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Gene: Adss2 (adenylosuccinate synthase 2) Rattus norvegicus

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Symbol:

Adss2

Name:

adenylosuccinate synthase 2

RGD ID:

1310508

Description:

Enables adenylosuccinate synthase activity. Involved in several processes, including IMP metabolic process; aspartate metabolic process; and cellular response to electrical stimulus. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Biomarker of sarcoma. Orthologous to human ADSS2 (adenylosuccinate synthase 2); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adenylosuccinate synthase; adenylosuccinate synthetase 2, non muscle; adenylosuccinate synthetase isozyme 2; adenylosuccinate synthetase, non muscle; Adss; LOC289276

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADSS2 (adenylosuccinate synthase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Adss2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adss2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADSS2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADSS2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adss2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADSS2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADSS2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adss2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Adss2 (adenylosuccinate synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ADSS1 (adenylosuccinate synthase 1)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	ADSS2 (adenylosuccinate synthase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ADSS2 (adenylosuccinate synthase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Adss2 (adenylosuccinate synthase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adss (adenylosuccinate synthase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ADE12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	AdSS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	adss-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	adss-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	adss2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	92,301,302 - 92,331,638 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	92,301,302 - 92,331,638 (-)	Ensembl				GRCr8
mRatBN7.2	13	89,769,240 - 89,799,577 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	89,769,244 - 89,799,604 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	92,274,500 - 92,304,832 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	93,674,619 - 93,704,952 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	90,853,087 - 90,883,179 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	95,913,426 - 95,943,761 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	95,913,426 - 95,943,761 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	100,355,979 - 100,386,314 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	93,681,036 - 93,711,373 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	89,331,572 - 89,361,621 (-)	NCBI		Celera
RGSC_v3.1	13	93,869,972 - 93,900,303 (-)	NCBI
Cytogenetic Map	13	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

sarcoma (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

arsenous acid (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

clofibrate (ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

enzyme inhibitor (ISO)

fenvalerate (EXP)

finasteride (EXP)

folic acid (ISO)

gentamycin (EXP)

glafenine (EXP)

glycine betaine (EXP)

hydrogen peroxide (ISO)

inulin (ISO)

ivermectin (ISO)

MeIQx (ISO)

methoxychlor (EXP)

okadaic acid (ISO)

paclitaxel (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phosgene (ISO)

potassium chromate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

sulindac (EXP)

sunitinib (ISO)

tetrachloromethane (ISO)

thiram (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' AMP biosynthetic process (IBA,IEA,ISO)

amino acid metabolic process (IDA)

AMP biosynthetic process (IEA,ISO)

AMP salvage (IEA)

cellular response to electrical stimulus (IEP)

IMP metabolic process (IBA,IDA)

purine nucleotide biosynthetic process (IEA,ISO)

response to ammonium ion (IEP)

response to purine-containing compound (IEP)

Cellular Component

cytoplasm (IBA,IEA)

mitochondrion (IEA,ISO)

Molecular Function

adenylosuccinate synthase activity (IBA,IDA,IEA,ISO)

GTP binding (IEA)

ligase activity (IEA)

magnesium ion binding (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

alanine, aspartate and glutamate metabolic pathway (IEA)

azathioprine pharmacodynamics pathway (ISO)

de novo purine biosynthetic pathway (ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Changes in isozymes of adenylosuccinate synthetase.	Baugher BW, etal., Biochem Biophys Res Commun. 1980 May 14;94(1):123-9.
2.	Metabolism of threo-beta-fluoroaspartate by H4 cells. Inhibition of adenylosuccinate lyase by fluoro analogs of its substrates.	Casey PJ, etal., J Biol Chem. 1986 Oct 15;261(29):13637-42.
3.	Importance of purine nucleotide cycle to energy production in skeletal muscle.	Flanagan WF, etal., Am J Physiol. 1986 Nov;251(5 Pt 1):C795-802.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Adenylosuccinate synthetase: recent developments.	Honzatko RB, etal., Adv Enzymol Relat Areas Mol Biol. 1999;73:57-102, ix-x.
7.	Isozyme shift of adenylosuccinate synthase in rat and human neoplasms.	Ikegami T, etal., Adv Exp Med Biol. 1989;253A:417-21.
8.	Adenine nucleotide metabolism in hearts of diabetic rats. Comparison to diaphragm, liver, and kidney.	Jenkins RL, etal., Diabetes. 1988 May;37(5):629-36.
9.	Adenylosuccinate synthetase in rat liver: the existence of two types and their regulatory roles.	Matsuda Y, etal., Biochem Biophys Res Commun. 1977 Sep 23;78(2):766-71.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Effect of acidosis and uninephrectomy on isozymes of adenylosuccinate synthetase in rat kidney.	Tornheim K and Lowenstein LM, Biochim Biophys Acta. 1983 May 4;757(1):137-9.
15.	Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene.	Xia Y, etal., J Biol Chem. 2000 Jan 21;275(3):1855-63.

Additional References at PubMed

PMID:1592113	PMID:2004783	PMID:8308018	PMID:12482871	PMID:15786719	PMID:17347008	PMID:23533145

Genomics

Comparative Map Data

Adss2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	92,301,302 - 92,331,638 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	92,301,302 - 92,331,638 (-)	Ensembl				GRCr8
mRatBN7.2	13	89,769,240 - 89,799,577 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	89,769,244 - 89,799,604 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	92,274,500 - 92,304,832 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	93,674,619 - 93,704,952 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	90,853,087 - 90,883,179 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	95,913,426 - 95,943,761 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	95,913,426 - 95,943,761 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	100,355,979 - 100,386,314 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	93,681,036 - 93,711,373 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	89,331,572 - 89,361,621 (-)	NCBI		Celera
RGSC_v3.1	13	93,869,972 - 93,900,303 (-)	NCBI
Cytogenetic Map	13	q25	NCBI

ADSS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	244,408,494 - 244,452,060 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	244,408,494 - 244,451,909 (-)	Ensembl			hg38	GRCh38
GRCh37	1	244,571,796 - 244,615,362 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	242,638,419 - 242,682,036 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	240,897,836 - 240,941,454	NCBI
Celera	1	217,861,837 - 217,905,438 (-)	NCBI		Celera
Cytogenetic Map	1	q44	ENTREZGENE
HuRef	1	214,954,992 - 214,998,619 (-)	NCBI		HuRef
CHM1_1	1	245,844,434 - 245,888,075 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	243,824,815 - 243,868,543 (-)	NCBI		T2T-CHM13v2.0

Adss2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	177,590,742 - 177,624,064 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	177,590,528 - 177,624,077 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	177,763,176 - 177,796,695 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	177,762,962 - 177,796,511 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	179,693,309 - 179,726,640 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	179,599,853 - 179,633,184 (-)	NCBI		MGSCv36	mm8
Celera	1	184,815,169 - 184,848,493 (-)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	82.81	NCBI

Adss2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	7,683,596 - 7,715,616 (-)	Ensembl
ChiLan1.0	NW_004955406	7,684,979 - 7,715,179 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADSS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	4,687,297 - 4,730,341 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	4,909,338 - 4,952,688 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	220,020,480 - 220,063,658 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	225,401,544 - 225,444,984 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	225,401,544 - 225,444,984 (-)	Ensembl			panPan2	panpan1.1

ADSS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	35,440,250 - 35,477,470 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	35,440,676 - 35,476,795 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	34,914,701 - 34,951,923 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	35,267,843 - 35,305,065 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	35,267,844 - 35,304,386 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	35,103,992 - 35,141,205 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	35,120,419 - 35,155,914 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	35,385,151 - 35,422,371 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adss2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	48,366,561 - 48,404,882 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	6,342,221 - 6,380,840 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	6,342,233 - 6,380,736 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADSS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	17,220,207 - 17,259,182 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	17,220,081 - 17,259,141 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	19,583,927 - 19,606,684 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADSS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	81,441,792 - 81,485,344 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	81,442,787 - 81,485,292 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	83,656,557 - 83,700,262 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adss2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	15,059,876 - 15,097,518 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624771	15,059,845 - 15,097,518 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Adss2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	56,365,709 - 56,395,349 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Adss2
135 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	157
Count of miRNA genes:	120
Interacting mature miRNAs:	142
Transcripts:	ENSRNOT00000005961
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
1302791	Stl29	Serum triglyceride level QTL 29	3.3	0.0011	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	13	89333129	92500981	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

RH129208

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	89,769,325 - 89,769,523 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	95,913,512 - 95,913,709	NCBI	Rnor6.0
Rnor_5.0	13	100,356,065 - 100,356,262	UniSTS	Rnor5.0
RGSC_v3.4	13	93,681,122 - 93,681,319	UniSTS	RGSC3.4
Celera	13	89,331,658 - 89,331,855	UniSTS
Cytogenetic Map	13	q25	UniSTS

RH142786

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	89,795,235 - 89,795,489 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	95,939,421 - 95,939,674	NCBI	Rnor6.0
Rnor_5.0	13	100,381,974 - 100,382,227	UniSTS	Rnor5.0
RGSC_v3.4	13	93,707,032 - 93,707,285	UniSTS	RGSC3.4
Celera	13	89,357,307 - 89,357,560	UniSTS
RH 3.4 Map	13	605.8	UniSTS
Cytogenetic Map	13	q25	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005961 ⟹ ENSRNOP00000005961

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	92,301,302 - 92,331,638 (-)	Ensembl
mRatBN7.2 Ensembl	13	89,769,244 - 89,799,604 (-)	Ensembl
Rnor_6.0 Ensembl	13	95,913,426 - 95,943,761 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095288 ⟹ ENSRNOP00000082624

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	89,770,197 - 89,799,604 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100170 ⟹ ENSRNOP00000084186

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	92,301,302 - 92,331,638 (-)	Ensembl
mRatBN7.2 Ensembl	13	89,769,249 - 89,799,579 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111024 ⟹ ENSRNOP00000097735

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	92,301,302 - 92,331,638 (-)	Ensembl
mRatBN7.2 Ensembl	13	89,769,244 - 89,799,604 (-)	Ensembl

RefSeq Acc Id:

NM_001105975 ⟹ NP_001099445

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	92,301,302 - 92,331,638 (-)	NCBI
mRatBN7.2	13	89,769,240 - 89,799,577 (-)	NCBI
Rnor_6.0	13	95,913,426 - 95,943,761 (-)	NCBI
Rnor_5.0	13	100,355,979 - 100,386,314 (-)	NCBI
RGSC_v3.4	13	93,681,036 - 93,711,373 (-)	RGD
Celera	13	89,331,572 - 89,361,621 (-)	RGD

Sequence:

show sequence

GGCCGGCCTCTGGCTCCTTCTTCCTCCGCATGTCGCGGGCGGTCCCGCAGCAGTTAAGTTGAGG
TTCTGTTCTCCTGCCGAGTCTCCTCAAGGCTCTTCTTCCCTGCCGGGAGCCATGTCGATCTCTG
AGAGCAGCCCGGCGGCTACTTCCTTGCCGAACGGCGACTGCGGCCGCCCCAGGGCGCGGCCTGG
AGGGAACCGGGTGACTGTGGTGCTGGGAGCGCAGTGGGGCGACGAGGGCAAAGGGAAGGTGGTG
GATCTGCTGGCGCAGGACGCCGACATCGTGTGCCGTTGCCAGGGAGGGAATAACGCTGGCCACA
CAGTTGTCGTAGACTCGGTGGAGTATGACTTTCACCTCTTACCTAGTGGGATAATCAACCCAAA
TGTCACTGCCTTCATTGGCAATGGAGTGGTAATTCATCTTCCTGGACTGTTTGAAGAAGCAGAG
AAAAATGTTCAAAAGGGGAAAGGTCTAGATGGCTGGGAAAAAAGGCTTATCATATCGGACAGAG
CTCATATTGTGTTTGACTTTCATCAAGCAGCTGATGGTATCCAGGAACAGCAGAGACAAGAGCA
AGCAGGAAAAAATTTGGGTACCACGAAAAAGGGTATCGGCCCTGTATATTCCTCTAAAGCTGCT
CGGAGTGGACTTCGGATGTGTGATCTTGTTTCTGACTTCGATGGCTTCTCTGAGAGGTTCAAAG
TTCTAGCTAACCAGTATAAATCTATATATCCGACTTTGGAAATAGACATTGAAGGTGAATTACA
ACAACTCAAGGGTTATATGGAAAGGATTAAACCGATGGTGAGAGATGGAGTTTATTTCCTATAT
GAGGCCCTCCATGGACCCCCCAAGAAAATCTTGGTAGAAGGTGCGAACGCAGCACTGTTAGATA
TTGACTTTGGAACTTACCCTTTTGTAACCTCTTCAAACTGCACTGTTGGAGGTGTCTGTACAGG
TCTGGGTATGCCCCCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTACACCACTAGA
GTTGGGATTGGTGCCTTTCCCACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACACGGG
GTAGAGAATTTGGAGTAACTACTGGGAGGAAAAGAAGATGCGGCTGGTTGGACCTTGTCTTACT
CAAATACGCTCACATGATCAATGGATTTACTGCGTTGGCCCTTACCAAGTTGGATATTTTGGAT
ATGTTTACGGAGATCAAAGTCGGAGTTGCTTACAAATTAGATGGGGAAACCATACCTCATTTCC
CAGCAAACCAAGAAGTCTTAAATAAAGTGGAAGTTCAGTATAAGACTCTCCCAGGATGGAACAC
AGATATATCTAATGCAAGGACATTTAAGGAGCTACCTGTCAATGCACAAAATTATGTTCGGTTT
ATTGAAGATGAGCTTCAAATACCAGTTAAATGGATTGGTGTGGGTAAATCCAGAGAGTCCATGA
TTCAGCTCTTCTAAGGACTGCCAGCAATGCAAGAGACATTCCTTGAGAGGACTTATACATTTCT
CTGTGACCTACAAATTCAAGAATAAAGACATTGAAGTGCGTTTTCAGCTGGCATTGGTTTGCAG
TCTCTGGTGGACGGATGGCTGTCATGGCTGGCCTGGCGCTCTCCCCAGCTTCCAGATGGCCTGG
CTGCCACATCTGTTGCTCTGCTGCTCGTGGTGCCGCACAGTCCTTTCCATGGTTAGTAACTATG
TATCCCCGTTTGACATCTAGAACTTGCAGCCTTGCTTTTCTTCATTATGGCCATTGTGTTTGAG
TTTTACAACTAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTACATTCTGATCA
TTCACTTCTGCCATTGTAATCTTTGCTGTTAGGGAAAAAATGATGGAAAGATAAGTGTTCTGTC
AACTTTTGTAATGCTACAAATTCTGTTTAAATTGTGAACTGCTTTTTTTCTGCTGAGACCATTG
CAAAATTGAGCTTTGGTAGGGTGAGGGGAGTATGTTCATGGGACTTTTAATTTGTATAGAACAC
AGAACTTAGTTCTCTCTGCAATTTATTTAATACATTAAATTGAGTGTTCAAAAAGAGAGAGAGA
GAGAGAGAAATGTTTCCCTACAATAACAATCTTAATGTTGGAAAATAATTAAAAAAAAATCTGT
TGTGATATTTGGTGGATATTTTTCTTTGTTTTGCAGATATGAGCTCAATGTATATCTTTTCACT
TTCTTTTTTAAGCATACTGTTGTTTCTAAGACCGTGGGTTTGCTTCCAGCATTCCATCTGCCAG
TATACCTACAAAATGACCCTTAAGTAACCCACACAAGTCCAAGTTGTCAGCCAGAATTTTGATC
ATGCCTTCATTCCTCCTTTCTTGAAAAAGCAAAGAGGTATTACCTGACACTTAGGCTATATGTT
GTGCTGAGATTATCCTTCATGAACCATTAAATGTTTAATTAGGTATCACTTGAGATTATTTTAT
TATACCATCAATAGCTGATTAAAAGGAACCAAATATTTCCAGT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099445	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94793	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005961
	ENSRNOP00000005961.5
	ENSRNOP00000084186.1
	ENSRNOP00000097735.1

RefSeq Acc Id:

NP_001099445 ⟸ NM_001105975

- UniProtKB:

D4AEP0 (UniProtKB/TrEMBL), A6JGD7 (UniProtKB/TrEMBL), A0A8I6AT75 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSISESSPAATSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGN
NAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLDGWEKRLI
ISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFS
ERFKVLANQYKSIYPTLEIDIEGELQQLKGYMERIKPMVRDGVYFLYEALHGPPKKILVEGANA
ALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGEL
LQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGET
IPHFPANQEVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGVGKS
RESMIQLF

hide sequence

Ensembl Acc Id:

ENSRNOP00000005961 ⟸ ENSRNOT00000005961

Ensembl Acc Id:

ENSRNOP00000082624 ⟸ ENSRNOT00000095288

Ensembl Acc Id:

ENSRNOP00000084186 ⟸ ENSRNOT00000100170

Ensembl Acc Id:

ENSRNOP00000097735 ⟸ ENSRNOT00000111024

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AEP0-F1-model_v2	AlphaFold	D4AEP0	1-456	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699045

Promoter ID:

EPDNEW_R9570

Type:

initiation region

Name:

Adss_1

Description:

adenylosuccinate synthase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	95,943,742 - 95,943,802	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310508	AgrOrtholog
BioCyc Gene	G2FUF-17181	BioCyc
BioCyc Pathway	PWY-7219 [adenosine ribonucleotides de novo biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-7219	BioCyc
Ensembl Genes	ENSRNOG00000004481	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005961	ENTREZGENE
	ENSRNOT00000005961.7	UniProtKB/TrEMBL
	ENSRNOT00000100170.2	UniProtKB/TrEMBL
	ENSRNOT00000111024.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.300.10	UniProtKB/TrEMBL
	3.40.440.10	UniProtKB/TrEMBL
	3.90.170.10	UniProtKB/TrEMBL
InterPro	Adenylosuccin_syn_Lys_AS	UniProtKB/TrEMBL
	Adenylosuccinate_synth_dom1	UniProtKB/TrEMBL
	Adenylosuccinate_synth_dom2	UniProtKB/TrEMBL
	Adenylosuccinate_synth_dom3	UniProtKB/TrEMBL
	Adenylosuccinate_synthase_AS	UniProtKB/TrEMBL
	Adenylosuccinate_synthetase	UniProtKB/TrEMBL
	AdSS_2_vert	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:289276	UniProtKB/TrEMBL
NCBI Gene	289276	ENTREZGENE
PANTHER	ADENYLOSUCCINATE SYNTHETASE ISOZYME 2	UniProtKB/TrEMBL
	Asucc_synthtase	UniProtKB/TrEMBL
Pfam	Adenylsucc_synt	UniProtKB/TrEMBL
PhenoGen	Adss2	PhenoGen
PROSITE	ADENYLOSUCCIN_SYN_1	UniProtKB/TrEMBL
	ADENYLOSUCCIN_SYN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004481	RatGTEx
SMART	Adenylsucc_synt	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I6AT75	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GA01_RAT	UniProtKB/TrEMBL
	A6JGD7	ENTREZGENE, UniProtKB/TrEMBL
	D4AEP0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-10-05	Adss2	adenylosuccinate synthase 2	Adss	adenylosuccinate synthase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Adss	adenylosuccinate synthase	Adss	adenylosuccinate synthetase, non muscle	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Adss	adenylosuccinate synthetase, non muscle	Adss_predicted	adenylosuccinate synthetase, non muscle (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Adss_predicted	adenylosuccinate synthetase, non muscle (predicted)	Adss2_predicted	adenylosuccinate synthetase 2, non muscle (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Adss2_predicted	adenylosuccinate synthetase 2, non muscle (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways