Calml5 (calmodulin-like 5) - Rat Genome Database

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Gene: Calml5 (calmodulin-like 5) Rattus norvegicus
Analyze
Symbol: Calml5
Name: calmodulin-like 5
RGD ID: 1310047
Description: Orthologous to human CALML5 (calmodulin like 5); PARTICIPATES IN Alzheimer's disease pathway; calcium/calcium-mediated signaling pathway; glioma pathway; INTERACTS WITH acrylamide; bisphenol A; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Calm4; calmodulin 4; calmodulin-4; calmodulin-like protein 5; LOC364774
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,304,326 - 71,305,245 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1771,304,326 - 71,305,245 (-)EnsemblGRCr8
mRatBN7.21766,394,433 - 66,395,352 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1769,875,510 - 69,876,429 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,704,319 - 73,705,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,747,336 - 67,748,255 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,044,956 - 70,045,886 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01771,748,514 - 71,749,406 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,567,314 - 77,571,711 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,900,164 - 65,901,094 (-)NCBICelera
RGSC_v3.11777,574,768 - 77,578,923 (-)NCBI
Cytogenetic Map17q12.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Nättinen J, etal., Ocul Surf. 2018 Jan;16(1):84-92. doi: 10.1016/j.jtos.2017.09.003. Epub 2017 Sep 14.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Immunostaining of calmodulin and aluminium in Alzheimer's disease-affected brains. Solomon B, etal., Brain Res Bull. 2001 May 15;55(2):253-6.
Additional References at PubMed
PMID:12970338   PMID:20439489   PMID:21873635   PMID:23376485  


Genomics

Comparative Map Data
Calml5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,304,326 - 71,305,245 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1771,304,326 - 71,305,245 (-)EnsemblGRCr8
mRatBN7.21766,394,433 - 66,395,352 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1769,875,510 - 69,876,429 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,704,319 - 73,705,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,747,336 - 67,748,255 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01770,044,956 - 70,045,886 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01771,748,514 - 71,749,406 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,567,314 - 77,571,711 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,900,164 - 65,901,094 (-)NCBICelera
RGSC_v3.11777,574,768 - 77,578,923 (-)NCBI
Cytogenetic Map17q12.2NCBI
CALML5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,498,697 - 5,499,570 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,498,697 - 5,499,570 (-)Ensemblhg38GRCh38
GRCh37105,540,660 - 5,541,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,530,660 - 5,531,510 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34105,530,660 - 5,531,510NCBI
Celera105,471,713 - 5,472,588 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,470,562 - 5,471,437 (-)NCBIHuRef
CHM1_1105,540,560 - 5,541,435 (-)NCBICHM1_1
T2T-CHM13v2.0105,501,934 - 5,502,807 (-)NCBIT2T-CHM13v2.0
Calm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39133,887,757 - 3,888,671 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl133,887,757 - 3,888,673 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38133,837,757 - 3,838,671 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl133,837,757 - 3,838,673 (+)Ensemblmm10GRCm38
MGSCv37133,837,003 - 3,837,917 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36133,837,003 - 3,837,917 (+)NCBIMGSCv36mm8
MGSCv36133,642,313 - 3,643,227 (+)NCBIMGSCv36mm8
Celera133,820,901 - 3,821,772 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.15NCBI
CALML5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2818,051,489 - 18,052,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11018,056,812 - 18,057,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,539,954 - 5,540,829 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,525,980 - 5,526,849 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,526,283 - 5,526,723 (-)EnsemblpanPan2panpan1.1
CALML5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,431,088 - 30,431,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,429,338 - 30,431,948 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha227,460,882 - 27,461,739 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0230,812,107 - 30,812,964 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1227,908,372 - 27,909,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,745,562 - 28,746,419 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,463,256 - 29,464,113 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Calml5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,834,100 - 32,835,035 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364848,999,323 - 9,000,224 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALML5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,406,633 - 65,407,082 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11065,405,928 - 65,407,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,775,723 - 71,778,067 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALML5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.195,609,208 - 5,610,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl95,609,912 - 5,610,352 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605110,865,499 - 10,866,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Calml5
10 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat

Markers in Region
RH134762  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21766,394,635 - 66,394,823 (+)MAPPERmRatBN7.2
Rnor_6.01770,045,159 - 70,045,346NCBIRnor6.0
Rnor_5.01771,748,717 - 71,748,904UniSTSRnor5.0
RGSC_v3.41777,567,517 - 77,567,704UniSTSRGSC3.4
Celera1765,900,367 - 65,900,554UniSTS
RH 3.4 Map17635.5UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
5 1 5 11 4 24 13 4 8 6 10 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000155022   ⟹   ENSRNOP00000105090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1771,304,326 - 71,305,245 (-)Ensembl
RefSeq Acc Id: NM_001400752   ⟹   NP_001387681
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,304,326 - 71,305,245 (-)NCBI
mRatBN7.21766,394,433 - 66,395,352 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001387681 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000105090
  ENSRNOP00000105090.1
RefSeq Acc Id: NP_001387681   ⟸   NM_001400752
- UniProtKB: A6JLQ4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105090   ⟸   ENSRNOT00000155022
Protein Domains
EF-hand

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310047 AgrOrtholog
BioCyc Gene G2FUF-8820 BioCyc
Ensembl Genes ENSRNOG00000091280 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000155022 ENTREZGENE
  ENSRNOT00000155022.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro CALM/Myosin/TropC-like UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene 364774 ENTREZGENE
PANTHER EF-HAND SUPERFAMILY PROTEIN UniProtKB/TrEMBL
  MYOSIN LIGHT CHAIN 1, 3 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
PhenoGen Calml5 PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000091280 RatGTEx
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP EF-hand UniProtKB/TrEMBL
UniProt A0ABK0LHY7_RAT UniProtKB/TrEMBL
  A6JLQ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-14 Calml5  calmodulin-like 5  Calm4  calmodulin 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Calm4  calmodulin 4   Calm4_predicted  calmodulin 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Calm4_predicted  calmodulin 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED