Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sp5 | Rat | 1,2-dichloroethane | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of SP5 mRNA | CTD | PMID:28960355 | Sp5 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of SP5 mRNA | CTD | PMID:22206623 | Sp5 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of SP5 mRNA | CTD | PMID:32145629 | Sp5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sp5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SP5 mRNA | CTD | PMID:21570461|PMID:28922406 | Sp5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SP5 mRNA | CTD | PMID:20106945|PMID:21632981|PMID:26238291 | Sp5 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | bisphenol S results in increased expression of SP5 mRNA | CTD | PMID:30951980 | Sp5 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Sp5 (Mus musculus) | 6480464 | bisphenol S affects the methylation of SP5 gene | CTD | PMID:31683443 | Sp5 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | Fenretinide results in increased expression of SP5 mRNA | CTD | PMID:28973697 | Sp5 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SP5 mRNA | CTD | PMID:31881176 | Sp5 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of SP5 mRNA | CTD | PMID:28959563 | Sp5 | Rat | all-trans-retinoic acid | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SP5 mRNA | CTD | PMID:33167477 | Sp5 | Rat | aristolochic acid A | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SP5 mRNA | CTD | PMID:33212167 | Sp5 | Rat | azathioprine | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Azathioprine results in decreased expression of SP5 mRNA | CTD | PMID:22623647 | Sp5 | Rat | benzo[a]pyrene | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SP5 mRNA | CTD | PMID:21569818 | Sp5 | Rat | benzo[a]pyrene | increases methylation | ISO | SP5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SP5 5' UTR | CTD | PMID:27901495 | Sp5 | Rat | benzo[a]pyrene | affects methylation | ISO | SP5 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SP5 3' UTR | CTD | PMID:27901495 | Sp5 | Rat | benzo[a]pyrene | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SP5 mRNA | CTD | PMID:32417428 | Sp5 | Rat | benzo[a]pyrene | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SP5 mRNA | CTD | PMID:20106945|PMID:21632981|PMID:22316170|PMID:26238291 | Sp5 | Rat | benzo[b]fluoranthene | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of SP5 mRNA | CTD | PMID:26377693 | Sp5 | Rat | Benzo[ghi]perylene | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | 1,12-benzoperylene results in increased expression of SP5 mRNA | CTD | PMID:26377693 | Sp5 | Rat | Benzo[k]fluoranthene | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | benzo(k)fluoranthene results in increased expression of SP5 mRNA | CTD | PMID:26377693 | Sp5 | Rat | beta-lapachone | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of SP5 mRNA | CTD | PMID:38218311 | Sp5 | Rat | bilirubin IXalpha | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Bilirubin results in decreased expression of SP5 mRNA | CTD | PMID:20196124 | Sp5 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SP5 mRNA | CTD | PMID:31163220 | Sp5 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SP5 mRNA | CTD | PMID:25181051 | Sp5 | Rat | bisphenol A | affects expression | ISO | SP5 (Homo sapiens) | 6480464 | bisphenol A affects the expression of SP5 mRNA | CTD | PMID:30903817 | Sp5 | Rat | bisphenol A | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SP5 mRNA | CTD | PMID:30951980|PMID:32156529 | Sp5 | Rat | bisphenol F | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | bisphenol F results in increased expression of SP5 mRNA | CTD | PMID:30951980 | Sp5 | Rat | buta-1,3-diene | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | 1,3-butadiene results in decreased expression of SP5 mRNA | CTD | PMID:29038090 | Sp5 | Rat | butanal | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of SP5 mRNA | CTD | PMID:26079696 | Sp5 | Rat | butylated hydroxyanisole | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | Butylated Hydroxyanisole results in decreased expression of SP5 mRNA | CTD | PMID:28927898 | Sp5 | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of SP5 mRNA | CTD | PMID:19167457 | Sp5 | Rat | caffeine | decreases phosphorylation | ISO | SP5 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of SP5 protein | CTD | PMID:35688186 | Sp5 | Rat | carbamazepine | affects expression | ISO | SP5 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SP5 mRNA | CTD | PMID:25979313 | Sp5 | Rat | carbon nanotube | affects expression | ISO | Sp5 (Mus musculus) | 6480464 | Nanotubes, Carbon analog affects the expression of SP5 mRNA | CTD | PMID:25620056 | Sp5 | Rat | carbon nanotube | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | Nanotubes, Carbon results in decreased expression of SP5 mRNA | CTD | PMID:25620056 | Sp5 | Rat | carbon nanotube | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of SP5 mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25554681 | Sp5 | Rat | CGP 52608 | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SP5 gene] | CTD | PMID:28238834 | Sp5 | Rat | chloroprene | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | Chloroprene results in decreased expression of SP5 mRNA | CTD | PMID:23125180 | Sp5 | Rat | ciguatoxin CTX1B | affects expression | ISO | Sp5 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of SP5 mRNA | CTD | PMID:18353800 | Sp5 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of SP5 mRNA | CTD | PMID:30556269 | Sp5 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of SP5 mRNA | CTD | PMID:30556269 | Sp5 | Rat | copper(II) sulfate | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SP5 mRNA | CTD | PMID:19549813 | Sp5 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of SP5 mRNA | CTD | PMID:27523638 | Sp5 | Rat | cyclosporin A | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SP5 mRNA | CTD | PMID:20106945|PMID:25562108 | Sp5 | Rat | dexamethasone | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with Genistein] results in decreased expression of SP5 mRNA | CTD | PMID:25136773 | Sp5 | Rat | diethyl maleate | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | diethyl maleate results in decreased expression of SP5 mRNA | CTD | PMID:25270620 | Sp5 | Rat | dorsomorphin | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Sp5 | Rat | entinostat | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | entinostat results in increased expression of SP5 mRNA | CTD | PMID:26272509 | Sp5 | Rat | entinostat | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Sp5 | Rat | fluoxetine | affects expression | ISO | Sp5 (Mus musculus) | 6480464 | Fluoxetine affects the expression of SP5 mRNA | CTD | PMID:29893963 | Sp5 | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of SP5 gene | CTD | PMID:22079235 | Sp5 | Rat | genistein | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with Genistein] results in decreased expression of SP5 mRNA | CTD | PMID:25136773 | Sp5 | Rat | genistein | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | Genistein results in decreased expression of SP5 mRNA | CTD | PMID:32186404 | Sp5 | Rat | lead(0) | affects methylation | ISO | SP5 (Homo sapiens) | 6480464 | Lead affects the methylation of SP5 gene | CTD | PMID:31636367 | Sp5 | Rat | leflunomide | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | leflunomide results in increased expression of SP5 mRNA | CTD | PMID:19751817 | Sp5 | Rat | menadione | affects expression | ISO | SP5 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of SP5 mRNA | CTD | PMID:20044591 | Sp5 | Rat | mercury dibromide | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Sp5 | Rat | methylmercury chloride | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of SP5 mRNA | CTD | PMID:23179753|PMID:26272509 | Sp5 | Rat | methylmercury chloride | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SP5 mRNA | CTD | PMID:28001369 | Sp5 | Rat | methylmercury chloride | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Sp5 | Rat | methylparaben | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | methylparaben results in increased expression of SP5 mRNA | CTD | PMID:28927898 | Sp5 | Rat | Monobutylphthalate | affects expression | ISO | Sp5 (Mus musculus) | 6480464 | monobutyl phthalate affects the expression of SP5 mRNA | CTD | PMID:19162170 | Sp5 | Rat | N-nitrosodiethylamine | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Diethylnitrosamine results in decreased expression of SP5 mRNA | CTD | PMID:21527772 | Sp5 | Rat | p-chloromercuribenzoic acid | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of SP5 mRNA | CTD | PMID:26272509 | Sp5 | Rat | p-chloromercuribenzoic acid | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Sp5 | Rat | panobinostat | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Sp5 | Rat | panobinostat | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | panobinostat results in increased expression of SP5 mRNA | CTD | PMID:26272509 | Sp5 | Rat | paracetamol | affects expression | ISO | Sp5 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SP5 mRNA | CTD | PMID:17562736 | Sp5 | Rat | pentanal | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | pentanal results in increased expression of SP5 mRNA | CTD | PMID:26079696 | Sp5 | Rat | phenylmercury acetate | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of SP5 mRNA | CTD | PMID:26272509 | Sp5 | Rat | phenylmercury acetate | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Sp5 | Rat | pirinixic acid | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Sp5 | Rat | progesterone | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | Progesterone results in decreased expression of SP5 mRNA | CTD | PMID:22238285 | Sp5 | Rat | propanal | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of SP5 mRNA | CTD | PMID:26079696 | Sp5 | Rat | quercetin | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of SP5 mRNA | CTD | PMID:21632981 | Sp5 | Rat | resveratrol | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of SP5 mRNA | CTD | PMID:23557933 | Sp5 | Rat | SB 431542 | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Sp5 | Rat | silicon dioxide | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SP5 mRNA | CTD | PMID:25895662 | Sp5 | Rat | silver atom | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Silver results in decreased expression of SP5 mRNA | CTD | PMID:26014281 | Sp5 | Rat | silver(0) | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Silver results in decreased expression of SP5 mRNA | CTD | PMID:26014281 | Sp5 | Rat | sodium arsenite | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of SP5 mRNA | CTD | PMID:37682722 | Sp5 | Rat | styrene | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | Styrene results in increased expression of SP5 mRNA | CTD | PMID:28951217 | Sp5 | Rat | tetrachloroethene | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of SP5 mRNA | CTD | PMID:28973375 | Sp5 | Rat | thalidomide | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | Thalidomide results in decreased expression of SP5 mRNA | CTD | PMID:26217789 | Sp5 | Rat | thimerosal | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of SP5 mRNA | CTD | PMID:27188386 | Sp5 | Rat | titanium dioxide | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SP5 mRNA | CTD | PMID:23557971|PMID:27760801 | Sp5 | Rat | trichostatin A | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of SP5 mRNA | CTD | PMID:24935251|PMID:26272509 | Sp5 | Rat | trichostatin A | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Sp5 | Rat | trimellitic anhydride | decreases expression | ISO | Sp5 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of SP5 mRNA | CTD | PMID:19042947 | Sp5 | Rat | urethane | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Urethane results in decreased expression of SP5 mRNA | CTD | PMID:28818685 | Sp5 | Rat | valproic acid | decreases expression | ISO | SP5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SP5 mRNA | CTD | PMID:24383497 | Sp5 | Rat | valproic acid | affects expression | ISO | SP5 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SP5 mRNA | CTD | PMID:25979313 | Sp5 | Rat | valproic acid | increases expression | ISO | Sp5 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of SP5 mRNA | CTD | PMID:27693483 | Sp5 | Rat | vorinostat | multiple interactions | ISO | SP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Sp5 | Rat | vorinostat | increases expression | ISO | SP5 (Homo sapiens) | 6480464 | vorinostat results in increased expression of SP5 mRNA | CTD | PMID:26272509 | | |||||||||||||||||||||||||||||






















