromosomes 6-like 1; Smc6l1; structural maintenance of chromosomes protein 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391211,315,887 - 11,369,786 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1211,315,887 - 11,369,786 (+)EnsemblGRCm39 Ensembl
GRCm381211,265,886 - 11,319,785 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1211,265,886 - 11,319,785 (+)EnsemblGRCm38mm10GRCm38
MGSCv371211,272,692 - 11,326,591 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361211,292,229 - 11,346,128 (+)NCBIMGSCv36mm8
Celera1211,610,123 - 11,665,032 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map125.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11408570   PMID:11544199   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15226823   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693   PMID:19793919   PMID:20360068   PMID:21267068   PMID:21364888   PMID:21873635   PMID:23518413   PMID:23907463   PMID:26919979  
PMID:27480124   PMID:28302748   PMID:30281394   PMID:32325033   PMID:33200984  


Genomics

Comparative Map Data
Smc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391211,315,887 - 11,369,786 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1211,315,887 - 11,369,786 (+)EnsemblGRCm39 Ensembl
GRCm381211,265,886 - 11,319,785 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1211,265,886 - 11,319,785 (+)EnsemblGRCm38mm10GRCm38
MGSCv371211,272,692 - 11,326,591 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361211,292,229 - 11,346,128 (+)NCBIMGSCv36mm8
Celera1211,610,123 - 11,665,032 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map125.58NCBI
SMC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38217,663,812 - 17,753,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl217,663,812 - 17,800,242 (-)EnsemblGRCh38hg38GRCh38
GRCh37217,845,079 - 17,935,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36217,708,562 - 17,798,541 (-)NCBINCBI36Build 36hg18NCBI36
Build 34217,766,708 - 17,856,688NCBI
Celera217,724,884 - 17,815,383 (-)NCBICelera
Cytogenetic Map2p24.2NCBI
HuRef217,620,169 - 17,710,162 (-)NCBIHuRef
CHM1_1217,774,474 - 17,864,475 (-)NCBICHM1_1
T2T-CHM13v2.0217,695,556 - 17,785,539 (-)NCBIT2T-CHM13v2.0
Smc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8639,697,810 - 39,752,275 (+)NCBIGRCr8
mRatBN7.2633,978,730 - 34,033,201 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl633,978,716 - 34,031,746 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx634,271,336 - 34,324,302 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0634,587,277 - 34,640,243 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0634,058,056 - 34,111,010 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0636,941,233 - 36,995,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl636,941,233 - 36,995,138 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0646,691,346 - 46,746,033 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4634,710,177 - 34,763,158 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1634,718,849 - 34,765,945 (+)NCBI
Celera633,379,218 - 33,432,201 (+)NCBICelera
Cytogenetic Map6q15NCBI
Smc6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955469453,353 - 552,279 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955469456,023 - 552,794 (-)NCBIChiLan1.0ChiLan1.0
SMC6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212108,728,947 - 108,861,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A108,732,913 - 108,874,819 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A17,648,371 - 17,735,910 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A17,774,590 - 17,861,920 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A17,776,276 - 17,854,052 (-)Ensemblpanpan1.1panPan2
SMC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11713,132,945 - 13,201,214 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1713,133,236 - 13,201,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1713,085,159 - 13,153,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01713,269,396 - 13,337,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1713,269,693 - 13,337,904 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11713,127,707 - 13,196,134 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01713,138,902 - 13,207,328 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01713,165,157 - 13,233,234 (-)NCBIUU_Cfam_GSD_1.0
Smc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629257,587,323 - 57,648,207 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649313,191,455 - 13,252,578 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649313,191,389 - 13,250,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3120,097,379 - 120,170,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13120,097,361 - 120,170,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23128,245,265 - 128,318,831 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11489,917,621 - 90,005,604 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1489,917,518 - 90,000,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604522,208,586 - 22,296,770 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smc6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624738614,402 - 681,430 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624738612,758 - 689,191 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smc6
1928 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:437
Count of miRNA genes:327
Interacting mature miRNAs:357
Transcripts:ENSMUST00000020931
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
12792982Fbmd4_mfemoral bone mineral density 4, females only (mouse)121004319424365136Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse

Markers in Region
AW742439  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381211,318,593 - 11,318,857UniSTSGRCm38
MGSCv371211,325,399 - 11,325,663UniSTSGRCm37
Celera1211,663,840 - 11,664,104UniSTS
Cytogenetic Map12A2UniSTS
Whitehead/MRC_RH1287.67UniSTS
AU018782  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381211,317,906 - 11,318,038UniSTSGRCm38
MGSCv371211,324,712 - 11,324,844UniSTSGRCm37
Celera1211,663,153 - 11,663,285UniSTS
Cytogenetic Map12A2UniSTS
Whitehead/MRC_RH1286.84UniSTS
AA990493  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381211,318,584 - 11,318,713UniSTSGRCm38
MGSCv371211,325,390 - 11,325,519UniSTSGRCm37
Celera1211,663,831 - 11,663,960UniSTS
Cytogenetic Map12A2UniSTS
Whitehead/MRC_RH19457.14UniSTS
UniSTS:236808  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381211,317,946 - 11,318,050UniSTSGRCm38
MGSCv371211,324,752 - 11,324,856UniSTSGRCm37
Celera1211,663,193 - 11,663,297UniSTS
Cytogenetic Map12A2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001324476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_025695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC104880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC139207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ310552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000020931   ⟹   ENSMUSP00000020931
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,315,887 - 11,369,786 (+)Ensembl
GRCm38.p6 Ensembl1211,265,886 - 11,319,785 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217906   ⟹   ENSMUSP00000151382
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,316,170 - 11,330,403 (+)Ensembl
GRCm38.p6 Ensembl1211,266,169 - 11,280,402 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217930   ⟹   ENSMUSP00000151232
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,341,728 - 11,347,286 (+)Ensembl
GRCm38.p6 Ensembl1211,291,727 - 11,297,285 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217991   ⟹   ENSMUSP00000151378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,344,524 - 11,349,421 (+)Ensembl
GRCm38.p6 Ensembl1211,294,523 - 11,299,420 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218022   ⟹   ENSMUSP00000151643
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,316,106 - 11,369,780 (+)Ensembl
GRCm38.p6 Ensembl1211,266,105 - 11,319,779 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,350,657 - 11,369,786 (+)Ensembl
GRCm38.p6 Ensembl1211,300,656 - 11,319,785 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218815   ⟹   ENSMUSP00000151435
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,364,705 - 11,368,044 (+)Ensembl
GRCm38.p6 Ensembl1211,314,704 - 11,318,043 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218866   ⟹   ENSMUSP00000151976
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,316,130 - 11,337,655 (+)Ensembl
GRCm38.p6 Ensembl1211,266,129 - 11,287,654 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218958
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,316,509 - 11,320,732 (+)Ensembl
GRCm38.p6 Ensembl1211,266,508 - 11,270,731 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,316,131 - 11,320,796 (+)Ensembl
GRCm38.p6 Ensembl1211,266,130 - 11,270,795 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219776   ⟹   ENSMUSP00000152041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,316,202 - 11,329,728 (+)Ensembl
GRCm38.p6 Ensembl1211,266,201 - 11,279,727 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220289
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1211,340,770 - 11,345,644 (+)Ensembl
GRCm38.p6 Ensembl1211,290,769 - 11,295,643 (+)Ensembl
RefSeq Acc Id: NM_001324476   ⟹   NP_001311405
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391211,315,887 - 11,369,786 (+)NCBI
GRCm381211,265,886 - 11,319,785 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001361252   ⟹   NP_001348181
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391211,315,887 - 11,335,800 (+)NCBI
GRCm381211,265,886 - 11,285,799 (+)NCBI
Sequence:
RefSeq Acc Id: NM_025695   ⟹   NP_079971
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391211,315,887 - 11,369,786 (+)NCBI
GRCm381211,265,886 - 11,319,785 (+)ENTREZGENE
MGSCv371211,272,692 - 11,326,591 (+)RGD
Celera1211,610,123 - 11,665,032 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006515173   ⟹   XP_006515236
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391211,316,091 - 11,369,465 (+)NCBI
GRCm381211,266,104 - 11,319,467 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011243892   ⟹   XP_011242194
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391211,316,066 - 11,356,072 (+)NCBI
GRCm381211,266,027 - 11,306,071 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_079971   ⟸   NM_025695
- Peptide Label: isoform 1
- UniProtKB: Q9D169 (UniProtKB/Swiss-Prot),   Q9CZZ5 (UniProtKB/Swiss-Prot),   Q9CV94 (UniProtKB/Swiss-Prot),   Q9CSK7 (UniProtKB/Swiss-Prot),   Q8R0T4 (UniProtKB/Swiss-Prot),   Q8BFU9 (UniProtKB/Swiss-Prot),   Q5DTN2 (UniProtKB/Swiss-Prot),   Q499E1 (UniProtKB/Swiss-Prot),   Q3UX54 (UniProtKB/Swiss-Prot),   Q3UFI5 (UniProtKB/Swiss-Prot),   Q9D6B2 (UniProtKB/Swiss-Prot),   Q924W5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006515236   ⟸   XM_006515173
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011242194   ⟸   XM_011243892
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001311405   ⟸   NM_001324476
- Peptide Label: isoform 2
- UniProtKB: Q924W5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001348181   ⟸   NM_001361252
- Peptide Label: isoform 3
RefSeq Acc Id: ENSMUSP00000151643   ⟸   ENSMUST00000218022
RefSeq Acc Id: ENSMUSP00000151976   ⟸   ENSMUST00000218866
RefSeq Acc Id: ENSMUSP00000151435   ⟸   ENSMUST00000218815
RefSeq Acc Id: ENSMUSP00000151232   ⟸   ENSMUST00000217930
RefSeq Acc Id: ENSMUSP00000151382   ⟸   ENSMUST00000217906
RefSeq Acc Id: ENSMUSP00000151378   ⟸   ENSMUST00000217991
RefSeq Acc Id: ENSMUSP00000020931   ⟸   ENSMUST00000020931
RefSeq Acc Id: ENSMUSP00000152041   ⟸   ENSMUST00000219776

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924W5-F1-model_v2 AlphaFold Q924W5 1-1097 view protein structure

Promoters
RGD ID:8677914
Promoter ID:EPDNEW_M16988
Type:initiation region
Name:Smc6_2
Description:Mus musculus structural maintenance of chromosomes 6 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16989  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381211,265,830 - 11,265,890EPDNEW
RGD ID:8677916
Promoter ID:EPDNEW_M16989
Type:initiation region
Name:Smc6_1
Description:Mus musculus structural maintenance of chromosomes 6 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16988  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381211,266,150 - 11,266,210EPDNEW
RGD ID:6822971
Promoter ID:MM_KWN:11158
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000052581,   NM_025695,   UC007NAW.1,   UC007NAX.1,   UC007NAZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361211,271,741 - 11,273,067 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914491 AgrOrtholog
Ensembl Genes ENSMUSG00000020608 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020931 ENTREZGENE
  ENSMUST00000020931.6 UniProtKB/Swiss-Prot
  ENSMUST00000217906.2 UniProtKB/TrEMBL
  ENSMUST00000217930.2 UniProtKB/TrEMBL
  ENSMUST00000217991.2 UniProtKB/TrEMBL
  ENSMUST00000218022.2 UniProtKB/TrEMBL
  ENSMUST00000218815.2 UniProtKB/TrEMBL
  ENSMUST00000218866 ENTREZGENE
  ENSMUST00000218866.2 UniProtKB/Swiss-Prot
  ENSMUST00000219776.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Rad50/SbcC_AAA UniProtKB/Swiss-Prot
KEGG Report mmu:67241 UniProtKB/Swiss-Prot
MGD MGI:1914491 ENTREZGENE
NCBI Gene 67241 ENTREZGENE
PANTHER STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_23 UniProtKB/Swiss-Prot
PhenoGen Smc6 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A1W2P6F2_MOUSE UniProtKB/TrEMBL
  A0A1W2P6T0_MOUSE UniProtKB/TrEMBL
  A0A1W2P6V7_MOUSE UniProtKB/TrEMBL
  A0A1W2P6W0_MOUSE UniProtKB/TrEMBL
  A0A1W2P7G6_MOUSE UniProtKB/TrEMBL
  A0A1W2P8E7_MOUSE UniProtKB/TrEMBL
  Q3UFI5 ENTREZGENE
  Q3UX54 ENTREZGENE
  Q499E1 ENTREZGENE
  Q5DTN2 ENTREZGENE
  Q8BFU9 ENTREZGENE
  Q8R0T4 ENTREZGENE
  Q924W5 ENTREZGENE
  Q9CSK7 ENTREZGENE
  Q9CV94 ENTREZGENE
  Q9CZZ5 ENTREZGENE
  Q9D169 ENTREZGENE
  Q9D6B2 ENTREZGENE
  SMC6_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3UFI5 UniProtKB/Swiss-Prot
  Q3UX54 UniProtKB/Swiss-Prot
  Q499E1 UniProtKB/Swiss-Prot
  Q5DTN2 UniProtKB/Swiss-Prot
  Q8BFU9 UniProtKB/Swiss-Prot
  Q8R0T4 UniProtKB/Swiss-Prot
  Q9CSK7 UniProtKB/Swiss-Prot
  Q9CV94 UniProtKB/Swiss-Prot
  Q9CZZ5 UniProtKB/Swiss-Prot
  Q9D169 UniProtKB/Swiss-Prot
  Q9D6B2 UniProtKB/Swiss-Prot