Pmvk (phosphomevalonate kinase) - Rat Genome Database

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Gene: Pmvk (phosphomevalonate kinase) Rattus norvegicus
Analyze
Symbol: Pmvk
Name: phosphomevalonate kinase
RGD ID: 1310812
Description: Enables phosphomevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human PMVK (phosphomevalonate kinase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC310645; MGC105660
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,174,344 - 177,184,076 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2177,174,335 - 177,184,080 (+)EnsemblGRCr8
mRatBN7.22174,876,586 - 174,886,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,876,657 - 174,886,364 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2182,022,396 - 182,031,869 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,044,785 - 180,054,258 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,645,467 - 174,654,973 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,784,329 - 188,793,890 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,784,222 - 188,793,895 (+)Ensemblrn6Rnor6.0
Rnor_5.02208,198,238 - 208,207,794 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42181,655,658 - 181,665,214 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,817,684 - 168,827,240 (+)NCBICelera
RGSC_v3.12181,605,763 - 181,615,319 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
amiodarone  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
azoxystrobin  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
glyphosate  (EXP)
GSK-J4  (ISO)
hydralazine  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
pravastatin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenomethionine  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
peroxisome  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. Gupta SD, etal., J Lipid Res. 1999 Sep;40(9):1572-84.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. Olivier LM, etal., J Lipid Res. 1999 Apr;40(4):672-9.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Studies on mevalonate kinase, phosphomevalonate kinase and pyrophosphomevalonate decarboxylase in developing rat brain. Ramachandran CK and Shah SN, J Neurochem. 1977 Apr;28(4):751-7.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:8663599   PMID:11792727   PMID:12477932   PMID:14680974   PMID:14729858   PMID:16519518   PMID:17180682   PMID:19056867   PMID:19946888   PMID:23376485   PMID:27052676  


Genomics

Comparative Map Data
Pmvk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,174,344 - 177,184,076 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2177,174,335 - 177,184,080 (+)EnsemblGRCr8
mRatBN7.22174,876,586 - 174,886,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,876,657 - 174,886,364 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2182,022,396 - 182,031,869 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,044,785 - 180,054,258 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,645,467 - 174,654,973 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,784,329 - 188,793,890 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,784,222 - 188,793,895 (+)Ensemblrn6Rnor6.0
Rnor_5.02208,198,238 - 208,207,794 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42181,655,658 - 181,665,214 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,817,684 - 168,827,240 (+)NCBICelera
RGSC_v3.12181,605,763 - 181,615,319 (+)NCBI
Cytogenetic Map2q34NCBI
PMVK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381154,924,740 - 154,942,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1154,924,732 - 154,937,008 (-)Ensemblhg38GRCh38
GRCh371154,897,216 - 154,915,134 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,163,832 - 153,176,108 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341151,710,280 - 151,722,540NCBI
Celera1127,968,233 - 127,980,509 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1126,259,154 - 126,271,445 (-)NCBIHuRef
CHM1_11156,293,587 - 156,305,863 (-)NCBICHM1_1
T2T-CHM13v2.01154,064,101 - 154,082,019 (-)NCBIT2T-CHM13v2.0
Pmvk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,361,848 - 89,376,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,361,848 - 89,376,320 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38389,454,541 - 89,469,014 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,454,541 - 89,469,013 (+)Ensemblmm10GRCm38
MGSCv37389,263,040 - 89,272,931 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36389,545,243 - 89,554,933 (+)NCBIMGSCv36mm8
Celera389,494,449 - 89,504,138 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.13NCBI
Pmvk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,421,562 - 1,440,038 (-)Ensembl
ChiLan1.0NW_0049555451,421,562 - 1,440,038 (-)NCBIChiLan1.0ChiLan1.0
PMVK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,903,218 - 94,915,762 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,635,585 - 94,647,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,273,246 - 130,286,614 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,882,837 - 133,894,818 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,882,840 - 133,894,818 (-)EnsemblpanPan2panpan1.1
PMVK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,532,968 - 42,563,618 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,533,217 - 42,540,625 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha742,024,242 - 42,060,899 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0742,403,302 - 42,439,920 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,403,373 - 42,414,566 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,182,992 - 42,219,593 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,236,594 - 42,273,239 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,520,185 - 42,556,794 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pmvk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,443,172 - 25,452,234 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,473,359 - 4,482,631 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,473,554 - 4,482,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMVK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,861,712 - 94,874,771 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1494,861,500 - 94,913,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,634,269 - 103,685,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PMVK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,893,297 - 8,906,882 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,894,786 - 8,906,873 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660388,229,305 - 8,242,091 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmvk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,543,862 - 2,553,237 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248852,544,136 - 2,552,591 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pmvk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1364,199,570 - 64,208,856 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pmvk
1072 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:41
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000028095
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2176840779178247591Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
UniSTS:234731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,876,649 - 174,876,827 (+)MAPPERmRatBN7.2
Rnor_6.02188,784,173 - 188,784,350NCBIRnor6.0
Rnor_5.02208,198,082 - 208,198,259UniSTSRnor5.0
RGSC_v3.42181,655,502 - 181,655,679UniSTSRGSC3.4
Celera2168,817,528 - 168,817,705UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028095   ⟹   ENSRNOP00000028095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,174,335 - 177,184,080 (+)Ensembl
mRatBN7.2 Ensembl2174,876,676 - 174,886,364 (+)Ensembl
Rnor_6.0 Ensembl2188,784,222 - 188,793,895 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095826   ⟹   ENSRNOP00000076949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,175,034 - 177,184,080 (+)Ensembl
mRatBN7.2 Ensembl2174,877,320 - 174,886,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107817   ⟹   ENSRNOP00000084217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,174,568 - 177,184,080 (+)Ensembl
mRatBN7.2 Ensembl2174,876,657 - 174,886,364 (+)Ensembl
RefSeq Acc Id: NM_001008352   ⟹   NP_001008353
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,174,520 - 177,184,076 (+)NCBI
mRatBN7.22174,876,806 - 174,886,360 (+)NCBI
Rnor_6.02188,784,329 - 188,793,885 (+)NCBI
Rnor_5.02208,198,238 - 208,207,794 (+)NCBI
RGSC_v3.42181,655,658 - 181,665,214 (+)RGD
Celera2168,817,684 - 168,827,240 (+)RGD
Sequence:
RefSeq Acc Id: XM_017590894   ⟹   XP_017446383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,174,350 - 177,184,076 (+)NCBI
mRatBN7.22174,876,617 - 174,886,365 (+)NCBI
Rnor_6.02188,784,384 - 188,793,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102341   ⟹   XP_038958269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,174,344 - 177,184,076 (+)NCBI
mRatBN7.22174,876,586 - 174,886,365 (+)NCBI
RefSeq Acc Id: NP_001008353   ⟸   NM_001008352
- UniProtKB: Q5RK24 (UniProtKB/TrEMBL),   F7FJH6 (UniProtKB/TrEMBL),   A0A8I5ZXC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446383   ⟸   XM_017590894
- Peptide Label: isoform X2
- UniProtKB: A6J6G8 (UniProtKB/TrEMBL),   A6J6G7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028095   ⟸   ENSRNOT00000028095
RefSeq Acc Id: XP_038958269   ⟸   XM_039102341
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000076949   ⟸   ENSRNOT00000095826
Ensembl Acc Id: ENSRNOP00000084217   ⟸   ENSRNOT00000107817

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RK24-F1-model_v2 AlphaFold Q5RK24 1-194 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691479
Promoter ID:EPDNEW_R2004
Type:initiation region
Name:Pmvk_1
Description:phosphomevalonate kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,784,279 - 188,784,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310812 AgrOrtholog
BioCyc Gene G2FUF-52402 BioCyc
BioCyc Pathway PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
BioCyc Pathway Image PWY-922 BioCyc
Ensembl Genes ENSRNOG00000020696 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028095 ENTREZGENE
  ENSRNOT00000028095.7 UniProtKB/TrEMBL
  ENSRNOT00000095826.2 UniProtKB/TrEMBL
  ENSRNOT00000107817.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302798 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Pmev_kin_anim UniProtKB/TrEMBL
KEGG Report rno:310645 UniProtKB/TrEMBL
MGC_CLONE MGC:105660 IMAGE-MGC_LOAD
NCBI Gene 310645 ENTREZGENE
PANTHER PHOSPHOMEVALONATE KINASE UniProtKB/TrEMBL
  Pmev_kin_anim UniProtKB/TrEMBL
Pfam P-mevalo_kinase UniProtKB/TrEMBL
PharmGKB PMVK RGD
PhenoGen Pmvk PhenoGen
PIRSF PMK_anim UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020696 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5Y980_RAT UniProtKB/TrEMBL
  A0A8I5ZXC1 ENTREZGENE, UniProtKB/TrEMBL
  A6J6G7 ENTREZGENE, UniProtKB/TrEMBL
  A6J6G8 ENTREZGENE, UniProtKB/TrEMBL
  A6J6G9_RAT UniProtKB/TrEMBL
  F7FJH6 ENTREZGENE, UniProtKB/TrEMBL
  Q5RK24 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Pmvk  phosphomevalonate kinase  Pmvk_predicted  phosphomevalonate kinase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pmvk_predicted  phosphomevalonate kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED