RGD Reference Report - Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. - Rat Genome Database

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Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.

Authors: Olivier, LM  Chambliss, KL  Gibson, KM  Krisans, SK 
Citation: Olivier LM, etal., J Lipid Res. 1999 Apr;40(4):672-9.
RGD ID: 8553625
Pubmed: PMID:10191291   (View Abstract at PubMed)

Phosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In this study we have localized the phosphomevalonate kinase gene to chromosome 1p13-1q22-23 and present a genomic map indicating that the gene spans more than 8.4 kb in the human genome. Furthermore, we show that message levels and enzyme activity of rat liver phosphomevalonate kinase are regulated in response to dietary sterol levels and that this regulation is coordinate with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. In addition, we demonstrate that phosphomevalonate kinase is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cholesterol biosynthetic process involved_inNAS 8553625PMID:10191291UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Pmvk  (phosphomevalonate kinase)


Additional Information