WWP2 (WW domain containing E3 ubiquitin protein ligase 2) - Rat Genome Database

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Gene: WWP2 (WW domain containing E3 ubiquitin protein ligase 2) Canis lupus familiaris
Analyze
Symbol: WWP2
Name: WW domain containing E3 ubiquitin protein ligase 2
RGD ID: 12136881
Description: ENCODES a protein that exhibits ligase activity (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); transferase activity (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); protein ubiquitination (ortholog); transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); Knee Osteoarthritis (ortholog); spondyloepiphyseal dysplasia Nishimura type (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NEDD4-like E3 ubiquitin-protein ligase WWP2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,806,424 - 79,926,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl579,806,425 - 79,957,830 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha579,795,391 - 79,915,753 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0580,236,686 - 80,381,748 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,236,697 - 80,381,709 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,064,823 - 80,185,270 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0579,753,925 - 79,874,160 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0580,386,601 - 80,507,100 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WWP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,806,424 - 79,926,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl579,806,425 - 79,957,830 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha579,795,391 - 79,915,753 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0580,236,686 - 80,381,748 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,236,697 - 80,381,709 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,064,823 - 80,185,270 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0579,753,925 - 79,874,160 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0580,386,601 - 80,507,100 (-)NCBIUU_Cfam_GSD_1.0
WWP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,762,332 - 69,941,739 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,762,328 - 69,941,741 (+)EnsemblGRCh38hg38GRCh38
GRCh371669,796,235 - 69,975,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,353,775 - 68,533,144 (+)NCBINCBI36Build 36hg18NCBI36
Celera1654,311,024 - 54,490,955 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1655,674,737 - 55,853,946 (+)NCBIHuRef
CHM1_11671,204,171 - 71,383,517 (+)NCBICHM1_1
T2T-CHM13v2.01675,564,847 - 75,744,318 (+)NCBIT2T-CHM13v2.0
Wwp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398108,162,966 - 108,285,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8108,162,997 - 108,285,227 (+)EnsemblGRCm39 Ensembl
GRCm388107,436,334 - 107,559,290 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,436,365 - 107,558,595 (+)EnsemblGRCm38mm10GRCm38
MGSCv378109,960,298 - 110,082,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368110,325,527 - 110,447,724 (+)NCBIMGSCv36mm8
Celera8111,667,038 - 111,789,943 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map854.15NCBI
Wwp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,256,563 - 52,380,967 (+)NCBIGRCr8
mRatBN7.21935,346,826 - 35,471,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1935,346,814 - 35,472,699 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1942,162,280 - 42,286,677 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,815,647 - 42,940,037 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01945,124,358 - 45,244,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01939,543,246 - 39,614,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1939,543,242 - 39,614,625 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01950,405,611 - 50,476,926 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01949,207,226 - 49,255,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41937,302,346 - 37,428,377 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11937,307,245 - 37,433,162 (+)NCBI
Celera1934,768,243 - 34,893,337 (+)NCBICelera
Cytogenetic Map19q12NCBI
Wwp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554846,851,307 - 6,967,261 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554846,853,820 - 6,967,261 (-)NCBIChiLan1.0ChiLan1.0
WWP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21879,311,991 - 79,492,082 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11685,224,164 - 85,404,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01650,142,402 - 50,322,052 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11669,525,246 - 69,703,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1669,525,246 - 69,703,831 (+)Ensemblpanpan1.1panPan2
Wwp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934939,644,689 - 39,753,240 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647519,828,763 - 19,942,632 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647519,835,909 - 19,944,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,066,799 - 17,227,926 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,068,780 - 17,227,982 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
WWP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1557,465,559 - 57,676,224 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl557,465,441 - 57,644,461 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604720,195,261 - 20,373,652 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wwp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474616,501,324 - 16,654,691 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474616,501,320 - 16,661,423 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WWP2
1026 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 13 1 6 7 8 10 6
Low 1 5 9 6 5 6 6 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000032249   ⟹   ENSCAFP00000030034
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl579,808,296 - 79,926,834 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000059491   ⟹   ENSCAFP00000062945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl579,807,679 - 79,957,830 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000061404   ⟹   ENSCAFP00000045372
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl579,806,425 - 79,956,394 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000073829   ⟹   ENSCAFP00000050324
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl579,806,425 - 79,951,175 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000089023   ⟹   ENSCAFP00000050099
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl579,806,425 - 79,926,834 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000092527   ⟹   ENSCAFP00000065289
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl579,807,679 - 79,926,846 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845015613   ⟹   ENSCAFP00845012134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl580,236,697 - 80,381,672 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845015697   ⟹   ENSCAFP00845012208
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl580,237,439 - 80,381,709 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845015786   ⟹   ENSCAFP00845012277
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl580,237,946 - 80,357,259 (-)Ensembl
RefSeq Acc Id: NM_001284474   ⟹   NP_001271403
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1579,806,425 - 79,926,834 (-)NCBI
Dog10K_Boxer_Tasha579,795,391 - 79,915,753 (-)NCBI
ROS_Cfam_1.0580,236,687 - 80,357,247 (-)NCBI
UMICH_Zoey_3.1580,064,823 - 80,185,270 (-)NCBI
UNSW_CanFamBas_1.0579,753,925 - 79,874,160 (-)NCBI
UU_Cfam_GSD_1.0580,386,601 - 80,507,100 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038664121   ⟹   XP_038520049
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0580,236,686 - 80,381,748 (-)NCBI
RefSeq Acc Id: XM_038664122   ⟹   XP_038520050
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0580,236,686 - 80,381,691 (-)NCBI
RefSeq Acc Id: XM_038664123   ⟹   XP_038520051
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0580,236,686 - 80,348,627 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001271403   ⟸   NM_001284474
- UniProtKB: I3RSH9 (UniProtKB/TrEMBL),   A0A8C0L7Y5 (UniProtKB/TrEMBL),   A0A8C0NDB3 (UniProtKB/TrEMBL),   A0A8P0NVN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000062945   ⟸   ENSCAFT00000059491
RefSeq Acc Id: ENSCAFP00000065289   ⟸   ENSCAFT00000092527
RefSeq Acc Id: ENSCAFP00000050324   ⟸   ENSCAFT00000073829
RefSeq Acc Id: ENSCAFP00000050099   ⟸   ENSCAFT00000089023
RefSeq Acc Id: ENSCAFP00000045372   ⟸   ENSCAFT00000061404
RefSeq Acc Id: ENSCAFP00000030034   ⟸   ENSCAFT00000032249
RefSeq Acc Id: XP_038520049   ⟸   XM_038664121
- Peptide Label: isoform X1
- UniProtKB: A0A8P0NVN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038520050   ⟸   XM_038664122
- Peptide Label: isoform X1
- UniProtKB: A0A8P0NVN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038520051   ⟸   XM_038664123
- Peptide Label: isoform X2
- UniProtKB: A0A8I3N5D9 (UniProtKB/TrEMBL),   A0A8P0PDV7 (UniProtKB/TrEMBL),   A0A8P0NVN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845012277   ⟸   ENSCAFT00845015786
RefSeq Acc Id: ENSCAFP00845012208   ⟸   ENSCAFT00845015697
RefSeq Acc Id: ENSCAFP00845012134   ⟸   ENSCAFT00845015613
Protein Domains
C2   HECT   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020247 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011840 UniProtKB/TrEMBL
  ENSCAFG00040019865 UniProtKB/TrEMBL
  ENSCAFG00845008853 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000061404.2 UniProtKB/TrEMBL
  ENSCAFT00000073829.2 UniProtKB/TrEMBL
  ENSCAFT00000089023.2 UniProtKB/TrEMBL
  ENSCAFT00000092527.2 UniProtKB/TrEMBL
  ENSCAFT00030022032.1 UniProtKB/TrEMBL
  ENSCAFT00040036797.1 UniProtKB/TrEMBL
  ENSCAFT00845015613 ENTREZGENE
  ENSCAFT00845015613.1 UniProtKB/TrEMBL
  ENSCAFT00845015697.1 UniProtKB/TrEMBL
  ENSCAFT00845015786 ENTREZGENE
  ENSCAFT00845015786.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:479672 UniProtKB/TrEMBL
NCBI Gene WWP2 ENTREZGENE
PANTHER HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
  NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2 UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A8C0L7Y5 ENTREZGENE
  A0A8C0NDB3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T5M3_CANLF UniProtKB/TrEMBL
  A0A8I3N0R1_CANLF UniProtKB/TrEMBL
  A0A8I3N5D9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NVN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P055_CANLF UniProtKB/TrEMBL
  A0A8P0PDV7 ENTREZGENE, UniProtKB/TrEMBL
  I3RSH9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48444 ENTREZGENE