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Gene: Wwp2 (WW domain containing E3 ubiquitin protein ligase 2) Rattus norvegicus

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Symbol:

Wwp2

Name:

WW domain containing E3 ubiquitin protein ligase 2

RGD ID:

1310091

Description:

Predicted to enable several functions, including potassium channel inhibitor activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule biosynthetic process; negative regulation of transport; and protein ubiquitination. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and protein ubiquitination. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein ligase 2); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC103690129; LOC291999; NEDD4-like E3 ubiquitin-protein ligase WWP2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	52,256,563 - 52,380,967 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	52,256,551 - 52,382,415 (+)	Ensembl				GRCr8
mRatBN7.2	19	35,346,826 - 35,471,251 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	35,346,814 - 35,472,699 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	42,162,280 - 42,286,677 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	42,815,647 - 42,940,037 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	45,124,358 - 45,244,666 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	39,543,246 - 39,614,624 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	39,543,242 - 39,614,625 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	49,207,226 - 49,255,597 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	19	50,405,611 - 50,476,926 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	37,302,346 - 37,428,377 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	34,768,243 - 34,893,337 (+)	NCBI		Celera
RGSC_v3.1	19	37,307,245 - 37,433,162 (+)	NCBI
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Knee Osteoarthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

coumarin (ISO)

cypermethrin (EXP)

diarsenic trioxide (ISO)

diazinon (EXP)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dieldrin (EXP)

dioxygen (ISO)

folic acid (ISO)

FR900359 (ISO)

methapyrilene (ISO)

N-nitrosodiethylamine (EXP)

nickel dichloride (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

resveratrol (ISO)

selenomethionine (ISO)

sodium arsenite (ISO)

testosterone (ISO)

testosterone enanthate (ISO)

thiram (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

extracellular transport (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of potassium ion export across plasma membrane (ISO)

negative regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

positive regulation of transcription by RNA polymerase II (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA,IEA,ISO)

protein autoubiquitination (ISO)

protein K63-linked ubiquitination (ISO)

protein ubiquitination (IEA,ISO)

regulation of membrane potential (ISO)

regulation of monoatomic ion transmembrane transport (IBA)

ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

cytoplasm (IBA,IEA,ISO)

extracellular region (IEA)

nucleus (IEA,ISO)

Molecular Function

catalytic activity (IEA)

ligase activity (IEA)

molecular function inhibitor activity (IEA)

potassium channel inhibitor activity (ISO)

protein binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IBA,IEA,ISO)

transcription regulator inhibitor activity (ISO)

transferase activity (IEA)

transmembrane transporter binding (ISO)

ubiquitin protein ligase activity (IBA,IEA,ISO)

ubiquitin-protein transferase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15047715	PMID:17289006	PMID:18776082	PMID:19274063	PMID:19651900	PMID:19946888	PMID:19997087	PMID:21427722	PMID:22315426	PMID:23533145	PMID:24105792
PMID:26280536	PMID:32139900	PMID:35545948	PMID:37066940

Genomics

Comparative Map Data

Wwp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	52,256,563 - 52,380,967 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	52,256,551 - 52,382,415 (+)	Ensembl				GRCr8
mRatBN7.2	19	35,346,826 - 35,471,251 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	35,346,814 - 35,472,699 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	42,162,280 - 42,286,677 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	42,815,647 - 42,940,037 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	45,124,358 - 45,244,666 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	39,543,246 - 39,614,624 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	39,543,242 - 39,614,625 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	49,207,226 - 49,255,597 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	19	50,405,611 - 50,476,926 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	37,302,346 - 37,428,377 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	34,768,243 - 34,893,337 (+)	NCBI		Celera
RGSC_v3.1	19	37,307,245 - 37,433,162 (+)	NCBI
Cytogenetic Map	19	q12	NCBI

WWP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	69,762,332 - 69,941,739 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	69,762,281 - 69,944,553 (+)	Ensembl			hg38	GRCh38
GRCh37	16	69,796,235 - 69,975,642 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	68,353,775 - 68,533,144 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	16	54,311,024 - 54,490,955 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	55,674,737 - 55,853,946 (+)	NCBI		HuRef
CHM1_1	16	71,204,171 - 71,383,517 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	75,564,847 - 75,744,318 (+)	NCBI		T2T-CHM13v2.0

Wwp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	108,162,966 - 108,285,922 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	108,162,997 - 108,285,227 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	107,436,334 - 107,559,290 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	107,436,365 - 107,558,595 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	109,960,298 - 110,082,495 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	110,325,527 - 110,447,724 (+)	NCBI		MGSCv36	mm8
Celera	8	111,667,038 - 111,789,943 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	54.15	NCBI

Wwp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	6,851,307 - 6,967,261 (-)	Ensembl
ChiLan1.0	NW_004955484	6,853,820 - 6,967,261 (-)	NCBI	ChiLan1.0	ChiLan1.0

WWP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	79,311,991 - 79,492,082 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	85,224,164 - 85,404,265 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	50,142,402 - 50,322,052 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	69,525,246 - 69,703,831 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	69,525,246 - 69,703,831 (+)	Ensembl			panPan2	panpan1.1

WWP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	79,806,424 - 79,926,846 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	79,806,425 - 79,957,830 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	79,795,391 - 79,915,753 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	80,236,686 - 80,381,748 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	80,236,697 - 80,381,709 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	80,064,823 - 80,185,270 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	79,753,925 - 79,874,160 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	80,386,601 - 80,507,100 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Wwp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	39,644,689 - 39,753,240 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	19,828,763 - 19,942,632 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	19,835,909 - 19,944,426 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WWP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	17,066,799 - 17,227,926 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	17,068,780 - 17,227,982 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

WWP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	57,465,559 - 57,676,224 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	57,465,441 - 57,644,461 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	20,195,261 - 20,373,652 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wwp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	16,501,324 - 16,654,691 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624746	16,501,320 - 16,661,423 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Wwp2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	27,181,027 - 27,286,659 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Wwp2
1242 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	142
Count of miRNA genes:	107
Interacting mature miRNAs:	114
Transcripts:	ENSRNOT00000018837
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	46226778	74246245	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	44385134	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	40727092	54856850	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	40727092	54856850	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	41722546	74246245	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	40727092	54856850	Rat

Markers in Region

D19Rat33

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,368,681 - 35,368,908 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	38,363,833 - 38,364,059	NCBI	Rnor6.0
Rnor_5.0	19	49,233,526 - 49,233,752	UniSTS	Rnor5.0
RGSC_v3.4	19	37,324,190 - 37,324,417	RGD	RGSC3.4
RGSC_v3.4	19	37,324,191 - 37,324,417	UniSTS	RGSC3.4
Celera	19	34,790,088 - 34,790,314	UniSTS
RGSC_v3.1	19	37,329,071 - 37,329,298	RGD
RH 3.4 Map	19	294.9	RGD
RH 3.4 Map	19	294.9	UniSTS
RH 2.0 Map	19	433.1	RGD
FHH x ACI Map	19	29.1799	RGD
Cytogenetic Map	19	q12	UniSTS

RH143869

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,450,062 - 35,450,297 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	39,593,437 - 39,593,671	NCBI	Rnor6.0
Rnor_5.0	19	50,455,739 - 50,455,973	UniSTS	Rnor5.0
RGSC_v3.4	19	37,407,190 - 37,407,424	UniSTS	RGSC3.4
Celera	19	34,872,148 - 34,872,382	UniSTS
RH 3.4 Map	19	291.5	UniSTS
Cytogenetic Map	19	q12	UniSTS

RH129308

Rat Assembly	Chr	Position (strand)	Source
Celera	19	34,813,948 - 34,814,132	UniSTS
Celera	9	38,029,562 - 38,029,746	UniSTS
Cytogenetic Map	9	q21	UniSTS
Cytogenetic Map	19	q12	UniSTS

RH142865

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,347,281 - 35,347,445 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	38,385,285 - 38,385,448	NCBI	Rnor6.0
Rnor_5.0	19	49,254,978 - 49,255,141	UniSTS	Rnor5.0
RGSC_v3.4	19	37,302,802 - 37,302,965	UniSTS	RGSC3.4
Celera	19	34,768,699 - 34,768,862	UniSTS
RH 3.4 Map	19	294.9	UniSTS
Cytogenetic Map	19	q12	UniSTS

RH143578

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,385,297 - 35,385,486 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	38,347,258 - 38,347,446	NCBI	Rnor6.0
Rnor_5.0	19	49,216,951 - 49,217,139	UniSTS	Rnor5.0
RGSC_v3.4	19	37,340,804 - 37,340,992	UniSTS	RGSC3.4
Celera	19	34,807,499 - 34,807,687	UniSTS
RH 3.4 Map	19	291.1	UniSTS
Cytogenetic Map	19	q12	UniSTS

MARC_17527-17528:1016478546:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	35,466,791 - 35,468,141 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	39,610,166 - 39,611,515	NCBI	Rnor6.0
Rnor_5.0	19	50,472,468 - 50,473,817	UniSTS	Rnor5.0
RGSC_v3.4	19	37,423,919 - 37,425,268	UniSTS	RGSC3.4
Celera	19	34,888,879 - 34,890,228	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JN712752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018837 ⟹ ENSRNOP00000018837

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	52,256,551 - 52,382,415 (+)	Ensembl
mRatBN7.2 Ensembl	19	35,346,814 - 35,472,699 (+)	Ensembl
Rnor_6.0 Ensembl	19	39,543,242 - 39,614,625 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092177 ⟹ ENSRNOP00000079789

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	52,256,561 - 52,292,886 (+)	Ensembl
mRatBN7.2 Ensembl	19	35,346,814 - 35,383,575 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108430 ⟹ ENSRNOP00000090359

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	52,256,551 - 52,382,415 (+)	Ensembl
mRatBN7.2 Ensembl	19	35,346,814 - 35,472,699 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139816 ⟹ ENSRNOP00000108994

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	52,256,578 - 52,382,415 (+)	Ensembl

RefSeq Acc Id:

NM_001106184 ⟹ NP_001099654

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	52,256,563 - 52,380,966 (+)	NCBI
mRatBN7.2	19	35,346,826 - 35,471,250 (+)	NCBI
Rnor_6.0	19	39,543,246 - 39,614,624 (+)	NCBI
Rnor_5.0	19	49,207,226 - 49,255,597 (-)	NCBI
Rnor_5.0	19	50,405,611 - 50,476,926 (+)	NCBI
RGSC_v3.4	19	37,302,346 - 37,428,377 (+)	RGD
Celera	19	34,768,243 - 34,893,337 (+)	RGD

Sequence:

show sequence

CTGAGTGCGGGCGCTGGAAGGCGGAAGTGGAGCGGAGTTAGGCGCCGCTGGTGTGGCCGCGGCA
GTTCCATTGTGATGATATGGCGTCTGCCAGCTCCAGCCGGGCGGGGGTGGCCCTGCCTTTTGAG
AAGTCCCAGCTTACTCTGAGAGTGGTGTCAGCAAAGCCCAAGGTGCACAACCGCCAGCCCAGAA
TCAACTCCTATGTGGAGGTGGCAGTGGATGGACTCCCCAGTGAGACCAAGAAGACTGGGAAGCG
CATCGGGAGCTCTGAGCTTCTCTGGAATGAAGTCATCGTTCTGAATGTTACAGCCCAGAGTCAT
TTAGATTTGAAGGTCTGGAGCTGTCATACCTTGAGGAATGAACTACTGGGCACTGCCTCTGTCA
ACCTCTCCAATGTCCTGAAGAACAATGGCGGCAAAATGGAGAACACGCAACTGACCCTGAACCT
GCAGACAGAGAACAAAGGCAGCGTTGTCTCAGGAGGAGAGCTGACAATTTTCCTGGATGGGCCA
ACTGTTGATCTGGGCAGTGTGCCTAATGGCAGTGCAGTGACAGACGGATCACAACCACCTTCAA
GAGAATCCAGTGGGACTGCTCTAGCTCCAGAGACCCGGCACCAGCCCCCCAGTACAAACTGCTT
TGGTGGCAGATCCCGGACGCACAGACATTCAGGTGGCTCAGCCAGGACAGCCACAGCAACTGGC
GAACAAAGTCCTGGTGCTAGGAACCGCCACCGCCAACCTGTGAAGAACCCCAGCAGCAGTGGCT
TAGCCAATGGCACAGTGAGTGAGGAACCTACGACAGCCAGCGATCCTGAAGAACTGTCGGTTGT
TGGTGTGACATCGCCGCCTGCTGCAGCCTCCAGTGTGTCCCCAAATCCCAACACGACATCTCTC
CCTGCACCGTCCACACCAGCTGAGGGAGAAGAGCCCAGCACTTCCGGGACACAGCAGCTCCCTG
CTGCTGCCCAGGCCCCTGATGCTCTTCCTGCTGGATGGGAACAGAGACAGCTGCCCAATGGGCG
TGTCTATTATGTTGATCACAATACCAAGACCACCACCTGGGAGCGGCCTCTTCCTCCAGGATGG
GAAAAGCGCACAGACCCCCGAGGGAGGTTTTACTACGTGGACCACAACACCCGGACAACCACCT
GGCAGCGCCCGACTGCTGAGTACGTGCGGAACTATGAGCAGTGGCAGTCACAGCGGAATCAGCT
GCAGGGGGCCATGCAGCACTTCAGCCAAAGATTCCTCTACCAGTCTTCGAGTGCTTCGACTGAC
CATGATCCCTTGGGCCCCCTCCCGCCTGGCTGGGAGAAGAGGCAGGACAATGGCCGGGTGTATT
ACGTGAACCACAACACACGCACTACCCAATGGGAGGACCCGCGGACGCAGGGAATGATACAGGA
GCCAGCCCTGCCCCCAGGGTGGGAGATGAAGTACACCAGCGAGGGCGTGCGGTACTTTGTGGAT
CACAACACCCGCACTACCACCTTTAAGGATCCTCGCCCAGGGTTCGAGTCAGGGACAAAGCAGG
GCTCGCCTGGTGCCTATGAGCGAAGTTTCCGGTGGAAGTATCACCAGTTCCGCTTCCTCTGCCA
CTCAAATGCCCTACCCAGCCACGTGAAGATCAGCGTTTCCAGGCAGACTCTCTTTGAGGATTCT
TTCCAACAGATTATGAACATGAAACCTTACGACCTGCGCCGCCGGCTCTACATCATCATGCGTG
GTGAGGAGGGCCTGGACTACGGCGGCATCGCCAGAGAGTGGTTTTTCCTCCTGTCCCATGAGGT
GCTCAACCCTATGTACTGTTTGTTTGAATATGCTGGGAAGAACAATTACTGCCTGCAGATCAAC
CCGGCCTCTTCCATCAACCCTGACCACCTCACCTACTTCCGCTTTATCGGCAGATTCATCGCCA
TGGCTCTGTACCATGGAAAGTTCATCGACACAGGCTTCACCCTCCCTTTCTACAAGCGGATGCT
CAACAAGAGACCAACTCTCAGGGACCTGGAGTCTATTGACCCTGAGTTTTACAACTCCATTATC
TGGATCAAAGAGAACAACCTGGATGAGTGTGGCCTGGAGCTGTTCTTCATCCAGGACATGGAGA
TCCTGGGCAAGGTGACAACCCATGAACTGAAGGAAGGCGGAGAGAACATCCGAGTTACTGAGGA
GAACAAGGAGGAGTATATCATGCTGCTGACTGACTGGCGATTCACCCGAGGTGTGGAAGAGCAG
ACCAAAGCCTTCCTGGATGGCTTCAATGAGGTGGCCCCTCTGGAGTGGTTGAGATATTTTGATG
AAAAAGAGCTGGAGCTCATGCTGTGTGGCATGCAGGAGATTGACATGAGTGACTGGCAGAAGAA
CGCCATCTATCGGCACTACACCAAGAGCAGCAAGCAGATCCAGTGGTTCTGGCAGGTTGTGAAG
GAGATGGACAATGAGAAGAGGATCCGGCTACTGCAGTTTGTCACGGGAACCTGCCGCCTGCCTG
TTGGGGGCTTTGCTGAGCTCATTGGGAGCAATGGACCCCAGAAGTTCTGCATTGACAGAGTTGG
CAAGGAAACCTGGCTGCCTAGGAGCCATACATGCTTCAACCGCCTGGATCTGCCTCCCTACAAG
AGCTACGAGCAGCTGAAAGAGAAGCTGCTGTATGCCATCGAGGAGACTGAGGGTTTTGGACAGG
AGTAGCTGAGGCTGCCCCTCTCACACCCTCCAGCACATGTAGTCCTGAGTCCTGCCTGCCTGAG
AGGCCACCGGCTGCACAGCCCTCGAGAGGCCCCTTTGGATAGTGGCCCTGCACGAGACTGTGCT
TTGATCATGTTGGTGACTGAAGAGGCCTTGGGGACCCTTTCTTCTCTCTGATGATGGCAGTCTG
GAATAAAGCCCTGTCACCTTTGACTCC

hide sequence

RefSeq Acc Id:

XM_039097630 ⟹ XP_038953558

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	52,365,048 - 52,380,967 (+)	NCBI
mRatBN7.2	19	35,457,424 - 35,471,251 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099654	(Get FASTA)	NCBI Sequence Viewer
	XP_038953558	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68152	(Get FASTA)	NCBI Sequence Viewer
	AFK29261	(Get FASTA)	NCBI Sequence Viewer
	EDL92480	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018837
	ENSRNOP00000018837.7
	ENSRNOP00000079789.1
	ENSRNOP00000090359.1
	ENSRNOP00000108994.1

RefSeq Acc Id:

NP_001099654 ⟸ NM_001106184

- UniProtKB:

B4F767 (UniProtKB/TrEMBL), F7EYF1 (UniProtKB/TrEMBL), A0A9K3Y6T9 (UniProtKB/TrEMBL), A0A8I6ADN0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASASSSRAGVALPFEKSQLTLRVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSE
LLWNEVIVLNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENTQLTLNLQTENK
GSVVSGGELTIFLDGPTVDLGSVPNGSAVTDGSQPPSRESSGTALAPETRHQPPSTNCFGGRSR
THRHSGGSARTATATGEQSPGARNRHRQPVKNPSSSGLANGTVSEEPTTASDPEELSVVGVTSP
PAAASSVSPNPNTTSLPAPSTPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRQLPNGRVYYVD
HNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQ
HFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPP
GWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYERSFRWKYHQFRFLCHSNALP
SHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY
CLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPT
LRDLESIDPEFYNSIIWIKENNLDECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEY
IMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRH
YTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWL
PRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE

hide sequence

Ensembl Acc Id:

ENSRNOP00000018837 ⟸ ENSRNOT00000018837

RefSeq Acc Id:	XP_038953558 ⟸ XM_039097630
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000079789 ⟸ ENSRNOT00000092177

Ensembl Acc Id:

ENSRNOP00000090359 ⟸ ENSRNOT00000108430

Ensembl Acc Id:

ENSRNOP00000108994 ⟸ ENSRNOT00000139816

Protein Domains

C2 HECT WW

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310091	AgrOrtholog
BioCyc Gene	G2FUF-5757	BioCyc
Ensembl Genes	ENSRNOG00000012937	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018837	ENTREZGENE
	ENSRNOT00000018837.9	UniProtKB/TrEMBL
	ENSRNOT00000092177.3	UniProtKB/TrEMBL
	ENSRNOT00000108430.2	UniProtKB/TrEMBL
	ENSRNOT00000139816.1	UniProtKB/TrEMBL
Gene3D-CATH	2.20.70.10	UniProtKB/TrEMBL
	2.60.40.150	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domain	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domain	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domains	UniProtKB/TrEMBL
InterPro	C2_Ca-dep	UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/TrEMBL
	E3_ub_ligase_SMURF1	UniProtKB/TrEMBL
	E3_ubiq-protein_ligase	UniProtKB/TrEMBL
	HECT	UniProtKB/TrEMBL
	Hect_E3_ubiquitin_ligase	UniProtKB/TrEMBL
	WW_dom_sf	UniProtKB/TrEMBL
	WW_Rsp5_WWP	UniProtKB/TrEMBL
KEGG Report	rno:291999	UniProtKB/TrEMBL
NCBI Gene	291999	ENTREZGENE
PANTHER	HECT DOMAIN UBIQUITIN-PROTEIN LIGASE	UniProtKB/TrEMBL
	NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2	UniProtKB/TrEMBL
Pfam	HECT	UniProtKB/TrEMBL
	PF00168	UniProtKB/TrEMBL
	PF00397	UniProtKB/TrEMBL
PhenoGen	Wwp2	PhenoGen
PIRSF	E3_ub_ligase_SMURF1	UniProtKB/TrEMBL
PROSITE	HECT	UniProtKB/TrEMBL
	PS50004	UniProtKB/TrEMBL
	WW_DOMAIN_1	UniProtKB/TrEMBL
	WW_DOMAIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012937	RatGTEx
SMART	HECTc	UniProtKB/TrEMBL
	SM00239	UniProtKB/TrEMBL
	SM00456	UniProtKB/TrEMBL
Superfamily-SCOP	HECT	UniProtKB/TrEMBL
	SSF49562	UniProtKB/TrEMBL
	WW_Rsp5_WWP	UniProtKB/TrEMBL
UniProt	A0A8I5ZP91_RAT	UniProtKB/TrEMBL
	A0A8I6ADN0	ENTREZGENE, UniProtKB/TrEMBL
	A0A9K3Y6T9	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LVG9_RAT	UniProtKB/TrEMBL
	B4F767	ENTREZGENE, UniProtKB/TrEMBL
	F7EYF1	ENTREZGENE
UniProt Secondary	F7EYF1	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Wwp2	WW domain containing E3 ubiquitin protein ligase 2	LOC103690129	NEDD4-like E3 ubiquitin-protein ligase WWP2	Data merged from RGD:9466589	737654	PROVISIONAL
2014-08-25	LOC103690129	NEDD4-like E3 ubiquitin-protein ligase WWP2			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-04-30	Wwp2	WW domain containing E3 ubiquitin protein ligase 2	Wwp2_predicted	WW domain containing E3 ubiquitin protein ligase 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Wwp2_predicted	WW domain containing E3 ubiquitin protein ligase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)